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P28565 (5HT1D_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 1D

Short name=5-HT-1D
Short name=5-HT1D
Alternative name(s):
Serotonin receptor 1D
Gene names
Name:Htr1d
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. Ref.1 Ref.2

Subunit structure

Homodimer. Heterodimer with HTR1B By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1 Ref.2.

Tissue specificity

Detected in dorsal raphe. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3743745-hydroxytryptamine receptor 1D
PRO_0000068931

Regions

Topological domain1 – 3535Extracellular By similarity
Transmembrane36 – 6126Helical; Name=1; By similarity
Topological domain62 – 7211Cytoplasmic By similarity
Transmembrane73 – 9523Helical; Name=2; By similarity
Topological domain96 – 10914Extracellular By similarity
Transmembrane110 – 13122Helical; Name=3; By similarity
Topological domain132 – 15120Cytoplasmic By similarity
Transmembrane152 – 17322Helical; Name=4; By similarity
Topological domain174 – 19118Extracellular By similarity
Transmembrane192 – 21423Helical; Name=5; By similarity
Topological domain215 – 29985Cytoplasmic By similarity
Transmembrane300 – 32324Helical; Name=6; By similarity
Topological domain324 – 3329Extracellular By similarity
Transmembrane333 – 35725Helical; Name=7; By similarity
Topological domain358 – 37417Cytoplasmic By similarity
Region111 – 12010Agonist binding By similarity
Region311 – 3155Agonist binding By similarity
Motif132 – 1343DRY motif; important for ligand-induced conformation changes By similarity
Motif349 – 3535NPxxY motif; important for ligand-induced conformation changes and signaling By similarity

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation171N-linked (GlcNAc...) Potential
Glycosylation211N-linked (GlcNAc...) Potential
Disulfide bond108 ↔ 185 By similarity

Sequences

Sequence LengthMass (Da)Tools
P28565 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 345CBD528317DA21

FASTA37441,540
        10         20         30         40         50         60 
MSLPNQSLEG LPQEASNRSL NATGAWDPEV LQALRISLVV VLSIITLATV LSNAFVLTTI 

        70         80         90        100        110        120 
LLTKKLHTPA NYLIGSLATT DLLVSILVMP ISIAYTTTRT WNFGQILCDI WVSSDITCCT 

       130        140        150        160        170        180 
ASILHLCVIA LDRYWAITDA LEYSKRRTAG HAAAMIAAVW AISICISIPP LFWRQATAHE 

       190        200        210        220        230        240 
EMSDCLVNTS QISYTIYSTC GAFYIPSILL IILYGRIYVA ARSRILNPPS LYGKRFTTAQ 

       250        260        270        280        290        300 
LITGSAGSSL CSLNPSLHES HTHTVGSPLF FNQVKIKLAD SILERKRISA ARERKATKTL 

       310        320        330        340        350        360 
GIILGAFIIC WLPFFVVSLV LPICRDSCWI HPALFDFFTW LGYLNSLINP VIYTVFNEDF 

       370 
RQAFQRVVHF RKAS 

« Hide

References

[1]"Distinct 5-HT1B and 5-HT1D serotonin receptors in rat: structural and pharmacological comparison of the two cloned receptors."
Hamblin M.W., McGuffin R.W., Metcalf M.A., Dorsa D.M., Merchant K.M.
Mol. Cell. Neurosci. 3:578-587(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"Sequence and functional analysis of cloned guinea pig and rat serotonin 5-HT1D receptors: common pharmacological features within the 5-HT1D receptor subfamily."
Wurch T., Palmier C., Colpaert F.C., Pauwels P.J.
J. Neurochem. 68:410-418(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M89953 Genomic DNA. Translation: AAA40614.1.
PIRI77467.
RefSeqNP_036984.1. NM_012852.1.
UniGeneRn.34834.

3D structure databases

ProteinModelPortalP28565.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000016047.

Chemistry

BindingDBP28565.
ChEMBLCHEMBL2094123.
GuidetoPHARMACOLOGY3.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP28565.

Proteomic databases

PaxDbP28565.
PRIDEP28565.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000016046; ENSRNOP00000016047; ENSRNOG00000012038.
GeneID25323.
KEGGrno:25323.
UCSCRGD:2847. rat.

Organism-specific databases

CTD3352.
RGD2847. Htr1d.

Phylogenomic databases

eggNOGNOG249628.
GeneTreeENSGT00750000117301.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidP28565.
KOK04153.
OMACRDSCWI.
OrthoDBEOG7NCV3Q.
PhylomeDBP28565.
TreeFamTF316350.

Gene expression databases

GenevestigatorP28565.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000505. 5HT1D_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24247:SF17. PTHR24247:SF17. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00514. 5HT1DRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio606173.
PROP28565.

Entry information

Entry name5HT1D_RAT
AccessionPrimary (citable) accession number: P28565
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries