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P28654 (PGS2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Decorin
Alternative name(s):
Bone proteoglycan II
PG-S2
PG40
Gene names
Name:Dcn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May affect the rate of fibrils formation.

Subunit structure

Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT By similarity.

Subcellular location

Secreted › extracellular space › extracellular matrix.

Post-translational modification

The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin By similarity.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.

Contains 12 LRR (leucine-rich) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Propeptide17 – 3014
PRO_0000032711
Chain31 – 354324Decorin
PRO_0000032712

Regions

Repeat68 – 8821LRR 1
Repeat89 – 11224LRR 2
Repeat113 – 13624LRR 3
Repeat137 – 15721LRR 4
Repeat158 – 18124LRR 5
Repeat182 – 20726LRR 6
Repeat208 – 22821LRR 7
Repeat229 – 25224LRR 8
Repeat253 – 27624LRR 9
Repeat277 – 29923LRR 10
Repeat300 – 32930LRR 11
Repeat330 – 35425LRR 12
Compositional bias49 – 6214Cys-rich

Amino acid modifications

Glycosylation341O-linked (Xyl...) (glycosaminoglycan) By similarity
Glycosylation2061N-linked (GlcNAc...) Potential
Glycosylation2411N-linked (GlcNAc...) Potential
Glycosylation2571N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 55 By similarity
Disulfide bond53 ↔ 62 By similarity
Disulfide bond308 ↔ 341 By similarity

Sequences

Sequence LengthMass (Da)Tools
P28654 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: F05B5CC08DCABF6F

FASTA35439,809
        10         20         30         40         50         60 
MKATLIFFLL AQVSWAGPFE QRGLFDFMLE DEASGIIPYD PDNPLISMCP YRCQCHLRVV 

        70         80         90        100        110        120 
QCSDLGLDKV PWDFPPDTTL LDLQNNKITE IKEGAFKNLK DLHTLILVNN KISKISPEAF 

       130        140        150        160        170        180 
KPLVKLERLY LSKNQLKELP EKMPRTLQEL RVHENEITKL RKSDFNGLNN VLVIELGGNP 

       190        200        210        220        230        240 
LKNSGIENGA FQGLKSLSYI RISDTNITAI PQGLPTSLTE VHLDGNKITK VDAPSLKGLI 

       250        260        270        280        290        300 
NLSKLGLSFN SITVMENGSL ANVPHLRELH LDNNKLLRVP AGLAQHKYIQ VVYLHNNNIS 

       310        320        330        340        350 
AVGQNDFCRA GHPSRKASYS AVSLYGNPVR YWEIFPNTFR CVYVRSAIQL GNYK

« Hide

References

[1]Naitoh Y., Suzuki S.
Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NIH Swiss.
Tissue: Fibroblast.
[2]"The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation."
Scholzen T., Solursh M., Suzuki S., Reiter R., Morgan J.L., Buchberg A.M., Siracusa L.D., Iozzo R.V.
J. Biol. Chem. 269:28270-28281(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X53929 mRNA. Translation: CAA37876.1.
IPIIPI00123196.
PIRA55454.
RefSeqNP_001177380.1. NM_001190451.1.
NP_031859.1. NM_007833.5.
UniGeneMm.56769.

3D structure databases

ProteinModelPortalP28654.
SMRP28654. Positions 48-350.
ModBaseSearch...

PTM databases

PhosphoSiteP28654.

Proteomic databases

PaxDbP28654.
PRIDEP28654.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000105287; ENSMUSP00000100924; ENSMUSG00000019929.
ENSMUST00000163448; ENSMUSP00000131431; ENSMUSG00000019929.
GeneID13179.
KEGGmmu:13179.

Organism-specific databases

CTD1634.
MGIMGI:94872. Dcn.

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000261690.
HOVERGENHBG016052.
InParanoidP28654.
KOK04660.
OMAPLGPVCP.
OrthoDBEOG4ZS93P.

Gene expression databases

ArrayExpressP28654.
BgeeP28654.
CleanExMM_DCN.
GenevestigatorP28654.
GermOnlineENSMUSG00000019929. Mus musculus.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PfamPF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFPIRSF002490. SLRP_I. 1 hit.
SMARTSM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDCN. mouse.
NextBio283292.
SOURCESearch...

Entry information

Entry namePGS2_MOUSE
AccessionPrimary (citable) accession number: P28654
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 3, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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