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Protein

Biglycan

Gene

Bgn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in collagen fiber assembly.By similarity

GO - Molecular functioni

  • extracellular matrix binding Source: MGI
  • glycosaminoglycan binding Source: MGI
  • protein kinase inhibitor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022870. Chondroitin sulfate biosynthesis.
R-MMU-2022923. Dermatan sulfate biosynthesis.
R-MMU-2024101. CS/DS degradation.
R-MMU-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Biglycan
Alternative name(s):
Bone/cartilage proteoglycan I
PG-S1
Gene namesi
Name:Bgn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:88158. Bgn.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: MGI
  • cytoplasm Source: GO_Central
  • extracellular exosome Source: MGI
  • intracellular Source: MGI
  • proteinaceous extracellular matrix Source: MGI
  • sarcolemma Source: MGI
  • transport vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
PropeptideiPRO_000003269317 – 37By similarityAdd BLAST21
ChainiPRO_000003269438 – 369BiglycanAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42O-linked (Xyl...) (glycosaminoglycan)By similarity1
Glycosylationi48O-linked (Xyl...) (glycosaminoglycan)By similarity1
Disulfide bondi64 ↔ 70By similarity
Disulfide bondi68 ↔ 77By similarity
Glycosylationi271N-linked (GlcNAc...)Sequence analysis1
Glycosylationi312N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi322 ↔ 355By similarity

Post-translational modificationi

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP28653.
PeptideAtlasiP28653.
PRIDEiP28653.

PTM databases

PhosphoSitePlusiP28653.

Expressioni

Tissue specificityi

Found in several connective tissues, especially in articular cartilages.

Gene expression databases

BgeeiENSMUSG00000031375.
CleanExiMM_BGN.
ExpressionAtlasiP28653. baseline and differential.
GenevisibleiP28653. MM.

Interactioni

Protein-protein interaction databases

IntActiP28653. 6 interactors.
MINTiMINT-4107374.
STRINGi10090.ENSMUSP00000033741.

Structurei

3D structure databases

ProteinModelPortaliP28653.
SMRiP28653.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati83 – 103LRR 1Add BLAST21
Repeati104 – 127LRR 2Add BLAST24
Repeati128 – 151LRR 3Add BLAST24
Repeati152 – 172LRR 4Add BLAST21
Repeati173 – 196LRR 5Add BLAST24
Repeati197 – 221LRR 6Add BLAST25
Repeati222 – 242LRR 7Add BLAST21
Repeati243 – 266LRR 8Add BLAST24
Repeati267 – 290LRR 9Add BLAST24
Repeati291 – 313LRR 10Add BLAST23
Repeati314 – 343LRR 11Add BLAST30
Repeati344 – 369LRR 12Add BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi64 – 77Cys-richAdd BLAST14

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiP28653.
KOiK08118.
OMAiQRGFWDF.
OrthoDBiEOG091G044B.
PhylomeDBiP28653.
TreeFamiTF334562.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR028547. Biglycan.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF6. PTHR24369:SF6. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00369. LRR_TYP. 8 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPLWLLTLL LALSQALPFE QKGFWDFTLD DGLLMMNDEE ASGSDTTSGV
60 70 80 90 100
PDLDSVTPTF SAMCPFGCHC HLRVVQCSDL GLKTVPKEIS PDTTLLDLQN
110 120 130 140 150
NDISELRKDD FKGLQHLYAL VLVNNKISKI HEKAFSPLRK LQKLYISKNH
160 170 180 190 200
LVEIPPNLPS SLVELRIHDN RIRKVPKGVF SGLRNMNCIE MGGNPLENSG
210 220 230 240 250
FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN KIQAIELEDL
260 270 280 290 300
LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL
310 320 330 340 350
KLLQVVYLHS NNITKVGIND FCPMGFGVKR AYYNGISLFN NPVPYWEVQP
360
ATFRCVTDRL AIQFGNYKK
Length:369
Mass (Da):41,639
Last modified:December 1, 1992 - v1
Checksum:i4B57FCC9A1026BE6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68C → W in AAA64360 (PubMed:8043960).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53928 mRNA. Translation: CAA37875.1.
L20276 mRNA. Translation: AAA64360.1.
BC005452 mRNA. Translation: AAH05452.1.
BC019502 mRNA. Translation: AAH19502.1.
Y11758 mRNA. Translation: CAA72422.1.
CCDSiCCDS30204.1.
PIRiS20811.
RefSeqiNP_031568.2. NM_007542.5.
UniGeneiMm.2608.

Genome annotation databases

EnsembliENSMUST00000033741; ENSMUSP00000033741; ENSMUSG00000031375.
ENSMUST00000169489; ENSMUSP00000126768; ENSMUSG00000031375.
GeneIDi12111.
KEGGimmu:12111.
UCSCiuc012hkf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53928 mRNA. Translation: CAA37875.1.
L20276 mRNA. Translation: AAA64360.1.
BC005452 mRNA. Translation: AAH05452.1.
BC019502 mRNA. Translation: AAH19502.1.
Y11758 mRNA. Translation: CAA72422.1.
CCDSiCCDS30204.1.
PIRiS20811.
RefSeqiNP_031568.2. NM_007542.5.
UniGeneiMm.2608.

3D structure databases

ProteinModelPortaliP28653.
SMRiP28653.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP28653. 6 interactors.
MINTiMINT-4107374.
STRINGi10090.ENSMUSP00000033741.

PTM databases

PhosphoSitePlusiP28653.

Proteomic databases

PaxDbiP28653.
PeptideAtlasiP28653.
PRIDEiP28653.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033741; ENSMUSP00000033741; ENSMUSG00000031375.
ENSMUST00000169489; ENSMUSP00000126768; ENSMUSG00000031375.
GeneIDi12111.
KEGGimmu:12111.
UCSCiuc012hkf.1. mouse.

Organism-specific databases

CTDi633.
MGIiMGI:88158. Bgn.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiP28653.
KOiK08118.
OMAiQRGFWDF.
OrthoDBiEOG091G044B.
PhylomeDBiP28653.
TreeFamiTF334562.

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022870. Chondroitin sulfate biosynthesis.
R-MMU-2022923. Dermatan sulfate biosynthesis.
R-MMU-2024101. CS/DS degradation.
R-MMU-3000178. ECM proteoglycans.

Miscellaneous databases

ChiTaRSiBgn. mouse.
PROiP28653.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031375.
CleanExiMM_BGN.
ExpressionAtlasiP28653. baseline and differential.
GenevisibleiP28653. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR028547. Biglycan.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF6. PTHR24369:SF6. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00369. LRR_TYP. 8 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGS1_MOUSE
AccessioniPrimary (citable) accession number: P28653
Secondary accession number(s): Q61355
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.