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Protein

Sodium-dependent proline transporter

Gene

Slc6a7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals.

GO - Molecular functioni

GO - Biological processi

  • proline transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Neurotransmitter transport, Symport, Transport

Protein family/group databases

TCDBi2.A.22.2.1. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent proline transporter
Alternative name(s):
Solute carrier family 6 member 7
Gene namesi
Name:Slc6a7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620928. Slc6a7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545CytoplasmicSequence analysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei74 – 9320Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 21477ExtracellularSequence analysisAdd
BLAST
Transmembranei215 – 23319Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei242 – 25918Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei295 – 31218Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei324 – 34522Helical; Name=7Sequence analysisAdd
BLAST
Transmembranei378 – 39720Helical; Name=8Sequence analysisAdd
BLAST
Transmembranei425 – 44319Helical; Name=9Sequence analysisAdd
BLAST
Transmembranei459 – 47921Helical; Name=10Sequence analysisAdd
BLAST
Transmembranei500 – 51920Helical; Name=11Sequence analysisAdd
BLAST
Transmembranei538 – 55619Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini557 – 63781CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637Sodium-dependent proline transporterPRO_0000214772Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201PhosphothreonineCombined sources
Modified residuei22 – 221PhosphoserineCombined sources
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence analysis
Modified residuei573 – 5731PhosphoserineCombined sources
Modified residuei582 – 5821PhosphoserineCombined sources
Modified residuei588 – 5881PhosphothreonineCombined sources
Modified residuei591 – 5911PhosphotyrosineCombined sources
Modified residuei598 – 5981PhosphoserineBy similarity
Modified residuei600 – 6001PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP28573.
PRIDEiP28573.

PTM databases

iPTMnetiP28573.
PhosphoSiteiP28573.

Expressioni

Tissue specificityi

Expressed in subpopulations of putative glutamatergic pathways of rat brain.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025209.

Structurei

3D structure databases

ProteinModelPortaliP28573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP28573.
KOiK05038.
PhylomeDBiP28573.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLQEAHLR KPVTPDLLMT PSDQGDVDLD VDFAADRGNW TGKLDFLLSC
60 70 80 90 100
IGYCVGLGNV WRFPYRAYTN GGGAFLVPYF LMLAICGIPL FFLELSLGQF
110 120 130 140 150
SSLGPLAVWK ISPLFKGAGA AMLLIVGLVA IYYNMIIAYV LFYLFASLTS
160 170 180 190 200
NLPWEHCGNW WNTERCLEHR GPKDGNGALP LNLSSTVSPS EEYWSRYVLH
210 220 230 240 250
IQGSQGIGRP GEIRWNLCLC LLLAWVIVFL CILKGVKSSG KVVYFTATFP
260 270 280 290 300
YLILLMLLVR GVTLPGAWKG IQFYLTPQFH HLLSSKVWIE AALQIFYSLG
310 320 330 340 350
VGFGGLLTFA SYNTFHQNIY RDTFIVTLGN AITSILAGFA IFSVLGYMSQ
360 370 380 390 400
ELGVPVDQVA KAGPGLAFVI YPQAMTMLPL SPFWSFLFFF MLLTLGLDSQ
410 420 430 440 450
FAFLETIVTA VTDEFPYYLR PKKAVFSGLI CVAMYLMGLI LTTDGGMYWL
460 470 480 490 500
VLLDDYSASF GLMVVVITTC LAVTRVYGIQ RFCRDIHMML GFKPGLYFRA
510 520 530 540 550
CWLFLSPATL LALLVYSIVK YQPSEYGSYR FPAWAELLGI LMGLLSCLMI
560 570 580 590 600
PAGMLVAVLR EEGSLWERLQ QASRPAIDWG PSLEENRTGM YVATLAGSQS
610 620 630
PKPLMVHMRK YGGITSFENT AIEVDREIAE EEEESMM
Length:637
Mass (Da):71,091
Last modified:August 29, 2001 - v2
Checksum:i9627E6DD5BBC9408
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88111 mRNA. Translation: AAA41541.1. Different termination.
PIRiJH0674.
RefSeqiNP_446448.2. NM_053996.2.
UniGeneiRn.9663.

Genome annotation databases

GeneIDi117100.
KEGGirno:117100.
UCSCiRGD:620928. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88111 mRNA. Translation: AAA41541.1. Different termination.
PIRiJH0674.
RefSeqiNP_446448.2. NM_053996.2.
UniGeneiRn.9663.

3D structure databases

ProteinModelPortaliP28573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025209.

Protein family/group databases

TCDBi2.A.22.2.1. the neurotransmitter:sodium symporter (nss) family.

PTM databases

iPTMnetiP28573.
PhosphoSiteiP28573.

Proteomic databases

PaxDbiP28573.
PRIDEiP28573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117100.
KEGGirno:117100.
UCSCiRGD:620928. rat.

Organism-specific databases

CTDi6534.
RGDi620928. Slc6a7.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP28573.
KOiK05038.
PhylomeDBiP28573.

Miscellaneous databases

PROiP28573.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of a high affinity L-proline transporter expressed in putative glutamatergic pathways of rat brain."
    Fremeau R.T. Jr., Caron M.G., Blakely R.D.
    Neuron 8:915-926(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-573; SER-582; THR-588 AND TYR-591, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20 AND SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSC6A7_RAT
AccessioniPrimary (citable) accession number: P28573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: August 29, 2001
Last modified: July 6, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.