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Protein

Low-affinity potassium transport protein

Gene

TRK2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is required for low-affinity potassium transport.

GO - Molecular functioni

  • potassium ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular potassium ion homeostasis Source: SGD
  • regulation of membrane potential Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciYEAST:G3O-32020-MONOMER.

Protein family/group databases

TCDBi2.A.38.2.3. the k(+) transporter (trk) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Low-affinity potassium transport protein
Gene namesi
Name:TRK2
Synonyms:RPD2
Ordered Locus Names:YKR050W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR050W.
SGDiS000001758. TRK2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 73HelicalSequence analysisAdd BLAST22
Topological domaini74 – 80ExtracellularSequence analysis7
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 109CytoplasmicSequence analysis8
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 464ExtracellularSequence analysisAdd BLAST334
Transmembranei465 – 487HelicalSequence analysisAdd BLAST23
Topological domaini488 – 499CytoplasmicSequence analysisAdd BLAST12
Transmembranei500 – 521HelicalSequence analysisAdd BLAST22
Topological domaini522 – 524ExtracellularSequence analysis3
Transmembranei525 – 545HelicalSequence analysisAdd BLAST21
Topological domaini546 – 548CytoplasmicSequence analysis3
Transmembranei549 – 569HelicalSequence analysisAdd BLAST21
Topological domaini570 – 584ExtracellularSequence analysisAdd BLAST15
Transmembranei585 – 605HelicalSequence analysisAdd BLAST21
Topological domaini606 – 609CytoplasmicSequence analysis4
Transmembranei610 – 630HelicalSequence analysisAdd BLAST21
Topological domaini631 – 657ExtracellularSequence analysisAdd BLAST27
Transmembranei658 – 678HelicalSequence analysisAdd BLAST21
Topological domaini679 – 743CytoplasmicSequence analysisAdd BLAST65
Transmembranei744 – 764HelicalSequence analysisAdd BLAST21
Topological domaini765 – 776ExtracellularSequence analysisAdd BLAST12
Transmembranei777 – 797HelicalSequence analysisAdd BLAST21
Topological domaini798 – 889CytoplasmicSequence analysisAdd BLAST92

GO - Cellular componenti

  • integral component of plasma membrane Source: InterPro
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704641 – 889Low-affinity potassium transport proteinAdd BLAST889

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi216N-linked (GlcNAc...)Sequence analysis1
Glycosylationi233N-linked (GlcNAc...)Sequence analysis1
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP28584.

Interactioni

Protein-protein interaction databases

BioGridi34181. 40 interactors.
DIPiDIP-5225N.
IntActiP28584. 2 interactors.
MINTiMINT-536870.

Structurei

3D structure databases

ProteinModelPortaliP28584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrkH potassium transport family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000069355.
HOGENOMiHOG000161114.
InParanoidiP28584.
OMAiPTWWAFF.
OrthoDBiEOG092C1608.

Family and domain databases

InterProiIPR003445. Cat_transpt.
IPR004773. K/Na_transp_Trk/HKT.
IPR015958. Ktransp_fun.
[Graphical view]
PfamiPF02386. TrkH. 1 hit.
[Graphical view]
PIRSFiPIRSF002450. K+_transpter_TRK. 1 hit.
TIGRFAMsiTIGR00934. 2a38euk. 1 hit.

Sequencei

Sequence statusi: Complete.

P28584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTAKRTSSR ASLALPFQLR LVHKKSWGHR LRDFISGFLK SCRPIAKYVF
60 70 80 90 100
PNFIVVHYIY LITLSIIGSI LLYPCKNTAF IDVLFLAAGA STQGGLATKS
110 120 130 140 150
TNDFNLYQQI VVYVITLLST PILIHGFLAF VRLYWFERYF DNIRDISKQN
160 170 180 190 200
FKLRRTMTLQ QRELSGSSGN AARSRSFKDN LFRGKFVSRE DPRQSASDVP
210 220 230 240 250
MDSPDTSALS SISPLNVSSS KEESSDTQSS PPNFSSKRQP SDVDPRDIYK
260 270 280 290 300
SIMMLQKQQE KSNANSTDSF SSETNGPAFI VQERHERRAP HCSLKRHSVL
310 320 330 340 350
PSSQELNKLA QTKSFQKLLG LRRDEGDHDY FDGAPHKYMV TKKKKISRTQ
360 370 380 390 400
SCNIPTYTAS PSPKTSGQVV ENHRNLAKSA PSSFVDEEMS FSPQESLNLQ
410 420 430 440 450
FQAHPPKPKR REGDIGHPFT RTMSTNYLSW QPTFGRNSVF IGLTKQQKEE
460 470 480 490 500
LGGVEYRALR LLCCILMVYY IGFNILAFVT IVPWACTRHH YSEIIRRNGV
510 520 530 540 550
SPTWWGFFTA MSAFSNLGLS LTADSMVSFD TAPYPLIFMM FFIIIGNTGF
560 570 580 590 600
PIMLRFIIWI MFKTSRDLSQ FKESLGFLLD HPRRCFTLLF PSGPTWWLFT
610 620 630 640 650
TLVVLNATDW ILFIILDFNS AVVRQVAKGY RALMGLFQSV CTRTAGFNVV
660 670 680 690 700
DLSKLHPSIQ VSYMLMMYVS VLPLAISIRR TNVYEEQSLG LYDSGQDDEN
710 720 730 740 750
ITHEDDIKET DHDGESEERD TVSTKSKPKK QSPKSFVGAH LRRQLSFDLW
760 770 780 790 800
YLFLGLFIIC ICEGRKIEDV NKPDFNVFAI LFEVVSAYGT VGLSLGYPNT
810 820 830 840 850
NTSLSAQFTV LSKLVIIAML IRGRNRGLPY TLDRAIMLPS DKLEQIDRLQ
860 870 880
DMKAKGKLLA KVGEDPMTTY VKKRSHKLKK IATKFWGKH
Length:889
Mass (Da):101,087
Last modified:December 1, 1992 - v1
Checksum:i4A41448C9560276C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65215 Genomic DNA. Translation: AAA35172.1.
Z28275 Genomic DNA. Translation: CAA82128.1.
BK006944 Genomic DNA. Translation: DAA09201.1.
PIRiA41259.
RefSeqiNP_012976.1. NM_001179840.1.

Genome annotation databases

EnsemblFungiiYKR050W; YKR050W; YKR050W.
GeneIDi853924.
KEGGisce:YKR050W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65215 Genomic DNA. Translation: AAA35172.1.
Z28275 Genomic DNA. Translation: CAA82128.1.
BK006944 Genomic DNA. Translation: DAA09201.1.
PIRiA41259.
RefSeqiNP_012976.1. NM_001179840.1.

3D structure databases

ProteinModelPortaliP28584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34181. 40 interactors.
DIPiDIP-5225N.
IntActiP28584. 2 interactors.
MINTiMINT-536870.

Protein family/group databases

TCDBi2.A.38.2.3. the k(+) transporter (trk) family.

Proteomic databases

PRIDEiP28584.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR050W; YKR050W; YKR050W.
GeneIDi853924.
KEGGisce:YKR050W.

Organism-specific databases

EuPathDBiFungiDB:YKR050W.
SGDiS000001758. TRK2.

Phylogenomic databases

GeneTreeiENSGT00530000069355.
HOGENOMiHOG000161114.
InParanoidiP28584.
OMAiPTWWAFF.
OrthoDBiEOG092C1608.

Enzyme and pathway databases

BioCyciYEAST:G3O-32020-MONOMER.

Miscellaneous databases

PROiP28584.

Family and domain databases

InterProiIPR003445. Cat_transpt.
IPR004773. K/Na_transp_Trk/HKT.
IPR015958. Ktransp_fun.
[Graphical view]
PfamiPF02386. TrkH. 1 hit.
[Graphical view]
PIRSFiPIRSF002450. K+_transpter_TRK. 1 hit.
TIGRFAMsiTIGR00934. 2a38euk. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRK2_YEAST
AccessioniPrimary (citable) accession number: P28584
Secondary accession number(s): D6VXB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.