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P28629 (ADIA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biodegradative arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:adiA
Synonyms:adi
Ordered Locus Names:b4117, JW5731
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length755 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

ADC can be found in two forms: biodegradative and biosynthetic. The biodegradative form may play a role in regulating pH by consuming proteins.

Catalytic activity

L-arginine = agmatine + CO2.

Cofactor

Pyridoxal phosphate.

Subunit structure

Homodecamer.

Subcellular location

Cytoplasm.

Induction

Under conditions of acidic pH, anaerobiosis and rich medium.

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-I family.

Sequence caution

The sequence AAA97017.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAE78119.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 755755Biodegradative arginine decarboxylase
PRO_0000201149

Amino acid modifications

Modified residue3861N6-(pyridoxal phosphate)lysine

Experimental info

Sequence conflict751L → P Ref.5

Secondary structure

............................................................................................................................................... 755
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P28629 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 0FCB715144649F8F

FASTA75584,425
        10         20         30         40         50         60 
MKVLIVESEF LHQDTWVGNA VERLADALSQ QNVTVIKSTS FDDGFAILSS NEAIDCLMFS 

        70         80         90        100        110        120 
YQMEHPDEHQ NVRQLIGKLH ERQQNVPVFL LGDREKALAA MDRDLLELVD EFAWILEDTA 

       130        140        150        160        170        180 
DFIAGRAVAA MTRYRQQLLP PLFSALMKYS DIHEYSWAAP GHQGGVGFTK TPAGRFYHDY 

       190        200        210        220        230        240 
YGENLFRTDM GIERTSLGSL LDHTGAFGES EKYAARVFGA DRSWSVVVGT SGSNRTIMQA 

       250        260        270        280        290        300 
CMTDNDVVVV DRNCHKSIEQ GLMLTGAKPV YMVPSRNRYG IIGPIYPQEM QPETLQKKIS 

       310        320        330        340        350        360 
ESPLTKDKAG QKPSYCVVTN CTYDGVCYNA KEAQDLLEKT SDRLHFDEAW YGYARFNPIY 

       370        380        390        400        410        420 
ADHYAMRGEP GDHNGPTVFA THSTHKLLNA LSQASYIHVR EGRGAINFSR FNQAYMMHAT 

       430        440        450        460        470        480 
TSPLYAICAS NDVAVSMMDG NSGLSLTQEV IDEAVDFRQA MARLYKEFTA DGSWFFKPWN 

       490        500        510        520        530        540 
KEVVTDPQTG KTYDFADAPT KLLTTVQDCW VMHPGESWHG FKDIPDNWSM LDPIKVSILA 

       550        560        570        580        590        600 
PGMGEDGELE ETGVPAALVT AWLGRHGIVP TRTTDFQIMF LFSMGVTRGK WGTLVNTLCS 

       610        620        630        640        650        660 
FKRHYDANTP LAQVMPELVE QYPDTYANMG IHDLGDTMFA WLKENNPGAR LNEAYSGLPV 

       670        680        690        700        710        720 
AEVTPREAYN AIVDNNVELV SIENLPGRIA ANSVIPYPPG IPMLLSGENF GDKNSPQVSY 

       730        740        750 
LRSLQSWDHH FPGFEHETEG TEIIDGIYHV MCVKA 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the adi gene, which encodes the biodegradative acid-induced arginine decarboxylase of Escherichia coli."
Stim K.P., Bennett G.N.
J. Bacteriol. 175:1221-1234(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Organisation of the regulatory region of the Escherichia coli melibiose operon."
Webster C., Kempsell K., Booth I., Busby S.
Gene 59:253-263(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-78.
[6]"Chemical properties of Escherichia coli lysine decarboxylase including a segment of its pyridoxal 5'-phosphate binding site."
Sabo D.L., Fischer E.H.
Biochemistry 13:670-676(1974) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-7.
Strain: B.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M93362 Genomic DNA. Translation: AAA23481.1.
U14003 Genomic DNA. Translation: AAA97017.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77078.2.
AP009048 Genomic DNA. Translation: BAE78119.1. Different initiation.
M18425 Genomic DNA. No translation available.
PIRS56346.
RefSeqNP_418541.2. NC_000913.3.
YP_492260.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2VYCX-ray2.40A/B/C/D/E/F/G/H/I/J1-755[»]
ProteinModelPortalP28629.
SMRP28629. Positions 1-755.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-2903N.
IntActP28629. 6 interactions.
MINTMINT-1241522.
STRING511145.b4117.

Proteomic databases

PaxDbP28629.
PRIDEP28629.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC77078; AAC77078; b4117.
BAE78119; BAE78119; BAE78119.
GeneID12934085.
948638.
KEGGecj:Y75_p4004.
eco:b4117.
PATRIC32123799. VBIEscCol129921_4248.

Organism-specific databases

EchoBASEEB1464.
EcoGeneEG11501. adiA.

Phylogenomic databases

eggNOGCOG1982.
HOGENOMHOG000164394.
KOK01584.
OMAPSCWVLK.
OrthoDBEOG696BRZ.
PhylomeDBP28629.
ProtClustDBPRK15029.

Enzyme and pathway databases

BioCycEcoCyc:ARGDECARBOXDEG-MONOMER.
ECOL316407:JW5731-MONOMER.
MetaCyc:ARGDECARBOXDEG-MONOMER.
BRENDA4.1.1.19. 2026.

Gene expression databases

GenevestigatorP28629.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF009393. Orn_decarb. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP28629.
PROP28629.

Entry information

Entry nameADIA_ECOLI
AccessionPrimary (citable) accession number: P28629
Secondary accession number(s): P78138, Q2M6I7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene