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Protein

Ataxin-10

Gene

Atxn10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-10
Alternative name(s):
Brain protein E46
Spinocerebellar ataxia type 10 protein homolog
Gene namesi
Name:Atxn10
Synonyms:Sca10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1859293. Atxn10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Ataxin-10PRO_0000064749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP28658.
PaxDbiP28658.
PRIDEiP28658.

PTM databases

PhosphoSiteiP28658.

Expressioni

Tissue specificityi

In high cell density areas; cerebellar cortex, dentate gyrus, hippocampus, anterior olfactory nucleus, primary olfactory cortex.1 Publication

Gene expression databases

BgeeiP28658.
CleanExiMM_ATXN10.
GenevisibleiP28658. MM.

Interactioni

Subunit structurei

Homooligomer (By similarity). Interacts with GNB2 (By similarity). Interacts with OGT. Interacts with IQCB1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Iqcb1Q8BP002EBI-4284019,EBI-4282243

Protein-protein interaction databases

BioGridi207574. 3 interactions.
IntActiP28658. 3 interactions.
MINTiMINT-4088847.
STRINGi10090.ENSMUSP00000132450.

Structurei

3D structure databases

ProteinModelPortaliP28658.
SMRiP28658. Positions 133-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ataxin-10 family.Curated

Phylogenomic databases

eggNOGiNOG330117.
GeneTreeiENSGT00390000010377.
HOGENOMiHOG000034224.
HOVERGENiHBG050622.
InParanoidiP28658.
OMAiNNQERVT.
OrthoDBiEOG7WHH9W.
PhylomeDBiP28658.
TreeFamiTF323870.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019156. Ataxin-10_domain.
[Graphical view]
PfamiPF09759. Atx10homo_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

P28658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRMPPSR LSGIMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV
60 70 80 90 100
LDILKKSTHA VELACRDPSQ VEHLASSLQL ITECFRCLRN ACIECSVNQN
110 120 130 140 150
SIRNLDTIGV AVDLVLLFRE LRVEQDSLLT AFRCGLQFLG NVASRNEESQ
160 170 180 190 200
SIVWVHAFPE LFMSCLNHPD KKIVAYCSMI LFTSLNAERM KDLEENLNIA
210 220 230 240 250
INVIEAHQKH PASEWPFLII SDHFLKSPEL VEAMYGKLSN QERITLLDIV
260 270 280 290 300
IAKLVGEEQL TKDDISIFVR HAELIANSFM DQCRNVLKLT SEPHTEDKEA
310 320 330 340 350
LVTIRLLDVL CEMTSNTELL GYLQVFPGLM ERVIDVLRVI HEVGKESTNI
360 370 380 390 400
FSPSDSLKAE GDIEHMTEGF KSHLIRLIGN LCYKNKENQD KVNELDGIPL
410 420 430 440 450
ILDSSNIDDN NPFMMQWVVY AVRNLTEDNS QNQDVIAKME EQGLADASLL
460 470
KKMGFEIEKS GDKLILKSNN DIPPP
Length:475
Mass (Da):53,707
Last modified:October 18, 2001 - v2
Checksum:i273FDB6EDFE519C7
GO

Sequence cautioni

The sequence CAA43722.1 differs from that shown. Reason: Frameshift at position 409. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311A → V in CAA43722 (PubMed:12106288).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61506 mRNA. Translation: CAA43722.1. Frameshift.
AK003530 mRNA. Translation: BAB22840.1.
AK047170 mRNA. Translation: BAC32981.1.
AK078459 mRNA. Translation: BAC37285.1.
AK153271 mRNA. Translation: BAE31858.1.
AK165941 mRNA. Translation: BAE38473.1.
AK170507 mRNA. Translation: BAE41845.1.
BC002285 mRNA. Translation: AAH02285.1.
BC016410 mRNA. Translation: AAH16410.1.
BC046802 mRNA. Translation: AAH46802.1.
CCDSiCCDS37170.1.
PIRiS16416.
RefSeqiNP_058539.2. NM_016843.3.
UniGeneiMm.248906.

Genome annotation databases

EnsembliENSMUST00000163242; ENSMUSP00000132450; ENSMUSG00000016541.
GeneIDi54138.
KEGGimmu:54138.
UCSCiuc007xdd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61506 mRNA. Translation: CAA43722.1. Frameshift.
AK003530 mRNA. Translation: BAB22840.1.
AK047170 mRNA. Translation: BAC32981.1.
AK078459 mRNA. Translation: BAC37285.1.
AK153271 mRNA. Translation: BAE31858.1.
AK165941 mRNA. Translation: BAE38473.1.
AK170507 mRNA. Translation: BAE41845.1.
BC002285 mRNA. Translation: AAH02285.1.
BC016410 mRNA. Translation: AAH16410.1.
BC046802 mRNA. Translation: AAH46802.1.
CCDSiCCDS37170.1.
PIRiS16416.
RefSeqiNP_058539.2. NM_016843.3.
UniGeneiMm.248906.

3D structure databases

ProteinModelPortaliP28658.
SMRiP28658. Positions 133-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207574. 3 interactions.
IntActiP28658. 3 interactions.
MINTiMINT-4088847.
STRINGi10090.ENSMUSP00000132450.

PTM databases

PhosphoSiteiP28658.

Proteomic databases

MaxQBiP28658.
PaxDbiP28658.
PRIDEiP28658.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163242; ENSMUSP00000132450; ENSMUSG00000016541.
GeneIDi54138.
KEGGimmu:54138.
UCSCiuc007xdd.1. mouse.

Organism-specific databases

CTDi25814.
MGIiMGI:1859293. Atxn10.

Phylogenomic databases

eggNOGiNOG330117.
GeneTreeiENSGT00390000010377.
HOGENOMiHOG000034224.
HOVERGENiHBG050622.
InParanoidiP28658.
OMAiNNQERVT.
OrthoDBiEOG7WHH9W.
PhylomeDBiP28658.
TreeFamiTF323870.

Miscellaneous databases

NextBioi310953.
PROiP28658.
SOURCEiSearch...

Gene expression databases

BgeeiP28658.
CleanExiMM_ATXN10.
GenevisibleiP28658. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019156. Ataxin-10_domain.
[Graphical view]
PfamiPF09759. Atx10homo_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A collection of cDNA clones with specific expression patterns in mouse brain."
    Kato K.
    Eur. J. Neurosci. 2:704-711(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Cerebellum, Embryo and Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Mammary gland.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 244-253, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons."
    Maerz P., Probst A., Lang S., Schwager M., Rose-John S., Otten U., Ozbek S.
    J. Biol. Chem. 279:35542-35550(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Ataxin-10 interacts with O-GlcNAc transferase OGT in pancreatic beta cells."
    Andrali S.S., Maerz P., Ozcan S.
    Biochem. Biophys. Res. Commun. 337:149-153(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OGT.

Entry informationi

Entry nameiATX10_MOUSE
AccessioniPrimary (citable) accession number: P28658
Secondary accession number(s): Q543S3, Q99LP5, Q9D1I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 18, 2001
Last modified: June 24, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.