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P28581 (PHOC_MORMO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major phosphate-irrepressible acid phosphatase

Short name=HPAP
EC=3.1.3.2
Gene names
Name:phoC
OrganismMorganella morganii (Proteus morganii)
Taxonomic identifier582 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeMorganella

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subunit structure

Homotetramer.

Subcellular location

Periplasm.

Sequence similarities

Belongs to the class A bacterial acid phosphatase family.

Biophysicochemical properties

pH dependence:

Optimum pH is about 6.

Ontologies

Keywords
   Cellular componentPeriplasm
   DomainSignal
   Molecular functionHydrolase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentmembrane

Inferred from electronic annotation. Source: InterPro

outer membrane-bounded periplasmic space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.1
Chain21 – 249229Major phosphate-irrepressible acid phosphatase
PRO_0000023999

Sequences

Sequence LengthMass (Da)Tools
P28581 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: C43F3698052B6A5C

FASTA24926,999
        10         20         30         40         50         60 
MKKNIIAGCL FSLFSLSALA AIPAGNDATT KPDLYYLKNE QAIDSLKLLP PPPEVGSIQF 

        70         80         90        100        110        120 
LNDQAMYEKG RMLRNTERGK QAQADADLAA GGVATAFSGA FGYPITEKDS PELYKLLTNM 

       130        140        150        160        170        180 
IEDAGDLATR SAKEHYMRIR PFAFYGTETC NTKDQKKLST NGSYPSGHTS IGWATALVLA 

       190        200        210        220        230        240 
EVNPANQDAI LERGYQLGQS RVICGYHWQS DVDAARIVGS AAVATLHSDP AFQAQLAKAK 


QEFAQKSQK 

« Hide

References

[1]"Characterization and sequence of PhoC, the principal phosphate-irrepressible acid phosphatase of Morganella morganii."
Thaller M.C., Berlutti F., Schippa S., Lombardi G., Rossolini G.M.
Microbiology 140:1341-1350(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 21-40.
Strain: RS12.
[2]"Phosphorylation of nucleosides by the mutated acid phosphatase from Morganella morganii."
Mihara Y., Utagawa T., Yamada H., Asano Y.
Appl. Environ. Microbiol. 66:2811-2816(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 8019 / CCM 680 / DSM 30117 / NCIMB 10466.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64444 Genomic DNA. Translation: CAA45774.1.
AB035805 Genomic DNA. Translation: BAA96744.1.
PIRS19187.

3D structure databases

ProteinModelPortalP28581.
SMRP28581. Positions 25-245.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.144.10. 1 hit.
InterProIPR011158. Acid_Pase_ClassA.
IPR001011. Acid_Pase_classA_bac.
IPR018296. Acid_Pase_classA_bac_CS.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFPIRSF000897. Acid_Ptase_ClsA. 1 hit.
PRINTSPR00483. BACPHPHTASE.
SMARTSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMSSF48317. SSF48317. 1 hit.
PROSITEPS01157. ACID_PHOSPH_CL_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePHOC_MORMO
AccessionPrimary (citable) accession number: P28581
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families