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Protein

Beta-soluble NSF attachment protein

Gene

Napb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

GO - Molecular functioni

  • soluble NSF attachment protein activity Source: GO_Central
  • syntaxin binding Source: MGI

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • membrane fusion Source: GO_Central
  • regulation of synaptic vesicle priming Source: MGI
  • SNARE complex disassembly Source: MGI
  • synaptic transmission, glutamatergic Source: MGI
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-soluble NSF attachment protein
Short name:
SNAP-beta
Alternative name(s):
Brain protein I47
N-ethylmaleimide-sensitive factor attachment protein beta
Gene namesi
Name:Napb
Synonyms:Snapb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104562. Napb.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • myelin sheath Source: UniProtKB
  • synaptobrevin 2-SNAP-25-syntaxin-1a complex Source: MGI
  • vacuolar membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Beta-soluble NSF attachment proteinPRO_0000219061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei26 – 261PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP28663.
MaxQBiP28663.
PaxDbiP28663.
PeptideAtlasiP28663.
PRIDEiP28663.

PTM databases

iPTMnetiP28663.
PhosphoSiteiP28663.

Expressioni

Tissue specificityi

Cerebral cortex, cerebellar cortex, hippocampus, and dentate gyrus, weakly expressed in the putamen, the thalamus and the brain stem.1 Publication

Gene expression databases

BgeeiP28663.
ExpressionAtlasiP28663. baseline and differential.
GenevisibleiP28663. MM.

Interactioni

Subunit structurei

Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2.By similarity

GO - Molecular functioni

  • soluble NSF attachment protein activity Source: GO_Central
  • syntaxin binding Source: MGI

Protein-protein interaction databases

BioGridi201693. 3 interactions.
IntActiP28663. 7 interactions.
MINTiMINT-4135008.
STRINGi10090.ENSMUSP00000028926.

Structurei

3D structure databases

ProteinModelPortaliP28663.
SMRiP28663. Positions 19-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGiKOG1586. Eukaryota.
ENOG410XPQ6. LUCA.
GeneTreeiENSGT00390000005826.
HOGENOMiHOG000165015.
HOVERGENiHBG001325.
InParanoidiP28663.
OMAiQAGSAFC.
OrthoDBiEOG7FNC80.
PhylomeDBiP28663.
TreeFamiTF316547.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR000744. NSF_attach.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13768. PTHR13768. 1 hit.
PRINTSiPR00448. NSFATTACHMNT.
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

P28663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNAGKEREA VQLMAEAEKR VKASHSFLRG LFGGNTRIEE ACEMYTRAAN
60 70 80 90 100
MFKMAKNWSA AGNAFCQAAK LHMQLQSKHD SATSFVDAGN AYKKADPQEA
110 120 130 140 150
INCLNAAIDI YTDMGRFTIA AKHHITIAEI YETELVDIEK AIAHYEQSAD
160 170 180 190 200
YYKGEESNSS ANKCLLKVAA YAAQLEQYQK AIEIYEQVGA NTMDNPLLKY
210 220 230 240 250
SAKDYFFKAA LCHFIVDELN AKLALEKYEE MFPAFTDSRE CKLLKKLLEA
260 270 280 290
HEEQNSEAYT EAVKEFDSIS RLDQWLTTML LRIKKSIQGD GEGDGDLK
Length:298
Mass (Da):33,557
Last modified:May 10, 2004 - v2
Checksum:i5B7BE0FB84BABD83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083184 mRNA. Translation: BAC38798.1.
BC038362 mRNA. Translation: AAH38362.1.
BC049874 mRNA. Translation: AAH49874.1.
X61455 mRNA. Translation: CAA43695.1.
CCDSiCCDS16842.1.
PIRiS16869.
RefSeqiNP_062606.1. NM_019632.3.
UniGeneiMm.274308.
Mm.391579.

Genome annotation databases

EnsembliENSMUST00000028926; ENSMUSP00000028926; ENSMUSG00000027438.
GeneIDi17957.
KEGGimmu:17957.
UCSCiuc008mti.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083184 mRNA. Translation: BAC38798.1.
BC038362 mRNA. Translation: AAH38362.1.
BC049874 mRNA. Translation: AAH49874.1.
X61455 mRNA. Translation: CAA43695.1.
CCDSiCCDS16842.1.
PIRiS16869.
RefSeqiNP_062606.1. NM_019632.3.
UniGeneiMm.274308.
Mm.391579.

3D structure databases

ProteinModelPortaliP28663.
SMRiP28663. Positions 19-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201693. 3 interactions.
IntActiP28663. 7 interactions.
MINTiMINT-4135008.
STRINGi10090.ENSMUSP00000028926.

PTM databases

iPTMnetiP28663.
PhosphoSiteiP28663.

Proteomic databases

EPDiP28663.
MaxQBiP28663.
PaxDbiP28663.
PeptideAtlasiP28663.
PRIDEiP28663.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028926; ENSMUSP00000028926; ENSMUSG00000027438.
GeneIDi17957.
KEGGimmu:17957.
UCSCiuc008mti.1. mouse.

Organism-specific databases

CTDi63908.
MGIiMGI:104562. Napb.

Phylogenomic databases

eggNOGiKOG1586. Eukaryota.
ENOG410XPQ6. LUCA.
GeneTreeiENSGT00390000005826.
HOGENOMiHOG000165015.
HOVERGENiHBG001325.
InParanoidiP28663.
OMAiQAGSAFC.
OrthoDBiEOG7FNC80.
PhylomeDBiP28663.
TreeFamiTF316547.

Miscellaneous databases

PROiP28663.
SOURCEiSearch...

Gene expression databases

BgeeiP28663.
ExpressionAtlasiP28663. baseline and differential.
GenevisibleiP28663. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR000744. NSF_attach.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13768. PTHR13768. 1 hit.
PRINTSiPR00448. NSFATTACHMNT.
SUPFAMiSSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "A collection of cDNA clones with specific expression patterns in mouse brain."
    Kato K.
    Eur. J. Neurosci. 2:704-711(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 52-298.
    Strain: BALB/cJ.
    Tissue: Brain.
  4. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 123-140; 209-222 AND 228-239, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  5. "SNAP family of NSF attachment proteins includes a brain-specific isoform."
    Whiteheart S.W., Griff I.C., Brunner M., Clary D.O., Mayer T., Buhrow S.A., Rothman J.E.
    Nature 362:353-355(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSNAB_MOUSE
AccessioniPrimary (citable) accession number: P28663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: May 10, 2004
Last modified: July 6, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.