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P28666

- MUG2_MOUSE

UniProt

P28666 - MUG2_MOUSE

Protein

Murinoglobulin-2

Gene

Mug2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective.

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_199052. Degradation of the extracellular matrix.
    REACT_210090. Rho GTPase cycle.
    REACT_213857. HDL-mediated lipid transport.

    Protein family/group databases

    MEROPSiI39.005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Murinoglobulin-2
    Short name:
    MuG2
    Gene namesi
    Name:Mug2
    Synonyms:Mug-2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:99836. Mug2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727By similarityAdd
    BLAST
    Chaini28 – 14511424Murinoglobulin-2PRO_0000000060Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi48 ↔ 86By similarity
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi251 ↔ 276By similarity
    Disulfide bondi269 ↔ 288By similarity
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi461 ↔ 555By similarity
    Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi587 ↔ 773By similarity
    Disulfide bondi634 ↔ 680By similarity
    Glycosylationi749 – 7491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi776 – 7761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi849 ↔ 885By similarity
    Glycosylationi871 – 8711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi923 ↔ 1274By similarity
    Cross-linki974 ↔ 977Isoglutamyl cysteine thioester (Cys-Gln)By similarity
    Disulfide bondi1081 ↔ 1104By similarity
    Disulfide bondi1298 ↔ 1444By similarity
    Glycosylationi1401 – 14011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Thioester bond

    Proteomic databases

    MaxQBiP28666.
    PaxDbiP28666.
    PRIDEiP28666.

    Expressioni

    Tissue specificityi

    Plasma.

    Gene expression databases

    BgeeiP28666.
    CleanExiMM_MUG2.
    GenevestigatoriP28666.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    IntActiP28666. 1 interaction.
    MINTiMINT-1849506.
    STRINGi10090.ENSMUSP00000080469.

    Structurei

    3D structure databases

    ProteinModelPortaliP28666.
    SMRiP28666. Positions 31-621, 733-1445.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni677 – 73458Bait regionAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Bait region, Signal

    Phylogenomic databases

    eggNOGiCOG2373.
    GeneTreeiENSGT00740000115177.
    HOGENOMiHOG000220939.
    HOVERGENiHBG000039.
    InParanoidiP28666.
    OMAiRTNMVII.
    OrthoDBiEOG7PGDPR.
    TreeFamiTF313285.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProiIPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    IPR010916. TonB_box_CS.
    [Graphical view]
    PfamiPF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28666-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWKSRRAQLC LFSVLLAFLP SASSLNGDSK YMVLVPSQLY TETPEKICLH     50
    LYHLNETVTV TASLVSQTGR RNLFDELVVD KDLFQCVSFI IPTLNSPDEE 100
    EFLYVDIKGP THEFSKRNAV LVKNKESVVF VQTDKPVYKP GQSVKFRVVS 150
    MDKTLRPLNE LLPLAYIEDP KKNRIMQWRD IKTENGLKQM SFSLAAEPIQ 200
    GPYKIVVHKQ SGVKEEHSFT VMEFVLPRFN VDLKVPNAIS VNDEVLQVTV 250
    CGKYTYGKPV PGQVKISICH ETEAGCKEVN SKLDNNGCST QEVNITELQS 300
    KKRNYEVQLF HVNATVTEEG TGLEFNGYGT TKIERITNKL IFLKADSHFR 350
    HGIPFFVKVR LVDIKGDPIP NERVFIKAQV LGYTSATTTD QHGLAKFSID 400
    TAGFSGSSLH IKVNHKGKDS CYFFYCMEER YASAEHVAYA VYSLSKSYIY 450
    LVKETSSILP CNQIHTVQAH FILKGDLGVL KELVFYYLVM AQGSIIQTGN 500
    HTHQVEPGEA PVKGNFDLEI PVEFSMAPMA KMLIYTILPD GEVIADSVNF 550
    EIEKCLRNKV DLSFSSSQSL PASQTRLQVT ASPQSLCGLR AVDQSVLLLK 600
    PEDELSPSWI YNLPGMQHNK FIPSSSLSED REDCILYSSW VAEKHTDWVP 650
    HGREKDVYRY VEDMDLKAFT NLKIKLPKIC FDSAPMSGPR GKFDLAFSSE 700
    VSGTLQKGSS KRPQPEEPPR EDPPPKDPLA ETIRKYFPET WVWDIVTVNS 750
    TGVAEVEMTV PDTITEWKAG ALCLSNDTGL GLSSVVPLQA FQPFFVEVSL 800
    PYSVVRGEAF MLKATVMNYL PTSMRMSVQL EASPDFTAVP VGDDHDSYCL 850
    SANGRHTSSW LVTPKSLGNV NFSVSVEAQQ SSEPCGSEVA TVPETGRKDT 900
    VVKVLIVEPE GIKQEHTFNS LFCASDAEIS EKMSLVLPPT VVKDSARAHF 950
    SVMGDILSSA IKNTQNLLHM PYGCGEQNMV LFAPNIYVLK YLDKTQQLTQ 1000
    KIKTKALGFL RAGYQRELNY KHKDGSYSAF GDQNGEREGN TWLTAFVLKS 1050
    FAQARAFIFI DESHITHAFT WLSQQQKDNG CFRSSGSLFH NDIKHPVVSK 1100
    ALSCLESSWK TIEQGRNANF VYTKALMAYA FALAGNQDKR NEILKSLDEE 1150
    AIKEDNSIHW ERPQKPRKSE HNLYKPQASS VEVEMNAYVV LARLTAQPAP 1200
    SPEDLTLSRS TIMWLTKQQN SNGGFSSTQD TVVALDALSK YGAVTFSRRQ 1250
    KTSLVTIQST GSFSQKFQVE NSNCLLLQQV PLPDIPGDYT ISVSGEGCVY 1300
    AQTTLRYNMH LEKQQSAFAL RVQTVPLTCN NPKGHNSFQI SLEISYTGSR 1350
    PASNMVIADV KMLSGFIPLK PTVKKLERLE HISRTEVSNN NVLLYLDQVT 1400
    NQTLAFSFII QQDISVRNLQ PAIVKVYDYY ETDEVAYAEY SSPCSSDKQN 1450
    V 1451
    Length:1,451
    Mass (Da):162,382
    Last modified:June 28, 2011 - v2
    Checksum:i8DB472A6C033C35D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti386 – 3861A → T in AAA73041. (PubMed:1840592)Curated
    Sequence conflicti894 – 8941E → A in AAA73041. (PubMed:1840592)Curated
    Sequence conflicti1181 – 11811V → I in AAA73041. (PubMed:1840592)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65238 mRNA. Translation: AAA73041.1.
    AC153582 Genomic DNA. No translation available.
    AC153838 Genomic DNA. No translation available.
    AC156279 Genomic DNA. No translation available.
    CCDSiCCDS39619.1.
    PIRiB41185.
    RefSeqiNP_032672.2. NM_008646.3.
    UniGeneiMm.479223.

    Genome annotation databases

    EnsembliENSMUST00000081777; ENSMUSP00000080469; ENSMUSG00000030131.
    GeneIDi17837.
    KEGGimmu:17837.
    UCSCiuc009dos.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65238 mRNA. Translation: AAA73041.1 .
    AC153582 Genomic DNA. No translation available.
    AC153838 Genomic DNA. No translation available.
    AC156279 Genomic DNA. No translation available.
    CCDSi CCDS39619.1.
    PIRi B41185.
    RefSeqi NP_032672.2. NM_008646.3.
    UniGenei Mm.479223.

    3D structure databases

    ProteinModelPortali P28666.
    SMRi P28666. Positions 31-621, 733-1445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P28666. 1 interaction.
    MINTi MINT-1849506.
    STRINGi 10090.ENSMUSP00000080469.

    Protein family/group databases

    MEROPSi I39.005.

    Proteomic databases

    MaxQBi P28666.
    PaxDbi P28666.
    PRIDEi P28666.

    Protocols and materials databases

    DNASUi 17837.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081777 ; ENSMUSP00000080469 ; ENSMUSG00000030131 .
    GeneIDi 17837.
    KEGGi mmu:17837.
    UCSCi uc009dos.1. mouse.

    Organism-specific databases

    CTDi 17837.
    MGIi MGI:99836. Mug2.

    Phylogenomic databases

    eggNOGi COG2373.
    GeneTreei ENSGT00740000115177.
    HOGENOMi HOG000220939.
    HOVERGENi HBG000039.
    InParanoidi P28666.
    OMAi RTNMVII.
    OrthoDBi EOG7PGDPR.
    TreeFami TF313285.

    Enzyme and pathway databases

    Reactomei REACT_199052. Degradation of the extracellular matrix.
    REACT_210090. Rho GTPase cycle.
    REACT_213857. HDL-mediated lipid transport.

    Miscellaneous databases

    NextBioi 292555.
    PROi P28666.
    SOURCEi Search...

    Gene expression databases

    Bgeei P28666.
    CleanExi MM_MUG2.
    Genevestigatori P28666.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProi IPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    IPR010916. TonB_box_CS.
    [Graphical view ]
    Pfami PF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of the murinoglobulins."
      Overbergh L., Torrekens S., van Leuven F., van den Berghe H.
      J. Biol. Chem. 266:16903-16910(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiMUG2_MOUSE
    AccessioniPrimary (citable) accession number: P28666
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3