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Protein

Biodegradative arginine decarboxylase

Gene

adiA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ADC can be found in two forms: biodegradative and biosynthetic. The biodegradative form may play a role in regulating pH by consuming proteins.

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

GO - Molecular functioni

  • arginine decarboxylase activity Source: EcoliWiki
  • pyridoxal phosphate binding Source: EcoCyc

GO - Biological processi

  • arginine catabolic process Source: EcoliWiki
  • intracellular pH elevation Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciEcoCyc:ARGDECARBOXDEG-MONOMER.
ECOL316407:JW5731-MONOMER.
MetaCyc:ARGDECARBOXDEG-MONOMER.
BRENDAi4.1.1.19. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Biodegradative arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:adiA
Synonyms:adi
Ordered Locus Names:b4117, JW5731
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11501. adiA.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011491 – 755Biodegradative arginine decarboxylaseAdd BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei386N6-(pyridoxal phosphate)lysine1

Proteomic databases

PaxDbiP28629.
PRIDEiP28629.

Expressioni

Inductioni

Under conditions of acidic pH, anaerobiosis and rich medium.

Interactioni

Subunit structurei

Homodecamer.

Protein-protein interaction databases

BioGridi4263079. 10 interactors.
DIPiDIP-2903N.
IntActiP28629. 6 interactors.
MINTiMINT-1241522.
STRINGi511145.b4117.

Structurei

Secondary structure

1755
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi15 – 30Combined sources16
Beta strandi34 – 40Combined sources7
Helixi41 – 48Combined sources8
Turni49 – 51Combined sources3
Beta strandi55 – 60Combined sources6
Helixi66 – 82Combined sources17
Beta strandi88 – 92Combined sources5
Helixi94 – 99Combined sources6
Helixi103 – 108Combined sources6
Beta strandi110 – 114Combined sources5
Turni115 – 117Combined sources3
Helixi120 – 136Combined sources17
Helixi141 – 150Combined sources10
Beta strandi156 – 160Combined sources5
Turni161 – 166Combined sources6
Helixi167 – 170Combined sources4
Helixi172 – 181Combined sources10
Helixi183 – 187Combined sources5
Turni194 – 197Combined sources4
Turni200 – 203Combined sources4
Helixi205 – 218Combined sources14
Beta strandi221 – 228Combined sources8
Helixi229 – 241Combined sources13
Beta strandi247 – 253Combined sources7
Helixi256 – 265Combined sources10
Beta strandi268 – 272Combined sources5
Helixi287 – 290Combined sources4
Helixi292 – 301Combined sources10
Turni303 – 305Combined sources3
Helixi306 – 308Combined sources3
Beta strandi316 – 321Combined sources6
Beta strandi325 – 328Combined sources4
Helixi330 – 337Combined sources8
Turni338 – 340Combined sources3
Beta strandi342 – 347Combined sources6
Helixi354 – 356Combined sources3
Helixi358 – 360Combined sources3
Beta strandi363 – 366Combined sources4
Beta strandi374 – 383Combined sources10
Turni384 – 386Combined sources3
Beta strandi387 – 389Combined sources3
Beta strandi395 – 400Combined sources6
Helixi408 – 417Combined sources10
Helixi425 – 438Combined sources14
Helixi441 – 469Combined sources29
Turni470 – 472Combined sources3
Beta strandi477 – 480Combined sources4
Beta strandi482 – 485Combined sources4
Turni487 – 489Combined sources3
Beta strandi492 – 494Combined sources3
Helixi495 – 497Combined sources3
Helixi500 – 505Combined sources6
Helixi507 – 509Combined sources3
Turni517 – 519Combined sources3
Beta strandi528 – 531Combined sources4
Beta strandi535 – 539Combined sources5
Beta strandi547 – 549Combined sources3
Helixi556 – 564Combined sources9
Turni565 – 567Combined sources3
Beta strandi571 – 573Combined sources3
Beta strandi575 – 581Combined sources7
Turni588 – 591Combined sources4
Helixi592 – 607Combined sources16
Helixi611 – 614Combined sources4
Helixi616 – 621Combined sources6
Turni623 – 625Combined sources3
Helixi631 – 645Combined sources15
Helixi647 – 656Combined sources10
Beta strandi661 – 663Combined sources3
Helixi665 – 673Combined sources9
Beta strandi677 – 681Combined sources5
Helixi682 – 684Combined sources3
Beta strandi689 – 692Combined sources4
Beta strandi694 – 696Combined sources3
Turni697 – 699Combined sources3
Helixi716 – 730Combined sources15
Beta strandi741 – 744Combined sources4
Beta strandi747 – 753Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VYCX-ray2.40A/B/C/D/E/F/G/H/I/J1-755[»]
ProteinModelPortaliP28629.
SMRiP28629.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28629.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN. Bacteria.
COG1982. LUCA.
HOGENOMiHOG000164394.
InParanoidiP28629.
KOiK01584.
OMAiPSCWVLK.
PhylomeDBiP28629.

Family and domain databases

CDDicd00615. Orn_deC_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009393. Orn_decarb. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28629-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLIVESEF LHQDTWVGNA VERLADALSQ QNVTVIKSTS FDDGFAILSS
60 70 80 90 100
NEAIDCLMFS YQMEHPDEHQ NVRQLIGKLH ERQQNVPVFL LGDREKALAA
110 120 130 140 150
MDRDLLELVD EFAWILEDTA DFIAGRAVAA MTRYRQQLLP PLFSALMKYS
160 170 180 190 200
DIHEYSWAAP GHQGGVGFTK TPAGRFYHDY YGENLFRTDM GIERTSLGSL
210 220 230 240 250
LDHTGAFGES EKYAARVFGA DRSWSVVVGT SGSNRTIMQA CMTDNDVVVV
260 270 280 290 300
DRNCHKSIEQ GLMLTGAKPV YMVPSRNRYG IIGPIYPQEM QPETLQKKIS
310 320 330 340 350
ESPLTKDKAG QKPSYCVVTN CTYDGVCYNA KEAQDLLEKT SDRLHFDEAW
360 370 380 390 400
YGYARFNPIY ADHYAMRGEP GDHNGPTVFA THSTHKLLNA LSQASYIHVR
410 420 430 440 450
EGRGAINFSR FNQAYMMHAT TSPLYAICAS NDVAVSMMDG NSGLSLTQEV
460 470 480 490 500
IDEAVDFRQA MARLYKEFTA DGSWFFKPWN KEVVTDPQTG KTYDFADAPT
510 520 530 540 550
KLLTTVQDCW VMHPGESWHG FKDIPDNWSM LDPIKVSILA PGMGEDGELE
560 570 580 590 600
ETGVPAALVT AWLGRHGIVP TRTTDFQIMF LFSMGVTRGK WGTLVNTLCS
610 620 630 640 650
FKRHYDANTP LAQVMPELVE QYPDTYANMG IHDLGDTMFA WLKENNPGAR
660 670 680 690 700
LNEAYSGLPV AEVTPREAYN AIVDNNVELV SIENLPGRIA ANSVIPYPPG
710 720 730 740 750
IPMLLSGENF GDKNSPQVSY LRSLQSWDHH FPGFEHETEG TEIIDGIYHV

MCVKA
Length:755
Mass (Da):84,425
Last modified:December 1, 1992 - v1
Checksum:i0FCB715144649F8F
GO

Sequence cautioni

The sequence AAA97017 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE78119 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75L → P (PubMed:2830169).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93362 Genomic DNA. Translation: AAA23481.1.
U14003 Genomic DNA. Translation: AAA97017.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77078.2.
AP009048 Genomic DNA. Translation: BAE78119.1. Different initiation.
M18425 Genomic DNA. No translation available.
PIRiS56346.
RefSeqiNP_418541.2. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC77078; AAC77078; b4117.
BAE78119; BAE78119; BAE78119.
GeneIDi948638.
KEGGiecj:JW5731.
eco:b4117.
PATRICi32123799. VBIEscCol129921_4248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93362 Genomic DNA. Translation: AAA23481.1.
U14003 Genomic DNA. Translation: AAA97017.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77078.2.
AP009048 Genomic DNA. Translation: BAE78119.1. Different initiation.
M18425 Genomic DNA. No translation available.
PIRiS56346.
RefSeqiNP_418541.2. NC_000913.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VYCX-ray2.40A/B/C/D/E/F/G/H/I/J1-755[»]
ProteinModelPortaliP28629.
SMRiP28629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263079. 10 interactors.
DIPiDIP-2903N.
IntActiP28629. 6 interactors.
MINTiMINT-1241522.
STRINGi511145.b4117.

Proteomic databases

PaxDbiP28629.
PRIDEiP28629.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77078; AAC77078; b4117.
BAE78119; BAE78119; BAE78119.
GeneIDi948638.
KEGGiecj:JW5731.
eco:b4117.
PATRICi32123799. VBIEscCol129921_4248.

Organism-specific databases

EchoBASEiEB1464.
EcoGeneiEG11501. adiA.

Phylogenomic databases

eggNOGiENOG4105CXN. Bacteria.
COG1982. LUCA.
HOGENOMiHOG000164394.
InParanoidiP28629.
KOiK01584.
OMAiPSCWVLK.
PhylomeDBiP28629.

Enzyme and pathway databases

BioCyciEcoCyc:ARGDECARBOXDEG-MONOMER.
ECOL316407:JW5731-MONOMER.
MetaCyc:ARGDECARBOXDEG-MONOMER.
BRENDAi4.1.1.19. 2026.

Miscellaneous databases

EvolutionaryTraceiP28629.
PROiP28629.

Family and domain databases

CDDicd00615. Orn_deC_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009393. Orn_decarb. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADIA_ECOLI
AccessioniPrimary (citable) accession number: P28629
Secondary accession number(s): P78138, Q2M6I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.