P28565 (5HT1D_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-hydroxytryptamine receptor 1D
Short name=5-HT-1D
Short name=5-HT1D

Alternative name(s):
Serotonin receptor 1D

Gene names

Name:

Htr1d

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	5-hydroxytryptamine receptor 1D		PRO_0000068931
Regions
	Topological domain	1 – 35	35	Extracellular By similarity
	Transmembrane	36 – 59	24	Helical; Name=1; By similarity
	Topological domain	60 – 72	13	Cytoplasmic By similarity
	Transmembrane	73 – 95	23	Helical; Name=2; By similarity
	Topological domain	96 – 105	10	Extracellular By similarity
	Transmembrane	106 – 131	26	Helical; Name=3; By similarity
	Topological domain	132 – 151	20	Cytoplasmic By similarity
	Transmembrane	152 – 173	22	Helical; Name=4; By similarity
	Topological domain	174 – 191	18	Extracellular By similarity
	Transmembrane	192 – 215	24	Helical; Name=5; By similarity
	Topological domain	216 – 299	84	Cytoplasmic By similarity
	Transmembrane	300 – 323	24	Helical; Name=6; By similarity
	Topological domain	324 – 332	9	Extracellular By similarity
	Transmembrane	333 – 357	25	Helical; Name=7; By similarity
	Topological domain	358 – 374	17	Cytoplasmic By similarity
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Disulfide bond	108 ↔ 185		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P28565 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 345CBD528317DA21	FASTA	374	41,540
	10 20 30 40 50 60 MSLPNQSLEG LPQEASNRSL NATGAWDPEV LQALRISLVV VLSIITLATV LSNAFVLTTI 70 80 90 100 110 120 LLTKKLHTPA NYLIGSLATT DLLVSILVMP ISIAYTTTRT WNFGQILCDI WVSSDITCCT 130 140 150 160 170 180 ASILHLCVIA LDRYWAITDA LEYSKRRTAG HAAAMIAAVW AISICISIPP LFWRQATAHE 190 200 210 220 230 240 EMSDCLVNTS QISYTIYSTC GAFYIPSILL IILYGRIYVA ARSRILNPPS LYGKRFTTAQ 250 260 270 280 290 300 LITGSAGSSL CSLNPSLHES HTHTVGSPLF FNQVKIKLAD SILERKRISA ARERKATKTL 310 320 330 340 350 360 GIILGAFIIC WLPFFVVSLV LPICRDSCWI HPALFDFFTW LGYLNSLINP VIYTVFNEDF 370 RQAFQRVVHF RKAS

References

[1]	"Distinct 5-HT1B and 5-HT1D serotonin receptors in rat: structural and pharmacological comparison of the two cloned receptors." Hamblin M.W., McGuffin R.W., Metcalf M.A., Dorsa D.M., Merchant K.M. Mol. Cell. Neurosci. 3:578-587(1992) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M89953 Genomic DNA. Translation: AAA40614.1.
IPI	IPI00201815.
PIR	I77467.
RefSeq	NP_036984.1. NM_012852.1.
UniGene	Rn.34834.
3D structure databases
ProteinModelPortal	P28565.
ModBase	Search...
Protein-protein interaction databases
STRING	P28565.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P28565.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000016046; ENSRNOP00000016047; ENSRNOG00000012038.
GeneID	25323.
KEGG	rno:25323.
UCSC	NM_012852. rat.
Organism-specific databases
CTD	3352.
RGD	2847. Htr1d.
Phylogenomic databases
eggNOG	maNOG08798.
GeneTree	ENSGT00590000082831.
HOVERGEN	HBG106962.
InParanoid	P28565.
OMA	LHEGHSH.
OrthoDB	EOG4R7VB6.
PhylomeDB	P28565.
Gene expression databases
ArrayExpress	P28565.
Genevestigator	P28565.
GermOnline	ENSRNOG00000012038. Rattus norvegicus.
Family and domain databases
InterPro	IPR000505. 5HT1D_rcpt. IPR002231. 5HT_rcpt. IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
KO	K04153.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00514. 5HT1DRECEPTR. PR01101. 5HTRECEPTOR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	606173.

Entry information

Entry name

5HT1D_RAT

Accession

Primary (citable) accession number: P28565

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	November 16, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program