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P28605

- GLNA_SYNP2

UniProt

P28605 - GLNA_SYNP2

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Protein

Glutamine synthetase

Gene

glnA

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP32049:GKF7-1631-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:SYNPCC7002_A1630
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001688: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Glutamine synthetasePRO_0000153271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei401 – 4011O-AMP-tyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A1630.

Structurei

3D structure databases

ProteinModelPortaliP28605.
SMRiP28605. Positions 2-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005157.
KOiK01915.
OMAiSGREENP.
OrthoDBiEOG6B360N.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28605-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQTATDVLR LIQEENIQII DLKFVDLPGI WQHCSFYQDQ LDEASFVDGV
60 70 80 90 100
PFDGSSIRGW KAINESDMAM VPDPTTAWID PFCKEKTLSL ICSIKEPRTG
110 120 130 140 150
EWYSRDPRSI AQKAVDYLAA SGIGDTAYFG PEAEFFVFDD VRFDQTENKG
160 170 180 190 200
FYYVDSVEGR WNSGRKEPGG NLAHKPGYKQ GYFPVPPTDT LQDMRTEMLL
210 220 230 240 250
TMAKCGVPIE KHHHEVATGG QNELGFRFAT LLKAADYLMT YKYVIKNVAR
260 270 280 290 300
KYGRTVTFMP KPLFNDNGSG MHTHQSLWKE GQPLFWGDRY ANLSQLALHY
310 320 330 340 350
IGGILKHAPA LLAFSNPSTN SYKRLVPGFE APVNLAYSQG NRSASVRIPL
360 370 380 390 400
SGPNPKAKRL EFRCPDATAN PYLAFAAMLC AGIDGIKNAI DPGDPLDVDI
410 420 430 440 450
YDLTPEELSK IPSTPASLEA ALEALQQDHD FLTAGGVFTT DFIENWIEYK
460 470
LDAEVNPLRL RPHPYEFALY YDC
Length:473
Mass (Da):53,004
Last modified:June 10, 2008 - v2
Checksum:i62323C804178884B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201A → P in CAA78366. (PubMed:7678591)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z13965 Genomic DNA. Translation: CAA78366.1.
CP000951 Genomic DNA. Translation: ACA99620.1.
RefSeqiWP_012307243.1. NC_010475.1.
YP_001734876.1. NC_010475.1.

Genome annotation databases

EnsemblBacteriaiACA99620; ACA99620; SYNPCC7002_A1630.
GeneIDi6055475.
KEGGisyp:SYNPCC7002_A1630.
PATRICi23817880. VBISynSp37135_1883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z13965 Genomic DNA. Translation: CAA78366.1 .
CP000951 Genomic DNA. Translation: ACA99620.1 .
RefSeqi WP_012307243.1. NC_010475.1.
YP_001734876.1. NC_010475.1.

3D structure databases

ProteinModelPortali P28605.
SMRi P28605. Positions 2-473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 32049.SYNPCC7002_A1630.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA99620 ; ACA99620 ; SYNPCC7002_A1630 .
GeneIDi 6055475.
KEGGi syp:SYNPCC7002_A1630.
PATRICi 23817880. VBISynSp37135_1883.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000005157.
KOi K01915.
OMAi SGREENP.
OrthoDBi EOG6B360N.

Enzyme and pathway databases

BioCyci SSP32049:GKF7-1631-MONOMER.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The glnA gene of the cyanobacterium Agmenellum quadruplicatum PR-6 is nonessential for ammonium assimilation."
    Wagner S.J., Thomas S.P., Kaufman R.I., Nixon B.T., Stevens S.E. Jr.
    J. Bacteriol. 175:604-612(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PR-6.
  2. "Complete sequence of Synechococcus sp. PCC 7002."
    Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27264 / PCC 7002 / PR-6.

Entry informationi

Entry nameiGLNA_SYNP2
AccessioniPrimary (citable) accession number: P28605
Secondary accession number(s): B1XNU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: June 10, 2008
Last modified: October 29, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3