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Protein

Actin-binding protein IPP

Gene

Ipp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in organizing the actin cytoskeleton.

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-binding protein IPP
Alternative name(s):
Intracisternal A particle-promoted polypeptide
Short name:
IPP
Murine IAP-promoted placenta-expressed protein
Protein MIPP
Gene namesi
Name:Ipp
Synonyms:Mipp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:96581. Ipp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Actin-binding protein IPPPRO_0000119076Add
BLAST

Proteomic databases

PaxDbiP28575.
PRIDEiP28575.

PTM databases

iPTMnetiP28575.
PhosphoSiteiP28575.

Expressioni

Tissue specificityi

Expression seems confined to tissues derived from trophectoderm and primitive endoderm.1 Publication

Gene expression databases

CleanExiMM_IPP.
GenevisibleiP28575. MM.

Interactioni

Protein-protein interaction databases

BioGridi200781. 1 interaction.
STRINGi10090.ENSMUSP00000030461.

Structurei

3D structure databases

ProteinModelPortaliP28575.
SMRiP28575. Positions 14-583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 10468BTBPROSITE-ProRule annotationAdd
BLAST
Repeati296 – 34348Kelch 1Add
BLAST
Repeati344 – 39047Kelch 2Add
BLAST
Repeati391 – 43747Kelch 3Add
BLAST
Repeati439 – 48547Kelch 4Add
BLAST
Repeati487 – 53347Kelch 5Add
BLAST
Repeati535 – 58349Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000119153.
HOGENOMiHOG000230814.
HOVERGENiHBG014286.
InParanoidiP28575.
KOiK13956.
OMAiNLCCEFL.
OrthoDBiEOG7KQ214.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR030104. IPP.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF35. PTHR24412:SF35. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKEECPKAA DNSFSSDKHA QLILAQMNKM RSGQHFCDVQ LQVGKETFQV
60 70 80 90 100
HRLVLAASSP YFAALFTGGM KESSKDVVQI LGVEAGIFQL LLDFIYTGVV
110 120 130 140 150
NIAVTNVQEL IVAADMLQLT EVVNLCCDFL KGQIDPQNCI GLFQFSEQIA
160 170 180 190 200
CHDLLEFTEN YIHVHFLEVH TGEEFLGLTK DQLIKILRSE ELSIEDEYQV
210 220 230 240 250
FLAAMQWILK DLGKRRKHVV EVLDPVRFPL LPSQRLLKYI EGVSDFNLRV
260 270 280 290 300
ALQTLLKEYC EVCKSPKENK FCSFLQTSKV RPRKKARKYL YAVGGYTRLQ
310 320 330 340 350
GGRWSDSRAL SCVERFDTFS QYWTTVSSLH QARCGLGVAV VGGMVYAIGG
360 370 380 390 400
EKDSMIFDCT ECYDPVTKQW TTVASMNHPR CGLGVCVCYG AIYALGGWVG
410 420 430 440 450
AEIGNTIERF DPDENKWEVV GSMAVSRYYF GCCEMQGLIY AVGGISNEGL
460 470 480 490 500
ELRSFEVYDP LSKRWSPLPP MGTRRAYLGV AALNDCIYAI GGWNETQDAL
510 520 530 540 550
HTVEKYSFEE EKWVEVASMK VPRAGMCAVT VNGLLYVSGG RSSSHDFLAP
560 570 580
GTLDSVEVYN PHSDTWTEIG NMITSRCEGG VAVL
Length:584
Mass (Da):65,216
Last modified:October 3, 2012 - v3
Checksum:iBE8CE11A53F7CFED
GO

Sequence cautioni

The sequence AAK00278.1 differs from that shown. Reason: Frameshift at positions 109, 119, 273 and 293. Curated
The sequence CAA41413.1 differs from that shown. Reason: Frameshift at position 554. Curated
The sequence CAA41414.1 differs from that shown. Reason: Frameshift at position 379. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 72CP → YA in AAK00278 (PubMed:11536049).Curated
Sequence conflicti12 – 121N → S in AAK00278 (PubMed:11536049).Curated
Sequence conflicti32 – 321S → T in AAK00278 (PubMed:11536049).Curated
Sequence conflicti59 – 591S → K in AAK00278 (PubMed:11536049).Curated
Sequence conflicti164 – 1652VH → SI in AAK00278 (PubMed:11536049).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285178 mRNA. Translation: AAK00278.1. Frameshift.
AK131718 mRNA. Translation: BAE20777.1.
AL669953 Genomic DNA. Translation: CAM18218.1.
X58523 mRNA. Translation: CAA41413.1. Frameshift.
X58524 Genomic DNA. Translation: CAA41414.1. Frameshift.
CCDSiCCDS38851.1.
PIRiS16442.
RefSeqiNP_032415.2. NM_008389.3.
UniGeneiMm.1350.

Genome annotation databases

EnsembliENSMUST00000030461; ENSMUSP00000030461; ENSMUSG00000028696.
ENSMUST00000106479; ENSMUSP00000102088; ENSMUSG00000028696.
GeneIDi16351.
KEGGimmu:16351.
UCSCiuc008ugp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285178 mRNA. Translation: AAK00278.1. Frameshift.
AK131718 mRNA. Translation: BAE20777.1.
AL669953 Genomic DNA. Translation: CAM18218.1.
X58523 mRNA. Translation: CAA41413.1. Frameshift.
X58524 Genomic DNA. Translation: CAA41414.1. Frameshift.
CCDSiCCDS38851.1.
PIRiS16442.
RefSeqiNP_032415.2. NM_008389.3.
UniGeneiMm.1350.

3D structure databases

ProteinModelPortaliP28575.
SMRiP28575. Positions 14-583.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200781. 1 interaction.
STRINGi10090.ENSMUSP00000030461.

PTM databases

iPTMnetiP28575.
PhosphoSiteiP28575.

Proteomic databases

PaxDbiP28575.
PRIDEiP28575.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030461; ENSMUSP00000030461; ENSMUSG00000028696.
ENSMUST00000106479; ENSMUSP00000102088; ENSMUSG00000028696.
GeneIDi16351.
KEGGimmu:16351.
UCSCiuc008ugp.1. mouse.

Organism-specific databases

CTDi3652.
MGIiMGI:96581. Ipp.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000119153.
HOGENOMiHOG000230814.
HOVERGENiHBG014286.
InParanoidiP28575.
KOiK13956.
OMAiNLCCEFL.
OrthoDBiEOG7KQ214.
TreeFamiTF329218.

Miscellaneous databases

ChiTaRSiIpp. mouse.
NextBioi289458.
PROiP28575.
SOURCEiSearch...

Gene expression databases

CleanExiMM_IPP.
GenevisibleiP28575. MM.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR030104. IPP.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF35. PTHR24412:SF35. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas."
    VanHouten J.N., Asch H.L., Asch B.B.
    Oncogene 20:5366-5372(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Identification of a novel murine IAP-promoted placenta-expressed gene."
    Chang-Yeh A., Mold D.E., Huang R.C.C.
    Nucleic Acids Res. 19:3667-3672(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 355-556.
  5. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiIPP_MOUSE
AccessioniPrimary (citable) accession number: P28575
Secondary accession number(s): Q3V2M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 3, 2012
Last modified: May 11, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.