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Protein

Biglycan

Gene

Bgn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in collagen fiber assembly.By similarity

GO - Molecular functioni

  • extracellular matrix binding Source: MGI
  • glycosaminoglycan binding Source: MGI
  • protein kinase inhibitor activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022870 Chondroitin sulfate biosynthesis
R-MMU-2022923 Dermatan sulfate biosynthesis
R-MMU-2024101 CS/DS degradation
R-MMU-3000178 ECM proteoglycans

Names & Taxonomyi

Protein namesi
Recommended name:
Biglycan
Alternative name(s):
Bone/cartilage proteoglycan I
PG-S1
Gene namesi
Name:Bgn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:88158 Bgn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
PropeptideiPRO_000003269317 – 37By similarityAdd BLAST21
ChainiPRO_000003269438 – 369BiglycanAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1
Glycosylationi48O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1
Disulfide bondi64 ↔ 70By similarity
Disulfide bondi68 ↔ 77By similarity
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi322 ↔ 355By similarity

Post-translational modificationi

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP28653
PeptideAtlasiP28653
PRIDEiP28653

PTM databases

PhosphoSitePlusiP28653

Expressioni

Tissue specificityi

Found in several connective tissues, especially in articular cartilages.

Gene expression databases

BgeeiENSMUSG00000031375
CleanExiMM_BGN
ExpressionAtlasiP28653 baseline and differential
GenevisibleiP28653 MM

Interactioni

Protein-protein interaction databases

IntActiP28653, 6 interactors
MINTiP28653
STRINGi10090.ENSMUSP00000033741

Structurei

3D structure databases

ProteinModelPortaliP28653
SMRiP28653
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati83 – 103LRR 1Add BLAST21
Repeati104 – 127LRR 2Add BLAST24
Repeati128 – 151LRR 3Add BLAST24
Repeati152 – 172LRR 4Add BLAST21
Repeati173 – 196LRR 5Add BLAST24
Repeati197 – 221LRR 6Add BLAST25
Repeati222 – 242LRR 7Add BLAST21
Repeati243 – 266LRR 8Add BLAST24
Repeati267 – 290LRR 9Add BLAST24
Repeati291 – 313LRR 10Add BLAST23
Repeati314 – 343LRR 11Add BLAST30
Repeati344 – 369LRR 12Add BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi64 – 77Cys-richAdd BLAST14

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000261690
HOVERGENiHBG016052
InParanoidiP28653
KOiK08118
OMAiPVNYWEV
OrthoDBiEOG091G044B
PhylomeDBiP28653
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR028547 Biglycan
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR016352 SLRP_I_decor/aspor/byglycan
PANTHERiPTHR44053:SF4 PTHR44053:SF4, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
PIRSFiPIRSF002490 SLRP_I, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPLWLLTLL LALSQALPFE QKGFWDFTLD DGLLMMNDEE ASGSDTTSGV
60 70 80 90 100
PDLDSVTPTF SAMCPFGCHC HLRVVQCSDL GLKTVPKEIS PDTTLLDLQN
110 120 130 140 150
NDISELRKDD FKGLQHLYAL VLVNNKISKI HEKAFSPLRK LQKLYISKNH
160 170 180 190 200
LVEIPPNLPS SLVELRIHDN RIRKVPKGVF SGLRNMNCIE MGGNPLENSG
210 220 230 240 250
FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN KIQAIELEDL
260 270 280 290 300
LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL
310 320 330 340 350
KLLQVVYLHS NNITKVGIND FCPMGFGVKR AYYNGISLFN NPVPYWEVQP
360
ATFRCVTDRL AIQFGNYKK
Length:369
Mass (Da):41,639
Last modified:December 1, 1992 - v1
Checksum:i4B57FCC9A1026BE6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68C → W in AAA64360 (PubMed:8043960).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53928 mRNA Translation: CAA37875.1
L20276 mRNA Translation: AAA64360.1
BC005452 mRNA Translation: AAH05452.1
BC019502 mRNA Translation: AAH19502.1
Y11758 mRNA Translation: CAA72422.1
CCDSiCCDS30204.1
PIRiS20811
RefSeqiNP_031568.2, NM_007542.5
UniGeneiMm.2608

Genome annotation databases

EnsembliENSMUST00000033741; ENSMUSP00000033741; ENSMUSG00000031375
ENSMUST00000169489; ENSMUSP00000126768; ENSMUSG00000031375
GeneIDi12111
KEGGimmu:12111
UCSCiuc012hkf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPGS1_MOUSE
AccessioniPrimary (citable) accession number: P28653
Secondary accession number(s): Q61355
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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