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Protein

Decorin

Gene

Dcn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May affect the rate of fibrils formation.

GO - Molecular functioni

  • collagen binding Source: Ensembl
  • extracellular matrix binding Source: MGI
  • glycosaminoglycan binding Source: MGI
  • protein kinase inhibitor activity Source: GO_Central
  • protein N-terminus binding Source: Ensembl

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix
R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022870 Chondroitin sulfate biosynthesis
R-MMU-2022923 Dermatan sulfate biosynthesis
R-MMU-2024101 CS/DS degradation
R-MMU-3000178 ECM proteoglycans

Names & Taxonomyi

Protein namesi
Recommended name:
Decorin
Alternative name(s):
Bone proteoglycan II
PG-S2
PG40
Gene namesi
Name:Dcn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:94872 Dcn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
PropeptideiPRO_000003271117 – 30By similarityAdd BLAST14
ChainiPRO_000003271231 – 354DecorinAdd BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1
Disulfide bondi49 ↔ 55By similarity
Disulfide bondi53 ↔ 62By similarity
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi308 ↔ 341By similarity

Post-translational modificationi

The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP28654
PeptideAtlasiP28654
PRIDEiP28654

PTM databases

iPTMnetiP28654
PhosphoSitePlusiP28654

Expressioni

Gene expression databases

BgeeiENSMUSG00000019929
CleanExiMM_DCN
ExpressionAtlasiP28654 baseline and differential
GenevisibleiP28654 MM

Interactioni

Subunit structurei

Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP28654, 1 interactor
MINTiP28654
STRINGi10090.ENSMUSP00000100924

Structurei

3D structure databases

ProteinModelPortaliP28654
SMRiP28654
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati68 – 88LRR 1Add BLAST21
Repeati89 – 112LRR 2Add BLAST24
Repeati113 – 136LRR 3Add BLAST24
Repeati137 – 157LRR 4Add BLAST21
Repeati158 – 181LRR 5Add BLAST24
Repeati182 – 207LRR 6Add BLAST26
Repeati208 – 228LRR 7Add BLAST21
Repeati229 – 252LRR 8Add BLAST24
Repeati253 – 276LRR 9Add BLAST24
Repeati277 – 299LRR 10Add BLAST23
Repeati300 – 329LRR 11Add BLAST30
Repeati330 – 354LRR 12Add BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 62Cys-richAdd BLAST14

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000261690
HOVERGENiHBG016052
InParanoidiP28654
KOiK04660
OMAiPLGPVCP
OrthoDBiEOG091G044B
PhylomeDBiP28654
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR028549 Decorin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR016352 SLRP_I_decor/aspor/byglycan
PANTHERiPTHR44053:SF2 PTHR44053:SF2, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
PIRSFiPIRSF002490 SLRP_I, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKATLIFFLL AQVSWAGPFE QRGLFDFMLE DEASGIIPYD PDNPLISMCP
60 70 80 90 100
YRCQCHLRVV QCSDLGLDKV PWDFPPDTTL LDLQNNKITE IKEGAFKNLK
110 120 130 140 150
DLHTLILVNN KISKISPEAF KPLVKLERLY LSKNQLKELP EKMPRTLQEL
160 170 180 190 200
RVHENEITKL RKSDFNGLNN VLVIELGGNP LKNSGIENGA FQGLKSLSYI
210 220 230 240 250
RISDTNITAI PQGLPTSLTE VHLDGNKITK VDAPSLKGLI NLSKLGLSFN
260 270 280 290 300
SITVMENGSL ANVPHLRELH LDNNKLLRVP AGLAQHKYIQ VVYLHNNNIS
310 320 330 340 350
AVGQNDFCRA GHPSRKASYS AVSLYGNPVR YWEIFPNTFR CVYVRSAIQL

GNYK
Length:354
Mass (Da):39,809
Last modified:December 1, 1992 - v1
Checksum:iF05B5CC08DCABF6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53929 mRNA Translation: CAA37876.1
CCDSiCCDS24141.1
PIRiA55454
RefSeqiNP_001177380.1, NM_001190451.2
NP_031859.1, NM_007833.6
UniGeneiMm.56769

Genome annotation databases

EnsembliENSMUST00000105287; ENSMUSP00000100924; ENSMUSG00000019929
ENSMUST00000163448; ENSMUSP00000131431; ENSMUSG00000019929
GeneIDi13179
KEGGimmu:13179
UCSCiuc007gwx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPGS2_MOUSE
AccessioniPrimary (citable) accession number: P28654
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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