Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P28649 (CP19A_MOUSE)

Last modified June 16, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Cytochrome P450 19A1
    EC=1.14.14.1
Alternative name(s):
    CYPXIX
    Aromatase
    Estrogen synthetase
    P-450AROM
Gene names
Name: Cyp19a1
Synonyms: Arom, Cyp19
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Hide | Top

Ontologies

Keywords
   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionaromatase activity

Inferred from electronic annotation. Source: EC

electron carrier activity

Inferred from electronic annotation. Source: InterPro

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 19A1
PRO_0000051957

Sites

Metal binding4371Iron (heme axial ligand) By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P28649-1 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 737400389D1AEFF1

FASTA50358,015
        10         20         30         40         50         60 
MFLEMLNPMQ YNVTIMVPET VTVSAMPLLL IMGLLLLIWN CESSSSIPGP GYCLGIGPLI 

        70         80         90        100        110        120 
SHGRFLWMGI GSACNYYNKM YGEFMRVWIS GEETLIISKS SSMFHVMKHS HYISRFGSKR 

       130        140        150        160        170        180 
GLQCIGMHEN GIIFNNNPSL WRTIRPFFMK ALTGPGLVRM VEVCVESIKQ HLDRLGEVTD 

       190        200        210        220        230        240 
TSGYVDVLTL MRHIMLDTSN MLFLGIPLDE SAIVKKIQGY FNAWQALLIK PNIFFKISWL 

       250        260        270        280        290        300 
YRKYERSVKD LKDEIAVLVE KKRHKVSTAE KLEDCMDFAT DLIFAERRGD LTKENVNQCI 

       310        320        330        340        350        360 
LEMLIAAPDT MSVTLYFMLL LVAEYPEVEA AILKEIHTVV GDRDIKIEDI QNLKVVENFI 

       370        380        390        400        410        420 
NESMRYQPVV DLVMRRALED DVIDGYPVKK GTNIILNIGR MHRLEYFPKP NEFTLENFEK 

       430        440        450        460        470        480 
NVPYRYFQPF GFGPRGCAGK YIAMVMMKVV LVTLLRRFQV KTLQKRCIEN IPKKNDLSLH 

       490        500 
PNEDRHLVEI IFSPRNSDKY LQQ

« Hide

Hide | Top

References

[1]"Isolation of a full-length cDNA encoding mouse aromatase P450."
Terashima M., Toda K., Kawamoto T., Kuribayashi I., Ogawa Y., Maeda T., Shizuta Y.
Arch. Biochem. Biophys. 285:231-237(1991) [PubMed: 1897929] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

D00659 mRNA. Translation: BAA00551.1.
IPIIPI00123174.
PIRS13912.
RefSeqNP_031836.1.
UniGeneMm.5199

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteP28649.

Genome annotation databases

EnsemblENSMUSG00000032274. Mus musculus. [Contig view]
GeneID13075.
KEGGmmu:13075.

Organism-specific databases

MGIMGI:88587. Cyp19a1.

Phylogenomic databases

HOGENOMP28649.
HOVERGENP28649.
OMAP28649. TRENVNQ.

Enzyme and pathway databases

BRENDA1.14.14.1. 244.

Gene expression databases

ArrayExpressP28649.
BgeeP28649.
GermOnlineENSMUSG00000032274. Mus musculus.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017973. Cyt_P450_C.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio283016.
SOURCESearch...

Hide | Top

Entry information

Entry nameCP19A_MOUSE
AccessionPrimary (citable) accession number: P28649
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents