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Protein

Beta-soluble NSF attachment protein

Gene

Napb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

GO - Molecular functioni

  • soluble NSF attachment protein activity Source: GO_Central
  • syntaxin binding Source: MGI

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • membrane fusion Source: GO_Central
  • regulation of synaptic vesicle priming Source: MGI
  • SNARE complex disassembly Source: MGI
  • synaptic transmission, glutamatergic Source: MGI
  • synaptic vesicle endocytosis Source: SynGO

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-soluble NSF attachment protein
Short name:
SNAP-beta
Alternative name(s):
Brain protein I47
N-ethylmaleimide-sensitive factor attachment protein beta
Gene namesi
Name:Napb
Synonyms:Snapb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104562. Napb.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190611 – 298Beta-soluble NSF attachment proteinAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP28663.
PaxDbiP28663.
PeptideAtlasiP28663.
PRIDEiP28663.

PTM databases

iPTMnetiP28663.
PhosphoSitePlusiP28663.

Expressioni

Tissue specificityi

Cerebral cortex, cerebellar cortex, hippocampus, and dentate gyrus, weakly expressed in the putamen, the thalamus and the brain stem.1 Publication

Gene expression databases

BgeeiENSMUSG00000027438.
ExpressionAtlasiP28663. baseline and differential.
GenevisibleiP28663. MM.

Interactioni

Subunit structurei

Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2.By similarity

GO - Molecular functioni

  • soluble NSF attachment protein activity Source: GO_Central
  • syntaxin binding Source: MGI

Protein-protein interaction databases

BioGridi201693. 3 interactors.
IntActiP28663. 7 interactors.
MINTiMINT-4135008.
STRINGi10090.ENSMUSP00000028926.

Structurei

3D structure databases

ProteinModelPortaliP28663.
SMRiP28663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGiKOG1586. Eukaryota.
ENOG410XPQ6. LUCA.
GeneTreeiENSGT00390000005826.
HOGENOMiHOG000165015.
HOVERGENiHBG001325.
InParanoidiP28663.
OMAiKVGHYSA.
OrthoDBiEOG091G0KSY.
PhylomeDBiP28663.
TreeFamiTF316547.

Family and domain databases

CDDicd15832. SNAP. 1 hit.
Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR000744. NSF_attach.
IPR011990. TPR-like_helical_dom.
PANTHERiPTHR13768. PTHR13768. 1 hit.
PRINTSiPR00448. NSFATTACHMNT.
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

P28663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNAGKEREA VQLMAEAEKR VKASHSFLRG LFGGNTRIEE ACEMYTRAAN
60 70 80 90 100
MFKMAKNWSA AGNAFCQAAK LHMQLQSKHD SATSFVDAGN AYKKADPQEA
110 120 130 140 150
INCLNAAIDI YTDMGRFTIA AKHHITIAEI YETELVDIEK AIAHYEQSAD
160 170 180 190 200
YYKGEESNSS ANKCLLKVAA YAAQLEQYQK AIEIYEQVGA NTMDNPLLKY
210 220 230 240 250
SAKDYFFKAA LCHFIVDELN AKLALEKYEE MFPAFTDSRE CKLLKKLLEA
260 270 280 290
HEEQNSEAYT EAVKEFDSIS RLDQWLTTML LRIKKSIQGD GEGDGDLK
Length:298
Mass (Da):33,557
Last modified:May 10, 2004 - v2
Checksum:i5B7BE0FB84BABD83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083184 mRNA. Translation: BAC38798.1.
BC038362 mRNA. Translation: AAH38362.1.
BC049874 mRNA. Translation: AAH49874.1.
X61455 mRNA. Translation: CAA43695.1.
CCDSiCCDS16842.1.
PIRiS16869.
RefSeqiNP_062606.1. NM_019632.3.
UniGeneiMm.274308.
Mm.391579.

Genome annotation databases

EnsembliENSMUST00000028926; ENSMUSP00000028926; ENSMUSG00000027438.
GeneIDi17957.
KEGGimmu:17957.
UCSCiuc008mti.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiSNAB_MOUSE
AccessioniPrimary (citable) accession number: P28663
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: May 10, 2004
Last modified: August 30, 2017
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families