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Protein

D-methionine-binding lipoprotein MetQ

Gene

metQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system.1 Publication

GO - Biological processi

  • amino acid transport Source: UniProtKB-KW
  • D-methionine transport Source: CACAO
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:METQ-MONOMER.
ECOL316407:JW0193-MONOMER.
MetaCyc:METQ-MONOMER.

Protein family/group databases

TCDBi3.A.1.24.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
D-methionine-binding lipoprotein MetQ
Gene namesi
Name:metQ
Synonyms:yaeC
Ordered Locus Names:b0197, JW0193
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11504. metQ.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22PROSITE-ProRule annotationAdd BLAST22
ChainiPRO_000001973923 – 271D-methionine-binding lipoprotein MetQAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi23N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi23S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiP28635.
PaxDbiP28635.
PRIDEiP28635.

2D gel databases

SWISS-2DPAGEP28635.

Interactioni

Protein-protein interaction databases

BioGridi4263377. 8 interactors.
DIPiDIP-11196N.
IntActiP28635. 3 interactors.
STRINGi511145.b0197.

Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 38Combined sources7
Helixi41 – 57Combined sources17
Beta strandi60 – 70Combined sources11
Helixi71 – 77Combined sources7
Beta strandi80 – 88Combined sources9
Helixi89 – 99Combined sources11
Beta strandi103 – 108Combined sources6
Beta strandi115 – 117Combined sources3
Helixi124 – 126Combined sources3
Beta strandi132 – 136Combined sources5
Helixi139 – 151Combined sources13
Helixi167 – 169Combined sources3
Beta strandi170 – 172Combined sources3
Beta strandi178 – 182Combined sources5
Helixi184 – 186Combined sources3
Helixi187 – 190Combined sources4
Beta strandi196 – 201Combined sources6
Helixi203 – 206Combined sources4
Helixi207 – 209Combined sources3
Helixi213 – 216Combined sources4
Beta strandi218 – 220Combined sources3
Beta strandi229 – 234Combined sources6
Helixi235 – 237Combined sources3
Helixi241 – 250Combined sources10
Helixi253 – 262Combined sources10
Turni263 – 265Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YAHX-ray1.60X1-271[»]
ProteinModelPortaliP28635.
SMRiP28635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NlpA lipoprotein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105D01. Bacteria.
COG1464. LUCA.
HOGENOMiHOG000222926.
InParanoidiP28635.
KOiK02073.
OMAiNDPANQG.
PhylomeDBiP28635.

Family and domain databases

InterProiIPR004872. Lipoprotein_NlpA.
[Graphical view]
PANTHERiPTHR30429. PTHR30429. 1 hit.
PfamiPF03180. Lipoprotein_9. 1 hit.
[Graphical view]
PIRSFiPIRSF002854. MetQ. 1 hit.
TIGRFAMsiTIGR00363. TIGR00363. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFKFKTFAA VGALIGSLAL VGCGQDEKDP NHIKVGVIVG AEQQVAEVAQ
60 70 80 90 100
KVAKDKYGLD VELVTFNDYV LPNEALSKGD IDANAFQHKP YLDQQLKDRG
110 120 130 140 150
YKLVAVGNTF VYPIAGYSKK IKSLDELQDG SQVAVPNDPT NLGRSLLLLQ
160 170 180 190 200
KVGLIKLKDG VGLLPTVLDV VENPKNLKIV ELEAPQLPRS LDDAQIALAV
210 220 230 240 250
INTTYASQIG LTPAKDGIFV EDKESPYVNL IVTREDNKDA ENVKKFVQAY
260 270
QSDEVYEAAN KVFNGGAVKG W
Length:271
Mass (Da):29,432
Last modified:July 1, 1993 - v2
Checksum:iB50CBC6FB5CD2BF7
GO

Sequence cautioni

The sequence AAA24507 differs from that shown. Reason: Frameshift at position 217.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200V → L in AAA24507 (PubMed:1459951).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D15061 Genomic DNA. Translation: BAA03657.1.
U70214 Genomic DNA. Translation: AAB08625.1.
U00096 Genomic DNA. Translation: AAC73308.1.
AP009048 Genomic DNA. Translation: BAA77874.1.
L04474 Genomic DNA. Translation: AAA24507.1. Frameshift.
PIRiE64744.
RefSeqiNP_414739.1. NC_000913.3.
WP_000874226.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73308; AAC73308; b0197.
BAA77874; BAA77874; BAA77874.
GeneIDi944893.
KEGGiecj:JW0193.
eco:b0197.
PATRICi32115507. VBIEscCol129921_0205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D15061 Genomic DNA. Translation: BAA03657.1.
U70214 Genomic DNA. Translation: AAB08625.1.
U00096 Genomic DNA. Translation: AAC73308.1.
AP009048 Genomic DNA. Translation: BAA77874.1.
L04474 Genomic DNA. Translation: AAA24507.1. Frameshift.
PIRiE64744.
RefSeqiNP_414739.1. NC_000913.3.
WP_000874226.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YAHX-ray1.60X1-271[»]
ProteinModelPortaliP28635.
SMRiP28635.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263377. 8 interactors.
DIPiDIP-11196N.
IntActiP28635. 3 interactors.
STRINGi511145.b0197.

Protein family/group databases

TCDBi3.A.1.24.1. the atp-binding cassette (abc) superfamily.

2D gel databases

SWISS-2DPAGEP28635.

Proteomic databases

EPDiP28635.
PaxDbiP28635.
PRIDEiP28635.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73308; AAC73308; b0197.
BAA77874; BAA77874; BAA77874.
GeneIDi944893.
KEGGiecj:JW0193.
eco:b0197.
PATRICi32115507. VBIEscCol129921_0205.

Organism-specific databases

EchoBASEiEB1467.
EcoGeneiEG11504. metQ.

Phylogenomic databases

eggNOGiENOG4105D01. Bacteria.
COG1464. LUCA.
HOGENOMiHOG000222926.
InParanoidiP28635.
KOiK02073.
OMAiNDPANQG.
PhylomeDBiP28635.

Enzyme and pathway databases

BioCyciEcoCyc:METQ-MONOMER.
ECOL316407:JW0193-MONOMER.
MetaCyc:METQ-MONOMER.

Miscellaneous databases

PROiP28635.

Family and domain databases

InterProiIPR004872. Lipoprotein_NlpA.
[Graphical view]
PANTHERiPTHR30429. PTHR30429. 1 hit.
PfamiPF03180. Lipoprotein_9. 1 hit.
[Graphical view]
PIRSFiPIRSF002854. MetQ. 1 hit.
TIGRFAMsiTIGR00363. TIGR00363. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMETQ_ECOLI
AccessioniPrimary (citable) accession number: P28635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The MetNIQ system is also to be able to transport the toxic methionine analog alpha-methyl-methionine.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.