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Protein

Carbonic anhydrase-related protein

Gene

Ca8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not have a carbonic anhydrase catalytic activity.

Caution

Although it belongs to the alpha-carbonic anhydrase family, Arg-117 is present instead of the conserved His which is a zinc-binding residue. It is therefore expected that this protein lacks carbonic anhydrase activity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Proton acceptorPROSITE-ProRule annotation1
Sitei117Ancestral zinc ligand1
Metal bindingi119ZincSequence analysis1
Metal bindingi142ZincSequence analysis1

GO - Molecular functioni

GO - Biological processi

  • one-carbon metabolic process Source: InterPro
  • phosphatidylinositol-mediated signaling Source: MGI

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase-related protein
Short name:
CARP
Alternative name(s):
Carbonic anhydrase VIII
Short name:
CA-VIII
Gene namesi
Name:Ca8
Synonyms:Cals, Cals1, Car8, Carp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88253 Car8

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi115 – 117EVR → QVH: Restores zinc-binding and activity. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774341 – 291Carbonic anhydrase-related proteinAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP28651
PaxDbiP28651
PeptideAtlasiP28651
PRIDEiP28651

PTM databases

iPTMnetiP28651
PhosphoSitePlusiP28651

Expressioni

Tissue specificityi

Expressed only in Purkinje cells.

Gene expression databases

BgeeiENSMUSG00000041261
CleanExiMM_CAR8
GenevisibleiP28651 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063511

Structurei

3D structure databases

ProteinModelPortaliP28651
SMRiP28651
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 290Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST263

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 37Glu-rich (acidic)Add BLAST23

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiP28651
KOiK01672
OMAiDGMLGDN
OrthoDBiEOG091G0XFM
PhylomeDBiP28651
TreeFamiTF316425

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLSFIEDA VAFPEKEEDE EEEEEEGVEW GYEEGVEWGL VFPDANGEYQ
60 70 80 90 100
SPINLNSREA RYDPSLLDVR LSPNYVVCRD CEVTNDGHTI QVILKSKSVL
110 120 130 140 150
SGGPLPQGQE FELYEVRFHW GRENQRGSEH TVNFKAFPME LHLIHWNSTL
160 170 180 190 200
FGSIDEAVGK PHGIAIIALF VQIGKEHVGL KAVTEILQDI QYKGKSKTIP
210 220 230 240 250
CFNPNTLLPD PLLRDYWVYE GSLTIPPCSE GVTWILFRYP LTISQMQIEE
260 270 280 290
FRRLRTHVKG AELVEGCDGI LGDNFRPTQP LSDRVIRAAF Q
Length:291
Mass (Da):33,081
Last modified:January 23, 2007 - v5
Checksum:iFAA2B1678A9AEF54
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261A → V in CAA43668 (PubMed:2121526).Curated1
Sequence conflicti285V → I in BAC25100 (PubMed:16141072).Curated1
Sequence conflicti291Q → SSQRDREQTHLHQ in CAA43668 (PubMed:2121526).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61397 mRNA Translation: CAA43668.1
AK004896 mRNA Translation: BAC25100.1
BC010773 mRNA Translation: AAH10773.1
CCDSiCCDS17954.1
PIRiS12867
RefSeqiNP_031618.2, NM_007592.3
UniGeneiMm.119320

Genome annotation databases

EnsembliENSMUST00000066674; ENSMUSP00000063511; ENSMUSG00000041261
GeneIDi12319
KEGGimmu:12319
UCSCiuc008rxv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCAH8_MOUSE
AccessioniPrimary (citable) accession number: P28651
Secondary accession number(s): Q8CF58, Q91XF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 138 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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