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Protein

Aromatase

Gene

Cyp19a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei309 – 3091SubstrateBy similarity
Binding sitei374 – 3741Substrate; via amide nitrogenBy similarity
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

  • androgen metabolic process Source: MGI
  • prostate gland growth Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_271563. Estrogen biosynthesis.
REACT_281686. Endogenous sterols.

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:Cyp19a1
Synonyms:Arom, Cyp19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88587. Cyp19a1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503AromatasePRO_0000051957Add
BLAST

Proteomic databases

PRIDEiP28649.

PTM databases

PhosphoSiteiP28649.

Expressioni

Gene expression databases

BgeeiP28649.
ExpressionAtlasiP28649. baseline.
GenevisibleiP28649. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034811.

Structurei

3D structure databases

ProteinModelPortaliP28649.
SMRiP28649. Positions 45-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP28649.
KOiK07434.
OMAiNFAKNVP.
OrthoDBiEOG7D85W5.
PhylomeDBiP28649.
TreeFamiTF352039.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLEMLNPMQ YNVTIMVPET VTVSAMPLLL IMGLLLLIWN CESSSSIPGP
60 70 80 90 100
GYCLGIGPLI SHGRFLWMGI GSACNYYNKM YGEFMRVWIS GEETLIISKS
110 120 130 140 150
SSMFHVMKHS HYISRFGSKR GLQCIGMHEN GIIFNNNPSL WRTIRPFFMK
160 170 180 190 200
ALTGPGLVRM VEVCVESIKQ HLDRLGEVTD TSGYVDVLTL MRHIMLDTSN
210 220 230 240 250
MLFLGIPLDE SAIVKKIQGY FNAWQALLIK PNIFFKISWL YRKYERSVKD
260 270 280 290 300
LKDEIAVLVE KKRHKVSTAE KLEDCMDFAT DLIFAERRGD LTKENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVTLYFMLL LVAEYPEVEA AILKEIHTVV GDRDIKIEDI
360 370 380 390 400
QNLKVVENFI NESMRYQPVV DLVMRRALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEYFPKP NEFTLENFEK NVPYRYFQPF GFGPRGCAGK YIAMVMMKVV
460 470 480 490 500
LVTLLRRFQV KTLQKRCIEN IPKKNDLSLH PNEDRHLVEI IFSPRNSDKY

LQQ
Length:503
Mass (Da):58,015
Last modified:December 1, 1992 - v1
Checksum:i737400389D1AEFF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00659 mRNA. Translation: BAA00551.1.
CCDSiCCDS23187.1.
PIRiS13912.
RefSeqiNP_031836.1. NM_007810.3.
XP_006510868.1. XM_006510805.2.
XP_006510869.1. XM_006510806.2.
XP_006510870.1. XM_006510807.2.
UniGeneiMm.478781.
Mm.5199.

Genome annotation databases

EnsembliENSMUST00000034811; ENSMUSP00000034811; ENSMUSG00000032274.
GeneIDi13075.
KEGGimmu:13075.
UCSCiuc009pmu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00659 mRNA. Translation: BAA00551.1.
CCDSiCCDS23187.1.
PIRiS13912.
RefSeqiNP_031836.1. NM_007810.3.
XP_006510868.1. XM_006510805.2.
XP_006510869.1. XM_006510806.2.
XP_006510870.1. XM_006510807.2.
UniGeneiMm.478781.
Mm.5199.

3D structure databases

ProteinModelPortaliP28649.
SMRiP28649. Positions 45-496.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034811.

PTM databases

PhosphoSiteiP28649.

Proteomic databases

PRIDEiP28649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034811; ENSMUSP00000034811; ENSMUSG00000032274.
GeneIDi13075.
KEGGimmu:13075.
UCSCiuc009pmu.1. mouse.

Organism-specific databases

CTDi1588.
MGIiMGI:88587. Cyp19a1.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP28649.
KOiK07434.
OMAiNFAKNVP.
OrthoDBiEOG7D85W5.
PhylomeDBiP28649.
TreeFamiTF352039.

Enzyme and pathway databases

ReactomeiREACT_271563. Estrogen biosynthesis.
REACT_281686. Endogenous sterols.

Miscellaneous databases

ChiTaRSiCyp19a1. mouse.
NextBioi283016.
PROiP28649.
SOURCEiSearch...

Gene expression databases

BgeeiP28649.
ExpressionAtlasiP28649. baseline.
GenevisibleiP28649. MM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCP19A_MOUSE
AccessioniPrimary (citable) accession number: P28649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 24, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.