Murinoglobulin-2 precursor - Mus musculus (Mouse)

Contribute

Read comments (?) or add your own

P28666 (MUG2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 100. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Murinoglobulin-2
Short name=MuG2

Gene names

Name:	Mug2
Synonyms:	Mug-2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1451 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective.
Subunit structure	Monomer.
Subcellular location	Secreted.
Tissue specificity	Plasma.
Sequence similarities	Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]

Ontologies

Keywords
Cellular component	Secreted
Domain	Bait region Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Disulfide bond Glycoprotein Thioester bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of endopeptidase activity Inferred from electronic annotation. Source: GOC
Cellular_component	extracellular space Inferred from electronic annotation. Source: InterPro
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

27

By similarity

Chain

1424

Murinoglobulin-2

PRO_0000000060

Regions

Region

58

Bait region

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Cross-link

Isoglutamyl cysteine thioester (Cys-Gln) By similarity

Experimental info

Sequence conflict

1

A → T in AAA73041. Ref.1

Sequence conflict

1

E → A in AAA73041. Ref.1

Sequence conflict

1

V → I in AAA73041. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P28666 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: 8DB472A6C033C35D
Show »

1,451

162,382

        10         20         30         40         50         60 
MWKSRRAQLC LFSVLLAFLP SASSLNGDSK YMVLVPSQLY TETPEKICLH LYHLNETVTV 

        70         80         90        100        110        120 
TASLVSQTGR RNLFDELVVD KDLFQCVSFI IPTLNSPDEE EFLYVDIKGP THEFSKRNAV 

       130        140        150        160        170        180 
LVKNKESVVF VQTDKPVYKP GQSVKFRVVS MDKTLRPLNE LLPLAYIEDP KKNRIMQWRD 

       190        200        210        220        230        240 
IKTENGLKQM SFSLAAEPIQ GPYKIVVHKQ SGVKEEHSFT VMEFVLPRFN VDLKVPNAIS 

       250        260        270        280        290        300 
VNDEVLQVTV CGKYTYGKPV PGQVKISICH ETEAGCKEVN SKLDNNGCST QEVNITELQS 

       310        320        330        340        350        360 
KKRNYEVQLF HVNATVTEEG TGLEFNGYGT TKIERITNKL IFLKADSHFR HGIPFFVKVR 

       370        380        390        400        410        420 
LVDIKGDPIP NERVFIKAQV LGYTSATTTD QHGLAKFSID TAGFSGSSLH IKVNHKGKDS 

       430        440        450        460        470        480 
CYFFYCMEER YASAEHVAYA VYSLSKSYIY LVKETSSILP CNQIHTVQAH FILKGDLGVL 

       490        500        510        520        530        540 
KELVFYYLVM AQGSIIQTGN HTHQVEPGEA PVKGNFDLEI PVEFSMAPMA KMLIYTILPD 

       550        560        570        580        590        600 
GEVIADSVNF EIEKCLRNKV DLSFSSSQSL PASQTRLQVT ASPQSLCGLR AVDQSVLLLK 

       610        620        630        640        650        660 
PEDELSPSWI YNLPGMQHNK FIPSSSLSED REDCILYSSW VAEKHTDWVP HGREKDVYRY 

       670        680        690        700        710        720 
VEDMDLKAFT NLKIKLPKIC FDSAPMSGPR GKFDLAFSSE VSGTLQKGSS KRPQPEEPPR 

       730        740        750        760        770        780 
EDPPPKDPLA ETIRKYFPET WVWDIVTVNS TGVAEVEMTV PDTITEWKAG ALCLSNDTGL 

       790        800        810        820        830        840 
GLSSVVPLQA FQPFFVEVSL PYSVVRGEAF MLKATVMNYL PTSMRMSVQL EASPDFTAVP 

       850        860        870        880        890        900 
VGDDHDSYCL SANGRHTSSW LVTPKSLGNV NFSVSVEAQQ SSEPCGSEVA TVPETGRKDT 

       910        920        930        940        950        960 
VVKVLIVEPE GIKQEHTFNS LFCASDAEIS EKMSLVLPPT VVKDSARAHF SVMGDILSSA 

       970        980        990       1000       1010       1020 
IKNTQNLLHM PYGCGEQNMV LFAPNIYVLK YLDKTQQLTQ KIKTKALGFL RAGYQRELNY 

      1030       1040       1050       1060       1070       1080 
KHKDGSYSAF GDQNGEREGN TWLTAFVLKS FAQARAFIFI DESHITHAFT WLSQQQKDNG 

      1090       1100       1110       1120       1130       1140 
CFRSSGSLFH NDIKHPVVSK ALSCLESSWK TIEQGRNANF VYTKALMAYA FALAGNQDKR 

      1150       1160       1170       1180       1190       1200 
NEILKSLDEE AIKEDNSIHW ERPQKPRKSE HNLYKPQASS VEVEMNAYVV LARLTAQPAP 

      1210       1220       1230       1240       1250       1260 
SPEDLTLSRS TIMWLTKQQN SNGGFSSTQD TVVALDALSK YGAVTFSRRQ KTSLVTIQST 

      1270       1280       1290       1300       1310       1320 
GSFSQKFQVE NSNCLLLQQV PLPDIPGDYT ISVSGEGCVY AQTTLRYNMH LEKQQSAFAL 

      1330       1340       1350       1360       1370       1380 
RVQTVPLTCN NPKGHNSFQI SLEISYTGSR PASNMVIADV KMLSGFIPLK PTVKKLERLE 

      1390       1400       1410       1420       1430       1440 
HISRTEVSNN NVLLYLDQVT NQTLAFSFII QQDISVRNLQ PAIVKVYDYY ETDEVAYAEY 

      1450 
SSPCSSDKQN V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of the murinoglobulins." Overbergh L., Torrekens S., van Leuven F., van den Berghe H. J. Biol. Chem. 266:16903-16910(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M65238 mRNA. Translation: AAA73041.1. AC153582 Genomic DNA. No translation available. AC153838 Genomic DNA. No translation available. AC156279 Genomic DNA. No translation available.
IPI	IPI00271262.
PIR	B41185.
RefSeq	NP_032672.2. NM_008646.3.
UniGene	Mm.479223.
3D structure databases
ProteinModelPortal	P28666.
SMR	P28666. Positions 31-621, 733-1445.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000080469.
Protein family/group databases
MEROPS	I39.005.
Proteomic databases
PaxDb	P28666.
PRIDE	P28666.
Protocols and materials databases
DNASU	17837.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000081777; ENSMUSP00000080469; ENSMUSG00000030131.
GeneID	17837.
KEGG	mmu:17837.
UCSC	uc009dor.1. mouse.
Organism-specific databases
CTD	17837.
MGI	MGI:99836. Mug2.
Phylogenomic databases
eggNOG	COG2373.
GeneTree	ENSGT00560000076685.
HOGENOM	HOG000220939.
HOVERGEN	HBG000039.
InParanoid	P28666.
OMA	ISICHET.
OrthoDB	EOG4H9XJN.
Gene expression databases
Bgee	P28666.
CleanEx	MM_MUG2.
Genevestigator	P28666.
GermOnline	ENSMUSG00000030131. Mus musculus.
Family and domain databases
Gene3D	2.60.40.690. 1 hit.
InterPro	IPR009048. A-macroglobulin_rcpt-bd. IPR011626. A2M_comp. IPR002890. A2M_N. IPR011625. A2M_N_2. IPR001599. Macroglobln_a2. IPR019742. MacrogloblnA2_CS. IPR019565. MacrogloblnA2_thiol-ester-bond. IPR008930. Terpenoid_cyclase/PrenylTrfase. IPR010916. TonB_box_CS. [Graphical view]
Pfam	PF00207. A2M. 1 hit. PF07678. A2M_comp. 1 hit. PF01835. A2M_N. 1 hit. PF07703. A2M_N_2. 1 hit. PF07677. A2M_recep. 1 hit. PF10569. Thiol-ester_cl. 1 hit. [Graphical view]
SUPFAM	SSF49410. AM_receptor_bind. 1 hit. SSF48239. Terp_cyc_toroid. 1 hit.
PROSITE	PS00477. ALPHA_2_MACROGLOBULIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	292555.
SOURCE	Search...

Entry information

Entry name

MUG2_MOUSE

Accession

Primary (citable) accession number: P28666

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	June 28, 2011
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents