P28649 (CP19A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 19A1
EC=1.14.14.1

Alternative name(s):
Aromatase
CYPXIX
Cytochrome P-450AROM
Estrogen synthase

Gene names

Name:	Cyp19a1
Synonyms:	Arom, Cyp19

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	androgen metabolic process Inferred from mutant phenotype PubMed 11356695. Source: MGI prostate gland growth Inferred from mutant phenotype PubMed 11356695PubMed 16723702. Source: MGI
Cellular_component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from sequence or structural similarity. Source: UniProtKB electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from sequence or structural similarity. Source: UniProtKB iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Cytochrome P450 19A1		PRO_0000051957
Sites
	Metal binding	437	1	Iron (heme axial ligand) By similarity
	Binding site	309	1	Substrate By similarity
	Binding site	374	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	P28649 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 737400389D1AEFF1	FASTA	503	58,015
	10 20 30 40 50 60 MFLEMLNPMQ YNVTIMVPET VTVSAMPLLL IMGLLLLIWN CESSSSIPGP GYCLGIGPLI 70 80 90 100 110 120 SHGRFLWMGI GSACNYYNKM YGEFMRVWIS GEETLIISKS SSMFHVMKHS HYISRFGSKR 130 140 150 160 170 180 GLQCIGMHEN GIIFNNNPSL WRTIRPFFMK ALTGPGLVRM VEVCVESIKQ HLDRLGEVTD 190 200 210 220 230 240 TSGYVDVLTL MRHIMLDTSN MLFLGIPLDE SAIVKKIQGY FNAWQALLIK PNIFFKISWL 250 260 270 280 290 300 YRKYERSVKD LKDEIAVLVE KKRHKVSTAE KLEDCMDFAT DLIFAERRGD LTKENVNQCI 310 320 330 340 350 360 LEMLIAAPDT MSVTLYFMLL LVAEYPEVEA AILKEIHTVV GDRDIKIEDI QNLKVVENFI 370 380 390 400 410 420 NESMRYQPVV DLVMRRALED DVIDGYPVKK GTNIILNIGR MHRLEYFPKP NEFTLENFEK 430 440 450 460 470 480 NVPYRYFQPF GFGPRGCAGK YIAMVMMKVV LVTLLRRFQV KTLQKRCIEN IPKKNDLSLH 490 500 PNEDRHLVEI IFSPRNSDKY LQQ

References

[1]	"Isolation of a full-length cDNA encoding mouse aromatase P450." Terashima M., Toda K., Kawamoto T., Kuribayashi I., Ogawa Y., Maeda T., Shizuta Y. Arch. Biochem. Biophys. 285:231-237(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D00659 mRNA. Translation: BAA00551.1.
IPI	IPI00123174.
PIR	S13912.
RefSeq	NP_031836.1. NM_007810.3.
UniGene	Mm.478781. Mm.5199.
3D structure databases
ProteinModelPortal	P28649.
SMR	P28649. Positions 45-496.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000034811.
PTM databases
PhosphoSite	P28649.
Proteomic databases
PRIDE	P28649.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000034811; ENSMUSP00000034811; ENSMUSG00000032274.
GeneID	13075.
KEGG	mmu:13075.
Organism-specific databases
CTD	1588.
MGI	MGI:88587. Cyp19a1.
Phylogenomic databases
eggNOG	COG2124.
HOGENOM	HOG000111912.
HOVERGEN	HBG050750.
InParanoid	P28649.
KO	K07434.
OMA	MRRIMLD.
OrthoDB	EOG4ZCT4K.
Gene expression databases
ArrayExpress	P28649.
Bgee	P28649.
Genevestigator	P28649.
GermOnline	ENSMUSG00000032274. Mus musculus.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	283016.
SOURCE	Search...

Entry information

Entry name

CP19A_MOUSE

Accession

Primary (citable) accession number: P28649

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program