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P28643 (FABG_CUPLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase, chloroplastic

EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Gene names
Name:CLKR27
OrganismCuphea lanceolata (Cigar flower)
Taxonomic identifier3930 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMyrtalesLythraceaeCuphea

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer Probable.

Subcellular location

Plastidchloroplast. Plastid. Note: And non-photosynthetic plastids.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity

Inferred from electronic annotation. Source: UniProtKB-EC

NAD binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 6161Chloroplast By similarity
Chain62 – 3202593-oxoacyl-[acyl-carrier-protein] reductase, chloroplastic
PRO_0000031981

Regions

Nucleotide binding82 – 10625NADP By similarity

Sites

Active site2271Proton acceptor By similarity
Binding site2141Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P28643 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 06BAF0522B2B8C87

FASTA32033,103
        10         20         30         40         50         60 
MATATAAGCS GAVALKSLGG RRLCIPQQLS PVLAGFGSHA AKSFPILSTR SIATSGIRAQ 

        70         80         90        100        110        120 
VATAEKVSAG AGQSVESPVV IVTGASRGIG KAIALSLGKA GCKVLVNYAR SSKEAEEVSK 

       130        140        150        160        170        180 
EIEAFGGQAL TFGGDVSKEE DVEAMIKTAV DAWGTVDILV NNAGITRDGL LMRMKKSQWQ 

       190        200        210        220        230        240 
EVIDLNLTGV FLCTQAAAKI MMKKKKGRII NIASVVGLVG NAGQANYSAA KAGVIGFTKT 

       250        260        270        280        290        300 
VAREYASRNI NVNAVAPGFI SSDMTSKLGD DINKKILETI PLGRYGQPEE VAGLVEFLAI 

       310        320 
NPASSYVTGQ VFTIDGGMTM 

« Hide

References

[1]"Isolation and characterization of a cDNA from Cuphea lanceolata encoding a beta-ketoacyl-ACP reductase."
Klein B., Pawlowski K., Hoericke-Grandpierre C., Schell J., Toepfer R.
Mol. Gen. Genet. 233:122-128(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64566 mRNA. Translation: CAA45866.1.
PIRS22450.

3D structure databases

ProteinModelPortalP28643.
SMRP28643. Positions 77-320.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABG_CUPLA
AccessionPrimary (citable) accession number: P28643
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways