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Protein

Casein kinase II subunit alpha

Gene

ACK2

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63ATP1
Active sitei151Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 48ATP9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 6752.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit alpha (EC:2.7.11.1)
Alternative name(s):
CK II
CK2-alpha
Gene namesi
Name:ACK2
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi30032.

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4514.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859011 – 332Casein kinase II subunit alphaAdd BLAST332

Proteomic databases

PaxDbiP28523.
PRIDEiP28523.

Expressioni

Gene expression databases

ExpressionAtlasiP28523. differential.
GenevisibleiP28523. ZM.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains (possible).

Protein-protein interaction databases

IntActiP28523. 1 interactor.
STRINGi4577.GRMZM2G143602_P03.

Chemistry databases

BindingDBiP28523.

Structurei

Secondary structure

1332
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 7Combined sources3
Helixi10 – 13Combined sources4
Helixi16 – 19Combined sources4
Helixi21 – 23Combined sources3
Helixi31 – 33Combined sources3
Beta strandi34 – 43Combined sources10
Beta strandi46 – 53Combined sources8
Turni54 – 57Combined sources4
Beta strandi58 – 65Combined sources8
Helixi70 – 83Combined sources14
Beta strandi92 – 97Combined sources6
Turni99 – 101Combined sources3
Beta strandi104 – 109Combined sources6
Helixi116 – 119Combined sources4
Helixi120 – 122Combined sources3
Helixi125 – 144Combined sources20
Helixi154 – 156Combined sources3
Beta strandi157 – 160Combined sources4
Turni161 – 164Combined sources4
Beta strandi165 – 168Combined sources4
Helixi171 – 173Combined sources3
Helixi190 – 192Combined sources3
Helixi195 – 198Combined sources4
Helixi207 – 222Combined sources16
Beta strandi225 – 228Combined sources4
Helixi233 – 244Combined sources12
Helixi246 – 255Combined sources10
Helixi262 – 268Combined sources7
Helixi276 – 279Combined sources4
Turni282 – 284Combined sources3
Helixi285 – 287Combined sources3
Helixi290 – 299Combined sources10
Helixi304 – 306Combined sources3
Helixi310 – 315Combined sources6
Helixi317 – 319Combined sources3
Helixi320 – 326Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DAWX-ray2.20A2-328[»]
1DAYX-ray2.20A2-328[»]
1DS5X-ray3.16A/B/C/D1-332[»]
1F0QX-ray2.63A1-332[»]
1J91X-ray2.22A/B1-332[»]
1JAMX-ray2.18A1-332[»]
1LP4X-ray1.86A1-332[»]
1LPUX-ray1.86A1-332[»]
1LR4X-ray2.00A1-332[»]
1M2PX-ray2.00A2-326[»]
1M2QX-ray1.79A2-328[»]
1M2RX-ray1.70A2-328[»]
1OM1X-ray1.68A1-332[»]
1ZOEX-ray1.77A1-332[»]
1ZOGX-ray2.30A1-332[»]
1ZOHX-ray1.81A1-332[»]
2OXDX-ray2.30A1-332[»]
2OXXX-ray2.30A1-332[»]
2OXYX-ray1.81A/B1-332[»]
2PVHX-ray2.20A1-332[»]
2PVJX-ray1.70A1-332[»]
2PVKX-ray1.90A1-332[»]
2PVLX-ray1.90A1-332[»]
2PVMX-ray2.00A1-332[»]
2PVNX-ray2.00A1-332[»]
2QC6X-ray1.85A1-332[»]
3BE9X-ray2.00A1-332[»]
3FL5X-ray2.30A1-332[»]
3KXGX-ray1.70A2-328[»]
3KXHX-ray1.70A2-328[»]
3KXMX-ray1.75A2-328[»]
3KXNX-ray2.00A2-328[»]
3PVGX-ray1.50A2-332[»]
3PWDX-ray2.20A1-332[»]
3PZHX-ray1.92A1-332[»]
4ANMX-ray1.70A2-332[»]
4DGMX-ray1.65A2-327[»]
4DGNX-ray1.75A2-327[»]
4DGOX-ray1.96A2-326[»]
4RLKX-ray1.24A1-332[»]
ProteinModelPortaliP28523.
SMRiP28523.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28523.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 319Protein kinasePROSITE-ProRule annotationAdd BLAST286

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0668. Eukaryota.
ENOG410XNPP. LUCA.
HOGENOMiHOG000233021.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKARVYADV NVLRPKEYWD YEALTVQWGE QDDYEVVRKV GRGKYSEVFE
60 70 80 90 100
GINVNNNEKC IIKILKPVKK KKIKREIKIL QNLCGGPNIV KLLDIVRDQH
110 120 130 140 150
SKTPSLIFEY VNNTDFKVLY PTLTDYDIRY YIYELLKALD YCHSQGIMHR
160 170 180 190 200
DVKPHNVMID HELRKLRLID WGLAEFYHPG KEYNVRVASR YFKGPELLVD
210 220 230 240 250
LQDYDYSLDM WSLGCMFAGM IFRKEPFFYG HDNHDQLVKI AKVLGTDGLN
260 270 280 290 300
VYLNKYRIEL DPQLEALVGR HSRKPWLKFM NADNQHLVSP EAIDFLDKLL
310 320 330
RYDHQERLTA LEAMTHPYFQ QVRAAENSRT RA
Length:332
Mass (Da):39,230
Last modified:December 1, 1992 - v1
Checksum:i85513A5A5C77235A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61387 mRNA. Translation: CAA43659.1.
PIRiS19726.
RefSeqiXP_008668648.1. XM_008670426.1.
UniGeneiZm.569.

Genome annotation databases

EnsemblPlantsiZm00001d007951_T001; Zm00001d007951_T001; Zm00001d007951.
GeneIDi542637.
GrameneiZm00001d007951_T001; Zm00001d007951_T001; Zm00001d007951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61387 mRNA. Translation: CAA43659.1.
PIRiS19726.
RefSeqiXP_008668648.1. XM_008670426.1.
UniGeneiZm.569.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DAWX-ray2.20A2-328[»]
1DAYX-ray2.20A2-328[»]
1DS5X-ray3.16A/B/C/D1-332[»]
1F0QX-ray2.63A1-332[»]
1J91X-ray2.22A/B1-332[»]
1JAMX-ray2.18A1-332[»]
1LP4X-ray1.86A1-332[»]
1LPUX-ray1.86A1-332[»]
1LR4X-ray2.00A1-332[»]
1M2PX-ray2.00A2-326[»]
1M2QX-ray1.79A2-328[»]
1M2RX-ray1.70A2-328[»]
1OM1X-ray1.68A1-332[»]
1ZOEX-ray1.77A1-332[»]
1ZOGX-ray2.30A1-332[»]
1ZOHX-ray1.81A1-332[»]
2OXDX-ray2.30A1-332[»]
2OXXX-ray2.30A1-332[»]
2OXYX-ray1.81A/B1-332[»]
2PVHX-ray2.20A1-332[»]
2PVJX-ray1.70A1-332[»]
2PVKX-ray1.90A1-332[»]
2PVLX-ray1.90A1-332[»]
2PVMX-ray2.00A1-332[»]
2PVNX-ray2.00A1-332[»]
2QC6X-ray1.85A1-332[»]
3BE9X-ray2.00A1-332[»]
3FL5X-ray2.30A1-332[»]
3KXGX-ray1.70A2-328[»]
3KXHX-ray1.70A2-328[»]
3KXMX-ray1.75A2-328[»]
3KXNX-ray2.00A2-328[»]
3PVGX-ray1.50A2-332[»]
3PWDX-ray2.20A1-332[»]
3PZHX-ray1.92A1-332[»]
4ANMX-ray1.70A2-332[»]
4DGMX-ray1.65A2-327[»]
4DGNX-ray1.75A2-327[»]
4DGOX-ray1.96A2-326[»]
4RLKX-ray1.24A1-332[»]
ProteinModelPortaliP28523.
SMRiP28523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP28523. 1 interactor.
STRINGi4577.GRMZM2G143602_P03.

Chemistry databases

BindingDBiP28523.
ChEMBLiCHEMBL4514.

Proteomic databases

PaxDbiP28523.
PRIDEiP28523.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiZm00001d007951_T001; Zm00001d007951_T001; Zm00001d007951.
GeneIDi542637.
GrameneiZm00001d007951_T001; Zm00001d007951_T001; Zm00001d007951.

Organism-specific databases

MaizeGDBi30032.

Phylogenomic databases

eggNOGiKOG0668. Eukaryota.
ENOG410XNPP. LUCA.
HOGENOMiHOG000233021.

Enzyme and pathway databases

BRENDAi2.7.11.1. 6752.

Miscellaneous databases

EvolutionaryTraceiP28523.
PROiP28523.

Gene expression databases

ExpressionAtlasiP28523. differential.
GenevisibleiP28523. ZM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSK2A_MAIZE
AccessioniPrimary (citable) accession number: P28523
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.