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P28504

- HIR2_HIRME

UniProt

P28504 - HIR2_HIRME

Protein

Hirudin-2

Gene
N/A
Organism
Hirudo medicinalis (Medicinal leech)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen.

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI14.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hirudin-2
    Alternative name(s):
    Hirudin II
    OrganismiHirudo medicinalis (Medicinal leech)
    Taxonomic identifieri6421 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataHirudinidaHirudineaArhynchobdellidaHirudiniformesHirudinidaeHirudo

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Protein family/group databases

    Allergomei9843. Hir me Hirudin.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6565Hirudin-2PRO_0000195644Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi6 ↔ 14By similarity
    Disulfide bondi16 ↔ 28By similarity
    Disulfide bondi22 ↔ 39By similarity
    Glycosylationi45 – 451O-linked (GalNAc...)By similarity
    Modified residuei63 – 631SulfotyrosineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Sulfation

    Structurei

    Secondary structure

    1
    65
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi61 – 633

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A3BX-ray1.80I49-64[»]
    1A3EX-ray1.85I49-64[»]
    1ABIX-ray2.30I54-64[»]
    1C1UX-ray1.75I55-65[»]
    1C1VX-ray1.98I55-65[»]
    1C1WX-ray1.90I55-65[»]
    1C4UX-ray2.10355-63[»]
    1C5LX-ray1.47I55-64[»]
    1C5NX-ray1.50I55-64[»]
    1C5OX-ray1.90I55-65[»]
    1D9IX-ray2.30I55-64[»]
    1FPCX-ray2.30I54-64[»]
    1GHVX-ray1.85I55-65[»]
    1GHWX-ray1.75I55-65[»]
    1GHXX-ray1.65I55-65[»]
    1GHYX-ray1.85I55-65[»]
    1GJ4X-ray1.81I55-65[»]
    1GJ5X-ray1.73I55-65[»]
    1IHSX-ray2.00I49-65[»]
    1NM6X-ray1.80B55-64[»]
    1NT1X-ray2.00H55-64[»]
    1NY2X-ray2.30355-64[»]
    1O2GX-ray1.58I55-65[»]
    1QBVX-ray1.80E55-65[»]
    1SB1X-ray1.90I55-63[»]
    1SL3X-ray1.81B55-64[»]
    1TA2X-ray2.30B55-64[»]
    1TA6X-ray1.90B55-64[»]
    1TMTX-ray2.20J53-65[»]
    1TWXX-ray2.40C55-64[»]
    1VR1X-ray1.90I55-64[»]
    1XM1X-ray2.30H55-64[»]
    1YPEX-ray1.81I55-64[»]
    1YPGX-ray1.80I55-64[»]
    1YPJX-ray1.78I55-64[»]
    1YPKX-ray1.78I55-64[»]
    1YPLX-ray1.85I55-64[»]
    1YPMX-ray1.85I55-64[»]
    1ZRBX-ray1.90B55-65[»]
    2GDEX-ray2.00D55-64[»]
    2HGTX-ray2.20J54-64[»]
    2PKSX-ray2.50D55-64[»]
    3VXEX-ray1.25J54-64[»]
    3VXFOther1.60J54-64[»]
    ProteinModelPortaliP28504.
    SMRiP28504. Positions 1-65.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP28504.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 33Interaction with thrombin active siteBy similarity
    Regioni55 – 6511Interaction with fibrinogen-binding exosite of thrombinBy similarityAdd
    BLAST

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.70.10.10. 1 hit.
    InterProiIPR024793. Hirudin.
    IPR011061. Hirudin/antistatin.
    IPR000429. Prot_inh_hirudin.
    [Graphical view]
    PfamiPF00713. Hirudin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001640. Hirudin. 1 hit.
    PRINTSiPR00777. HIRUDIN.
    ProDomiPD004216. Prot_inh_hirudin. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF57262. SSF57262. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P28504-1 [UniParc]FASTAAdd to Basket

    « Hide

    ITYTDCTESG QDLCLCEGSN VCGKGNKCIL GSNGEENQCV TGEGTPKPQS   50
    HNDGDFEEIP EEYLQ 65
    Length:65
    Mass (Da):6,987
    Last modified:December 1, 1992 - v1
    Checksum:i757EEAE55EAEB27E
    GO

    Sequence databases

    PIRiS05678.

    Cross-referencesi

    Sequence databases

    PIRi S05678.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A3B X-ray 1.80 I 49-64 [» ]
    1A3E X-ray 1.85 I 49-64 [» ]
    1ABI X-ray 2.30 I 54-64 [» ]
    1C1U X-ray 1.75 I 55-65 [» ]
    1C1V X-ray 1.98 I 55-65 [» ]
    1C1W X-ray 1.90 I 55-65 [» ]
    1C4U X-ray 2.10 3 55-63 [» ]
    1C5L X-ray 1.47 I 55-64 [» ]
    1C5N X-ray 1.50 I 55-64 [» ]
    1C5O X-ray 1.90 I 55-65 [» ]
    1D9I X-ray 2.30 I 55-64 [» ]
    1FPC X-ray 2.30 I 54-64 [» ]
    1GHV X-ray 1.85 I 55-65 [» ]
    1GHW X-ray 1.75 I 55-65 [» ]
    1GHX X-ray 1.65 I 55-65 [» ]
    1GHY X-ray 1.85 I 55-65 [» ]
    1GJ4 X-ray 1.81 I 55-65 [» ]
    1GJ5 X-ray 1.73 I 55-65 [» ]
    1IHS X-ray 2.00 I 49-65 [» ]
    1NM6 X-ray 1.80 B 55-64 [» ]
    1NT1 X-ray 2.00 H 55-64 [» ]
    1NY2 X-ray 2.30 3 55-64 [» ]
    1O2G X-ray 1.58 I 55-65 [» ]
    1QBV X-ray 1.80 E 55-65 [» ]
    1SB1 X-ray 1.90 I 55-63 [» ]
    1SL3 X-ray 1.81 B 55-64 [» ]
    1TA2 X-ray 2.30 B 55-64 [» ]
    1TA6 X-ray 1.90 B 55-64 [» ]
    1TMT X-ray 2.20 J 53-65 [» ]
    1TWX X-ray 2.40 C 55-64 [» ]
    1VR1 X-ray 1.90 I 55-64 [» ]
    1XM1 X-ray 2.30 H 55-64 [» ]
    1YPE X-ray 1.81 I 55-64 [» ]
    1YPG X-ray 1.80 I 55-64 [» ]
    1YPJ X-ray 1.78 I 55-64 [» ]
    1YPK X-ray 1.78 I 55-64 [» ]
    1YPL X-ray 1.85 I 55-64 [» ]
    1YPM X-ray 1.85 I 55-64 [» ]
    1ZRB X-ray 1.90 B 55-65 [» ]
    2GDE X-ray 2.00 D 55-64 [» ]
    2HGT X-ray 2.20 J 54-64 [» ]
    2PKS X-ray 2.50 D 55-64 [» ]
    3VXE X-ray 1.25 J 54-64 [» ]
    3VXF Other 1.60 J 54-64 [» ]
    ProteinModelPortali P28504.
    SMRi P28504. Positions 1-65.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 9843. Hir me Hirudin.
    MEROPSi I14.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P28504.

    Family and domain databases

    Gene3Di 2.70.10.10. 1 hit.
    InterProi IPR024793. Hirudin.
    IPR011061. Hirudin/antistatin.
    IPR000429. Prot_inh_hirudin.
    [Graphical view ]
    Pfami PF00713. Hirudin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001640. Hirudin. 1 hit.
    PRINTSi PR00777. HIRUDIN.
    ProDomi PD004216. Prot_inh_hirudin. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF57262. SSF57262. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structures of new 'iso-hirudins'."
      Scharf M., Engels J., Tripier D.
      FEBS Lett. 255:105-110(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiHIR2_HIRME
    AccessioniPrimary (citable) accession number: P28504
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3