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P28565

- 5HT1D_RAT

UniProt

P28565 - 5HT1D_RAT

Protein

5-hydroxytryptamine receptor 1D

Gene

Htr1d

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.2 Publications

    GO - Molecular functioni

    1. serotonin binding Source: Ensembl
    2. serotonin receptor activity Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
    2. intestine smooth muscle contraction Source: Ensembl
    3. regulation of behavior Source: InterPro
    4. regulation of locomotion Source: InterPro
    5. response to toxic substance Source: Ensembl
    6. synaptic transmission Source: InterPro
    7. vasoconstriction Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 1D
    Short name:
    5-HT-1D
    Short name:
    5-HT1D
    Alternative name(s):
    Serotonin receptor 1D
    Gene namesi
    Name:Htr1d
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi2847. Htr1d.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3743745-hydroxytryptamine receptor 1DPRO_0000068931Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi108 ↔ 185PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP28565.
    PRIDEiP28565.

    PTM databases

    PhosphoSiteiP28565.

    Expressioni

    Tissue specificityi

    Detected in dorsal raphe.1 Publication

    Gene expression databases

    GenevestigatoriP28565.

    Interactioni

    Subunit structurei

    Homodimer. Heterodimer with HTR1B By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016047.

    Structurei

    3D structure databases

    ProteinModelPortaliP28565.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularBy similarityAdd
    BLAST
    Topological domaini62 – 7211CytoplasmicBy similarityAdd
    BLAST
    Topological domaini96 – 10914ExtracellularBy similarityAdd
    BLAST
    Topological domaini132 – 15120CytoplasmicBy similarityAdd
    BLAST
    Topological domaini174 – 19118ExtracellularBy similarityAdd
    BLAST
    Topological domaini215 – 29985CytoplasmicBy similarityAdd
    BLAST
    Topological domaini324 – 3329ExtracellularBy similarity
    Topological domaini358 – 37417CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 6126Helical; Name=1By similarityAdd
    BLAST
    Transmembranei73 – 9523Helical; Name=2By similarityAdd
    BLAST
    Transmembranei110 – 13122Helical; Name=3By similarityAdd
    BLAST
    Transmembranei152 – 17322Helical; Name=4By similarityAdd
    BLAST
    Transmembranei192 – 21423Helical; Name=5By similarityAdd
    BLAST
    Transmembranei300 – 32324Helical; Name=6By similarityAdd
    BLAST
    Transmembranei333 – 35725Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni111 – 12010Agonist bindingBy similarity
    Regioni311 – 3155Agonist bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi132 – 1343DRY motif; important for ligand-induced conformation changesBy similarity
    Motifi349 – 3535NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    GeneTreeiENSGT00750000117301.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP28565.
    KOiK04153.
    OMAiCRDSCWI.
    OrthoDBiEOG7NCV3Q.
    PhylomeDBiP28565.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000505. 5HT1D_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF17. PTHR24247:SF17. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00514. 5HT1DRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28565-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPNQSLEG LPQEASNRSL NATGAWDPEV LQALRISLVV VLSIITLATV    50
    LSNAFVLTTI LLTKKLHTPA NYLIGSLATT DLLVSILVMP ISIAYTTTRT 100
    WNFGQILCDI WVSSDITCCT ASILHLCVIA LDRYWAITDA LEYSKRRTAG 150
    HAAAMIAAVW AISICISIPP LFWRQATAHE EMSDCLVNTS QISYTIYSTC 200
    GAFYIPSILL IILYGRIYVA ARSRILNPPS LYGKRFTTAQ LITGSAGSSL 250
    CSLNPSLHES HTHTVGSPLF FNQVKIKLAD SILERKRISA ARERKATKTL 300
    GIILGAFIIC WLPFFVVSLV LPICRDSCWI HPALFDFFTW LGYLNSLINP 350
    VIYTVFNEDF RQAFQRVVHF RKAS 374
    Length:374
    Mass (Da):41,540
    Last modified:December 1, 1992 - v1
    Checksum:i345CBD528317DA21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89953 Genomic DNA. Translation: AAA40614.1.
    PIRiI77467.
    RefSeqiNP_036984.1. NM_012852.1.
    UniGeneiRn.34834.

    Genome annotation databases

    EnsembliENSRNOT00000016046; ENSRNOP00000016047; ENSRNOG00000012038.
    GeneIDi25323.
    KEGGirno:25323.
    UCSCiRGD:2847. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89953 Genomic DNA. Translation: AAA40614.1 .
    PIRi I77467.
    RefSeqi NP_036984.1. NM_012852.1.
    UniGenei Rn.34834.

    3D structure databases

    ProteinModelPortali P28565.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016047.

    Chemistry

    BindingDBi P28565.
    ChEMBLi CHEMBL5450.
    GuidetoPHARMACOLOGYi 3.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P28565.

    Proteomic databases

    PaxDbi P28565.
    PRIDEi P28565.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000016046 ; ENSRNOP00000016047 ; ENSRNOG00000012038 .
    GeneIDi 25323.
    KEGGi rno:25323.
    UCSCi RGD:2847. rat.

    Organism-specific databases

    CTDi 3352.
    RGDi 2847. Htr1d.

    Phylogenomic databases

    eggNOGi NOG249628.
    GeneTreei ENSGT00750000117301.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P28565.
    KOi K04153.
    OMAi CRDSCWI.
    OrthoDBi EOG7NCV3Q.
    PhylomeDBi P28565.
    TreeFami TF316350.

    Miscellaneous databases

    NextBioi 606173.
    PROi P28565.

    Gene expression databases

    Genevestigatori P28565.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000505. 5HT1D_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF17. PTHR24247:SF17. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00514. 5HT1DRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distinct 5-HT1B and 5-HT1D serotonin receptors in rat: structural and pharmacological comparison of the two cloned receptors."
      Hamblin M.W., McGuffin R.W., Metcalf M.A., Dorsa D.M., Merchant K.M.
      Mol. Cell. Neurosci. 3:578-587(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Sequence and functional analysis of cloned guinea pig and rat serotonin 5-HT1D receptors: common pharmacological features within the 5-HT1D receptor subfamily."
      Wurch T., Palmier C., Colpaert F.C., Pauwels P.J.
      J. Neurochem. 68:410-418(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry namei5HT1D_RAT
    AccessioniPrimary (citable) accession number: P28565
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3