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P28646

- SSR1_RAT

UniProt

P28646 - SSR1_RAT

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Protein

Somatostatin receptor type 1

Gene

Sstr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled to phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.

GO - Molecular functioni

  1. somatostatin receptor activity Source: RGD

GO - Biological processi

  1. cellular response to estradiol stimulus Source: RGD
  2. cerebellum development Source: RGD
  3. forebrain development Source: RGD
  4. glutamate receptor signaling pathway Source: Ensembl
  5. response to starvation Source: RGD
  6. somatostatin signaling pathway Source: GOC
  7. spermatogenesis Source: RGD
  8. T cell differentiation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_250028. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 1
Short name:
SS-1-R
Short name:
SS1-R
Short name:
SS1R
Alternative name(s):
SRIF-2
Gene namesi
Name:Sstr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi3762. Sstr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656ExtracellularSequence AnalysisAdd
BLAST
Transmembranei57 – 8428Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini85 – 9410CytoplasmicSequence Analysis
Transmembranei95 – 12026Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini121 – 13111ExtracellularSequence AnalysisAdd
BLAST
Transmembranei132 – 15322Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini154 – 17522CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini197 – 21923ExtracellularSequence AnalysisAdd
BLAST
Transmembranei220 – 24425Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini245 – 27026CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei271 – 29626Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini297 – 3037ExtracellularSequence Analysis
Transmembranei304 – 32724Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini328 – 39164CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Somatostatin receptor type 1PRO_0000070118Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi130 ↔ 208PROSITE-ProRule annotation
Lipidationi339 – 3391S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP28646.

PTM databases

PhosphoSiteiP28646.

Expressioni

Tissue specificityi

Brain, pituitary, islet, jejunum, stomach, heart, spleen.

Gene expression databases

GenevestigatoriP28646.

Interactioni

Protein-protein interaction databases

BioGridi247112. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP28646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118797.
HOVERGENiHBG106919.
InParanoidiP28646.
KOiK04217.
OMAiLLHHWPF.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP28646.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28646-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPNGTAPSP TSSPSSSPGG CGEGVCSRGP GSGAADGMEE PGRNSSQNGT
60 70 80 90 100
LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL
110 120 130 140 150
AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV
160 170 180 190 200
LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA
210 220 230 240 250
NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM
260 270 280 290 300
RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD
310 320 330 340 350
DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP
360 370 380 390
VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCASRIST L
Length:391
Mass (Da):42,746
Last modified:December 1, 1992 - v1
Checksum:i28ED6E894B72FBB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62314 mRNA. Translation: CAA44193.1.
M97656 mRNA. No translation available.
PIRiA39297.
RefSeqiNP_036851.1. NM_012719.2.
XP_006240177.1. XM_006240115.2.
UniGeneiRn.234315.
Rn.42915.

Genome annotation databases

EnsembliENSRNOT00000073970; ENSRNOP00000067355; ENSRNOG00000048145.
GeneIDi25033.
KEGGirno:25033.
UCSCiRGD:3762. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62314 mRNA. Translation: CAA44193.1 .
M97656 mRNA. No translation available.
PIRi A39297.
RefSeqi NP_036851.1. NM_012719.2.
XP_006240177.1. XM_006240115.2.
UniGenei Rn.234315.
Rn.42915.

3D structure databases

ProteinModelPortali P28646.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247112. 1 interaction.

Chemistry

BindingDBi P28646.
ChEMBLi CHEMBL2096977.
GuidetoPHARMACOLOGYi 355.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P28646.

Proteomic databases

PRIDEi P28646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000073970 ; ENSRNOP00000067355 ; ENSRNOG00000048145 .
GeneIDi 25033.
KEGGi rno:25033.
UCSCi RGD:3762. rat.

Organism-specific databases

CTDi 6751.
RGDi 3762. Sstr1.

Phylogenomic databases

GeneTreei ENSGT00760000118797.
HOVERGENi HBG106919.
InParanoidi P28646.
KOi K04217.
OMAi LLHHWPF.
OrthoDBi EOG7BKCVQ.
PhylomeDBi P28646.

Enzyme and pathway databases

Reactomei REACT_233455. G alpha (i) signalling events.
REACT_250028. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi 605183.
PROi P28646.

Gene expression databases

Genevestigatori P28646.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a cDNA encoding a novel putative G-protein-coupled receptor expressed in specific rat brain regions."
    Meyerhof W., Paust H.J., Schoenrock C., Richter D.
    DNA Cell Biol. 10:689-694(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  2. "Cloning and expression of a rat somatostatin receptor enriched in brain."
    Li X.-J., Forte M.A., North R.A., Ross C.A., Snyder S.H.
    J. Biol. Chem. 267:21307-21312(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSSR1_RAT
AccessioniPrimary (citable) accession number: P28646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3