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P28564 (5HT1B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 1B
Short name=5-HT-1B
Short name=5-HT1B
Alternative name(s):
Serotonin receptor 1B
Gene names
Name:Htr1b
Synonyms:5ht1b
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

Phosphorylated By similarity.

Palmitoylated By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3863865-hydroxytryptamine receptor 1B
PRO_0000068921

Regions

Topological domain1 – 4747Extracellular By similarity
Transmembrane48 – 7124Helical; Name=1; By similarity
Topological domain72 – 8211Cytoplasmic By similarity
Transmembrane83 – 10927Helical; Name=2; By similarity
Topological domain110 – 11910Extracellular By similarity
Transmembrane120 – 14122Helical; Name=3; By similarity
Topological domain142 – 16322Cytoplasmic By similarity
Transmembrane164 – 18320Helical; Name=4; By similarity
Topological domain184 – 20421Extracellular By similarity
Transmembrane205 – 22420Helical; Name=5; By similarity
Topological domain225 – 31086Cytoplasmic By similarity
Transmembrane311 – 33222Helical; Name=6; By similarity
Topological domain333 – 34614Extracellular By similarity
Transmembrane347 – 36923Helical; Name=7; By similarity
Topological domain370 – 38617Cytoplasmic By similarity

Amino acid modifications

Lipidation3841S-palmitoyl cysteine Potential
Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation281N-linked (GlcNAc...) Potential
Disulfide bond118 ↔ 195 By similarity

Sequences

Sequence LengthMass (Da)Tools
P28564 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 4F4E9AC1C9AED214

FASTA38643,163
        10         20         30         40         50         60 
MEEQGIQCAP PPPATSQTGV PLANLSHNCS ADDYIYQDSI ALPWKVLLVA LLALITLATT 

        70         80         90        100        110        120 
LSNAFVIATV YRTRKLHTPA NYLIASLAVT DLLVSILVMP ISTMYTVTGR WTLGQVVCDF 

       130        140        150        160        170        180 
WLSSDITCCT ASIMHLCVIA LDRYWAITDA VDYSAKRTPK RAAIMIVLVW VFSISISLPP 

       190        200        210        220        230        240 
FFWRQAKAEE EVLDCFVNTD HVLYTVYSTV GAFYLPTLLL IALYGRIYVE ARSRILKQTP 

       250        260        270        280        290        300 
NKTGKRLTRA QLITDSPGST SSVTSINSRV PEVPSESGSP VYVNQVKVRV SDALLEKKKL 

       310        320        330        340        350        360 
MAARERKATK TLGIILGAFI VCWLPFFIIS LVMPICKDAC WFHMAIFDFF NWLGYLNSLI 

       370        380 
NPIIYTMSNE DFKQAFHKLI RFKCTG

« Hide

References

[1]"Distinct 5-HT1B and 5-HT1D serotonin receptors in rat: structural and pharmacological comparison of the two cloned receptors."
Hamblin M.W., McGuffin R.W., Metcalf M.A., Dorsa D.M., Merchant K.M.
Mol. Cell. Neurosci. 3:578-587(1992)
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor."
Voigt M.M., Laurie D.J., Seeburg P.H., Bach A.
EMBO J. 10:4017-4023(1991) [PubMed: 1836757] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M89954 Genomic DNA. Translation: AAA40613.1.
X62944 mRNA. Translation: CAA44716.1.
IPIIPI00201813.
PIRS18637.
RefSeqNP_071561.1. NM_022225.1.
UniGeneRn.138109.

3D structure databases

ProteinModelPortalP28564.
SMRP28564. Positions 130-161.
ModBaseSearch...

Protein-protein interaction databases

STRINGP28564.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP28564.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000017411; ENSRNOP00000017411; ENSRNOG00000013042.
GeneID25075.
KEGGrno:25075.

Organism-specific databases

CTD3351.
RGD2846. Htr1b.

Phylogenomic databases

eggNOGmaNOG13970.
GeneTreeENSGT00590000082831.
HOVERGENHBG106962.
InParanoidP28564.
OMAALPWKVL.
OrthoDBEOG4R7VB6.
PhylomeDBP28564.

Gene expression databases

ArrayExpressP28564.
GenevestigatorP28564.
GermOnlineENSRNOG00000013042. Rattus norvegicus.

Family and domain databases

InterProIPR002147. 5HT1B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
KOK04153.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00513. 5HT1BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio605318.

Entry information

Entry name5HT1B_RAT
AccessionPrimary (citable) accession number: P28564
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 16, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents