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Protein

Somatostatin receptor type 1

Gene

Sstr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled to phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.

GO - Molecular functioni

  • neuropeptide binding Source: GO_Central
  • somatostatin receptor activity Source: RGD

GO - Biological processi

  • cellular response to estradiol stimulus Source: RGD
  • cellular response to leukemia inhibitory factor Source: Ensembl
  • cerebellum development Source: RGD
  • forebrain development Source: RGD
  • glutamate receptor signaling pathway Source: Ensembl
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
  • negative regulation of cell proliferation Source: GO_Central
  • response to starvation Source: RGD
  • spermatogenesis Source: RGD
  • T cell differentiation Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 1
Short name:
SS-1-R
Short name:
SS1-R
Short name:
SS1R
Alternative name(s):
SRIF-2
Gene namesi
Name:Sstr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3762 Sstr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56ExtracellularSequence analysisAdd BLAST56
Transmembranei57 – 84Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini85 – 94CytoplasmicSequence analysis10
Transmembranei95 – 120Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini121 – 131ExtracellularSequence analysisAdd BLAST11
Transmembranei132 – 153Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini154 – 175CytoplasmicSequence analysisAdd BLAST22
Transmembranei176 – 196Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini197 – 219ExtracellularSequence analysisAdd BLAST23
Transmembranei220 – 244Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini245 – 270CytoplasmicSequence analysisAdd BLAST26
Transmembranei271 – 296Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini297 – 303ExtracellularSequence analysis7
Transmembranei304 – 327Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini328 – 391CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4652
GuidetoPHARMACOLOGYi355

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701181 – 391Somatostatin receptor type 1Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi130 ↔ 208PROSITE-ProRule annotation
Lipidationi339S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP28646
PRIDEiP28646

PTM databases

PhosphoSitePlusiP28646

Expressioni

Tissue specificityi

Brain, pituitary, islet, jejunum, stomach, heart, spleen.

Gene expression databases

BgeeiENSRNOG00000048145
GenevisibleiP28646 RN

Interactioni

Protein-protein interaction databases

BioGridi247112, 1 interactor
STRINGi10116.ENSRNOP00000067355

Chemistry databases

BindingDBiP28646

Structurei

3D structure databases

ProteinModelPortaliP28646
SMRiP28646
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOVERGENiHBG106919
InParanoidiP28646
KOiK04217
OMAiLLHHWPF
OrthoDBiEOG091G0HEN
PhylomeDBiP28646

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000586 Somatstn_rcpt
IPR001116 Somatstn_rcpt_1
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00246 SOMATOSTATNR
PR00587 SOMATOSTTN1R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPNGTAPSP TSSPSSSPGG CGEGVCSRGP GSGAADGMEE PGRNSSQNGT
60 70 80 90 100
LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL
110 120 130 140 150
AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV
160 170 180 190 200
LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA
210 220 230 240 250
NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM
260 270 280 290 300
RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD
310 320 330 340 350
DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP
360 370 380 390
VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCASRIST L
Length:391
Mass (Da):42,746
Last modified:December 1, 1992 - v1
Checksum:i28ED6E894B72FBB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62314 mRNA Translation: CAA44193.1
M97656 mRNA No translation available.
PIRiA39297
RefSeqiNP_036851.1, NM_012719.2
XP_006240177.1, XM_006240115.2
UniGeneiRn.234315
Rn.42915

Genome annotation databases

EnsembliENSRNOT00000073970; ENSRNOP00000067355; ENSRNOG00000048145
GeneIDi25033
KEGGirno:25033
UCSCiRGD:3762 rat

Similar proteinsi

Entry informationi

Entry nameiSSR1_RAT
AccessioniPrimary (citable) accession number: P28646
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
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