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Protein

Endoglucanase 4

Gene
N/A
Organism
Bacillus sp. (strain KSM-522)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Was originally thought to originate from Clostridium cellulovorans and was termed endoglucanase C (engC).1 Publication

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei400By similarity1
Active sitei438By similarity1
Active sitei447By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiCBM3 Carbohydrate-Binding Module Family 3
GH9 Glycoside Hydrolase Family 9

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase 4 (EC:3.2.1.4)
Alternative name(s):
Cellulase 4
EG-IV
Endo-1,4-beta-glucanase 4
OrganismiBacillus sp. (strain KSM-522)
Taxonomic identifieri120046 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000795226 – 636Endoglucanase 4Add BLAST611

Proteomic databases

PRIDEiP28622

Structurei

3D structure databases

ProteinModelPortaliP28622
SMRiP28622
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini478 – 635CBM3PROSITE-ProRule annotationAdd BLAST158

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.50.10.10, 1 hit
2.60.40.710, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR001701 Glyco_hydro_9
IPR033126 Glyco_hydro_9_Asp/Glu_AS
IPR018221 Glyco_hydro_9_His_AS
PfamiView protein in Pfam
PF00942 CBM_3, 1 hit
PF00759 Glyco_hydro_9, 1 hit
SMARTiView protein in SMART
SM01067 CBM_3, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF49384 SSF49384, 1 hit
PROSITEiView protein in PROSITE
PS51172 CBM3, 1 hit
PS00592 GLYCOSYL_HYDROL_F9_1, 1 hit
PS00698 GLYCOSYL_HYDROL_F9_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRWSFLVQ CFTFKKKEGV RSRYMSDYNY VEVLQKSILF YEAQRSGKLP
60 70 80 90 100
ESNRLNWRGD SGLEDGKDVG HDLTGGWYDA GDHVKFGLPM AYSAAVLAWT
110 120 130 140 150
VYEYREAYEE AELLDDMLDQ IKWATDYFLK AHTGPNEFWA QVGDGNADHG
160 170 180 190 200
WWGPAEVMPM NRPAFKIDEH CPGTEVAAQT AAALAAGSII FKETDAPYAA
210 220 230 240 250
KLLTHAKQLY AFADQYRGEY TDCVTNAQPF YNSWSGYIDE LIWGGIWLYL
260 270 280 290 300
ATNDQTYLNK ALKAVEEWPK DWDYTFTMSW DNTFFLSQIL LARITKEKRF
310 320 330 340 350
IESTERNLDY WSTGFVQNGK VERITYTPGG LAWLDQWGSL RYTANAAFLA
360 370 380 390 400
FVYADWVSDQ EKKNRYQTFA IRQTHYMLGD NPQNRSYVVG FGKNPPMHPH
410 420 430 440 450
HRTAHGSWSN QLTTPSSHRH TLYGPLVGGP NRQDQYTDDI SDYVSNEVAT
460 470 480 490 500
DYNAAFTGNG AAVWSGQSKL PNFPPKEKVE DEFFVEAAVM SNDTTSTQIK
510 520 530 540 550
AILYNRSGWP ARSSQSLSFR YYVNLSEIFA KGFTDKDIQV TAVYNEGASL
560 570 580 590 600
SPLTVYDASS HIYFTEIDFT GVAIFPGGES LHKKEIQFRL SAPNGANIWD
610 620 630
ASNDYSFQGL TSNMQKTARI PVFDQGDLVF GTLPNK
Length:636
Mass (Da):72,245
Last modified:May 30, 2000 - v2
Checksum:i76718BF57A8EF6A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti530 – 534AKGFT → CEGIH (PubMed:2113383).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004098 Genomic DNA Translation: BAA24918.1
PIRiJC5874

Similar proteinsi

Entry informationi

Entry nameiGUN4_BACS5
AccessioniPrimary (citable) accession number: P28622
Secondary accession number(s): O50589
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health