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P28653

- PGS1_MOUSE

UniProt

P28653 - PGS1_MOUSE

Protein

Biglycan

Gene

Bgn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    May be involved in collagen fiber assembly.By similarity

    GO - Molecular functioni

    1. extracellular matrix binding Source: MGI
    2. glycosaminoglycan binding Source: MGI

    GO - Biological processi

    1. blood vessel remodeling Source: Ensembl
    2. peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_196514. Chondroitin sulfate biosynthesis.
    REACT_196540. Dermatan sulfate biosynthesis.
    REACT_196606. ECM proteoglycans.
    REACT_198981. CS/DS degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biglycan
    Alternative name(s):
    Bone/cartilage proteoglycan I
    PG-S1
    Gene namesi
    Name:Bgn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:88158. Bgn.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. extracellular matrix Source: MGI
    3. intracellular Source: MGI
    4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
    5. sarcolemma Source: MGI
    6. transport vesicle Source: Ensembl

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 3718PRO_0000032693Add
    BLAST
    Chaini38 – 369332BiglycanPRO_0000032694Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421O-linked (Xyl...) (glycosaminoglycan)By similarity
    Glycosylationi48 – 481O-linked (Xyl...) (glycosaminoglycan)By similarity
    Disulfide bondi64 ↔ 70By similarity
    Disulfide bondi68 ↔ 77By similarity
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi322 ↔ 355By similarity

    Post-translational modificationi

    The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan

    Proteomic databases

    MaxQBiP28653.
    PaxDbiP28653.
    PRIDEiP28653.

    PTM databases

    PhosphoSiteiP28653.

    Expressioni

    Tissue specificityi

    Found in several connective tissues, especially in articular cartilages.

    Gene expression databases

    ArrayExpressiP28653.
    BgeeiP28653.
    CleanExiMM_BGN.
    GenevestigatoriP28653.

    Interactioni

    Protein-protein interaction databases

    IntActiP28653. 4 interactions.
    MINTiMINT-4107374.

    Structurei

    3D structure databases

    ProteinModelPortaliP28653.
    SMRiP28653. Positions 62-366.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati83 – 10321LRR 1Add
    BLAST
    Repeati104 – 12724LRR 2Add
    BLAST
    Repeati128 – 15124LRR 3Add
    BLAST
    Repeati152 – 17221LRR 4Add
    BLAST
    Repeati173 – 19624LRR 5Add
    BLAST
    Repeati197 – 22125LRR 6Add
    BLAST
    Repeati222 – 24221LRR 7Add
    BLAST
    Repeati243 – 26624LRR 8Add
    BLAST
    Repeati267 – 29024LRR 9Add
    BLAST
    Repeati291 – 31323LRR 10Add
    BLAST
    Repeati314 – 34330LRR 11Add
    BLAST
    Repeati344 – 36926LRR 12Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi64 – 7714Cys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 12 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000261690.
    HOVERGENiHBG016052.
    InParanoidiP28653.
    KOiK08118.
    OMAiIQFGNYK.
    OrthoDBiEOG76739V.
    PhylomeDBiP28653.
    TreeFamiTF334562.

    Family and domain databases

    InterProiIPR028547. Biglycan.
    IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    IPR016352. SLRP_I_decor/aspor/byglycan.
    [Graphical view]
    PANTHERiPTHR24369:SF6. PTHR24369:SF6. 1 hit.
    PfamiPF13855. LRR_8. 3 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002490. SLRP_I. 1 hit.
    SMARTiSM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28653-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCPLWLLTLL LALSQALPFE QKGFWDFTLD DGLLMMNDEE ASGSDTTSGV    50
    PDLDSVTPTF SAMCPFGCHC HLRVVQCSDL GLKTVPKEIS PDTTLLDLQN 100
    NDISELRKDD FKGLQHLYAL VLVNNKISKI HEKAFSPLRK LQKLYISKNH 150
    LVEIPPNLPS SLVELRIHDN RIRKVPKGVF SGLRNMNCIE MGGNPLENSG 200
    FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN KIQAIELEDL 250
    LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL 300
    KLLQVVYLHS NNITKVGIND FCPMGFGVKR AYYNGISLFN NPVPYWEVQP 350
    ATFRCVTDRL AIQFGNYKK 369
    Length:369
    Mass (Da):41,639
    Last modified:December 1, 1992 - v1
    Checksum:i4B57FCC9A1026BE6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681C → W in AAA64360. (PubMed:8043960)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53928 mRNA. Translation: CAA37875.1.
    L20276 mRNA. Translation: AAA64360.1.
    BC005452 mRNA. Translation: AAH05452.1.
    BC019502 mRNA. Translation: AAH19502.1.
    Y11758 mRNA. Translation: CAA72422.1.
    CCDSiCCDS30204.1.
    PIRiS20811.
    RefSeqiNP_031568.2. NM_007542.4.
    UniGeneiMm.2608.

    Genome annotation databases

    EnsembliENSMUST00000033741; ENSMUSP00000033741; ENSMUSG00000031375.
    ENSMUST00000169489; ENSMUSP00000126768; ENSMUSG00000031375.
    GeneIDi12111.
    KEGGimmu:12111.
    UCSCiuc012hkf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53928 mRNA. Translation: CAA37875.1 .
    L20276 mRNA. Translation: AAA64360.1 .
    BC005452 mRNA. Translation: AAH05452.1 .
    BC019502 mRNA. Translation: AAH19502.1 .
    Y11758 mRNA. Translation: CAA72422.1 .
    CCDSi CCDS30204.1.
    PIRi S20811.
    RefSeqi NP_031568.2. NM_007542.4.
    UniGenei Mm.2608.

    3D structure databases

    ProteinModelPortali P28653.
    SMRi P28653. Positions 62-366.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P28653. 4 interactions.
    MINTi MINT-4107374.

    PTM databases

    PhosphoSitei P28653.

    Proteomic databases

    MaxQBi P28653.
    PaxDbi P28653.
    PRIDEi P28653.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033741 ; ENSMUSP00000033741 ; ENSMUSG00000031375 .
    ENSMUST00000169489 ; ENSMUSP00000126768 ; ENSMUSG00000031375 .
    GeneIDi 12111.
    KEGGi mmu:12111.
    UCSCi uc012hkf.1. mouse.

    Organism-specific databases

    CTDi 633.
    MGIi MGI:88158. Bgn.

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000261690.
    HOVERGENi HBG016052.
    InParanoidi P28653.
    KOi K08118.
    OMAi IQFGNYK.
    OrthoDBi EOG76739V.
    PhylomeDBi P28653.
    TreeFami TF334562.

    Enzyme and pathway databases

    Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_196514. Chondroitin sulfate biosynthesis.
    REACT_196540. Dermatan sulfate biosynthesis.
    REACT_196606. ECM proteoglycans.
    REACT_198981. CS/DS degradation.

    Miscellaneous databases

    ChiTaRSi BGN. mouse.
    NextBioi 280425.
    PROi P28653.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28653.
    Bgeei P28653.
    CleanExi MM_BGN.
    Genevestigatori P28653.

    Family and domain databases

    InterProi IPR028547. Biglycan.
    IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    IPR016352. SLRP_I_decor/aspor/byglycan.
    [Graphical view ]
    PANTHERi PTHR24369:SF6. PTHR24369:SF6. 1 hit.
    Pfami PF13855. LRR_8. 3 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002490. SLRP_I. 1 hit.
    SMARTi SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Naitoh Y., Suzuki S.
      Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NIH Swiss.
      Tissue: Fibroblast.
    2. "A dinucleotide repeat in the mouse biglycan gene (EST) on the X chromosome."
      Rau W., Just W., Vetter U., Vogel W.
      Mamm. Genome 5:395-396(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NIH Swiss.
      Tissue: Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Mammary gland.
    4. "Murine fibromodulin: cDNA and genomic structure, and age-related expression and distribution in the knee joint."
      Saeaemaenen A.-M.K., Salminen H.J., Rantakokko A.J., Heinegaard D., Vuorio E.I.
      Biochem. J. 355:577-585(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-152.
      Strain: C57BL/6.

    Entry informationi

    Entry nameiPGS1_MOUSE
    AccessioniPrimary (citable) accession number: P28653
    Secondary accession number(s): Q61355
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3