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Protein

Nucleosome assembly protein 1-like 1

Gene

Nap1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in modulating chromatin formation and contribute to regulation of cell proliferation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 1
Alternative name(s):
Brain protein DN38
NAP-1-related protein
Gene namesi
Name:Nap1l1
Synonyms:Nrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1855693. Nap1l1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi359 – 3591E → D: Reduced polyglycylation. 1 Publication
Mutagenesisi360 – 3601E → D: Reduced polyglycylation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 388387Nucleosome assembly protein 1-like 1PRO_0000185653Add
BLAST
Propeptidei389 – 3913Removed in mature formBy similarityPRO_0000396686

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei62 – 621PhosphothreonineCombined sources
Modified residuei64 – 641PhosphothreonineCombined sources
Modified residuei69 – 691PhosphoserineBy similarity
Modified residuei116 – 1161N6-acetyllysineCombined sources
Modified residuei143 – 1431PhosphoserineCombined sources
Modified residuei359 – 35915-glutamyl polyglycine1 Publication
Modified residuei360 – 36015-glutamyl polyglycine1 Publication
Modified residuei388 – 3881Cysteine methyl esterCurated
Lipidationi388 – 3881S-farnesyl cysteineBy similarity

Post-translational modificationi

Polyglycylated by TTLL10 on glutamate residues, resulting in polyglycine chains on the gamma-carboxyl group. Both polyglutamylation and polyglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally.1 Publication
Polyglutamylated by TTLL4 on glutamate residues, resulting in polyglutamate chains on the gamma-carboxyl group. Both polyglutamylation and polyglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP28656.
MaxQBiP28656.
PaxDbiP28656.
PeptideAtlasiP28656.
PRIDEiP28656.

PTM databases

iPTMnetiP28656.
PhosphoSiteiP28656.
SwissPalmiP28656.

Expressioni

Tissue specificityi

High expression in cerebral cortex, not in cerebellar cortex.

Gene expression databases

BgeeiENSMUSG00000058799.
CleanExiMM_NAP1L1.
ExpressionAtlasiP28656. baseline and differential.
GenevisibleiP28656. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Map2k5Q9WVS720EBI-645055,EBI-446144

Protein-protein interaction databases

BioGridi207325. 4 interactions.
IntActiP28656. 6 interactions.
MINTiMINT-1728477.
STRINGi10090.ENSMUSP00000126850.

Structurei

3D structure databases

ProteinModelPortaliP28656.
SMRiP28656. Positions 65-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi273 – 2797Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 3020Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi129 – 14517Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi348 – 37831Asp/Glu-rich (acidic)Add
BLAST

Domaini

The acidic domains are probably involved in the interaction with histones.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1507. Eukaryota.
ENOG410XQN9. LUCA.
GeneTreeiENSGT00480000042668.
HOGENOMiHOG000171827.
HOVERGENiHBG052653.
InParanoidiP28656.
KOiK11279.
PhylomeDBiP28656.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 2 hits.
PfamiPF00956. NAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIDNKEQS ELDQDLEDVE EVEEEETGEE TKIKARQLTV QMMQNPQILA
60 70 80 90 100
ALQERLDGLV DTPTGYIESL PKVVKRRVNA LKNLQVKCAQ IEAKFYEEVH
110 120 130 140 150
DLERKYAVLY QPLFDKRFEI INAIYEPTEE ECEWKPDEED EVSEELKEKA
160 170 180 190 200
KIEDEKKDEE KEDPKGIPEF WLTVFKNVDL LSDMVQEHDE PILKHLKDIK
210 220 230 240 250
VKFSDAGQPM SFVLEFHFEP NDYFTNEVLT KTYRMRSEPD DSDPFSFDGP
260 270 280 290 300
EIMGCTGCQI DWKKGKNVTL KTIKKKQKHK GRGTVRTVTK TVSNDSFFNF
310 320 330 340 350
FAPPEVPENG DLDDDAEAIL AADFEIGHFL RERIIPRSVL YFTGEAIEDD
360 370 380 390
DDDYDEEGEE ADEEGEEEGD EENDPDYDPK KDQNPAECKQ Q
Length:391
Mass (Da):45,345
Last modified:October 1, 1996 - v2
Checksum:i48F17F3A44D9A597
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti377 – 39014YDPKK…AECKQ → MTQRRIRTQPSASSSE in CAA43689 (PubMed:12106288).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12618 mRNA. Translation: BAA02142.1.
AK050375 mRNA. Translation: BAC34219.1.
AK136161 mRNA. Translation: BAE22850.1.
AK145766 mRNA. Translation: BAE26637.1.
BC076591 mRNA. Translation: AAH76591.1.
X61449 mRNA. Translation: CAA43689.1.
CCDSiCCDS36058.1.
PIRiJS0707.
RefSeqiNP_001140179.1. NM_001146707.1.
NP_056596.1. NM_015781.4.
XP_006513954.1. XM_006513891.2.
UniGeneiMm.290407.

Genome annotation databases

EnsembliENSMUST00000065917; ENSMUSP00000070068; ENSMUSG00000058799.
GeneIDi53605.
KEGGimmu:53605.
UCSCiuc007hac.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12618 mRNA. Translation: BAA02142.1.
AK050375 mRNA. Translation: BAC34219.1.
AK136161 mRNA. Translation: BAE22850.1.
AK145766 mRNA. Translation: BAE26637.1.
BC076591 mRNA. Translation: AAH76591.1.
X61449 mRNA. Translation: CAA43689.1.
CCDSiCCDS36058.1.
PIRiJS0707.
RefSeqiNP_001140179.1. NM_001146707.1.
NP_056596.1. NM_015781.4.
XP_006513954.1. XM_006513891.2.
UniGeneiMm.290407.

3D structure databases

ProteinModelPortaliP28656.
SMRiP28656. Positions 65-347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207325. 4 interactions.
IntActiP28656. 6 interactions.
MINTiMINT-1728477.
STRINGi10090.ENSMUSP00000126850.

PTM databases

iPTMnetiP28656.
PhosphoSiteiP28656.
SwissPalmiP28656.

Proteomic databases

EPDiP28656.
MaxQBiP28656.
PaxDbiP28656.
PeptideAtlasiP28656.
PRIDEiP28656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065917; ENSMUSP00000070068; ENSMUSG00000058799.
GeneIDi53605.
KEGGimmu:53605.
UCSCiuc007hac.2. mouse.

Organism-specific databases

CTDi4673.
MGIiMGI:1855693. Nap1l1.

Phylogenomic databases

eggNOGiKOG1507. Eukaryota.
ENOG410XQN9. LUCA.
GeneTreeiENSGT00480000042668.
HOGENOMiHOG000171827.
HOVERGENiHBG052653.
InParanoidiP28656.
KOiK11279.
PhylomeDBiP28656.

Miscellaneous databases

ChiTaRSiNap1l1. mouse.
PROiP28656.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058799.
CleanExiMM_NAP1L1.
ExpressionAtlasiP28656. baseline and differential.
GenevisibleiP28656. MM.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 2 hits.
PfamiPF00956. NAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNP1L1_MOUSE
AccessioniPrimary (citable) accession number: P28656
Secondary accession number(s): Q3UL14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.