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P28658

- ATX10_MOUSE

UniProt

P28658 - ATX10_MOUSE

Protein

Ataxin-10

Gene

Atxn10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (18 Oct 2001)
      Previous versions | rss
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    Functioni

    Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. neuron projection development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ataxin-10
    Alternative name(s):
    Brain protein E46
    Spinocerebellar ataxia type 10 protein homolog
    Gene namesi
    Name:Atxn10
    Synonyms:Sca10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1859293. Atxn10.

    Subcellular locationi

    Cytoplasmperinuclear region By similarity

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. dendrite Source: Ensembl
    3. neuronal cell body Source: Ensembl
    4. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 475475Ataxin-10PRO_0000064749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP28658.
    PaxDbiP28658.
    PRIDEiP28658.

    PTM databases

    PhosphoSiteiP28658.

    Expressioni

    Tissue specificityi

    In high cell density areas; cerebellar cortex, dentate gyrus, hippocampus, anterior olfactory nucleus, primary olfactory cortex.1 Publication

    Gene expression databases

    BgeeiP28658.
    CleanExiMM_ATXN10.
    GenevestigatoriP28658.

    Interactioni

    Subunit structurei

    Homooligomer By similarity. Interacts with GNB2 By similarity. Interacts with OGT. Interacts with IQCB1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Iqcb1Q8BP002EBI-4284019,EBI-4282243

    Protein-protein interaction databases

    BioGridi207574. 3 interactions.
    IntActiP28658. 3 interactions.
    MINTiMINT-4088847.

    Structurei

    3D structure databases

    ProteinModelPortaliP28658.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ataxin-10 family.Curated

    Phylogenomic databases

    eggNOGiNOG330117.
    GeneTreeiENSGT00390000010377.
    HOGENOMiHOG000034224.
    HOVERGENiHBG050622.
    InParanoidiP28658.
    OMAiNNQERVT.
    OrthoDBiEOG7WHH9W.
    PhylomeDBiP28658.
    TreeFamiTF323870.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR019156. Ataxin-10_domain.
    [Graphical view]
    PfamiPF09759. Atx10homo_assoc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P28658-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPRMPPSR LSGIMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV    50
    LDILKKSTHA VELACRDPSQ VEHLASSLQL ITECFRCLRN ACIECSVNQN 100
    SIRNLDTIGV AVDLVLLFRE LRVEQDSLLT AFRCGLQFLG NVASRNEESQ 150
    SIVWVHAFPE LFMSCLNHPD KKIVAYCSMI LFTSLNAERM KDLEENLNIA 200
    INVIEAHQKH PASEWPFLII SDHFLKSPEL VEAMYGKLSN QERITLLDIV 250
    IAKLVGEEQL TKDDISIFVR HAELIANSFM DQCRNVLKLT SEPHTEDKEA 300
    LVTIRLLDVL CEMTSNTELL GYLQVFPGLM ERVIDVLRVI HEVGKESTNI 350
    FSPSDSLKAE GDIEHMTEGF KSHLIRLIGN LCYKNKENQD KVNELDGIPL 400
    ILDSSNIDDN NPFMMQWVVY AVRNLTEDNS QNQDVIAKME EQGLADASLL 450
    KKMGFEIEKS GDKLILKSNN DIPPP 475
    Length:475
    Mass (Da):53,707
    Last modified:October 18, 2001 - v2
    Checksum:i273FDB6EDFE519C7
    GO

    Sequence cautioni

    The sequence CAA43722.1 differs from that shown. Reason: Frameshift at position 409.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311A → V in CAA43722. (PubMed:12106288)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61506 mRNA. Translation: CAA43722.1. Frameshift.
    AK003530 mRNA. Translation: BAB22840.1.
    AK047170 mRNA. Translation: BAC32981.1.
    AK078459 mRNA. Translation: BAC37285.1.
    AK153271 mRNA. Translation: BAE31858.1.
    AK165941 mRNA. Translation: BAE38473.1.
    AK170507 mRNA. Translation: BAE41845.1.
    BC002285 mRNA. Translation: AAH02285.1.
    BC016410 mRNA. Translation: AAH16410.1.
    BC046802 mRNA. Translation: AAH46802.1.
    CCDSiCCDS37170.1.
    PIRiS16416.
    RefSeqiNP_058539.2. NM_016843.3.
    UniGeneiMm.248906.

    Genome annotation databases

    EnsembliENSMUST00000163242; ENSMUSP00000132450; ENSMUSG00000016541.
    GeneIDi54138.
    KEGGimmu:54138.
    UCSCiuc007xdd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61506 mRNA. Translation: CAA43722.1 . Frameshift.
    AK003530 mRNA. Translation: BAB22840.1 .
    AK047170 mRNA. Translation: BAC32981.1 .
    AK078459 mRNA. Translation: BAC37285.1 .
    AK153271 mRNA. Translation: BAE31858.1 .
    AK165941 mRNA. Translation: BAE38473.1 .
    AK170507 mRNA. Translation: BAE41845.1 .
    BC002285 mRNA. Translation: AAH02285.1 .
    BC016410 mRNA. Translation: AAH16410.1 .
    BC046802 mRNA. Translation: AAH46802.1 .
    CCDSi CCDS37170.1.
    PIRi S16416.
    RefSeqi NP_058539.2. NM_016843.3.
    UniGenei Mm.248906.

    3D structure databases

    ProteinModelPortali P28658.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207574. 3 interactions.
    IntActi P28658. 3 interactions.
    MINTi MINT-4088847.

    PTM databases

    PhosphoSitei P28658.

    Proteomic databases

    MaxQBi P28658.
    PaxDbi P28658.
    PRIDEi P28658.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000163242 ; ENSMUSP00000132450 ; ENSMUSG00000016541 .
    GeneIDi 54138.
    KEGGi mmu:54138.
    UCSCi uc007xdd.1. mouse.

    Organism-specific databases

    CTDi 25814.
    MGIi MGI:1859293. Atxn10.

    Phylogenomic databases

    eggNOGi NOG330117.
    GeneTreei ENSGT00390000010377.
    HOGENOMi HOG000034224.
    HOVERGENi HBG050622.
    InParanoidi P28658.
    OMAi NNQERVT.
    OrthoDBi EOG7WHH9W.
    PhylomeDBi P28658.
    TreeFami TF323870.

    Miscellaneous databases

    NextBioi 310953.
    PROi P28658.
    SOURCEi Search...

    Gene expression databases

    Bgeei P28658.
    CleanExi MM_ATXN10.
    Genevestigatori P28658.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR019156. Ataxin-10_domain.
    [Graphical view ]
    Pfami PF09759. Atx10homo_assoc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "A collection of cDNA clones with specific expression patterns in mouse brain."
      Kato K.
      Eur. J. Neurosci. 2:704-711(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow, Cerebellum, Embryo and Lung.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Mammary gland.
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 244-253, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    5. "Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons."
      Maerz P., Probst A., Lang S., Schwager M., Rose-John S., Otten U., Ozbek S.
      J. Biol. Chem. 279:35542-35550(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Ataxin-10 interacts with O-GlcNAc transferase OGT in pancreatic beta cells."
      Andrali S.S., Maerz P., Ozcan S.
      Biochem. Biophys. Res. Commun. 337:149-153(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH OGT.

    Entry informationi

    Entry nameiATX10_MOUSE
    AccessioniPrimary (citable) accession number: P28658
    Secondary accession number(s): Q543S3, Q99LP5, Q9D1I1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: October 18, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3