Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5-hydroxytryptamine receptor 1D

Gene

Htr1d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-390666 Serotonin receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1D
Short name:
5-HT-1D
Short name:
5-HT1D
Alternative name(s):
Serotonin receptor 1D
Gene namesi
Name:Htr1d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2847 Htr1d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularBy similarityAdd BLAST35
Transmembranei36 – 61Helical; Name=1By similarityAdd BLAST26
Topological domaini62 – 72CytoplasmicBy similarityAdd BLAST11
Transmembranei73 – 95Helical; Name=2By similarityAdd BLAST23
Topological domaini96 – 109ExtracellularBy similarityAdd BLAST14
Transmembranei110 – 131Helical; Name=3By similarityAdd BLAST22
Topological domaini132 – 151CytoplasmicBy similarityAdd BLAST20
Transmembranei152 – 173Helical; Name=4By similarityAdd BLAST22
Topological domaini174 – 191ExtracellularBy similarityAdd BLAST18
Transmembranei192 – 214Helical; Name=5By similarityAdd BLAST23
Topological domaini215 – 299CytoplasmicBy similarityAdd BLAST85
Transmembranei300 – 323Helical; Name=6By similarityAdd BLAST24
Topological domaini324 – 332ExtracellularBy similarity9
Transmembranei333 – 357Helical; Name=7By similarityAdd BLAST25
Topological domaini358 – 374CytoplasmicBy similarityAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5450
GuidetoPHARMACOLOGYi3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689311 – 3745-hydroxytryptamine receptor 1DAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi108 ↔ 185PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP28565
PRIDEiP28565

PTM databases

PhosphoSitePlusiP28565

Expressioni

Tissue specificityi

Detected in dorsal raphe.1 Publication

Gene expression databases

BgeeiENSRNOG00000012038
GenevisibleiP28565 RN

Interactioni

Subunit structurei

Homodimer. Heterodimer with HTR1B (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016047

Chemistry databases

BindingDBiP28565

Structurei

3D structure databases

ProteinModelPortaliP28565
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 120Agonist bindingBy similarity10
Regioni311 – 315Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi132 – 134DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi349 – 353NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP28565
KOiK04153
OMAiYGKRFTT
OrthoDBiEOG091G06VI
PhylomeDBiP28565
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR000505 5HT1D_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF17 PTHR24247:SF17, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00514 5HT1DRECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28565-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPNQSLEG LPQEASNRSL NATGAWDPEV LQALRISLVV VLSIITLATV
60 70 80 90 100
LSNAFVLTTI LLTKKLHTPA NYLIGSLATT DLLVSILVMP ISIAYTTTRT
110 120 130 140 150
WNFGQILCDI WVSSDITCCT ASILHLCVIA LDRYWAITDA LEYSKRRTAG
160 170 180 190 200
HAAAMIAAVW AISICISIPP LFWRQATAHE EMSDCLVNTS QISYTIYSTC
210 220 230 240 250
GAFYIPSILL IILYGRIYVA ARSRILNPPS LYGKRFTTAQ LITGSAGSSL
260 270 280 290 300
CSLNPSLHES HTHTVGSPLF FNQVKIKLAD SILERKRISA ARERKATKTL
310 320 330 340 350
GIILGAFIIC WLPFFVVSLV LPICRDSCWI HPALFDFFTW LGYLNSLINP
360 370
VIYTVFNEDF RQAFQRVVHF RKAS
Length:374
Mass (Da):41,540
Last modified:December 1, 1992 - v1
Checksum:i345CBD528317DA21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89953 Genomic DNA Translation: AAA40614.1
PIRiI77467
RefSeqiNP_036984.1, NM_012852.1
XP_008762430.1, XM_008764208.2
XP_017448642.1, XM_017593153.1
XP_017448643.1, XM_017593154.1
XP_017448644.1, XM_017593155.1
XP_017448645.1, XM_017593156.1
XP_017448646.1, XM_017593157.1
XP_017448647.1, XM_017593158.1
UniGeneiRn.34834

Genome annotation databases

EnsembliENSRNOT00000016046; ENSRNOP00000016047; ENSRNOG00000012038
GeneIDi25323
KEGGirno:25323
UCSCiRGD:2847 rat

Similar proteinsi

Entry informationi

Entry namei5HT1D_RAT
AccessioniPrimary (citable) accession number: P28565
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health