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P28649

- CP19A_MOUSE

UniProt

P28649 - CP19A_MOUSE

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Protein

Aromatase

Gene

Cyp19a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei309 – 3091SubstrateBy similarity
Binding sitei374 – 3741Substrate; via amide nitrogenBy similarity
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: MGI

GO - Biological processi

  1. androgen metabolic process Source: MGI
  2. prostate gland growth Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_210526. Estrogen biosynthesis.
REACT_227038. Endogenous sterols.

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:Cyp19a1
Synonyms:Arom, Cyp19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88587. Cyp19a1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503AromatasePRO_0000051957Add
BLAST

Proteomic databases

PRIDEiP28649.

PTM databases

PhosphoSiteiP28649.

Expressioni

Gene expression databases

BgeeiP28649.
ExpressionAtlasiP28649. baseline.
GenevestigatoriP28649.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034811.

Structurei

3D structure databases

ProteinModelPortaliP28649.
SMRiP28649. Positions 45-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP28649.
KOiK07434.
OMAiNFAKNVP.
OrthoDBiEOG7D85W5.
PhylomeDBiP28649.
TreeFamiTF352039.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28649-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLEMLNPMQ YNVTIMVPET VTVSAMPLLL IMGLLLLIWN CESSSSIPGP
60 70 80 90 100
GYCLGIGPLI SHGRFLWMGI GSACNYYNKM YGEFMRVWIS GEETLIISKS
110 120 130 140 150
SSMFHVMKHS HYISRFGSKR GLQCIGMHEN GIIFNNNPSL WRTIRPFFMK
160 170 180 190 200
ALTGPGLVRM VEVCVESIKQ HLDRLGEVTD TSGYVDVLTL MRHIMLDTSN
210 220 230 240 250
MLFLGIPLDE SAIVKKIQGY FNAWQALLIK PNIFFKISWL YRKYERSVKD
260 270 280 290 300
LKDEIAVLVE KKRHKVSTAE KLEDCMDFAT DLIFAERRGD LTKENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVTLYFMLL LVAEYPEVEA AILKEIHTVV GDRDIKIEDI
360 370 380 390 400
QNLKVVENFI NESMRYQPVV DLVMRRALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEYFPKP NEFTLENFEK NVPYRYFQPF GFGPRGCAGK YIAMVMMKVV
460 470 480 490 500
LVTLLRRFQV KTLQKRCIEN IPKKNDLSLH PNEDRHLVEI IFSPRNSDKY

LQQ
Length:503
Mass (Da):58,015
Last modified:December 1, 1992 - v1
Checksum:i737400389D1AEFF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00659 mRNA. Translation: BAA00551.1.
CCDSiCCDS23187.1.
PIRiS13912.
RefSeqiNP_031836.1. NM_007810.3.
XP_006510868.1. XM_006510805.1.
XP_006510869.1. XM_006510806.1.
XP_006510870.1. XM_006510807.1.
UniGeneiMm.478781.
Mm.5199.

Genome annotation databases

EnsembliENSMUST00000034811; ENSMUSP00000034811; ENSMUSG00000032274.
GeneIDi13075.
KEGGimmu:13075.
UCSCiuc009pmu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00659 mRNA. Translation: BAA00551.1 .
CCDSi CCDS23187.1.
PIRi S13912.
RefSeqi NP_031836.1. NM_007810.3.
XP_006510868.1. XM_006510805.1.
XP_006510869.1. XM_006510806.1.
XP_006510870.1. XM_006510807.1.
UniGenei Mm.478781.
Mm.5199.

3D structure databases

ProteinModelPortali P28649.
SMRi P28649. Positions 45-496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000034811.

PTM databases

PhosphoSitei P28649.

Proteomic databases

PRIDEi P28649.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034811 ; ENSMUSP00000034811 ; ENSMUSG00000032274 .
GeneIDi 13075.
KEGGi mmu:13075.
UCSCi uc009pmu.1. mouse.

Organism-specific databases

CTDi 1588.
MGIi MGI:88587. Cyp19a1.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000111912.
HOVERGENi HBG050750.
InParanoidi P28649.
KOi K07434.
OMAi NFAKNVP.
OrthoDBi EOG7D85W5.
PhylomeDBi P28649.
TreeFami TF352039.

Enzyme and pathway databases

Reactomei REACT_210526. Estrogen biosynthesis.
REACT_227038. Endogenous sterols.

Miscellaneous databases

ChiTaRSi Cyp19a1. mouse.
NextBioi 283016.
PROi P28649.
SOURCEi Search...

Gene expression databases

Bgeei P28649.
ExpressionAtlasi P28649. baseline.
Genevestigatori P28649.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCP19A_MOUSE
AccessioniPrimary (citable) accession number: P28649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3