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P28605

- GLNA_SYNP2

UniProt

P28605 - GLNA_SYNP2

Protein

Glutamine synthetase

Gene

glnA

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP32049:GKF7-1631-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Ordered Locus Names:SYNPCC7002_A1630
    OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
    Taxonomic identifieri32049 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001688: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473Glutamine synthetasePRO_0000153271Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei401 – 4011O-AMP-tyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Oligomer of 12 subunits arranged in the form of two hexagons.

    Protein-protein interaction databases

    STRINGi32049.SYNPCC7002_A1630.

    Structurei

    3D structure databases

    ProteinModelPortaliP28605.
    SMRiP28605. Positions 2-473.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    HOGENOMiHOG000005157.
    KOiK01915.
    OMAiSGREENP.
    OrthoDBiEOG6B360N.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28605-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQTATDVLR LIQEENIQII DLKFVDLPGI WQHCSFYQDQ LDEASFVDGV    50
    PFDGSSIRGW KAINESDMAM VPDPTTAWID PFCKEKTLSL ICSIKEPRTG 100
    EWYSRDPRSI AQKAVDYLAA SGIGDTAYFG PEAEFFVFDD VRFDQTENKG 150
    FYYVDSVEGR WNSGRKEPGG NLAHKPGYKQ GYFPVPPTDT LQDMRTEMLL 200
    TMAKCGVPIE KHHHEVATGG QNELGFRFAT LLKAADYLMT YKYVIKNVAR 250
    KYGRTVTFMP KPLFNDNGSG MHTHQSLWKE GQPLFWGDRY ANLSQLALHY 300
    IGGILKHAPA LLAFSNPSTN SYKRLVPGFE APVNLAYSQG NRSASVRIPL 350
    SGPNPKAKRL EFRCPDATAN PYLAFAAMLC AGIDGIKNAI DPGDPLDVDI 400
    YDLTPEELSK IPSTPASLEA ALEALQQDHD FLTAGGVFTT DFIENWIEYK 450
    LDAEVNPLRL RPHPYEFALY YDC 473
    Length:473
    Mass (Da):53,004
    Last modified:June 10, 2008 - v2
    Checksum:i62323C804178884B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti120 – 1201A → P in CAA78366. (PubMed:7678591)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z13965 Genomic DNA. Translation: CAA78366.1.
    CP000951 Genomic DNA. Translation: ACA99620.1.
    RefSeqiWP_012307243.1. NC_010475.1.
    YP_001734876.1. NC_010475.1.

    Genome annotation databases

    EnsemblBacteriaiACA99620; ACA99620; SYNPCC7002_A1630.
    GeneIDi6055475.
    KEGGisyp:SYNPCC7002_A1630.
    PATRICi23817880. VBISynSp37135_1883.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z13965 Genomic DNA. Translation: CAA78366.1 .
    CP000951 Genomic DNA. Translation: ACA99620.1 .
    RefSeqi WP_012307243.1. NC_010475.1.
    YP_001734876.1. NC_010475.1.

    3D structure databases

    ProteinModelPortali P28605.
    SMRi P28605. Positions 2-473.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 32049.SYNPCC7002_A1630.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA99620 ; ACA99620 ; SYNPCC7002_A1630 .
    GeneIDi 6055475.
    KEGGi syp:SYNPCC7002_A1630.
    PATRICi 23817880. VBISynSp37135_1883.

    Phylogenomic databases

    eggNOGi COG0174.
    HOGENOMi HOG000005157.
    KOi K01915.
    OMAi SGREENP.
    OrthoDBi EOG6B360N.

    Enzyme and pathway databases

    BioCyci SSP32049:GKF7-1631-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The glnA gene of the cyanobacterium Agmenellum quadruplicatum PR-6 is nonessential for ammonium assimilation."
      Wagner S.J., Thomas S.P., Kaufman R.I., Nixon B.T., Stevens S.E. Jr.
      J. Bacteriol. 175:604-612(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: PR-6.
    2. "Complete sequence of Synechococcus sp. PCC 7002."
      Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27264 / PCC 7002 / PR-6.

    Entry informationi

    Entry nameiGLNA_SYNP2
    AccessioniPrimary (citable) accession number: P28605
    Secondary accession number(s): B1XNU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3