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P28566

- 5HT1E_HUMAN

UniProt

P28566 - 5HT1E_HUMAN

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Protein
5-hydroxytryptamine receptor 1E
Gene
HTR1E
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.5 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. serotonin binding Source: MGI
  3. serotonin receptor activity Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  3. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
  4. negative regulation of cAMP metabolic process Source: InterPro
  5. serotonin receptor signaling pathway Source: GOC
  6. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_17064. Serotonin receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1E
Short name:
5-HT-1E
Short name:
5-HT1E
Alternative name(s):
S31
Serotonin receptor 1E
Gene namesi
Name:HTR1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:5291. HTR1E.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 5 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222Extracellular By similarity
Add
BLAST
Transmembranei23 – 4725Helical; Name=1; By similarity
Add
BLAST
Topological domaini48 – 5912Cytoplasmic By similarity
Add
BLAST
Transmembranei60 – 8223Helical; Name=2; By similarity
Add
BLAST
Topological domaini83 – 9614Extracellular By similarity
Add
BLAST
Transmembranei97 – 11822Helical; Name=3; By similarity
Add
BLAST
Topological domaini119 – 13820Cytoplasmic By similarity
Add
BLAST
Transmembranei139 – 15921Helical; Name=4; By similarity
Add
BLAST
Topological domaini160 – 17920Extracellular By similarity
Add
BLAST
Transmembranei180 – 20223Helical; Name=5; By similarity
Add
BLAST
Topological domaini203 – 29189Cytoplasmic By similarity
Add
BLAST
Transmembranei292 – 31423Helical; Name=6; By similarity
Add
BLAST
Topological domaini315 – 32410Extracellular By similarity
Transmembranei325 – 34723Helical; Name=7; By similarity
Add
BLAST
Topological domaini348 – 36518Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29552.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3653655-hydroxytryptamine receptor 1E
PRO_0000068933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 173 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP28566.
PRIDEiP28566.

Expressioni

Tissue specificityi

Detected in brain.1 Publication

Gene expression databases

BgeeiP28566.
CleanExiHS_HTR1E.
GenevestigatoriP28566.

Organism-specific databases

HPAiHPA004931.

Interactioni

Protein-protein interaction databases

BioGridi109586. 2 interactions.
STRINGi9606.ENSP00000307766.

Structurei

3D structure databases

ProteinModelPortaliP28566.
SMRiP28566. Positions 22-360.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 10710Agonist binding By similarity
Regioni304 – 3085Agonist binding By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi119 – 1213DRY motif; important for ligand-induced conformation changes By similarity
Motifi340 – 3445NPxxY motif; important for ligand-induced conformation changes and signaling By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP28566.
KOiK04153.
OMAiPLSITYI.
OrthoDBiEOG7NCV3Q.
PhylomeDBiP28566.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR027425. 5HT1E_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF33. PTHR24247:SF33. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28566-1 [UniParc]FASTAAdd to Basket

« Hide

MNITNCTTEA SMAIRPKTIT EKMLICMTLV VITTLTTLLN LAVIMAIGTT    50
KKLHQPANYL ICSLAVTDLL VAVLVMPLSI IYIVMDRWKL GYFLCEVWLS 100
VDMTCCTCSI LHLCVIALDR YWAITNAIEY ARKRTAKRAA LMILTVWTIS 150
IFISMPPLFW RSHRRLSPPP SQCTIQHDHV IYTIYSTLGA FYIPLTLILI 200
LYYRIYHAAK SLYQKRGSSR HLSNRSTDSQ NSFASCKLTQ TFCVSDFSTS 250
DPTTEFEKFH ASIRIPPFDN DLDHPGERQQ ISSTRERKAA RILGLILGAF 300
ILSWLPFFIK ELIVGLSIYT VSSEVADFLT WLGYVNSLIN PLLYTSFNED 350
FKLAFKKLIR CREHT 365
Length:365
Mass (Da):41,682
Last modified:December 1, 1992 - v1
Checksum:i4C31DD783A3F7483
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti208 – 2081A → T.
Corresponds to variant rs3828741 [ dbSNP | Ensembl ].
VAR_022061
Natural varianti262 – 2621S → F.1 Publication
Corresponds to variant rs6303 [ dbSNP | Ensembl ].
VAR_014165

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91467 mRNA. Translation: AAA58353.1.
Z11166 Genomic DNA. Translation: CAA77558.1.
M92826 Genomic DNA. Translation: AAA58355.1.
AF498980 mRNA. Translation: AAM21127.1.
AL157777 Genomic DNA. Translation: CAC10582.1.
CH471051 Genomic DNA. Translation: EAW48616.1.
CH471051 Genomic DNA. Translation: EAW48617.1.
BC069751 mRNA. Translation: AAH69751.1.
AB041373 Genomic DNA. Translation: BAA94458.1.
CCDSiCCDS5006.1.
PIRiS20579. A45260.
RefSeqiNP_000856.1. NM_000865.2.
UniGeneiHs.1611.

Genome annotation databases

EnsembliENST00000305344; ENSP00000307766; ENSG00000168830.
GeneIDi3354.
KEGGihsa:3354.
UCSCiuc003pli.3. human.

Polymorphism databases

DMDMi112822.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91467 mRNA. Translation: AAA58353.1 .
Z11166 Genomic DNA. Translation: CAA77558.1 .
M92826 Genomic DNA. Translation: AAA58355.1 .
AF498980 mRNA. Translation: AAM21127.1 .
AL157777 Genomic DNA. Translation: CAC10582.1 .
CH471051 Genomic DNA. Translation: EAW48616.1 .
CH471051 Genomic DNA. Translation: EAW48617.1 .
BC069751 mRNA. Translation: AAH69751.1 .
AB041373 Genomic DNA. Translation: BAA94458.1 .
CCDSi CCDS5006.1.
PIRi S20579. A45260.
RefSeqi NP_000856.1. NM_000865.2.
UniGenei Hs.1611.

3D structure databases

ProteinModelPortali P28566.
SMRi P28566. Positions 22-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109586. 2 interactions.
STRINGi 9606.ENSP00000307766.

Chemistry

BindingDBi P28566.
ChEMBLi CHEMBL2096904.
DrugBanki DB00216. Eletriptan.
GuidetoPHARMACOLOGYi 4.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 112822.

Proteomic databases

PaxDbi P28566.
PRIDEi P28566.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305344 ; ENSP00000307766 ; ENSG00000168830 .
GeneIDi 3354.
KEGGi hsa:3354.
UCSCi uc003pli.3. human.

Organism-specific databases

CTDi 3354.
GeneCardsi GC06P087647.
HGNCi HGNC:5291. HTR1E.
HPAi HPA004931.
MIMi 182132. gene.
neXtProti NX_P28566.
PharmGKBi PA29552.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249628.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P28566.
KOi K04153.
OMAi PLSITYI.
OrthoDBi EOG7NCV3Q.
PhylomeDBi P28566.
TreeFami TF316350.

Enzyme and pathway databases

Reactomei REACT_17064. Serotonin receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii 5-HT1E_receptor.
GenomeRNAii 3354.
NextBioi 13262.
PROi P28566.
SOURCEi Search...

Gene expression databases

Bgeei P28566.
CleanExi HS_HTR1E.
Genevestigatori P28566.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR027425. 5HT1E_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24247:SF33. PTHR24247:SF33. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype."
    McAllister G., Charlesworth A., Snodin C., Beer M.S., Noble A.J., Middlemiss D.N., Iversen L.L., Whiting P.
    Proc. Natl. Acad. Sci. U.S.A. 89:5517-5521(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Brain.
  2. "Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase."
    Levy F.O., Gudermann T., Birnbaumer M., Kaumann A.J., Birnbaumer L.
    FEBS Lett. 296:201-206(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  3. "Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor."
    Zgombick J.M., Schechter L.E., Macchi M., Hartig P.R., Branchek T.A., Weinshank R.L.
    Mol. Pharmacol. 42:180-185(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Human-specific amino acid changes found in 103 protein-coding genes."
    Kitano T., Liu Y.-H., Ueda S., Saitou N.
    Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-363.
  9. "Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor."
    Bai F., Yin T., Johnstone E.M., Su C., Varga G., Little S.P., Nelson D.L.
    Eur. J. Pharmacol. 484:127-139(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  10. Cited for: REVIEW.
  11. "Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships."
    Klein M.T., Dukat M., Glennon R.A., Teitler M.
    J. Pharmacol. Exp. Ther. 337:860-867(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  12. "Serotonin receptors - from molecular biology to clinical applications."
    Pytliak M., Vargova V., Mechirova V., Felsoci M.
    Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  13. Cited for: VARIANT PHE-262.

Entry informationi

Entry namei5HT1E_HUMAN
AccessioniPrimary (citable) accession number: P28566
Secondary accession number(s): E1P503, Q9P1Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 3, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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