Reviewed, UniProtKB/Swiss-Prot P28581 (PHOC_MORMO)

Names and origin

Protein names

Recommended name:
    Major phosphate-irrepressible acid phosphatase
      Short name=HPAP
    EC=3.1.3.2

Gene names

Name:

phoC

Organism

Morganella morganii (Proteus morganii)

Taxonomic identifier

582 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Morganella

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Subunit structure	Homotetramer.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the class A bacterial acid phosphatase family.
biophysicochemical properties	pH dependence: Optimum pH is about 6.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Molecular function	Hydrolase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	membrane Inferred from electronic annotation. Source: InterPro outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	acid phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Ref.1
	Chain	21 – 249	229	Major phosphate-irrepressible acid phosphatase		PRO_0000023999

Sequences

	Sequence		Length	Mass (Da)
	P28581-1 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: C43F3698052B6A5C	FASTA	249	26,999
	10 20 30 40 50 60 MKKNIIAGCL FSLFSLSALA AIPAGNDATT KPDLYYLKNE QAIDSLKLLP PPPEVGSIQF 70 80 90 100 110 120 LNDQAMYEKG RMLRNTERGK QAQADADLAA GGVATAFSGA FGYPITEKDS PELYKLLTNM 130 140 150 160 170 180 IEDAGDLATR SAKEHYMRIR PFAFYGTETC NTKDQKKLST NGSYPSGHTS IGWATALVLA 190 200 210 220 230 240 EVNPANQDAI LERGYQLGQS RVICGYHWQS DVDAARIVGS AAVATLHSDP AFQAQLAKAK QEFAQKSQK

References

[1]	"Characterization and sequence of PhoC, the principal phosphate-irrepressible acid phosphatase of Morganella morganii." Thaller M.C., Berlutti F., Schippa S., Lombardi G., Rossolini G.M. Microbiology 140:1341-1350(1994) [PubMed: 8081499] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 21-40. Strain: RS12.
[2]	"Phosphorylation of nucleosides by the mutated acid phosphatase from Morganella morganii." Mihara Y., Utagawa T., Yamada H., Asano Y. Appl. Environ. Microbiol. 66:2811-2816(2000) [PubMed: 10877772] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 8019 / CCM 680 / DSM 30117 / NCIMB 10466.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X64444 Genomic DNA. Translation: CAA45774.1. AB035805 Genomic DNA. Translation: BAA96744.1.
PIR	S19187.
3D structure databases
HSSP	HSSP built from PDB template 1D2T based on UniProtKB Q9S1A6.
SMR	P28581. Positions 25-245.
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.1.3.2. 2621.
Family and domain databases
InterPro	IPR011158. Acid_Pase_ClassA. IPR001011. Acid_Pase_classA_bac. IPR018296. Acid_Pase_classA_bac_CS. IPR016118. P_Acid_Pase/Cl_peroxidase_N. IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Gene3D	G3DSA:1.20.144.10. P_Acid_Pase/Cl_peroxidase_N. 1 hit.
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
PIRSF	PIRSF000897. Acid_Ptase_ClsA. 1 hit.
PRINTS	PR00483. BACPHPHTASE.
ProDom	PD009838. Bac_AcPataseA. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
PROSITE	PS01157. ACID_PHOSPH_CL_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHOC_MORMO

Accession

Primary (citable) accession number: P28581

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)