Reviewed,
UniProtKB/Swiss-Prot P28562 (DUS1_HUMAN)
Last modified
July 7, 2009.
Version 93.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dual specificity protein phosphatase 1 EC=3.1.3.48 EC=3.1.3.16 Alternative name(s): MAP kinase phosphatase 1 Short name=MKP-1 Protein-tyrosine phosphatase CL100 Dual specificity protein phosphatase hVH1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 367 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Dual specificity phosphatase that dephosphorylates MAP kinase ERK2 on both 'Thr-183' and 'Tyr-185'. |
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate. |
| Tissue specificity | Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. Ref.2 |
| Induction | By oxidative stress and heat shock. |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 rhodanese domain. Contains 1 tyrosine-protein phosphatase domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Stress response |
| Coding sequence diversity | Polymorphism |
| Molecular function | Hydrolase Protein phosphatase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell cycle Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid dephosphorylationInferred from electronic annotation. Source: InterPro response to oxidative stress Ref.1Traceable author statement. Source: ProtInc |
| Molecular function | MAP kinase tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine phosphatase activity Ref.1Traceable author statement. Source: ProtInc protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| MAPK1 | P28482 | 2 | EBI-975493,EBI-959949 | |
| RPS27A | P62988 | 1 | EBI-975493,EBI-413034 | |
| SKP2 | Q13309 | 1 | EBI-975493,EBI-456291 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 367 | 367 | Dual specificity protein phosphatase 1 | PRO_0000094790 | |||||
Regions | |||||||||
| Domain | 20 – 137 | 118 | Rhodanese | ||||||
| Domain | 175 – 367 | 193 | Tyrosine-protein phosphatase | ||||||
Sites | |||||||||
| Active site | 258 | 1 | Phosphocysteine intermediate By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 56 | 1 | A → T Ref.3 | VAR_025201 | |||||
| Natural variant | 187 | 1 | Y → H: dbSNP rs34471628. Ref.3 | VAR_025202 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase." Keyes S.M., Emslie E.A. Nature 359:644-647(1992) [PubMed: 1406996] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Foreskin. |
| [2] | "Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene." Kwak S.P., Hakes D.J., Martell K.J., Dixon J.E. J. Biol. Chem. 269:3596-3604(1994) [PubMed: 8106404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [3] | NIEHS SNPs program Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-56 AND HIS-187. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X68277 mRNA. Translation: CAA48338.1. DQ301957 Genomic DNA. Translation: ABB96250.1. BC022463 mRNA. Translation: AAH22463.1. | |
| IPI | IPI00003928. |
| PIR | S29090. |
| RefSeq | NP_004408.1. |
| UniGene | Hs.171695 Hs.710943 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1M3G based on UniProtKB Q05923. |
| SMR | P28562. Positions 171-313. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P28562. 7 interactions. |
PTM databases | |
| PhosphoSite | P28562. |
Proteomic databases | |
| PRIDE | P28562. |
Genome annotation databases | |
| Ensembl | ENSG00000120129. Homo sapiens. [Contig view] |
| GeneID | 1843. |
| KEGG | hsa:1843. |
| UCSC | uc003mbv.1. human. |
Organism-specific databases | |
| GeneCards | GC05M172127. |
| H-InvDB | HIX0005420. |
| HGNC | HGNC:3064. DUSP1. |
| HPA | CAB018554. |
| MIM | 600714. gene. |
| PharmGKB | PA27519. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P28562. |
| HOVERGEN | P28562. |
| OMA | P28562. MEVGILD. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.16. 247. 3.1.3.48. 247. |
| Pathway_Interaction_DB | fcer1pathway. Fc-epsilon receptor I signaling in mast cells. p38alphabetapathway. Regulation of p38-alpha and p38-beta. |
Gene expression databases | |
| ArrayExpress | P28562. |
| Bgee | P28562. |
| CleanEx | HS_DUSP1. |
| GermOnline | ENSG00000120129. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR014393. Dual_MAP_Kinase_Phosphatase. IPR008343. MAPK_phosph. IPR001763. Rhodanese-like. IPR000387. Tyr_Pase. IPR016130. Tyr_Pase_AS. IPR000340. Tyr_Pase_dual_specific. [Graphical view] |
| Gene3D | G3DSA:3.40.250.10. Rhodanese-like. 1 hit. |
| Pfam | PF00782. DSPc. 1 hit. PF00581. Rhodanese. 1 hit. [Graphical view] |
| PIRSF | PIRSF000939. MAPK_Ptase. 1 hit. |
| PRINTS | PR01764. MAPKPHPHTASE. |
| SMART | SM00195. DSPc. 1 hit. SM00450. RHOD. 1 hit. [Graphical view] |
| PROSITE | PS50206. RHODANESE_3. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 7547. |
| SOURCE | Search... |
Entry information
| Entry name | DUS1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P28562 Secondary accession number(s): Q2V508 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


