Reviewed,
UniProtKB/Swiss-Prot P28566 (5HT1E_HUMAN)
Last modified
July 7, 2009.
Version 92.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 5-hydroxytryptamine receptor 1E Short name=5-HT-1E Short name=5-HT1E Alternative name(s): Serotonin receptor 1E S31 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 365 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
| Subcellular location | |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | G-protein signaling, coupled to cyclic nucleotide second messenger Ref.2 Traceable author statement. Source: ProtInc synaptic transmission Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | integral to plasma membrane Ref.2 Traceable author statement. Source: ProtInc |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct serotonin binding Ref.1Inferred from direct assay. Source: MGI serotonin receptor activity Ref.1Inferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| PSMC3 | P17980 | 1 | EBI-1043151,EBI-359720 | |
| PSMC4 | P43686 | 1 | EBI-1043151,EBI-743997 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 365 | 365 | 5-hydroxytryptamine receptor 1E | PRO_0000068933 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 22 | 22 | Extracellular By similarity | ||||||||
| Transmembrane | 23 – 47 | 25 | 1 By similarity | ||||||||
| Topological domain | 48 – 59 | 12 | Cytoplasmic By similarity | ||||||||
| Transmembrane | 60 – 81 | 22 | 2 By similarity | ||||||||
| Topological domain | 82 – 96 | 15 | Extracellular By similarity | ||||||||
| Transmembrane | 97 – 118 | 22 | 3 By similarity | ||||||||
| Topological domain | 119 – 138 | 20 | Cytoplasmic By similarity | ||||||||
| Transmembrane | 139 – 159 | 21 | 4 By similarity | ||||||||
| Topological domain | 160 – 179 | 20 | Extracellular By similarity | ||||||||
| Transmembrane | 180 – 201 | 22 | 5 By similarity | ||||||||
| Topological domain | 202 – 291 | 90 | Cytoplasmic By similarity | ||||||||
| Transmembrane | 292 – 314 | 23 | 6 By similarity | ||||||||
| Topological domain | 315 – 324 | 10 | Extracellular By similarity | ||||||||
| Transmembrane | 325 – 347 | 23 | 7 By similarity | ||||||||
| Topological domain | 348 – 365 | 18 | Cytoplasmic By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 2 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 5 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 95 ↔ 173 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 208 | 1 | A → T: dbSNP rs3828741. | VAR_022061 | |||||||
| Natural variant | 262 | 1 | S → F: dbSNP rs6303. Ref.8 | VAR_014165 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype." McAllister G., Charlesworth A., Snodin C., Beer M.S., Noble A.J., Middlemiss D.N., Iversen L.L., Whiting P. Proc. Natl. Acad. Sci. U.S.A. 89:5517-5521(1992) [PubMed: 1608964] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase." Levy F.O., Gudermann T., Birnbaumer M., Kaumann A.J., Birnbaumer L. FEBS Lett. 296:201-206(1992) [PubMed: 1733778] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor." Zgombick J.M., Schechter L.E., Macchi M., Hartig P.R., Branchek T.A., Weinshank R.L. Mol. Pharmacol. 42:180-185(1992) [PubMed: 1513320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [5] | "The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S.Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [7] | "Human-specific amino acid changes found in 103 protein-coding genes." Kitano T., Liu Y.-H., Ueda S., Saitou N. Mol. Biol. Evol. 21:936-944(2004) [PubMed: 15014171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-363. |
| [8] | "Characterization of single-nucleotide polymorphisms in coding regions of human genes." Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S. Nat. Genet. 22:231-238(1999) [PubMed: 10391209] [Abstract] Cited for: VARIANT PHE-262. |
| [9] | Erratum Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S. Nat. Genet. 23:373-373(1999) |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M91467 mRNA. Translation: AAA58353.1. Z11166 Genomic DNA. Translation: CAA77558.1. M92826 Genomic DNA. Translation: AAA58355.1. AF498980 mRNA. Translation: AAM21127.1. AL157777 Genomic DNA. Translation: CAC10582.1. BC069751 mRNA. Translation: AAH69751.1. AB041373 Genomic DNA. Translation: BAA94458.1. | |
| IPI | IPI00003932. |
| PIR | A45260. S20579. |
| RefSeq | NP_000856.1. |
| UniGene | Hs.1611 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HLL based on UniProtKB P08913. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P28566. 2 interactions. |
Protein family/group databases | |
| GPCRDB | Search... |
Proteomic databases | |
| PRIDE | P28566. |
Genome annotation databases | |
| Ensembl | ENSG00000168830. Homo sapiens. [Contig view] |
| GeneID | 3354. |
| KEGG | hsa:3354. |
| UCSC | uc003plg.1. human. |
Organism-specific databases | |
| GeneCards | GC06P087704. |
| H-InvDB | HIX0032800. |
| HGNC | HGNC:5291. HTR1E. |
| HPA | HPA004931. |
| MIM | 182132. gene. |
| PharmGKB | PA29552. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P28566. |
| HOVERGEN | P28566. |
| OMA | P28566. FNEDFKL. |
Enzyme and pathway databases | |
| Reactome | REACT_14797. Signaling by GPCR. |
Gene expression databases | |
| ArrayExpress | P28566. |
| Bgee | P28566. |
| CleanEx | HS_HTR1E. |
| GermOnline | ENSG00000168830. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000450. 5HT1F_rcpt. IPR002231. 5HT_rcpt. IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view] |
| PANTHER | PTHR19266:SF65. 5HT1F_rcpt. 1 hit. |
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] |
| PRINTS | PR01101. 5HTRECEPTOR. PR00237. GPCRRHODOPSN. |
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB00216. Eletriptan. |
| NextBio | 13262. |
| SOURCE | Search... |
Entry information
| Entry name | 5HT1E_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P28566 Secondary accession number(s): Q9P1Y1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


