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Protein

Dual specificity protein phosphatase 1

Gene

DUSP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation1 Publication
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei258Phosphocysteine intermediatePROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Stress response

Enzyme and pathway databases

BRENDAi3.1.3.16 2681
ReactomeiR-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5675221 Negative regulation of MAPK pathway
SABIO-RKiP28562
SignaLinkiP28562
SIGNORiP28562

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 1Curated (EC:3.1.3.16By similarity, EC:3.1.3.481 Publication)
Alternative name(s):
Dual specificity protein phosphatase hVH11 Publication
Mitogen-activated protein kinase phosphatase 1
Short name:
MAP kinase phosphatase 1
Short name:
MKP-1
Protein-tyrosine phosphatase CL1001 Publication
Gene namesi
Name:DUSP1Imported
Synonyms:CL1001 Publication, MKP1, PTPN10Imported, VH11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000120129.5
HGNCiHGNC:3064 DUSP1
MIMi600714 gene
neXtProtiNX_P28562

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi258C → S: Loss of phosphatase activity. 1 Publication1

Organism-specific databases

DisGeNETi1843
OpenTargetsiENSG00000120129
PharmGKBiPA27519

Chemistry databases

ChEMBLiCHEMBL6026

Polymorphism and mutation databases

BioMutaiDUSP1
DMDMi1346900

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947901 – 367Dual specificity protein phosphatase 1Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei359Phosphoserine; by MAPK1 and MAPK3By similarity1
Modified residuei364Phosphoserine; by MAPK1 and MAPK3By similarity1

Post-translational modificationi

Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP28562
PaxDbiP28562
PeptideAtlasiP28562
PRIDEiP28562
ProteomicsDBi54489

PTM databases

DEPODiP28562
iPTMnetiP28562
PhosphoSitePlusiP28562

Expressioni

Tissue specificityi

Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.1 Publication

Inductioni

By oxidative stress and heat shock.1 Publication

Gene expression databases

BgeeiENSG00000120129
CleanExiHS_DUSP1
GenevisibleiP28562 HS

Organism-specific databases

HPAiCAB018554
HPA069577

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108176, 38 interactors
IntActiP28562, 14 interactors
MINTiP28562
STRINGi9606.ENSP00000239223

Chemistry databases

BindingDBiP28562

Structurei

Secondary structure

1367
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi175 – 178Combined sources4
Beta strandi181 – 185Combined sources5
Helixi188 – 190Combined sources3
Helixi192 – 197Combined sources6
Beta strandi202 – 206Combined sources5
Beta strandi218 – 223Combined sources6
Helixi234 – 236Combined sources3
Helixi237 – 249Combined sources13
Beta strandi254 – 263Combined sources10
Helixi264 – 277Combined sources14
Helixi281 – 291Combined sources11
Helixi299 – 312Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6APXX-ray2.49A172-314[»]
ProteinModelPortaliP28562
SMRiP28562
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 137RhodanesePROSITE-ProRule annotationAdd BLAST118
Domaini175 – 367Tyrosine-protein phosphataseAdd BLAST193

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOGENOMiHOG000294080
HOVERGENiHBG007347
InParanoidiP28562
KOiK21278
OMAiMVIMEVP
OrthoDBiEOG091G0249
PhylomeDBiP28562
TreeFamiTF105122

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PIRSFiPIRSF000939 MAPK_Ptase, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

P28562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST
60 70 80 90 100
IVRRRAKGAM GLEHIVPNAE LRGRLLAGAY HAVVLLDERS AALDGAKRDG
110 120 130 140 150
TLALAAGALC REARAAQVFF LKGGYEAFSA SCPELCSKQS TPMGLSLPLS
160 170 180 190 200
TSVPDSAESG CSSCSTPLYD QGGPVEILPF LYLGSAYHAS RKDMLDALGI
210 220 230 240 250
TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA IDFIDSIKNA
260 270 280 290 300
GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS
310 320 330 340 350
FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHST
360
NSALSYLQSP ITTSPSC
Length:367
Mass (Da):39,298
Last modified:February 1, 1996 - v3
Checksum:i11BD1D39A9FCD51F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02520156A → T1 PublicationCorresponds to variant dbSNP:rs34013988Ensembl.1
Natural variantiVAR_025202187Y → H1 PublicationCorresponds to variant dbSNP:rs34471628Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68277 mRNA Translation: CAA48338.1
DQ301957 Genomic DNA Translation: ABB96250.1
CH471062 Genomic DNA Translation: EAW61425.1
CH471062 Genomic DNA Translation: EAW61426.1
BC022463 mRNA Translation: AAH22463.1
CCDSiCCDS4380.1
PIRiS29090
RefSeqiNP_004408.1, NM_004417.3
UniGeneiHs.171695

Genome annotation databases

EnsembliENST00000239223; ENSP00000239223; ENSG00000120129
GeneIDi1843
KEGGihsa:1843
UCSCiuc003mbv.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDUS1_HUMAN
AccessioniPrimary (citable) accession number: P28562
Secondary accession number(s): D3DQL9, Q2V508
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 179 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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