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P28646

- SSR1_RAT

UniProt

P28646 - SSR1_RAT

Protein

Somatostatin receptor type 1

Gene

Sstr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled to phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.

    GO - Molecular functioni

    1. somatostatin receptor activity Source: RGD

    GO - Biological processi

    1. cellular response to estradiol stimulus Source: RGD
    2. cerebellum development Source: RGD
    3. forebrain development Source: RGD
    4. glutamate receptor signaling pathway Source: Ensembl
    5. response to starvation Source: RGD
    6. somatostatin signaling pathway Source: GOC
    7. spermatogenesis Source: RGD
    8. T cell differentiation Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin receptor type 1
    Short name:
    SS-1-R
    Short name:
    SS1-R
    Short name:
    SS1R
    Alternative name(s):
    SRIF-2
    Gene namesi
    Name:Sstr1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi3762. Sstr1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Somatostatin receptor type 1PRO_0000070118Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi130 ↔ 208PROSITE-ProRule annotation
    Lipidationi339 – 3391S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP28646.

    PTM databases

    PhosphoSiteiP28646.

    Expressioni

    Tissue specificityi

    Brain, pituitary, islet, jejunum, stomach, heart, spleen.

    Gene expression databases

    GenevestigatoriP28646.

    Interactioni

    Protein-protein interaction databases

    BioGridi247112. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP28646.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5656ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini85 – 9410CytoplasmicSequence Analysis
    Topological domaini121 – 13111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini154 – 17522CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini197 – 21923ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini245 – 27026CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini297 – 3037ExtracellularSequence Analysis
    Topological domaini328 – 39164CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei57 – 8428Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei95 – 12026Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei132 – 15322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei220 – 24425Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29626Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei304 – 32724Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00630000089736.
    HOVERGENiHBG106919.
    InParanoidiP28646.
    KOiK04217.
    OMAiLLHHWPF.
    OrthoDBiEOG7BKCVQ.
    PhylomeDBiP28646.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001116. Somatstn_rcpt_1.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00587. SOMATOSTTN1R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28646-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPNGTAPSP TSSPSSSPGG CGEGVCSRGP GSGAADGMEE PGRNSSQNGT    50
    LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL 100
    AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV 150
    LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA 200
    NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM 250
    RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD 300
    DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP 350
    VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCASRIST L 391
    Length:391
    Mass (Da):42,746
    Last modified:December 1, 1992 - v1
    Checksum:i28ED6E894B72FBB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62314 mRNA. Translation: CAA44193.1.
    M97656 mRNA. No translation available.
    PIRiA39297.
    RefSeqiNP_036851.1. NM_012719.2.
    XP_006240177.1. XM_006240115.1.
    UniGeneiRn.234315.
    Rn.42915.

    Genome annotation databases

    EnsembliENSRNOT00000073970; ENSRNOP00000067355; ENSRNOG00000048145.
    GeneIDi25033.
    KEGGirno:25033.
    UCSCiRGD:3762. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62314 mRNA. Translation: CAA44193.1 .
    M97656 mRNA. No translation available.
    PIRi A39297.
    RefSeqi NP_036851.1. NM_012719.2.
    XP_006240177.1. XM_006240115.1.
    UniGenei Rn.234315.
    Rn.42915.

    3D structure databases

    ProteinModelPortali P28646.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247112. 1 interaction.

    Chemistry

    BindingDBi P28646.
    ChEMBLi CHEMBL2096977.
    GuidetoPHARMACOLOGYi 355.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P28646.

    Proteomic databases

    PRIDEi P28646.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000073970 ; ENSRNOP00000067355 ; ENSRNOG00000048145 .
    GeneIDi 25033.
    KEGGi rno:25033.
    UCSCi RGD:3762. rat.

    Organism-specific databases

    CTDi 6751.
    RGDi 3762. Sstr1.

    Phylogenomic databases

    GeneTreei ENSGT00630000089736.
    HOVERGENi HBG106919.
    InParanoidi P28646.
    KOi K04217.
    OMAi LLHHWPF.
    OrthoDBi EOG7BKCVQ.
    PhylomeDBi P28646.

    Miscellaneous databases

    NextBioi 605183.
    PROi P28646.

    Gene expression databases

    Genevestigatori P28646.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001116. Somatstn_rcpt_1.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00587. SOMATOSTTN1R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a cDNA encoding a novel putative G-protein-coupled receptor expressed in specific rat brain regions."
      Meyerhof W., Paust H.J., Schoenrock C., Richter D.
      DNA Cell Biol. 10:689-694(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.
    2. "Cloning and expression of a rat somatostatin receptor enriched in brain."
      Li X.-J., Forte M.A., North R.A., Ross C.A., Snyder S.H.
      J. Biol. Chem. 267:21307-21312(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiSSR1_RAT
    AccessioniPrimary (citable) accession number: P28646
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3