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Protein

Dual specificity protein phosphatase 1

Gene

Dusp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei258Phosphocysteine intermediate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-MMU-112409 RAF-independent MAPK1/3 activation
R-MMU-5675221 Negative regulation of MAPK pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 1 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Mitogen-activated protein kinase phosphatase 1
Short name:
MAP kinase phosphatase 1
Short name:
MKP-1
Protein-tyrosine phosphatase 3CH134
Protein-tyrosine phosphatase ERP
Gene namesi
Name:Dusp1
Synonyms:3ch134, Mkp1, Ptpn10, Ptpn16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:105120 Dusp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi258C → S: Loss of activity. 1

Chemistry databases

ChEMBLiCHEMBL5623

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947911 – 367Dual specificity protein phosphatase 1Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei359Phosphoserine; by MAPK1 and MAPK31 Publication1
Modified residuei364Phosphoserine; by MAPK1 and MAPK31 Publication1

Post-translational modificationi

Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP28563
PRIDEiP28563

PTM databases

iPTMnetiP28563
PhosphoSitePlusiP28563

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiENSMUSG00000024190
CleanExiMM_DUSP1
ExpressionAtlasiP28563 baseline and differential
GenevisibleiP28563 MM

Interactioni

Protein-protein interaction databases

BioGridi202482, 2 interactors
DIPiDIP-29877N
IntActiP28563, 1 interactor
STRINGi10090.ENSMUSP00000025025

Chemistry databases

BindingDBiP28563

Structurei

3D structure databases

ProteinModelPortaliP28563
SMRiP28563
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 137RhodanesePROSITE-ProRule annotationAdd BLAST118
Domaini175 – 367Tyrosine-protein phosphataseAdd BLAST193

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOGENOMiHOG000294080
HOVERGENiHBG007347
InParanoidiP28563
KOiK21278
OMAiMVIMEVP
OrthoDBiEOG091G0249
PhylomeDBiP28563
TreeFamiTF105122

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020420 Atypical_DUSP_famB
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PIRSFiPIRSF000939 MAPK_Ptase, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01910 ADSPHPHTASEB
PR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

P28563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMEVGILDA GGLRALLREG AAQCLLLDCR SFFAFNAGHI AGSVNVRFST
60 70 80 90 100
IVRRRAKGAM GLEHIVPNAE LRGRLLAGAY HAVVLLDERS ASLDGAKRDG
110 120 130 140 150
TLALAAGALC REARSTQVFF LQGGYEAFSA SCPELCSKQS TPTGLSLPLS
160 170 180 190 200
TSVPDSAESG CSSCSTPLYD QGGPVEILSF LYLGSAYHAS RKDMLDALGI
210 220 230 240 250
TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA IDFIDSIKDA
260 270 280 290 300
GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS
310 320 330 340 350
FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHPT
360
NSALNYLKSP ITTSPSC
Length:367
Mass (Da):39,370
Last modified:December 1, 1992 - v1
Checksum:i50B5F90FEBBD19AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61940 mRNA Translation: CAA43944.1
S64851 Genomic DNA Translation: AAB27882.1
BC006967 mRNA Translation: AAH06967.1
CCDSiCCDS28552.1
PIRiA54681 S24411
RefSeqiNP_038670.1, NM_013642.3
UniGeneiMm.239041

Genome annotation databases

EnsembliENSMUST00000025025; ENSMUSP00000025025; ENSMUSG00000024190
GeneIDi19252
KEGGimmu:19252
UCSCiuc008bee.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDUS1_MOUSE
AccessioniPrimary (citable) accession number: P28563
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health