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P28649

- CP19A_MOUSE

UniProt

P28649 - CP19A_MOUSE

Protein

Aromatase

Gene

Cyp19a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei309 – 3091SubstrateBy similarity
    Binding sitei374 – 3741Substrate; via amide nitrogenBy similarity
    Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: MGI

    GO - Biological processi

    1. androgen metabolic process Source: MGI
    2. prostate gland growth Source: MGI

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_210526. Estrogen biosynthesis.
    REACT_227038. Endogenous sterols.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:Cyp19a1
    Synonyms:Arom, Cyp19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:88587. Cyp19a1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503AromatasePRO_0000051957Add
    BLAST

    Proteomic databases

    PRIDEiP28649.

    PTM databases

    PhosphoSiteiP28649.

    Expressioni

    Gene expression databases

    BgeeiP28649.
    GenevestigatoriP28649.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000034811.

    Structurei

    3D structure databases

    ProteinModelPortaliP28649.
    SMRiP28649. Positions 45-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000111912.
    HOVERGENiHBG050750.
    InParanoidiP28649.
    KOiK07434.
    OMAiNFAKNVP.
    OrthoDBiEOG7D85W5.
    PhylomeDBiP28649.
    TreeFamiTF352039.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28649-1 [UniParc]FASTAAdd to Basket

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    MFLEMLNPMQ YNVTIMVPET VTVSAMPLLL IMGLLLLIWN CESSSSIPGP    50
    GYCLGIGPLI SHGRFLWMGI GSACNYYNKM YGEFMRVWIS GEETLIISKS 100
    SSMFHVMKHS HYISRFGSKR GLQCIGMHEN GIIFNNNPSL WRTIRPFFMK 150
    ALTGPGLVRM VEVCVESIKQ HLDRLGEVTD TSGYVDVLTL MRHIMLDTSN 200
    MLFLGIPLDE SAIVKKIQGY FNAWQALLIK PNIFFKISWL YRKYERSVKD 250
    LKDEIAVLVE KKRHKVSTAE KLEDCMDFAT DLIFAERRGD LTKENVNQCI 300
    LEMLIAAPDT MSVTLYFMLL LVAEYPEVEA AILKEIHTVV GDRDIKIEDI 350
    QNLKVVENFI NESMRYQPVV DLVMRRALED DVIDGYPVKK GTNIILNIGR 400
    MHRLEYFPKP NEFTLENFEK NVPYRYFQPF GFGPRGCAGK YIAMVMMKVV 450
    LVTLLRRFQV KTLQKRCIEN IPKKNDLSLH PNEDRHLVEI IFSPRNSDKY 500
    LQQ 503
    Length:503
    Mass (Da):58,015
    Last modified:December 1, 1992 - v1
    Checksum:i737400389D1AEFF1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00659 mRNA. Translation: BAA00551.1.
    CCDSiCCDS23187.1.
    PIRiS13912.
    RefSeqiNP_031836.1. NM_007810.3.
    XP_006510868.1. XM_006510805.1.
    XP_006510869.1. XM_006510806.1.
    XP_006510870.1. XM_006510807.1.
    UniGeneiMm.478781.
    Mm.5199.

    Genome annotation databases

    EnsembliENSMUST00000034811; ENSMUSP00000034811; ENSMUSG00000032274.
    GeneIDi13075.
    KEGGimmu:13075.
    UCSCiuc009pmu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00659 mRNA. Translation: BAA00551.1 .
    CCDSi CCDS23187.1.
    PIRi S13912.
    RefSeqi NP_031836.1. NM_007810.3.
    XP_006510868.1. XM_006510805.1.
    XP_006510869.1. XM_006510806.1.
    XP_006510870.1. XM_006510807.1.
    UniGenei Mm.478781.
    Mm.5199.

    3D structure databases

    ProteinModelPortali P28649.
    SMRi P28649. Positions 45-496.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000034811.

    PTM databases

    PhosphoSitei P28649.

    Proteomic databases

    PRIDEi P28649.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034811 ; ENSMUSP00000034811 ; ENSMUSG00000032274 .
    GeneIDi 13075.
    KEGGi mmu:13075.
    UCSCi uc009pmu.1. mouse.

    Organism-specific databases

    CTDi 1588.
    MGIi MGI:88587. Cyp19a1.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000111912.
    HOVERGENi HBG050750.
    InParanoidi P28649.
    KOi K07434.
    OMAi NFAKNVP.
    OrthoDBi EOG7D85W5.
    PhylomeDBi P28649.
    TreeFami TF352039.

    Enzyme and pathway databases

    Reactomei REACT_210526. Estrogen biosynthesis.
    REACT_227038. Endogenous sterols.

    Miscellaneous databases

    NextBioi 283016.
    PROi P28649.
    SOURCEi Search...

    Gene expression databases

    Bgeei P28649.
    Genevestigatori P28649.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiCP19A_MOUSE
    AccessioniPrimary (citable) accession number: P28649
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3