P28566 (5HT1E_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-hydroxytryptamine receptor 1E
Short name=5-HT-1E
Short name=5-HT1E

Alternative name(s):
S31
Serotonin receptor 1E

Gene names

Name:

HTR1E

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement Ref.2. Source: ProtInc synaptic transmission Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	serotonin binding Inferred from direct assay Ref.1. Source: MGI serotonin receptor activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	5-hydroxytryptamine receptor 1E		PRO_0000068933
Regions
	Topological domain	1 – 22	22	Extracellular By similarity
	Transmembrane	23 – 47	25	Helical; Name=1; By similarity
	Topological domain	48 – 59	12	Cytoplasmic By similarity
	Transmembrane	60 – 81	22	Helical; Name=2; By similarity
	Topological domain	82 – 96	15	Extracellular By similarity
	Transmembrane	97 – 118	22	Helical; Name=3; By similarity
	Topological domain	119 – 138	20	Cytoplasmic By similarity
	Transmembrane	139 – 159	21	Helical; Name=4; By similarity
	Topological domain	160 – 179	20	Extracellular By similarity
	Transmembrane	180 – 201	22	Helical; Name=5; By similarity
	Topological domain	202 – 291	90	Cytoplasmic By similarity
	Transmembrane	292 – 314	23	Helical; Name=6; By similarity
	Topological domain	315 – 324	10	Extracellular By similarity
	Transmembrane	325 – 347	23	Helical; Name=7; By similarity
	Topological domain	348 – 365	18	Cytoplasmic By similarity
Amino acid modifications
	Glycosylation	2	1	N-linked (GlcNAc...) Potential
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 173		By similarity
Natural variations
	Natural variant	208	1	A → T. Corresponds to variant rs3828741 [ dbSNP | Ensembl ].		VAR_022061
	Natural variant	262	1	S → F. Ref.9 Corresponds to variant rs6303 [ dbSNP | Ensembl ].		VAR_014165

Sequences

	Sequence		Length	Mass (Da)
	P28566 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 4C31DD783A3F7483	FASTA	365	41,682
	10 20 30 40 50 60 MNITNCTTEA SMAIRPKTIT EKMLICMTLV VITTLTTLLN LAVIMAIGTT KKLHQPANYL 70 80 90 100 110 120 ICSLAVTDLL VAVLVMPLSI IYIVMDRWKL GYFLCEVWLS VDMTCCTCSI LHLCVIALDR 130 140 150 160 170 180 YWAITNAIEY ARKRTAKRAA LMILTVWTIS IFISMPPLFW RSHRRLSPPP SQCTIQHDHV 190 200 210 220 230 240 IYTIYSTLGA FYIPLTLILI LYYRIYHAAK SLYQKRGSSR HLSNRSTDSQ NSFASCKLTQ 250 260 270 280 290 300 TFCVSDFSTS DPTTEFEKFH ASIRIPPFDN DLDHPGERQQ ISSTRERKAA RILGLILGAF 310 320 330 340 350 360 ILSWLPFFIK ELIVGLSIYT VSSEVADFLT WLGYVNSLIN PLLYTSFNED FKLAFKKLIR CREHT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype." McAllister G., Charlesworth A., Snodin C., Beer M.S., Noble A.J., Middlemiss D.N., Iversen L.L., Whiting P. Proc. Natl. Acad. Sci. U.S.A. 89:5517-5521(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase." Levy F.O., Gudermann T., Birnbaumer M., Kaumann A.J., Birnbaumer L. FEBS Lett. 296:201-206(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor." Zgombick J.M., Schechter L.E., Macchi M., Hartig P.R., Branchek T.A., Weinshank R.L. Mol. Pharmacol. 42:180-185(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	"Human-specific amino acid changes found in 103 protein-coding genes." Kitano T., Liu Y.-H., Ueda S., Saitou N. Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-363.
[9]	"Characterization of single-nucleotide polymorphisms in coding regions of human genes." Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S. Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT PHE-262.
[10]	Erratum Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S. Nat. Genet. 23:373-373(1999)
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M91467 mRNA. Translation: AAA58353.1. Z11166 Genomic DNA. Translation: CAA77558.1. M92826 Genomic DNA. Translation: AAA58355.1. AF498980 mRNA. Translation: AAM21127.1. AL157777 Genomic DNA. Translation: CAC10582.1. CH471051 Genomic DNA. Translation: EAW48616.1. CH471051 Genomic DNA. Translation: EAW48617.1. BC069751 mRNA. Translation: AAH69751.1. AB041373 Genomic DNA. Translation: BAA94458.1.
IPI	IPI00003932.
PIR	A45260. S20579.
RefSeq	NP_000856.1. NM_000865.2.
UniGene	Hs.1611.
3D structure databases
ProteinModelPortal	P28566.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000307766.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	112822.
Proteomic databases
PaxDb	P28566.
PRIDE	P28566.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000305344; ENSP00000307766; ENSG00000168830. ENST00000369584; ENSP00000358597; ENSG00000168830.
GeneID	3354.
KEGG	hsa:3354.
UCSC	uc003pli.3. human.
Organism-specific databases
CTD	3354.
GeneCards	GC06P087647.
HGNC	HGNC:5291. HTR1E.
HPA	HPA004931.
MIM	182132. gene.
neXtProt	NX_P28566.
PharmGKB	PA29552.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG249628.
HOGENOM	HOG000239242.
HOVERGEN	HBG106962.
InParanoid	P28566.
KO	K04153.
OMA	KLGYFIC.
OrthoDB	EOG43XV41.
PhylomeDB	P28566.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P28566.
CleanEx	HS_HTR1E.
Genevestigator	P28566.
GermOnline	ENSG00000168830. Homo sapiens.
Family and domain databases
InterPro	IPR002231. 5HT_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01101. 5HTRECEPTOR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P28566.
ChEMBL	CHEMBL2182.
DrugBank	DB00216. Eletriptan.
GenomeRNAi	3354.
NextBio	13262.
SOURCE	Search...

Entry information

Entry name

5HT1E_HUMAN

Accession

Primary (citable) accession number: P28566
Secondary accession number(s): E1P503, Q9P1Y1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	May 1, 2013
This is version 127 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.