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Protein

Somatostatin receptor type 1

Gene

Sstr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled to phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.

GO - Molecular functioni

  • neuropeptide binding Source: GO_Central
  • somatostatin receptor activity Source: RGD

GO - Biological processi

  • cellular response to estradiol stimulus Source: RGD
  • cerebellum development Source: RGD
  • chemical synaptic transmission Source: GO_Central
  • forebrain development Source: RGD
  • glutamate receptor signaling pathway Source: Ensembl
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
  • negative regulation of cell proliferation Source: GO_Central
  • response to starvation Source: RGD
  • spermatogenesis Source: RGD
  • T cell differentiation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 1
Short name:
SS-1-R
Short name:
SS1-R
Short name:
SS1R
Alternative name(s):
SRIF-2
Gene namesi
Name:Sstr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3762. Sstr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56ExtracellularSequence analysisAdd BLAST56
Transmembranei57 – 84Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini85 – 94CytoplasmicSequence analysis10
Transmembranei95 – 120Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini121 – 131ExtracellularSequence analysisAdd BLAST11
Transmembranei132 – 153Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini154 – 175CytoplasmicSequence analysisAdd BLAST22
Transmembranei176 – 196Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini197 – 219ExtracellularSequence analysisAdd BLAST23
Transmembranei220 – 244Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini245 – 270CytoplasmicSequence analysisAdd BLAST26
Transmembranei271 – 296Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini297 – 303ExtracellularSequence analysis7
Transmembranei304 – 327Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini328 – 391CytoplasmicSequence analysisAdd BLAST64

GO - Cellular componenti

  • cytoplasm Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • neuron projection Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4652.
GuidetoPHARMACOLOGYi355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701181 – 391Somatostatin receptor type 1Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi130 ↔ 208PROSITE-ProRule annotation
Lipidationi339S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP28646.
PRIDEiP28646.

PTM databases

PhosphoSitePlusiP28646.

Expressioni

Tissue specificityi

Brain, pituitary, islet, jejunum, stomach, heart, spleen.

Gene expression databases

BgeeiENSRNOG00000048145.
GenevisibleiP28646. RN.

Interactioni

Protein-protein interaction databases

BioGridi247112. 1 interactor.
STRINGi10116.ENSRNOP00000067355.

Chemistry databases

BindingDBiP28646.

Structurei

3D structure databases

ProteinModelPortaliP28646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOVERGENiHBG106919.
InParanoidiP28646.
KOiK04217.
OMAiLLHHWPF.
OrthoDBiEOG091G0HEN.
PhylomeDBiP28646.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPNGTAPSP TSSPSSSPGG CGEGVCSRGP GSGAADGMEE PGRNSSQNGT
60 70 80 90 100
LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL
110 120 130 140 150
AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV
160 170 180 190 200
LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA
210 220 230 240 250
NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM
260 270 280 290 300
RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD
310 320 330 340 350
DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP
360 370 380 390
VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCASRIST L
Length:391
Mass (Da):42,746
Last modified:December 1, 1992 - v1
Checksum:i28ED6E894B72FBB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62314 mRNA. Translation: CAA44193.1.
M97656 mRNA. No translation available.
PIRiA39297.
RefSeqiNP_036851.1. NM_012719.2.
XP_006240177.1. XM_006240115.2.
UniGeneiRn.234315.
Rn.42915.

Genome annotation databases

EnsembliENSRNOT00000073970; ENSRNOP00000067355; ENSRNOG00000048145.
GeneIDi25033.
KEGGirno:25033.
UCSCiRGD:3762. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62314 mRNA. Translation: CAA44193.1.
M97656 mRNA. No translation available.
PIRiA39297.
RefSeqiNP_036851.1. NM_012719.2.
XP_006240177.1. XM_006240115.2.
UniGeneiRn.234315.
Rn.42915.

3D structure databases

ProteinModelPortaliP28646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247112. 1 interactor.
STRINGi10116.ENSRNOP00000067355.

Chemistry databases

BindingDBiP28646.
ChEMBLiCHEMBL4652.
GuidetoPHARMACOLOGYi355.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP28646.

Proteomic databases

PaxDbiP28646.
PRIDEiP28646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073970; ENSRNOP00000067355; ENSRNOG00000048145.
GeneIDi25033.
KEGGirno:25033.
UCSCiRGD:3762. rat.

Organism-specific databases

CTDi6751.
RGDi3762. Sstr1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOVERGENiHBG106919.
InParanoidiP28646.
KOiK04217.
OMAiLLHHWPF.
OrthoDBiEOG091G0HEN.
PhylomeDBiP28646.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP28646.

Gene expression databases

BgeeiENSRNOG00000048145.
GenevisibleiP28646. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSR1_RAT
AccessioniPrimary (citable) accession number: P28646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.