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P28653

- PGS1_MOUSE

UniProt

P28653 - PGS1_MOUSE

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Protein
Biglycan
Gene
Bgn
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in collagen fiber assembly By similarity.

GO - Molecular functioni

  1. extracellular matrix binding Source: MGI
  2. glycosaminoglycan binding Source: MGI

GO - Biological processi

  1. blood vessel remodeling Source: Ensembl
  2. peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196514. Chondroitin sulfate biosynthesis.
REACT_196540. Dermatan sulfate biosynthesis.
REACT_196606. ECM proteoglycans.
REACT_198981. CS/DS degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Biglycan
Alternative name(s):
Bone/cartilage proteoglycan I
PG-S1
Gene namesi
Name:Bgn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:88158. Bgn.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. extracellular matrix Source: MGI
  3. intracellular Source: MGI
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
  5. sarcolemma Source: MGI
  6. transport vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Propeptidei20 – 3718
PRO_0000032693Add
BLAST
Chaini38 – 369332Biglycan
PRO_0000032694Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421O-linked (Xyl...) (glycosaminoglycan) By similarity
Glycosylationi48 – 481O-linked (Xyl...) (glycosaminoglycan) By similarity
Disulfide bondi64 ↔ 70 By similarity
Disulfide bondi68 ↔ 77 By similarity
Glycosylationi271 – 2711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi312 – 3121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi322 ↔ 355 By similarity

Post-translational modificationi

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiP28653.
PaxDbiP28653.
PRIDEiP28653.

PTM databases

PhosphoSiteiP28653.

Expressioni

Tissue specificityi

Found in several connective tissues, especially in articular cartilages.

Gene expression databases

ArrayExpressiP28653.
BgeeiP28653.
CleanExiMM_BGN.
GenevestigatoriP28653.

Interactioni

Protein-protein interaction databases

IntActiP28653. 4 interactions.
MINTiMINT-4107374.

Structurei

3D structure databases

ProteinModelPortaliP28653.
SMRiP28653. Positions 62-366.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati83 – 10321LRR 1
Add
BLAST
Repeati104 – 12724LRR 2
Add
BLAST
Repeati128 – 15124LRR 3
Add
BLAST
Repeati152 – 17221LRR 4
Add
BLAST
Repeati173 – 19624LRR 5
Add
BLAST
Repeati197 – 22125LRR 6
Add
BLAST
Repeati222 – 24221LRR 7
Add
BLAST
Repeati243 – 26624LRR 8
Add
BLAST
Repeati267 – 29024LRR 9
Add
BLAST
Repeati291 – 31323LRR 10
Add
BLAST
Repeati314 – 34330LRR 11
Add
BLAST
Repeati344 – 36926LRR 12
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 7714Cys-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiP28653.
KOiK08118.
OMAiIQFGNYK.
OrthoDBiEOG76739V.
PhylomeDBiP28653.
TreeFamiTF334562.

Family and domain databases

InterProiIPR028547. Biglycan.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF6. PTHR24369:SF6. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28653-1 [UniParc]FASTAAdd to Basket

« Hide

MCPLWLLTLL LALSQALPFE QKGFWDFTLD DGLLMMNDEE ASGSDTTSGV    50
PDLDSVTPTF SAMCPFGCHC HLRVVQCSDL GLKTVPKEIS PDTTLLDLQN 100
NDISELRKDD FKGLQHLYAL VLVNNKISKI HEKAFSPLRK LQKLYISKNH 150
LVEIPPNLPS SLVELRIHDN RIRKVPKGVF SGLRNMNCIE MGGNPLENSG 200
FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN KIQAIELEDL 250
LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL 300
KLLQVVYLHS NNITKVGIND FCPMGFGVKR AYYNGISLFN NPVPYWEVQP 350
ATFRCVTDRL AIQFGNYKK 369
Length:369
Mass (Da):41,639
Last modified:December 1, 1992 - v1
Checksum:i4B57FCC9A1026BE6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681C → W in AAA64360. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53928 mRNA. Translation: CAA37875.1.
L20276 mRNA. Translation: AAA64360.1.
BC005452 mRNA. Translation: AAH05452.1.
BC019502 mRNA. Translation: AAH19502.1.
Y11758 mRNA. Translation: CAA72422.1.
CCDSiCCDS30204.1.
PIRiS20811.
RefSeqiNP_031568.2. NM_007542.4.
UniGeneiMm.2608.

Genome annotation databases

EnsembliENSMUST00000033741; ENSMUSP00000033741; ENSMUSG00000031375.
ENSMUST00000169489; ENSMUSP00000126768; ENSMUSG00000031375.
GeneIDi12111.
KEGGimmu:12111.
UCSCiuc012hkf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53928 mRNA. Translation: CAA37875.1 .
L20276 mRNA. Translation: AAA64360.1 .
BC005452 mRNA. Translation: AAH05452.1 .
BC019502 mRNA. Translation: AAH19502.1 .
Y11758 mRNA. Translation: CAA72422.1 .
CCDSi CCDS30204.1.
PIRi S20811.
RefSeqi NP_031568.2. NM_007542.4.
UniGenei Mm.2608.

3D structure databases

ProteinModelPortali P28653.
SMRi P28653. Positions 62-366.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P28653. 4 interactions.
MINTi MINT-4107374.

PTM databases

PhosphoSitei P28653.

Proteomic databases

MaxQBi P28653.
PaxDbi P28653.
PRIDEi P28653.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033741 ; ENSMUSP00000033741 ; ENSMUSG00000031375 .
ENSMUST00000169489 ; ENSMUSP00000126768 ; ENSMUSG00000031375 .
GeneIDi 12111.
KEGGi mmu:12111.
UCSCi uc012hkf.1. mouse.

Organism-specific databases

CTDi 633.
MGIi MGI:88158. Bgn.

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000261690.
HOVERGENi HBG016052.
InParanoidi P28653.
KOi K08118.
OMAi IQFGNYK.
OrthoDBi EOG76739V.
PhylomeDBi P28653.
TreeFami TF334562.

Enzyme and pathway databases

Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196514. Chondroitin sulfate biosynthesis.
REACT_196540. Dermatan sulfate biosynthesis.
REACT_196606. ECM proteoglycans.
REACT_198981. CS/DS degradation.

Miscellaneous databases

ChiTaRSi BGN. mouse.
NextBioi 280425.
PROi P28653.
SOURCEi Search...

Gene expression databases

ArrayExpressi P28653.
Bgeei P28653.
CleanExi MM_BGN.
Genevestigatori P28653.

Family and domain databases

InterProi IPR028547. Biglycan.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view ]
PANTHERi PTHR24369:SF6. PTHR24369:SF6. 1 hit.
Pfami PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view ]
PIRSFi PIRSF002490. SLRP_I. 1 hit.
SMARTi SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Naitoh Y., Suzuki S.
    Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
    Tissue: Fibroblast.
  2. "A dinucleotide repeat in the mouse biglycan gene (EST) on the X chromosome."
    Rau W., Just W., Vetter U., Vogel W.
    Mamm. Genome 5:395-396(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Mammary gland.
  4. "Murine fibromodulin: cDNA and genomic structure, and age-related expression and distribution in the knee joint."
    Saeaemaenen A.-M.K., Salminen H.J., Rantakokko A.J., Heinegaard D., Vuorio E.I.
    Biochem. J. 355:577-585(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-152.
    Strain: C57BL/6.

Entry informationi

Entry nameiPGS1_MOUSE
AccessioniPrimary (citable) accession number: P28653
Secondary accession number(s): Q61355
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 3, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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