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Protein

Low-affinity potassium transport protein

Gene

TRK2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is required for low-affinity potassium transport.

GO - Molecular functioni

  • potassium ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular potassium ion homeostasis Source: SGD
  • regulation of membrane potential Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciYEAST:G3O-32020-MONOMER.

Protein family/group databases

TCDBi2.A.38.2.3. the k(+) transporter (trk) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Low-affinity potassium transport protein
Gene namesi
Name:TRK2
Synonyms:RPD2
Ordered Locus Names:YKR050W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR050W.
SGDiS000001758. TRK2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence analysisAdd
BLAST
Transmembranei52 – 7322HelicalSequence analysisAdd
BLAST
Topological domaini74 – 807ExtracellularSequence analysis
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Topological domaini102 – 1098CytoplasmicSequence analysis
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST
Topological domaini131 – 464334ExtracellularSequence analysisAdd
BLAST
Transmembranei465 – 48723HelicalSequence analysisAdd
BLAST
Topological domaini488 – 49912CytoplasmicSequence analysisAdd
BLAST
Transmembranei500 – 52122HelicalSequence analysisAdd
BLAST
Topological domaini522 – 5243ExtracellularSequence analysis
Transmembranei525 – 54521HelicalSequence analysisAdd
BLAST
Topological domaini546 – 5483CytoplasmicSequence analysis
Transmembranei549 – 56921HelicalSequence analysisAdd
BLAST
Topological domaini570 – 58415ExtracellularSequence analysisAdd
BLAST
Transmembranei585 – 60521HelicalSequence analysisAdd
BLAST
Topological domaini606 – 6094CytoplasmicSequence analysis
Transmembranei610 – 63021HelicalSequence analysisAdd
BLAST
Topological domaini631 – 65727ExtracellularSequence analysisAdd
BLAST
Transmembranei658 – 67821HelicalSequence analysisAdd
BLAST
Topological domaini679 – 74365CytoplasmicSequence analysisAdd
BLAST
Transmembranei744 – 76421HelicalSequence analysisAdd
BLAST
Topological domaini765 – 77612ExtracellularSequence analysisAdd
BLAST
Transmembranei777 – 79721HelicalSequence analysisAdd
BLAST
Topological domaini798 – 88992CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: InterPro
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 889889Low-affinity potassium transport proteinPRO_0000070464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence analysis
Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence analysis
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

BioGridi34181. 40 interactions.
DIPiDIP-5225N.
IntActiP28584. 2 interactions.
MINTiMINT-536870.

Structurei

3D structure databases

ProteinModelPortaliP28584.
SMRiP28584. Positions 55-133, 632-673.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrkH potassium transport family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000069355.
HOGENOMiHOG000161114.
InParanoidiP28584.
OMAiPTWWAFF.
OrthoDBiEOG75MW52.

Family and domain databases

InterProiIPR003445. Cat_transpt.
IPR004773. K/Na_transp_Trk/HKT.
IPR015958. Ktransp_fun.
[Graphical view]
PfamiPF02386. TrkH. 1 hit.
[Graphical view]
PIRSFiPIRSF002450. K+_transpter_TRK. 1 hit.
TIGRFAMsiTIGR00934. 2a38euk. 1 hit.

Sequencei

Sequence statusi: Complete.

P28584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTAKRTSSR ASLALPFQLR LVHKKSWGHR LRDFISGFLK SCRPIAKYVF
60 70 80 90 100
PNFIVVHYIY LITLSIIGSI LLYPCKNTAF IDVLFLAAGA STQGGLATKS
110 120 130 140 150
TNDFNLYQQI VVYVITLLST PILIHGFLAF VRLYWFERYF DNIRDISKQN
160 170 180 190 200
FKLRRTMTLQ QRELSGSSGN AARSRSFKDN LFRGKFVSRE DPRQSASDVP
210 220 230 240 250
MDSPDTSALS SISPLNVSSS KEESSDTQSS PPNFSSKRQP SDVDPRDIYK
260 270 280 290 300
SIMMLQKQQE KSNANSTDSF SSETNGPAFI VQERHERRAP HCSLKRHSVL
310 320 330 340 350
PSSQELNKLA QTKSFQKLLG LRRDEGDHDY FDGAPHKYMV TKKKKISRTQ
360 370 380 390 400
SCNIPTYTAS PSPKTSGQVV ENHRNLAKSA PSSFVDEEMS FSPQESLNLQ
410 420 430 440 450
FQAHPPKPKR REGDIGHPFT RTMSTNYLSW QPTFGRNSVF IGLTKQQKEE
460 470 480 490 500
LGGVEYRALR LLCCILMVYY IGFNILAFVT IVPWACTRHH YSEIIRRNGV
510 520 530 540 550
SPTWWGFFTA MSAFSNLGLS LTADSMVSFD TAPYPLIFMM FFIIIGNTGF
560 570 580 590 600
PIMLRFIIWI MFKTSRDLSQ FKESLGFLLD HPRRCFTLLF PSGPTWWLFT
610 620 630 640 650
TLVVLNATDW ILFIILDFNS AVVRQVAKGY RALMGLFQSV CTRTAGFNVV
660 670 680 690 700
DLSKLHPSIQ VSYMLMMYVS VLPLAISIRR TNVYEEQSLG LYDSGQDDEN
710 720 730 740 750
ITHEDDIKET DHDGESEERD TVSTKSKPKK QSPKSFVGAH LRRQLSFDLW
760 770 780 790 800
YLFLGLFIIC ICEGRKIEDV NKPDFNVFAI LFEVVSAYGT VGLSLGYPNT
810 820 830 840 850
NTSLSAQFTV LSKLVIIAML IRGRNRGLPY TLDRAIMLPS DKLEQIDRLQ
860 870 880
DMKAKGKLLA KVGEDPMTTY VKKRSHKLKK IATKFWGKH
Length:889
Mass (Da):101,087
Last modified:December 1, 1992 - v1
Checksum:i4A41448C9560276C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65215 Genomic DNA. Translation: AAA35172.1.
Z28275 Genomic DNA. Translation: CAA82128.1.
BK006944 Genomic DNA. Translation: DAA09201.1.
PIRiA41259.
RefSeqiNP_012976.1. NM_001179840.1.

Genome annotation databases

EnsemblFungiiYKR050W; YKR050W; YKR050W.
GeneIDi853924.
KEGGisce:YKR050W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65215 Genomic DNA. Translation: AAA35172.1.
Z28275 Genomic DNA. Translation: CAA82128.1.
BK006944 Genomic DNA. Translation: DAA09201.1.
PIRiA41259.
RefSeqiNP_012976.1. NM_001179840.1.

3D structure databases

ProteinModelPortaliP28584.
SMRiP28584. Positions 55-133, 632-673.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34181. 40 interactions.
DIPiDIP-5225N.
IntActiP28584. 2 interactions.
MINTiMINT-536870.

Protein family/group databases

TCDBi2.A.38.2.3. the k(+) transporter (trk) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR050W; YKR050W; YKR050W.
GeneIDi853924.
KEGGisce:YKR050W.

Organism-specific databases

EuPathDBiFungiDB:YKR050W.
SGDiS000001758. TRK2.

Phylogenomic databases

GeneTreeiENSGT00530000069355.
HOGENOMiHOG000161114.
InParanoidiP28584.
OMAiPTWWAFF.
OrthoDBiEOG75MW52.

Enzyme and pathway databases

BioCyciYEAST:G3O-32020-MONOMER.

Miscellaneous databases

PROiP28584.

Family and domain databases

InterProiIPR003445. Cat_transpt.
IPR004773. K/Na_transp_Trk/HKT.
IPR015958. Ktransp_fun.
[Graphical view]
PfamiPF02386. TrkH. 1 hit.
[Graphical view]
PIRSFiPIRSF002450. K+_transpter_TRK. 1 hit.
TIGRFAMsiTIGR00934. 2a38euk. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TRK1 and TRK2 encode structurally related K+ transporters in Saccharomyces cerevisiae."
    Ko C.H., Gaber R.F.
    Mol. Cell. Biol. 11:4266-4273(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiTRK2_YEAST
AccessioniPrimary (citable) accession number: P28584
Secondary accession number(s): D6VXB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.