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P28653 (PGS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biglycan
Alternative name(s):
Bone/cartilage proteoglycan I
PG-S1
Gene names
Name:Bgn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in collagen fiber assembly By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Found in several connective tissues, especially in articular cartilages.

Post-translational modification

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate By similarity.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.

Contains 12 LRR (leucine-rich) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 3718
PRO_0000032693
Chain38 – 369332Biglycan
PRO_0000032694

Regions

Repeat83 – 10321LRR 1
Repeat104 – 12724LRR 2
Repeat128 – 15124LRR 3
Repeat152 – 17221LRR 4
Repeat173 – 19624LRR 5
Repeat197 – 22125LRR 6
Repeat222 – 24221LRR 7
Repeat243 – 26624LRR 8
Repeat267 – 29024LRR 9
Repeat291 – 31323LRR 10
Repeat314 – 34330LRR 11
Repeat344 – 36926LRR 12
Compositional bias64 – 7714Cys-rich

Amino acid modifications

Glycosylation421O-linked (Xyl...) (glycosaminoglycan) By similarity
Glycosylation481O-linked (Xyl...) (glycosaminoglycan) By similarity
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Disulfide bond64 ↔ 70 By similarity
Disulfide bond68 ↔ 77 By similarity
Disulfide bond322 ↔ 355 By similarity

Experimental info

Sequence conflict681C → W in AAA64360. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P28653 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 4B57FCC9A1026BE6

FASTA36941,639
        10         20         30         40         50         60 
MCPLWLLTLL LALSQALPFE QKGFWDFTLD DGLLMMNDEE ASGSDTTSGV PDLDSVTPTF 

        70         80         90        100        110        120 
SAMCPFGCHC HLRVVQCSDL GLKTVPKEIS PDTTLLDLQN NDISELRKDD FKGLQHLYAL 

       130        140        150        160        170        180 
VLVNNKISKI HEKAFSPLRK LQKLYISKNH LVEIPPNLPS SLVELRIHDN RIRKVPKGVF 

       190        200        210        220        230        240 
SGLRNMNCIE MGGNPLENSG FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN 

       250        260        270        280        290        300 
KIQAIELEDL LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL 

       310        320        330        340        350        360 
KLLQVVYLHS NNITKVGIND FCPMGFGVKR AYYNGISLFN NPVPYWEVQP ATFRCVTDRL 


AIQFGNYKK 

« Hide

References

« Hide 'large scale' references
[1]Naitoh Y., Suzuki S.
Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NIH Swiss.
Tissue: Fibroblast.
[2]"A dinucleotide repeat in the mouse biglycan gene (EST) on the X chromosome."
Rau W., Just W., Vetter U., Vogel W.
Mamm. Genome 5:395-396(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NIH Swiss.
Tissue: Embryo.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney and Mammary gland.
[4]"Murine fibromodulin: cDNA and genomic structure, and age-related expression and distribution in the knee joint."
Saeaemaenen A.-M.K., Salminen H.J., Rantakokko A.J., Heinegaard D., Vuorio E.I.
Biochem. J. 355:577-585(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-152.
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53928 mRNA. Translation: CAA37875.1.
L20276 mRNA. Translation: AAA64360.1.
BC005452 mRNA. Translation: AAH05452.1.
BC019502 mRNA. Translation: AAH19502.1.
Y11758 mRNA. Translation: CAA72422.1.
PIRS20811.
RefSeqNP_031568.2. NM_007542.4.
UniGeneMm.2608.

3D structure databases

ProteinModelPortalP28653.
SMRP28653. Positions 62-366.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP28653. 4 interactions.
MINTMINT-4107374.

PTM databases

PhosphoSiteP28653.

Proteomic databases

PaxDbP28653.
PRIDEP28653.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033741; ENSMUSP00000033741; ENSMUSG00000031375.
ENSMUST00000169489; ENSMUSP00000126768; ENSMUSG00000031375.
GeneID12111.
KEGGmmu:12111.
UCSCuc012hkf.1. mouse.

Organism-specific databases

CTD633.
MGIMGI:88158. Bgn.

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000261690.
HOVERGENHBG016052.
InParanoidP28653.
KOK08118.
OMAIQFGNYK.
OrthoDBEOG76739V.
PhylomeDBP28653.
TreeFamTF334562.

Gene expression databases

ArrayExpressP28653.
BgeeP28653.
CleanExMM_BGN.
GenevestigatorP28653.

Family and domain databases

InterProIPR028547. Biglycan.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERPTHR24369:SF6. PTHR24369:SF6. 1 hit.
PfamPF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFPIRSF002490. SLRP_I. 1 hit.
SMARTSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBGN. mouse.
NextBio280425.
PROP28653.
SOURCESearch...

Entry information

Entry namePGS1_MOUSE
AccessionPrimary (citable) accession number: P28653
Secondary accession number(s): Q61355
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot