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P28565 (5HT1D_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 1D
Short name=5-HT-1D
Short name=5-HT1D
Alternative name(s):
Serotonin receptor 1D
Gene names
Name:Htr1d
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3743745-hydroxytryptamine receptor 1D
PRO_0000068931

Regions

Topological domain1 – 3535Extracellular By similarity
Transmembrane36 – 5924Helical; Name=1; By similarity
Topological domain60 – 7213Cytoplasmic By similarity
Transmembrane73 – 9523Helical; Name=2; By similarity
Topological domain96 – 10510Extracellular By similarity
Transmembrane106 – 13126Helical; Name=3; By similarity
Topological domain132 – 15120Cytoplasmic By similarity
Transmembrane152 – 17322Helical; Name=4; By similarity
Topological domain174 – 19118Extracellular By similarity
Transmembrane192 – 21524Helical; Name=5; By similarity
Topological domain216 – 29984Cytoplasmic By similarity
Transmembrane300 – 32324Helical; Name=6; By similarity
Topological domain324 – 3329Extracellular By similarity
Transmembrane333 – 35725Helical; Name=7; By similarity
Topological domain358 – 37417Cytoplasmic By similarity

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation171N-linked (GlcNAc...) Potential
Glycosylation211N-linked (GlcNAc...) Potential
Disulfide bond108 ↔ 185 By similarity

Sequences

Sequence LengthMass (Da)Tools
P28565 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 345CBD528317DA21

FASTA37441,540
        10         20         30         40         50         60 
MSLPNQSLEG LPQEASNRSL NATGAWDPEV LQALRISLVV VLSIITLATV LSNAFVLTTI 

        70         80         90        100        110        120 
LLTKKLHTPA NYLIGSLATT DLLVSILVMP ISIAYTTTRT WNFGQILCDI WVSSDITCCT 

       130        140        150        160        170        180 
ASILHLCVIA LDRYWAITDA LEYSKRRTAG HAAAMIAAVW AISICISIPP LFWRQATAHE 

       190        200        210        220        230        240 
EMSDCLVNTS QISYTIYSTC GAFYIPSILL IILYGRIYVA ARSRILNPPS LYGKRFTTAQ 

       250        260        270        280        290        300 
LITGSAGSSL CSLNPSLHES HTHTVGSPLF FNQVKIKLAD SILERKRISA ARERKATKTL 

       310        320        330        340        350        360 
GIILGAFIIC WLPFFVVSLV LPICRDSCWI HPALFDFFTW LGYLNSLINP VIYTVFNEDF 

       370 
RQAFQRVVHF RKAS

« Hide

References

[1]"Distinct 5-HT1B and 5-HT1D serotonin receptors in rat: structural and pharmacological comparison of the two cloned receptors."
Hamblin M.W., McGuffin R.W., Metcalf M.A., Dorsa D.M., Merchant K.M.
Mol. Cell. Neurosci. 3:578-587(1992)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M89953 Genomic DNA. Translation: AAA40614.1.
IPIIPI00201815.
PIRI77467.
RefSeqNP_036984.1. NM_012852.1.
UniGeneRn.34834.

3D structure databases

ProteinModelPortalP28565.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000016047.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP28565.

Proteomic databases

PaxDbP28565.
PRIDEP28565.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000016046; ENSRNOP00000016047; ENSRNOG00000012038.
GeneID25323.
KEGGrno:25323.
UCSCRGD:2847. rat.

Organism-specific databases

CTD3352.
RGD2847. Htr1d.

Phylogenomic databases

eggNOGNOG249628.
GeneTreeENSGT00650000092921.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidP28565.
KOK04153.
OMACRDSCWI.
OrthoDBEOG4R7VB6.

Gene expression databases

GenevestigatorP28565.
GermOnlineENSRNOG00000012038. Rattus norvegicus.

Family and domain databases

InterProIPR000505. 5HT1D_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00514. 5HT1DRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP28565.
ChEMBLCHEMBL5450.
NextBio606173.

Entry information

Entry name5HT1D_RAT
AccessionPrimary (citable) accession number: P28565
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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