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P28653

- PGS1_MOUSE

UniProt

P28653 - PGS1_MOUSE

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Protein

Biglycan

Gene

Bgn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in collagen fiber assembly.By similarity

GO - Molecular functioni

  1. extracellular matrix binding Source: MGI
  2. glycosaminoglycan binding Source: MGI

GO - Biological processi

  1. blood vessel remodeling Source: Ensembl
  2. peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196514. Chondroitin sulfate biosynthesis.
REACT_196540. Dermatan sulfate biosynthesis.
REACT_196606. ECM proteoglycans.
REACT_198981. CS/DS degradation.
REACT_268952. Defective B3GAT3 causes JDSSDHD.
REACT_268957. Defective CHSY1 causes TPBS.
REACT_269050. Defective CHST3 causes SEDCJD.
REACT_269282. Defective B4GALT7 causes EDS, progeroid type.
REACT_271176. Defective CHST14 causes EDS, musculocontractural type.

Names & Taxonomyi

Protein namesi
Recommended name:
Biglycan
Alternative name(s):
Bone/cartilage proteoglycan I
PG-S1
Gene namesi
Name:Bgn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:88158. Bgn.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. extracellular matrix Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. intracellular Source: MGI
  5. proteinaceous extracellular matrix Source: UniProtKB-KW
  6. sarcolemma Source: MGI
  7. transport vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 3718PRO_0000032693Add
BLAST
Chaini38 – 369332BiglycanPRO_0000032694Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421O-linked (Xyl...) (glycosaminoglycan)By similarity
Glycosylationi48 – 481O-linked (Xyl...) (glycosaminoglycan)By similarity
Disulfide bondi64 ↔ 70By similarity
Disulfide bondi68 ↔ 77By similarity
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi322 ↔ 355By similarity

Post-translational modificationi

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiP28653.
PaxDbiP28653.
PRIDEiP28653.

PTM databases

PhosphoSiteiP28653.

Expressioni

Tissue specificityi

Found in several connective tissues, especially in articular cartilages.

Gene expression databases

BgeeiP28653.
CleanExiMM_BGN.
ExpressionAtlasiP28653. baseline and differential.
GenevestigatoriP28653.

Interactioni

Protein-protein interaction databases

IntActiP28653. 4 interactions.
MINTiMINT-4107374.

Structurei

3D structure databases

ProteinModelPortaliP28653.
SMRiP28653. Positions 62-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati83 – 10321LRR 1Add
BLAST
Repeati104 – 12724LRR 2Add
BLAST
Repeati128 – 15124LRR 3Add
BLAST
Repeati152 – 17221LRR 4Add
BLAST
Repeati173 – 19624LRR 5Add
BLAST
Repeati197 – 22125LRR 6Add
BLAST
Repeati222 – 24221LRR 7Add
BLAST
Repeati243 – 26624LRR 8Add
BLAST
Repeati267 – 29024LRR 9Add
BLAST
Repeati291 – 31323LRR 10Add
BLAST
Repeati314 – 34330LRR 11Add
BLAST
Repeati344 – 36926LRR 12Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 7714Cys-richAdd
BLAST

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiP28653.
KOiK08118.
OMAiIQFGNYK.
OrthoDBiEOG76739V.
PhylomeDBiP28653.
TreeFamiTF334562.

Family and domain databases

InterProiIPR028547. Biglycan.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF6. PTHR24369:SF6. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28653-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCPLWLLTLL LALSQALPFE QKGFWDFTLD DGLLMMNDEE ASGSDTTSGV
60 70 80 90 100
PDLDSVTPTF SAMCPFGCHC HLRVVQCSDL GLKTVPKEIS PDTTLLDLQN
110 120 130 140 150
NDISELRKDD FKGLQHLYAL VLVNNKISKI HEKAFSPLRK LQKLYISKNH
160 170 180 190 200
LVEIPPNLPS SLVELRIHDN RIRKVPKGVF SGLRNMNCIE MGGNPLENSG
210 220 230 240 250
FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN KIQAIELEDL
260 270 280 290 300
LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL
310 320 330 340 350
KLLQVVYLHS NNITKVGIND FCPMGFGVKR AYYNGISLFN NPVPYWEVQP
360
ATFRCVTDRL AIQFGNYKK
Length:369
Mass (Da):41,639
Last modified:December 1, 1992 - v1
Checksum:i4B57FCC9A1026BE6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681C → W in AAA64360. (PubMed:8043960)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53928 mRNA. Translation: CAA37875.1.
L20276 mRNA. Translation: AAA64360.1.
BC005452 mRNA. Translation: AAH05452.1.
BC019502 mRNA. Translation: AAH19502.1.
Y11758 mRNA. Translation: CAA72422.1.
CCDSiCCDS30204.1.
PIRiS20811.
RefSeqiNP_031568.2. NM_007542.4.
UniGeneiMm.2608.

Genome annotation databases

EnsembliENSMUST00000033741; ENSMUSP00000033741; ENSMUSG00000031375.
ENSMUST00000169489; ENSMUSP00000126768; ENSMUSG00000031375.
GeneIDi12111.
KEGGimmu:12111.
UCSCiuc012hkf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53928 mRNA. Translation: CAA37875.1 .
L20276 mRNA. Translation: AAA64360.1 .
BC005452 mRNA. Translation: AAH05452.1 .
BC019502 mRNA. Translation: AAH19502.1 .
Y11758 mRNA. Translation: CAA72422.1 .
CCDSi CCDS30204.1.
PIRi S20811.
RefSeqi NP_031568.2. NM_007542.4.
UniGenei Mm.2608.

3D structure databases

ProteinModelPortali P28653.
SMRi P28653. Positions 62-366.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P28653. 4 interactions.
MINTi MINT-4107374.

PTM databases

PhosphoSitei P28653.

Proteomic databases

MaxQBi P28653.
PaxDbi P28653.
PRIDEi P28653.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033741 ; ENSMUSP00000033741 ; ENSMUSG00000031375 .
ENSMUST00000169489 ; ENSMUSP00000126768 ; ENSMUSG00000031375 .
GeneIDi 12111.
KEGGi mmu:12111.
UCSCi uc012hkf.1. mouse.

Organism-specific databases

CTDi 633.
MGIi MGI:88158. Bgn.

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000261690.
HOVERGENi HBG016052.
InParanoidi P28653.
KOi K08118.
OMAi IQFGNYK.
OrthoDBi EOG76739V.
PhylomeDBi P28653.
TreeFami TF334562.

Enzyme and pathway databases

Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196514. Chondroitin sulfate biosynthesis.
REACT_196540. Dermatan sulfate biosynthesis.
REACT_196606. ECM proteoglycans.
REACT_198981. CS/DS degradation.
REACT_268952. Defective B3GAT3 causes JDSSDHD.
REACT_268957. Defective CHSY1 causes TPBS.
REACT_269050. Defective CHST3 causes SEDCJD.
REACT_269282. Defective B4GALT7 causes EDS, progeroid type.
REACT_271176. Defective CHST14 causes EDS, musculocontractural type.

Miscellaneous databases

ChiTaRSi Bgn. mouse.
NextBioi 280425.
PROi P28653.
SOURCEi Search...

Gene expression databases

Bgeei P28653.
CleanExi MM_BGN.
ExpressionAtlasi P28653. baseline and differential.
Genevestigatori P28653.

Family and domain databases

InterProi IPR028547. Biglycan.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view ]
PANTHERi PTHR24369:SF6. PTHR24369:SF6. 1 hit.
Pfami PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view ]
PIRSFi PIRSF002490. SLRP_I. 1 hit.
SMARTi SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Naitoh Y., Suzuki S.
    Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
    Tissue: Fibroblast.
  2. "A dinucleotide repeat in the mouse biglycan gene (EST) on the X chromosome."
    Rau W., Just W., Vetter U., Vogel W.
    Mamm. Genome 5:395-396(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Mammary gland.
  4. "Murine fibromodulin: cDNA and genomic structure, and age-related expression and distribution in the knee joint."
    Saeaemaenen A.-M.K., Salminen H.J., Rantakokko A.J., Heinegaard D., Vuorio E.I.
    Biochem. J. 355:577-585(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-152.
    Strain: C57BL/6.

Entry informationi

Entry nameiPGS1_MOUSE
AccessioniPrimary (citable) accession number: P28653
Secondary accession number(s): Q61355
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 26, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3