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P28666

- MUG2_MOUSE

UniProt

P28666 - MUG2_MOUSE

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Protein

Murinoglobulin-2

Gene
Mug2, Mug-2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective.

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiREACT_199052. Degradation of the extracellular matrix.
REACT_210090. Rho GTPase cycle.
REACT_213857. HDL-mediated lipid transport.

Protein family/group databases

MEROPSiI39.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Murinoglobulin-2
Short name:
MuG2
Gene namesi
Name:Mug2
Synonyms:Mug-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:99836. Mug2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 By similarityAdd
BLAST
Chaini28 – 14511424Murinoglobulin-2PRO_0000000060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 86 By similarity
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi251 ↔ 276 By similarity
Disulfide bondi269 ↔ 288 By similarity
Glycosylationi294 – 2941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi313 – 3131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi461 ↔ 555 By similarity
Glycosylationi500 – 5001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi587 ↔ 773 By similarity
Disulfide bondi634 ↔ 680 By similarity
Glycosylationi749 – 7491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi776 – 7761N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi849 ↔ 885 By similarity
Glycosylationi871 – 8711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi923 ↔ 1274 By similarity
Cross-linki974 ↔ 977Isoglutamyl cysteine thioester (Cys-Gln) By similarity
Disulfide bondi1081 ↔ 1104 By similarity
Disulfide bondi1298 ↔ 1444 By similarity
Glycosylationi1401 – 14011N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Thioester bond

Proteomic databases

MaxQBiP28666.
PaxDbiP28666.
PRIDEiP28666.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiP28666.
CleanExiMM_MUG2.
GenevestigatoriP28666.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiP28666. 1 interaction.
MINTiMINT-1849506.
STRINGi10090.ENSMUSP00000080469.

Structurei

3D structure databases

ProteinModelPortaliP28666.
SMRiP28666. Positions 31-621, 733-1445.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni677 – 73458Bait regionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

eggNOGiCOG2373.
GeneTreeiENSGT00740000115177.
HOGENOMiHOG000220939.
HOVERGENiHBG000039.
InParanoidiP28666.
OMAiRTNMVII.
OrthoDBiEOG7PGDPR.
TreeFamiTF313285.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
IPR010916. TonB_box_CS.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28666-1 [UniParc]FASTAAdd to Basket

« Hide

MWKSRRAQLC LFSVLLAFLP SASSLNGDSK YMVLVPSQLY TETPEKICLH     50
LYHLNETVTV TASLVSQTGR RNLFDELVVD KDLFQCVSFI IPTLNSPDEE 100
EFLYVDIKGP THEFSKRNAV LVKNKESVVF VQTDKPVYKP GQSVKFRVVS 150
MDKTLRPLNE LLPLAYIEDP KKNRIMQWRD IKTENGLKQM SFSLAAEPIQ 200
GPYKIVVHKQ SGVKEEHSFT VMEFVLPRFN VDLKVPNAIS VNDEVLQVTV 250
CGKYTYGKPV PGQVKISICH ETEAGCKEVN SKLDNNGCST QEVNITELQS 300
KKRNYEVQLF HVNATVTEEG TGLEFNGYGT TKIERITNKL IFLKADSHFR 350
HGIPFFVKVR LVDIKGDPIP NERVFIKAQV LGYTSATTTD QHGLAKFSID 400
TAGFSGSSLH IKVNHKGKDS CYFFYCMEER YASAEHVAYA VYSLSKSYIY 450
LVKETSSILP CNQIHTVQAH FILKGDLGVL KELVFYYLVM AQGSIIQTGN 500
HTHQVEPGEA PVKGNFDLEI PVEFSMAPMA KMLIYTILPD GEVIADSVNF 550
EIEKCLRNKV DLSFSSSQSL PASQTRLQVT ASPQSLCGLR AVDQSVLLLK 600
PEDELSPSWI YNLPGMQHNK FIPSSSLSED REDCILYSSW VAEKHTDWVP 650
HGREKDVYRY VEDMDLKAFT NLKIKLPKIC FDSAPMSGPR GKFDLAFSSE 700
VSGTLQKGSS KRPQPEEPPR EDPPPKDPLA ETIRKYFPET WVWDIVTVNS 750
TGVAEVEMTV PDTITEWKAG ALCLSNDTGL GLSSVVPLQA FQPFFVEVSL 800
PYSVVRGEAF MLKATVMNYL PTSMRMSVQL EASPDFTAVP VGDDHDSYCL 850
SANGRHTSSW LVTPKSLGNV NFSVSVEAQQ SSEPCGSEVA TVPETGRKDT 900
VVKVLIVEPE GIKQEHTFNS LFCASDAEIS EKMSLVLPPT VVKDSARAHF 950
SVMGDILSSA IKNTQNLLHM PYGCGEQNMV LFAPNIYVLK YLDKTQQLTQ 1000
KIKTKALGFL RAGYQRELNY KHKDGSYSAF GDQNGEREGN TWLTAFVLKS 1050
FAQARAFIFI DESHITHAFT WLSQQQKDNG CFRSSGSLFH NDIKHPVVSK 1100
ALSCLESSWK TIEQGRNANF VYTKALMAYA FALAGNQDKR NEILKSLDEE 1150
AIKEDNSIHW ERPQKPRKSE HNLYKPQASS VEVEMNAYVV LARLTAQPAP 1200
SPEDLTLSRS TIMWLTKQQN SNGGFSSTQD TVVALDALSK YGAVTFSRRQ 1250
KTSLVTIQST GSFSQKFQVE NSNCLLLQQV PLPDIPGDYT ISVSGEGCVY 1300
AQTTLRYNMH LEKQQSAFAL RVQTVPLTCN NPKGHNSFQI SLEISYTGSR 1350
PASNMVIADV KMLSGFIPLK PTVKKLERLE HISRTEVSNN NVLLYLDQVT 1400
NQTLAFSFII QQDISVRNLQ PAIVKVYDYY ETDEVAYAEY SSPCSSDKQN 1450
V 1451
Length:1,451
Mass (Da):162,382
Last modified:June 28, 2011 - v2
Checksum:i8DB472A6C033C35D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti386 – 3861A → T in AAA73041. 1 Publication
Sequence conflicti894 – 8941E → A in AAA73041. 1 Publication
Sequence conflicti1181 – 11811V → I in AAA73041. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M65238 mRNA. Translation: AAA73041.1.
AC153582 Genomic DNA. No translation available.
AC153838 Genomic DNA. No translation available.
AC156279 Genomic DNA. No translation available.
CCDSiCCDS39619.1.
PIRiB41185.
RefSeqiNP_032672.2. NM_008646.3.
UniGeneiMm.479223.

Genome annotation databases

EnsembliENSMUST00000081777; ENSMUSP00000080469; ENSMUSG00000030131.
GeneIDi17837.
KEGGimmu:17837.
UCSCiuc009dos.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M65238 mRNA. Translation: AAA73041.1 .
AC153582 Genomic DNA. No translation available.
AC153838 Genomic DNA. No translation available.
AC156279 Genomic DNA. No translation available.
CCDSi CCDS39619.1.
PIRi B41185.
RefSeqi NP_032672.2. NM_008646.3.
UniGenei Mm.479223.

3D structure databases

ProteinModelPortali P28666.
SMRi P28666. Positions 31-621, 733-1445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P28666. 1 interaction.
MINTi MINT-1849506.
STRINGi 10090.ENSMUSP00000080469.

Protein family/group databases

MEROPSi I39.005.

Proteomic databases

MaxQBi P28666.
PaxDbi P28666.
PRIDEi P28666.

Protocols and materials databases

DNASUi 17837.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081777 ; ENSMUSP00000080469 ; ENSMUSG00000030131 .
GeneIDi 17837.
KEGGi mmu:17837.
UCSCi uc009dos.1. mouse.

Organism-specific databases

CTDi 17837.
MGIi MGI:99836. Mug2.

Phylogenomic databases

eggNOGi COG2373.
GeneTreei ENSGT00740000115177.
HOGENOMi HOG000220939.
HOVERGENi HBG000039.
InParanoidi P28666.
OMAi RTNMVII.
OrthoDBi EOG7PGDPR.
TreeFami TF313285.

Enzyme and pathway databases

Reactomei REACT_199052. Degradation of the extracellular matrix.
REACT_210090. Rho GTPase cycle.
REACT_213857. HDL-mediated lipid transport.

Miscellaneous databases

NextBioi 292555.
PROi P28666.
SOURCEi Search...

Gene expression databases

Bgeei P28666.
CleanExi MM_MUG2.
Genevestigatori P28666.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProi IPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
IPR010916. TonB_box_CS.
[Graphical view ]
Pfami PF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the murinoglobulins."
    Overbergh L., Torrekens S., van Leuven F., van den Berghe H.
    J. Biol. Chem. 266:16903-16910(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiMUG2_MOUSE
AccessioniPrimary (citable) accession number: P28666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi