Reviewed, UniProtKB/Swiss-Prot P28493 (PR5_ARATH)

Names and origin

Protein names

Recommended name:
    Pathogenesis-related protein 5
      Short name=PR-5

Gene names

Ordered Locus Names:	At1g75040
ORF Names:	F9E10.11

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Partially responsible for acquired pathogen resistance.
Subcellular location	Secreted › extracellular space › apoplast. Note: Accumulates in the apoplast before secretion.
Induction	By 2,6-dichloroisonicotinic acid (INA) and salicylic acid (possibly an endogenous signal for acquired resistance). Strongly induced by pathogen infection.
Sequence similarities	Belongs to the thaumatin family.

Ontologies

Keywords
Biological process	Plant defense
Cellular component	Apoplast Secreted
Domain	Signal
Molecular function	Pathogenesis-related protein
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	regulation of anthocyanin biosynthetic process Inferred from expression pattern. Source: TAIR response to UV-B Inferred from genetic interaction. Source: TAIR systemic acquired resistance Ref.1 Inferred from expression pattern. Source: TAIR
Cellular component	apoplast Inferred from direct assay. Source: TAIR cell wall Inferred from direct assay. Source: TAIR extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell vacuole Inferred from direct assay. Source: TAIR
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TRX3	Q42403	1	EBI-449524,EBI-449157

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23
	Chain	24 – 239	216	Pathogenesis-related protein 5		PRO_0000034036
Amino acid modifications
	Disulfide bond	32 ↔ 238		By similarity
	Disulfide bond	79 ↔ 89		By similarity
	Disulfide bond	94 ↔ 99		By similarity
	Disulfide bond	146 ↔ 228		By similarity
	Disulfide bond	151 ↔ 211		By similarity
	Disulfide bond	159 ↔ 174		By similarity
	Disulfide bond	178 ↔ 187		By similarity
	Disulfide bond	188 ↔ 198		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P28493-1 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: CB376F61506ED093	FASTA	239	25,252
	10 20 30 40 50 60 MANISSIHIL FLVFITSGIA VMATDFTLRN NCPTTVWAGT LAGQGPKLGD GGFELTPGAS 70 80 90 100 110 120 RQLTAPAGWS GRFWARTGCN FDASGNGRCV TGDCGGLRCN GGGVPPVTLA EFTLVGDGGK 130 140 150 160 170 180 DFYDVSLVDG YNVKLGIRPS GGSGDCKYAG CVSDLNAACP DMLKVMDQNN VVACKSACER 190 200 210 220 230 FNTDQYCCRG ANDKPETCPP TDYSRIFKNA CPDAYSYAYD DETSTFTCTG ANYEITFCP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Acquired resistance in Arabidopsis." Uknes S., Mauch-Mani B., Moyer M., Potter S., Williams S., Dincher S., Chandler D., Slusarenko A., Ward E., Ryals J. Plant Cell 4:645-656(1992) [PubMed: 1392589] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Strain: cv. Landsberg erecta. Tissue: Leaf.
[2]	"Cloning and characterization of a novel cDNA encoding thaumatin-like protein PR5 from Arabidopsis thaliana." Arro M., Richard L., Than Van K.T., Ferrer A., Boronat A. Plant Gene Register PGR97-053 Cited for: NUCLEOTIDE SEQUENCE. Strain: cv. C24. Tissue: Flower.
[3]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[4]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M90510 mRNA. Translation: AAA32865.1. L78079 mRNA. Translation: AAB68336.1. AC013258 Genomic DNA. Translation: AAG51923.1. AY035168 mRNA. Translation: AAK59672.1. AY059114 mRNA. Translation: AAL15220.1.
IPI	IPI00524060.
PIR	JQ1695.
RefSeq	NP_177641.1.
UniGene	At.322 At.67351
3D structure databases
HSSP	HSSP built from PDB template 1DU5 based on UniProtKB P33679.
ModBase	Search...
Protein-protein interaction databases
IntAct	P28493. 1 interaction.
Proteomic databases
PRIDE	P28493.
Genome annotation databases
GeneID	843842.
GenomeReviews	Gene locus AT1G75040 in contig CT485782_GR.
KEGG	ath:AT1G75040.
NMPDR	fig|3702.1.peg.7021.
Organism-specific databases
TAIR	At1g75040.
Phylogenomic databases
OMA	P28493. MANISSI.
Gene expression databases
ArrayExpress	P28493.
GermOnline	AT1G75040. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001938. Thaumatin. IPR017949. Thaumatin_CS. [Graphical view]
Gene3D	G3DSA:2.60.110.10. Thaumatin. 1 hit.
Pfam	PF00314. Thaumatin. 1 hit. [Graphical view]
PIRSF	PIRSF002703. Thaumatin. 1 hit.
PRINTS	PR00347. THAUMATIN.
ProDom	PD001321. Thaumatin. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00205. THN. 1 hit. [Graphical view]
PROSITE	PS00316. THAUMATIN_1. 1 hit. PS51367. THAUMATIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PR5_ARATH

Accession

Primary (citable) accession number: P28493

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)