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Protein

Solute carrier family 2, facilitated glucose transporter member 3

Gene

SLC2A3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei316MonosaccharideBy similarity1
Binding sitei377MonosaccharideBy similarity1
Binding sitei385MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-GGA-352832 Glucose transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 3
Alternative name(s):
CEF-GT3
Glucose transporter type 3
Short name:
GLUT-3
Gene namesi
Name:SLC2A3
Synonyms:GLUT3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicBy similarityAdd BLAST11
Transmembranei12 – 33Helical; Name=1Sequence analysisBy similarityAdd BLAST22
Topological domaini34 – 65ExtracellularBy similarityAdd BLAST32
Transmembranei66 – 86Helical; Name=2Sequence analysisBy similarityAdd BLAST21
Topological domaini87 – 91CytoplasmicBy similarity5
Transmembranei92 – 112Helical; Name=3By similarityAdd BLAST21
Topological domaini113 – 119ExtracellularBy similarity7
Transmembranei120 – 143Helical; Name=4Sequence analysisBy similarityAdd BLAST24
Topological domaini144 – 154CytoplasmicBy similarityAdd BLAST11
Transmembranei155 – 175Helical; Name=5Sequence analysisBy similarityAdd BLAST21
Topological domaini176 – 184ExtracellularBy similarity9
Transmembranei185 – 205Helical; Name=6Sequence analysisBy similarityAdd BLAST21
Topological domaini206 – 270CytoplasmicBy similarityAdd BLAST65
Transmembranei271 – 291Helical; Name=7Sequence analysisBy similarityAdd BLAST21
Topological domaini292 – 305ExtracellularBy similarityAdd BLAST14
Transmembranei306 – 326Helical; Name=8Sequence analysisBy similarityAdd BLAST21
Topological domaini327 – 332CytoplasmicBy similarity6
Transmembranei333 – 353Helical; Name=9Sequence analysisBy similarityAdd BLAST21
Topological domaini354 – 362ExtracellularBy similarity9
Transmembranei363 – 388Helical; Name=10Sequence analysisBy similarityAdd BLAST26
Topological domaini389 – 398CytoplasmicBy similarity10
Transmembranei399 – 419Helical; Name=11Sequence analysisBy similarityAdd BLAST21
Topological domaini420 – 428ExtracellularBy similarity9
Transmembranei429 – 449Helical; Name=12Sequence analysisBy similarityAdd BLAST21
Topological domaini450 – 496CytoplasmicBy similarityAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503601 – 496Solute carrier family 2, facilitated glucose transporter member 3Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP28568

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036432

Structurei

3D structure databases

ProteinModelPortaliP28568
SMRiP28568
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni278 – 280Important for selectivity against fructoseBy similarity3
Regioni281 – 287Monosaccharide bindingBy similarity7

Domaini

Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP28568
KOiK08142
PhylomeDBiP28568

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002945 Glc_transpt_3
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01192 GLUCTRSPORT3
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKKKITAS LIYAVSVAAI GSLQFGYNTG VINAPEKIIQ AFYNRTLSQR
60 70 80 90 100
SGETISPELL TSLWSLSVAI FSVGGMIGSF SVSLFFNRFG RRNSMLLVNV
110 120 130 140 150
LAFAGGALMA LSKIAKAVEM LIIGRFIIGL FCGLCTGFVP MYISEVSPTS
160 170 180 190 200
LRGAFGTLNQ LGIVVGILVA QIFGLEGIMG TEALWPLLLG FTIVPAVLQC
210 220 230 240 250
VALLFCPESP RFLLINKMEE EKAQTVLQKL RGTQDVSQDI SEMKEESAKM
260 270 280 290 300
SQEKKATVLE LFRSPNYRQP IIISITLQLS QQLSGINAVF YYSTGIFERA
310 320 330 340 350
GITQPVYATI GAGVVNTVFT VVSLFLVERA GRRTLHLVGL GGMAVCAAVM
360 370 380 390 400
TIALALKEKW IRYISIVATF GFVALFEIGP GPIPWFIVAE LFSQGPRPAA
410 420 430 440 450
MAVAGCSNWT SNFLVGMLFP YAEKLCGPYV FLIFLVFLLI FFIFTYFKVP
460 470 480 490
ETKGRTFEDI SRGFEEQVET SSPSSPPIEK NPMVEMNSIE PDKEVA
Length:496
Mass (Da):54,175
Last modified:December 1, 1992 - v1
Checksum:i75B3C0F61A7A92A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37785 mRNA Translation: AAA48662.1
PIRiA41264
RefSeqiNP_990842.1, NM_205511.1
UniGeneiGga.871

Genome annotation databases

GeneIDi396517
KEGGigga:396517

Similar proteinsi

Entry informationi

Entry nameiGTR3_CHICK
AccessioniPrimary (citable) accession number: P28568
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health