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Protein

Solute carrier family 2, facilitated glucose transporter member 3

Gene

SLC2A3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei316MonosaccharideBy similarity1
Binding sitei377MonosaccharideBy similarity1
Binding sitei385MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-GGA-352832. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 3
Alternative name(s):
CEF-GT3
Glucose transporter type 3
Short name:
GLUT-3
Gene namesi
Name:SLC2A3
Synonyms:GLUT3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicBy similarityAdd BLAST11
Transmembranei12 – 33Helical; Name=1Sequence analysisBy similarityAdd BLAST22
Topological domaini34 – 65ExtracellularBy similarityAdd BLAST32
Transmembranei66 – 86Helical; Name=2Sequence analysisBy similarityAdd BLAST21
Topological domaini87 – 91CytoplasmicBy similarity5
Transmembranei92 – 112Helical; Name=3By similarityAdd BLAST21
Topological domaini113 – 119ExtracellularBy similarity7
Transmembranei120 – 143Helical; Name=4Sequence analysisBy similarityAdd BLAST24
Topological domaini144 – 154CytoplasmicBy similarityAdd BLAST11
Transmembranei155 – 175Helical; Name=5Sequence analysisBy similarityAdd BLAST21
Topological domaini176 – 184ExtracellularBy similarity9
Transmembranei185 – 205Helical; Name=6Sequence analysisBy similarityAdd BLAST21
Topological domaini206 – 270CytoplasmicBy similarityAdd BLAST65
Transmembranei271 – 291Helical; Name=7Sequence analysisBy similarityAdd BLAST21
Topological domaini292 – 305ExtracellularBy similarityAdd BLAST14
Transmembranei306 – 326Helical; Name=8Sequence analysisBy similarityAdd BLAST21
Topological domaini327 – 332CytoplasmicBy similarity6
Transmembranei333 – 353Helical; Name=9Sequence analysisBy similarityAdd BLAST21
Topological domaini354 – 362ExtracellularBy similarity9
Transmembranei363 – 388Helical; Name=10Sequence analysisBy similarityAdd BLAST26
Topological domaini389 – 398CytoplasmicBy similarity10
Transmembranei399 – 419Helical; Name=11Sequence analysisBy similarityAdd BLAST21
Topological domaini420 – 428ExtracellularBy similarity9
Transmembranei429 – 449Helical; Name=12Sequence analysisBy similarityAdd BLAST21
Topological domaini450 – 496CytoplasmicBy similarityAdd BLAST47

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503601 – 496Solute carrier family 2, facilitated glucose transporter member 3Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP28568.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036432.

Structurei

3D structure databases

ProteinModelPortaliP28568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni278 – 280Important for selectivity against fructoseBy similarity3
Regioni281 – 287Monosaccharide bindingBy similarity7

Domaini

Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP28568.
KOiK08142.
PhylomeDBiP28568.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002945. Glc_transpt_3.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01192. GLUCTRSPORT3.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKKKITAS LIYAVSVAAI GSLQFGYNTG VINAPEKIIQ AFYNRTLSQR
60 70 80 90 100
SGETISPELL TSLWSLSVAI FSVGGMIGSF SVSLFFNRFG RRNSMLLVNV
110 120 130 140 150
LAFAGGALMA LSKIAKAVEM LIIGRFIIGL FCGLCTGFVP MYISEVSPTS
160 170 180 190 200
LRGAFGTLNQ LGIVVGILVA QIFGLEGIMG TEALWPLLLG FTIVPAVLQC
210 220 230 240 250
VALLFCPESP RFLLINKMEE EKAQTVLQKL RGTQDVSQDI SEMKEESAKM
260 270 280 290 300
SQEKKATVLE LFRSPNYRQP IIISITLQLS QQLSGINAVF YYSTGIFERA
310 320 330 340 350
GITQPVYATI GAGVVNTVFT VVSLFLVERA GRRTLHLVGL GGMAVCAAVM
360 370 380 390 400
TIALALKEKW IRYISIVATF GFVALFEIGP GPIPWFIVAE LFSQGPRPAA
410 420 430 440 450
MAVAGCSNWT SNFLVGMLFP YAEKLCGPYV FLIFLVFLLI FFIFTYFKVP
460 470 480 490
ETKGRTFEDI SRGFEEQVET SSPSSPPIEK NPMVEMNSIE PDKEVA
Length:496
Mass (Da):54,175
Last modified:December 1, 1992 - v1
Checksum:i75B3C0F61A7A92A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37785 mRNA. Translation: AAA48662.1.
PIRiA41264.
RefSeqiNP_990842.1. NM_205511.1.
UniGeneiGga.871.

Genome annotation databases

GeneIDi396517.
KEGGigga:396517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37785 mRNA. Translation: AAA48662.1.
PIRiA41264.
RefSeqiNP_990842.1. NM_205511.1.
UniGeneiGga.871.

3D structure databases

ProteinModelPortaliP28568.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036432.

Proteomic databases

PaxDbiP28568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396517.
KEGGigga:396517.

Organism-specific databases

CTDi6515.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP28568.
KOiK08142.
PhylomeDBiP28568.

Enzyme and pathway databases

ReactomeiR-GGA-352832. Glucose transport.

Miscellaneous databases

PROiP28568.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002945. Glc_transpt_3.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01192. GLUCTRSPORT3.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR3_CHICK
AccessioniPrimary (citable) accession number: P28568
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.