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P28658

- ATX10_MOUSE

UniProt

P28658 - ATX10_MOUSE

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Protein
Ataxin-10
Gene
Atxn10, Sca10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Necessary for the survival of cerebellar neurons By similarity. Induces neuritogenesis by activating the Ras-MAP kinase pathway By similarity. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. neuron projection development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-10
Alternative name(s):
Brain protein E46
Spinocerebellar ataxia type 10 protein homolog
Gene namesi
Name:Atxn10
Synonyms:Sca10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1859293. Atxn10.

Subcellular locationi

Cytoplasmperinuclear region By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. dendrite Source: Ensembl
  3. neuronal cell body Source: Ensembl
  4. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Ataxin-10
PRO_0000064749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP28658.
PaxDbiP28658.
PRIDEiP28658.

PTM databases

PhosphoSiteiP28658.

Expressioni

Tissue specificityi

In high cell density areas; cerebellar cortex, dentate gyrus, hippocampus, anterior olfactory nucleus, primary olfactory cortex.1 Publication

Gene expression databases

BgeeiP28658.
CleanExiMM_ATXN10.
GenevestigatoriP28658.

Interactioni

Subunit structurei

Homooligomer By similarity. Interacts with GNB2 By similarity. Interacts with OGT. Interacts with IQCB1 By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Iqcb1Q8BP002EBI-4284019,EBI-4282243

Protein-protein interaction databases

BioGridi207574. 3 interactions.
IntActiP28658. 3 interactions.
MINTiMINT-4088847.

Structurei

3D structure databases

ProteinModelPortaliP28658.

Family & Domainsi

Sequence similaritiesi

Belongs to the ataxin-10 family.

Phylogenomic databases

eggNOGiNOG330117.
GeneTreeiENSGT00390000010377.
HOGENOMiHOG000034224.
HOVERGENiHBG050622.
InParanoidiP28658.
OMAiNNQERVT.
OrthoDBiEOG7WHH9W.
PhylomeDBiP28658.
TreeFamiTF323870.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019156. Ataxin-10_domain.
[Graphical view]
PfamiPF09759. Atx10homo_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

P28658-1 [UniParc]FASTAAdd to Basket

« Hide

MAAPRMPPSR LSGIMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV    50
LDILKKSTHA VELACRDPSQ VEHLASSLQL ITECFRCLRN ACIECSVNQN 100
SIRNLDTIGV AVDLVLLFRE LRVEQDSLLT AFRCGLQFLG NVASRNEESQ 150
SIVWVHAFPE LFMSCLNHPD KKIVAYCSMI LFTSLNAERM KDLEENLNIA 200
INVIEAHQKH PASEWPFLII SDHFLKSPEL VEAMYGKLSN QERITLLDIV 250
IAKLVGEEQL TKDDISIFVR HAELIANSFM DQCRNVLKLT SEPHTEDKEA 300
LVTIRLLDVL CEMTSNTELL GYLQVFPGLM ERVIDVLRVI HEVGKESTNI 350
FSPSDSLKAE GDIEHMTEGF KSHLIRLIGN LCYKNKENQD KVNELDGIPL 400
ILDSSNIDDN NPFMMQWVVY AVRNLTEDNS QNQDVIAKME EQGLADASLL 450
KKMGFEIEKS GDKLILKSNN DIPPP 475
Length:475
Mass (Da):53,707
Last modified:October 18, 2001 - v2
Checksum:i273FDB6EDFE519C7
GO

Sequence cautioni

The sequence CAA43722.1 differs from that shown. Reason: Frameshift at position 409.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311A → V in CAA43722. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61506 mRNA. Translation: CAA43722.1. Frameshift.
AK003530 mRNA. Translation: BAB22840.1.
AK047170 mRNA. Translation: BAC32981.1.
AK078459 mRNA. Translation: BAC37285.1.
AK153271 mRNA. Translation: BAE31858.1.
AK165941 mRNA. Translation: BAE38473.1.
AK170507 mRNA. Translation: BAE41845.1.
BC002285 mRNA. Translation: AAH02285.1.
BC016410 mRNA. Translation: AAH16410.1.
BC046802 mRNA. Translation: AAH46802.1.
CCDSiCCDS37170.1.
PIRiS16416.
RefSeqiNP_058539.2. NM_016843.3.
UniGeneiMm.248906.

Genome annotation databases

EnsembliENSMUST00000163242; ENSMUSP00000132450; ENSMUSG00000016541.
GeneIDi54138.
KEGGimmu:54138.
UCSCiuc007xdd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61506 mRNA. Translation: CAA43722.1 . Frameshift.
AK003530 mRNA. Translation: BAB22840.1 .
AK047170 mRNA. Translation: BAC32981.1 .
AK078459 mRNA. Translation: BAC37285.1 .
AK153271 mRNA. Translation: BAE31858.1 .
AK165941 mRNA. Translation: BAE38473.1 .
AK170507 mRNA. Translation: BAE41845.1 .
BC002285 mRNA. Translation: AAH02285.1 .
BC016410 mRNA. Translation: AAH16410.1 .
BC046802 mRNA. Translation: AAH46802.1 .
CCDSi CCDS37170.1.
PIRi S16416.
RefSeqi NP_058539.2. NM_016843.3.
UniGenei Mm.248906.

3D structure databases

ProteinModelPortali P28658.
ModBasei Search...

Protein-protein interaction databases

BioGridi 207574. 3 interactions.
IntActi P28658. 3 interactions.
MINTi MINT-4088847.

PTM databases

PhosphoSitei P28658.

Proteomic databases

MaxQBi P28658.
PaxDbi P28658.
PRIDEi P28658.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000163242 ; ENSMUSP00000132450 ; ENSMUSG00000016541 .
GeneIDi 54138.
KEGGi mmu:54138.
UCSCi uc007xdd.1. mouse.

Organism-specific databases

CTDi 25814.
MGIi MGI:1859293. Atxn10.

Phylogenomic databases

eggNOGi NOG330117.
GeneTreei ENSGT00390000010377.
HOGENOMi HOG000034224.
HOVERGENi HBG050622.
InParanoidi P28658.
OMAi NNQERVT.
OrthoDBi EOG7WHH9W.
PhylomeDBi P28658.
TreeFami TF323870.

Miscellaneous databases

NextBioi 310953.
PROi P28658.
SOURCEi Search...

Gene expression databases

Bgeei P28658.
CleanExi MM_ATXN10.
Genevestigatori P28658.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019156. Ataxin-10_domain.
[Graphical view ]
Pfami PF09759. Atx10homo_assoc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A collection of cDNA clones with specific expression patterns in mouse brain."
    Kato K.
    Eur. J. Neurosci. 2:704-711(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Cerebellum, Embryo and Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Mammary gland.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 244-253, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons."
    Maerz P., Probst A., Lang S., Schwager M., Rose-John S., Otten U., Ozbek S.
    J. Biol. Chem. 279:35542-35550(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Ataxin-10 interacts with O-GlcNAc transferase OGT in pancreatic beta cells."
    Andrali S.S., Maerz P., Ozcan S.
    Biochem. Biophys. Res. Commun. 337:149-153(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OGT.

Entry informationi

Entry nameiATX10_MOUSE
AccessioniPrimary (citable) accession number: P28658
Secondary accession number(s): Q543S3, Q99LP5, Q9D1I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 18, 2001
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi