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P28648 (CD63_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
CD63 antigen
Alternative name(s):
Mast cell antigen AD1
CD_antigen=CD63
Gene names
Name:Cd63
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the secretory process of mast cells and may play some role in signal transduction pathways.

Subcellular location

Lysosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle › secretory vesicle membrane; Multi-pass membrane protein. Note: Secretory granules and plasma membrane of many cultured cell lines.

Tissue specificity

On mast cells and platelets of rat tissues. Induced in other cells in culture.

Developmental stage

Increased expression in embryonal tissues.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 238237CD63 antigen
PRO_0000219219

Regions

Topological domain2 – 1110Cytoplasmic Potential
Transmembrane12 – 3221Helical; Potential
Topological domain33 – 5119Extracellular Potential
Transmembrane52 – 7221Helical; Potential
Topological domain73 – 819Cytoplasmic Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 203101Extracellular Potential
Transmembrane204 – 22421Helical; Potential
Topological domain225 – 23814Cytoplasmic Potential

Amino acid modifications

Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation1501N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P28648 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: B6F8C8B69E766690

FASTA23825,699
        10         20         30         40         50         60 
MAVEGGMKCV KFLLYVLLLA FCACAVGLIA IGVAVQVVLK QAITHETTAG SLLPVVIIAV 

        70         80         90        100        110        120 
GAFLFLVAFV GCCGACKENY CLMITFAIFL SLIMLVEVAV AIAGYVFRDQ VKSEFSKSFQ 

       130        140        150        160        170        180 
KQMQNYLTDN KTATILDKLQ KENKCCGASN YTDWERIPGM AKDRVPDSCC INITVGCGND 

       190        200        210        220        230 
FKESTIHTQG CVETIAAWLR KNVLLVAGAA LGIAFVEVLG IIFSCCLVKS IRSGYEVM

« Hide

References

« Hide 'large scale' references
[1]"The rat mast cell antigen AD1 (homologue to human CD63 or melanoma antigen ME491) is expressed in other cells in culture."
Nishikata H., Oliver C., Mergenhagen S.E., Siraganian R.P.
J. Immunol. 149:862-870(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[3]"A cell surface glycoprotein of rat basophilic leukemia cells close to the high affinity IgE receptor (Fc epsilon RI). Similarity to human melanoma differentiation antigen ME491."
Kitani S., Berenstein E., Mergenhagen S.E., Tempst P., Siraganian R.P.
J. Biol. Chem. 266:1903-1909(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-44.
[4]Lubec G., Kang S.U., Lubec S.
Submitted (SEP-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 183-200, MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X61654 mRNA. Translation: CAA43835.1.
BC063173 mRNA. Translation: AAH63173.1.
IPIIPI00231686.
PIRA46508.
RefSeqNP_058821.1. NM_017125.3.
UniGeneRn.11068.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000010180.

Proteomic databases

PaxDbP28648.
PRIDEP28648.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29186.
KEGGrno:29186.
UCSCRGD:62080. rat.

Organism-specific databases

CTD967.
RGD62080. Cd63.

Phylogenomic databases

eggNOGNOG268658.
HOGENOMHOG000230651.
HOVERGENHBG107306.
InParanoidP28648.
KOK06497.
OrthoDBEOG4HX51Z.

Gene expression databases

ArrayExpressP28648.
GenevestigatorP28648.
GermOnlineENSRNOG00000007650. Rattus norvegicus.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. Tetraspanin. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608299.

Entry information

Entry nameCD63_RAT
AccessionPrimary (citable) accession number: P28648
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents