P28481 (CO2A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-1(II) chain

Alternative name(s):
Alpha-1 type II collagen

Cleaved into the following 2 chains:

1. Collagen alpha-1(II) chain
2. Chondrocalcin

Gene names

Name:

Col2a1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1487 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Subunit structure	Homotrimers of alpha 1(II) chains.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Developmental stage	Expressed in chondrogenic tissues in advance of chondrocyte differentiation. Expressed early in embryogenesis at 9.5 days both in the cranial mesenchyme destined for the chondrocranium, and the sclerotome of the somites, and at 12.5 days in the primordia of the hyoid and the laryngeal cartilage. Detected in all the chondrogenic tissues of the axial and appendicular skeleton until the onset of endochondral ossification. Expression also observed in non-chondrogenic tissues such as the notochord. Also expressed much later in the tail tendon, at 16.5-18.5 days. Transiently expressed in the heart at 9.5-12.5 days, the epidermis at 10.5-14.5 days, the calvarial mesenchyme at 12.5-16.5 days, the inner ear at 14.5 days and the fetal brain from 9.5-14.5 days. Within the neural tube, expression is localized to the proliferative ventricular cells of the forebrain and midbrain of 9.5-10.5 day embryos, and subsequently, restricted to the rhombencephalic basal plate, the ventricular layer of the hindbrain and the cervical spinal cord. Ref.3
Domain	The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.
Post-translational modification	Probably 3-hydroxylated on prolines by LEPREL1 By similarity. Proline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains.
Involvement in disease	Defects in Col2a1 are the cause of a phenotype resembling human spondyloepiphyseal dysplasia congenita (sedc). Homozygous sedc mice can be identified at birth by their small size and shortened trunk. Adults have shortened noses, dysplastic vertebrae, femora and tibias, and retinoschisis and hearing loss.
Sequence similarities	Belongs to the fibrillar collagen family. Contains 1 fibrillar collagen NC1 domain. Contains 1 VWFC domain.
Sequence caution	The sequence BAC25865.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing
Disease	Disease mutation
Domain	Collagen Repeat Signal
Ligand	Calcium Metal-binding
PTM	Disulfide bond Glycoprotein Hydroxylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cartilage condensation Inferred from mutant phenotype PubMed 3070812. Source: MGI cartilage development involved in endochondral bone morphogenesis Inferred from mutant phenotype PubMed 11680679PubMed 8989518PubMed 9022054. Source: MGI cellular response to BMP stimulus Inferred from direct assay PubMed 20501701. Source: MGI central nervous system development Inferred from expression pattern PubMed 9119111. Source: UniProtKB chondrocyte differentiation Inferred from expression pattern PubMed 9119111. Source: UniProtKB collagen fibril organization Inferred from mutant phenotype PubMed 11171689PubMed 3070812PubMed 7276808PubMed 7590256PubMed 8989518PubMed 9022054PubMed 9832566PubMed 9915573. Source: MGI embryonic skeletal joint morphogenesis Inferred from electronic annotation. Source: Compara endochondral ossification Inferred from mutant phenotype PubMed 10100048. Source: MGI heart morphogenesis Inferred from mutant phenotype PubMed 7590256. Source: MGI inner ear morphogenesis Inferred from mutant phenotype PubMed 9165353. Source: MGI limb bud formation Inferred from expression pattern PubMed 20940257. Source: UniProtKB negative regulation of apoptotic process Inferred from mutant phenotype PubMed 9299161. Source: MGI notochord development Inferred from expression pattern PubMed 9119111. Source: UniProtKB otic vesicle development Inferred from expression pattern PubMed 9119111. Source: UniProtKB palate development Inferred from mutant phenotype PubMed 7276808. Source: MGI proteoglycan metabolic process Inferred from mutant phenotype PubMed 3070812PubMed 7276808. Source: MGI regulation of gene expression Inferred from mutant phenotype PubMed 9299161. Source: MGI sensory perception of sound Inferred from electronic annotation. Source: Compara tissue homeostasis Inferred from mutant phenotype PubMed 11237662. Source: MGI visual perception Inferred from electronic annotation. Source: Compara
Cellular_component	basement membrane Inferred from direct assay PubMed 11273670. Source: MGI collagen type II Inferred from direct assay PubMed 9880238. Source: MGI cytoplasm Inferred from direct assay PubMed 12799063PubMed 14614991. Source: MGI extracellular space Inferred from direct assay PubMed 12799063PubMed 14614991. Source: MGI
Molecular_function	extracellular matrix structural constituent Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-738477,EBI-738477

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P28481-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: P28481-1)

Also known as: Long;

The sequence of this isoform differs from the canonical sequence as follows:
     114-142: Missing.

Isoform 3 (identifier: P28481-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     29-97: QEAGSCLQNGQRYKDKDVWKPSSCRICVCDTGNVLCDDIICEDPDCLNPEIPFGECCPICPADLATASG → R
     114-142: Missing.

Isoform 4 (identifier: P28481-4)

The sequence of this isoform differs from the canonical sequence as follows:
     103-113: Missing.
     125-142: Missing.

Isoform 5 (identifier: P28481-5)

The sequence of this isoform differs from the canonical sequence as follows:
     114-124: Missing.
     143-177: Missing.

Isoform 6 (identifier: P28481-6)

The sequence of this isoform differs from the canonical sequence as follows:
     103-113: Missing.
     143-177: Missing.

Isoform 7 (identifier: P28481-7)

The sequence of this isoform differs from the canonical sequence as follows:
     29-97: QEAGSCLQNGQRYKDKDVWKPSSCRICVCDTGNVLCDDIICEDPDCLNPEIPFGECCPICPADLATASG → R

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Propeptide	26 – 181	156	N-terminal propeptide By similarity		PRO_0000005732
	Chain	182 – 1241	1060	Collagen alpha-1(II) chain		PRO_0000005733
	Chain	1242 – 1487	246	Chondrocalcin		PRO_0000005734
Regions
	Domain	32 – 89	58	VWFC
	Domain	1253 – 1487	235	Fibrillar collagen NC1
	Region	201 – 1214	1014	Triple-helical region
	Region	1215 – 1241	27	Nonhelical region (C-terminal)
Sites
	Metal binding	1301	1	Calcium By similarity
	Metal binding	1303	1	Calcium By similarity
	Metal binding	1304	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	1306	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	1309	1	Calcium By similarity
	Site	181 – 182	2	Cleavage; by procollagen N-endopeptidase By similarity
	Site	1241 – 1242	2	Cleavage; by procollagen C-endopeptidase By similarity
Amino acid modifications
	Modified residue	190	1	5-hydroxylysine By similarity
	Modified residue	287	1	5-hydroxylysine By similarity
	Modified residue	299	1	5-hydroxylysine By similarity
	Modified residue	308	1	5-hydroxylysine By similarity
	Modified residue	374	1	5-hydroxylysine By similarity
	Modified residue	608	1	5-hydroxylysine By similarity
	Modified residue	620	1	5-hydroxylysine By similarity
	Modified residue	670	1	3-hydroxyproline By similarity
	Modified residue	907	1	3-hydroxyproline By similarity
	Modified residue	1144	1	3-hydroxyproline By similarity
	Modified residue	1186	1	3-hydroxyproline By similarity
	Modified residue	1201	1	3-hydroxyproline By similarity
	Modified residue	1207	1	3-hydroxyproline By similarity
	Modified residue	1213	1	3-hydroxyproline By similarity
	Glycosylation	190	1	O-linked (Gal...) By similarity
	Glycosylation	287	1	O-linked (Gal...) By similarity
	Glycosylation	299	1	O-linked (Gal...) By similarity
	Glycosylation	308	1	O-linked (Gal...) By similarity
	Glycosylation	374	1	O-linked (Gal...) By similarity
	Glycosylation	608	1	O-linked (Gal...) By similarity
	Glycosylation	620	1	O-linked (Gal...) By similarity
	Disulfide bond	1283 ↔ 1315		By similarity
	Disulfide bond	1289		Interchain (with C-1306) By similarity
	Disulfide bond	1306		Interchain (with C-1289) By similarity
	Disulfide bond	1323 ↔ 1485		By similarity
	Disulfide bond	1393 ↔ 1438		By similarity
Natural variations
	Alternative sequence	29 – 97	69	QEAGS…ATASG → R in isoform 3 and isoform 7.		VSP_022780
	Alternative sequence	103 – 113	11	Missing in isoform 4 and isoform 6.		VSP_022781
	Alternative sequence	114 – 142	29	Missing in isoform 2 and isoform 3.		VSP_022782
	Alternative sequence	114 – 124	11	Missing in isoform 5.		VSP_022783
	Alternative sequence	125 – 142	18	Missing in isoform 4.		VSP_022784
	Alternative sequence	143 – 177	35	Missing in isoform 5 and isoform 6.		VSP_022785
	Natural variant	989	1	R → C in sedc mice. Ref.7
Experimental info
	Sequence conflict	97	1	G → GR in AAA68100. Ref.1
	Sequence conflict	97	1	G → GR in AAA68101. Ref.1
	Sequence conflict	97	1	G → GR in AAA68099. Ref.1
	Sequence conflict	97	1	G → GR in AAA68102. Ref.1
	Sequence conflict	272	1	Q → M in AAA68100. Ref.1
	Sequence conflict	272	1	Q → M in AAA68101. Ref.1
	Sequence conflict	272	1	Q → M in AAA68099. Ref.1
	Sequence conflict	272	1	Q → M in AAA68102. Ref.1
	Sequence conflict	539	1	T → A in AAA68100. Ref.1
	Sequence conflict	539	1	T → A in AAA68101. Ref.1
	Sequence conflict	539	1	T → A in AAA68099. Ref.1
	Sequence conflict	539	1	T → A in AAA68102. Ref.1
	Sequence conflict	806	1	V → A in AAA68100. Ref.1
	Sequence conflict	806	1	V → A in AAA68101. Ref.1
	Sequence conflict	806	1	V → A in AAA68099. Ref.1
	Sequence conflict	806	1	V → A in AAA68102. Ref.1
	Sequence conflict	824	1	R → P in AAA68100. Ref.1
	Sequence conflict	824	1	R → P in AAA68101. Ref.1
	Sequence conflict	824	1	R → P in AAA68099. Ref.1
	Sequence conflict	947	1	Q → E in AAA68100. Ref.1
	Sequence conflict	947	1	Q → E in AAA68101. Ref.1
	Sequence conflict	947	1	Q → E in AAA68099. Ref.1
	Sequence conflict	947	1	Q → E in AAA68102. Ref.1
	Sequence conflict	1119	1	G → R in AAH51383. Ref.2
	Sequence conflict	1141 – 1145	5	LPGPP → SAWPS in AAC06113. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 6, 2007. Version 2. Checksum: E52A7F3951C76701	FASTA	1,487	141,973
	10 20 30 40 50 60 MIRLGAPQSL VLLTLLIAAV LRCQGQDAQE AGSCLQNGQR YKDKDVWKPS SCRICVCDTG 70 80 90 100 110 120 NVLCDDIICE DPDCLNPEIP FGECCPICPA DLATASGKLG PKGQKGEPGD IRDIIGPRGP 130 140 150 160 170 180 PGPQGPAGEQ GPRGDRGDKG EKGAPGPRGR DGEPGTPGNP GPAGPPGPPG PPGLSAGNFA 190 200 210 220 230 240 AQMAGGYDEK AGGAQMGVMQ GPMGPMGPRG PPGPAGAPGP QGFQGNPGEP GEPGVSGPMG 250 260 270 280 290 300 PRGPPGPAGK PGDDGEAGKP GKSGERGLPG PQGARGFPGT PGLPGVKGHR GYPGLDGAKG 310 320 330 340 350 360 EAGAPGVKGE SGSPGENGSP GPMGPRGLPG ERGRTGPAGA AGARGNDGQP GPAGPPGPVG 370 380 390 400 410 420 PAGGPGFPGA PGAKGEAGPT GARGPEGAQG SRGEPGNPGS PGPAGASGNP GTDGIPGAKG 430 440 450 460 470 480 SAGAPGIAGA PGFPGPRGPP GPQGATGPLG PKGQAGEPGI AGFKGDQGPK GETGPAGPQG 490 500 510 520 530 540 APGPAGEEGK RGARGEPGGA GPIGPPGERG APGNRGFPGQ DGLAGPKGAP GERGPSGLTG 550 560 570 580 590 600 PKGANGDPGR PGEPGLPGAR GLTGRPGDAG PQGKVGPSGA PGEDGRPGPP GPQGARGQPG 610 620 630 640 650 660 VMGFPGPKGA NGEPGKAGEK GLAGAPGLRG LPGKDGETGA AGPPGPSGPA GERGEQGAPG 670 680 690 700 710 720 PSGFQGLPGP PGPPGEGGKQ GDQGIPGEAG APGLVGPRGE RGFPGERGSP GAQGLQGPRG 730 740 750 760 770 780 LPGTPGTDGP KGAAGPDGPP GAQGPPGLQG MPGERGAAGI AGPKGDRGDV GEKGPEGAPG 790 800 810 820 830 840 KDGGRGLTGP IGPPGPAGAN GEKGEVGPPG PSGSTGARGA PGERGETGPP GPAGFAGPPG 850 860 870 880 890 900 ADGQPGAKGD QGEAGQKGDA GAPGPQGPSG APGPQGPTGV TGPKGARGAQ GPPGATGFPG 910 920 930 940 950 960 AAGRVGPPGA NGNPGPAGPP GPAGKDGPKG VRGDSGPPGR AGDPGLQGPA GAPGEKGEPG 970 980 990 1000 1010 1020 DDGPSGLDGP PGPQGLAGQR GIVGLPGQRG ERGFPGLPGP SGEPGKQGAP GASGDRGPPG 1030 1040 1050 1060 1070 1080 PVGPPGLTGP AGEPGREGSP GADGPPGRDG AAGVKGDRGE TGALGAPGAP GPPGSPGPAG 1090 1100 1110 1120 1130 1140 PTGKQGDRGE AGAQGPMGPS GPAGARGIAG PQGPRGDKGE SGEQGERGLK GHRGFTGLQG 1150 1160 1170 1180 1190 1200 LPGPPGPSGD QGASGPAGPS GPRGPPGPVG PSGKDGSNGI PGPIGPPGPR GRSGETGPVG 1210 1220 1230 1240 1250 1260 PPGSPGPPGP PGPPGPGIDM SAFAGLGQRE KGPDPMQYMR ADEADSTLRQ HDVEVDATLK 1270 1280 1290 1300 1310 1320 SLNNQIESIR SPDGSRKNPA RTCQDLKLCH PEWKSGDYWI DPNQGCTLDA MKVFCNMETG 1330 1340 1350 1360 1370 1380 ETCVYPNPAT VPRKNWWSSK SKEKKHIWFG ETMNGGFHFS YGDGNLAPNT ANVQMTFLRL 1390 1400 1410 1420 1430 1440 LSTEGSQNIT YHCKNSIAYL DEAAGNLKKA LLIQGSNDVE MRAEGNSRFT YTALKDGCTK 1450 1460 1470 1480 HTGKWGKTVI EYRSQKTSRL PIIDIAPMDI GGAEQEFGVD IGPVCFL
	Isoform 2 (Long) [UniParc]. Checksum: 5B28FCBC6BFB3A95	FASTA	1,458	139,110
	10 20 30 40 50 60 MIRLGAPQSL VLLTLLIAAV LRCQGQDAQE AGSCLQNGQR YKDKDVWKPS SCRICVCDTG 70 80 90 100 110 120 NVLCDDIICE DPDCLNPEIP FGECCPICPA DLATASGKLG PKGQKGEPGD IRDGAPGPRG 130 140 150 160 170 180 RDGEPGTPGN PGPAGPPGPP GPPGLSAGNF AAQMAGGYDE KAGGAQMGVM QGPMGPMGPR 190 200 210 220 230 240 GPPGPAGAPG PQGFQGNPGE PGEPGVSGPM GPRGPPGPAG KPGDDGEAGK PGKSGERGLP 250 260 270 280 290 300 GPQGARGFPG TPGLPGVKGH RGYPGLDGAK GEAGAPGVKG ESGSPGENGS PGPMGPRGLP 310 320 330 340 350 360 GERGRTGPAG AAGARGNDGQ PGPAGPPGPV GPAGGPGFPG APGAKGEAGP TGARGPEGAQ 370 380 390 400 410 420 GSRGEPGNPG SPGPAGASGN PGTDGIPGAK GSAGAPGIAG APGFPGPRGP PGPQGATGPL 430 440 450 460 470 480 GPKGQAGEPG IAGFKGDQGP KGETGPAGPQ GAPGPAGEEG KRGARGEPGG AGPIGPPGER 490 500 510 520 530 540 GAPGNRGFPG QDGLAGPKGA PGERGPSGLT GPKGANGDPG RPGEPGLPGA RGLTGRPGDA 550 560 570 580 590 600 GPQGKVGPSG APGEDGRPGP PGPQGARGQP GVMGFPGPKG ANGEPGKAGE KGLAGAPGLR 610 620 630 640 650 660 GLPGKDGETG AAGPPGPSGP AGERGEQGAP GPSGFQGLPG PPGPPGEGGK QGDQGIPGEA 670 680 690 700 710 720 GAPGLVGPRG ERGFPGERGS PGAQGLQGPR GLPGTPGTDG PKGAAGPDGP PGAQGPPGLQ 730 740 750 760 770 780 GMPGERGAAG IAGPKGDRGD VGEKGPEGAP GKDGGRGLTG PIGPPGPAGA NGEKGEVGPP 790 800 810 820 830 840 GPSGSTGARG APGERGETGP PGPAGFAGPP GADGQPGAKG DQGEAGQKGD AGAPGPQGPS 850 860 870 880 890 900 GAPGPQGPTG VTGPKGARGA QGPPGATGFP GAAGRVGPPG ANGNPGPAGP PGPAGKDGPK 910 920 930 940 950 960 GVRGDSGPPG RAGDPGLQGP AGAPGEKGEP GDDGPSGLDG PPGPQGLAGQ RGIVGLPGQR 970 980 990 1000 1010 1020 GERGFPGLPG PSGEPGKQGA PGASGDRGPP GPVGPPGLTG PAGEPGREGS PGADGPPGRD 1030 1040 1050 1060 1070 1080 GAAGVKGDRG ETGALGAPGA PGPPGSPGPA GPTGKQGDRG EAGAQGPMGP SGPAGARGIA 1090 1100 1110 1120 1130 1140 GPQGPRGDKG ESGEQGERGL KGHRGFTGLQ GLPGPPGPSG DQGASGPAGP SGPRGPPGPV 1150 1160 1170 1180 1190 1200 GPSGKDGSNG IPGPIGPPGP RGRSGETGPV GPPGSPGPPG PPGPPGPGID MSAFAGLGQR 1210 1220 1230 1240 1250 1260 EKGPDPMQYM RADEADSTLR QHDVEVDATL KSLNNQIESI RSPDGSRKNP ARTCQDLKLC 1270 1280 1290 1300 1310 1320 HPEWKSGDYW IDPNQGCTLD AMKVFCNMET GETCVYPNPA TVPRKNWWSS KSKEKKHIWF 1330 1340 1350 1360 1370 1380 GETMNGGFHF SYGDGNLAPN TANVQMTFLR LLSTEGSQNI TYHCKNSIAY LDEAAGNLKK 1390 1400 1410 1420 1430 1440 ALLIQGSNDV EMRAEGNSRF TYTALKDGCT KHTGKWGKTV IEYRSQKTSR LPIIDIAPMD 1450 IGGAEQEFGV DIGPVCFL
	Isoform 3 (Short) [UniParc]. Checksum: 514E8A3086208F1B	FASTA	1,390	131,859
	10 20 30 40 50 60 MIRLGAPQSL VLLTLLIAAV LRCQGQDARK LGPKGQKGEP GDIRDGAPGP RGRDGEPGTP 70 80 90 100 110 120 GNPGPAGPPG PPGPPGLSAG NFAAQMAGGY DEKAGGAQMG VMQGPMGPMG PRGPPGPAGA 130 140 150 160 170 180 PGPQGFQGNP GEPGEPGVSG PMGPRGPPGP AGKPGDDGEA GKPGKSGERG LPGPQGARGF 190 200 210 220 230 240 PGTPGLPGVK GHRGYPGLDG AKGEAGAPGV KGESGSPGEN GSPGPMGPRG LPGERGRTGP 250 260 270 280 290 300 AGAAGARGND GQPGPAGPPG PVGPAGGPGF PGAPGAKGEA GPTGARGPEG AQGSRGEPGN 310 320 330 340 350 360 PGSPGPAGAS GNPGTDGIPG AKGSAGAPGI AGAPGFPGPR GPPGPQGATG PLGPKGQAGE 370 380 390 400 410 420 PGIAGFKGDQ GPKGETGPAG PQGAPGPAGE EGKRGARGEP GGAGPIGPPG ERGAPGNRGF 430 440 450 460 470 480 PGQDGLAGPK GAPGERGPSG LTGPKGANGD PGRPGEPGLP GARGLTGRPG DAGPQGKVGP 490 500 510 520 530 540 SGAPGEDGRP GPPGPQGARG QPGVMGFPGP KGANGEPGKA GEKGLAGAPG LRGLPGKDGE 550 560 570 580 590 600 TGAAGPPGPS GPAGERGEQG APGPSGFQGL PGPPGPPGEG GKQGDQGIPG EAGAPGLVGP 610 620 630 640 650 660 RGERGFPGER GSPGAQGLQG PRGLPGTPGT DGPKGAAGPD GPPGAQGPPG LQGMPGERGA 670 680 690 700 710 720 AGIAGPKGDR GDVGEKGPEG APGKDGGRGL TGPIGPPGPA GANGEKGEVG PPGPSGSTGA 730 740 750 760 770 780 RGAPGERGET GPPGPAGFAG PPGADGQPGA KGDQGEAGQK GDAGAPGPQG PSGAPGPQGP 790 800 810 820 830 840 TGVTGPKGAR GAQGPPGATG FPGAAGRVGP PGANGNPGPA GPPGPAGKDG PKGVRGDSGP 850 860 870 880 890 900 PGRAGDPGLQ GPAGAPGEKG EPGDDGPSGL DGPPGPQGLA GQRGIVGLPG QRGERGFPGL 910 920 930 940 950 960 PGPSGEPGKQ GAPGASGDRG PPGPVGPPGL TGPAGEPGRE GSPGADGPPG RDGAAGVKGD 970 980 990 1000 1010 1020 RGETGALGAP GAPGPPGSPG PAGPTGKQGD RGEAGAQGPM GPSGPAGARG IAGPQGPRGD 1030 1040 1050 1060 1070 1080 KGESGEQGER GLKGHRGFTG LQGLPGPPGP SGDQGASGPA GPSGPRGPPG PVGPSGKDGS 1090 1100 1110 1120 1130 1140 NGIPGPIGPP GPRGRSGETG PVGPPGSPGP PGPPGPPGPG IDMSAFAGLG QREKGPDPMQ 1150 1160 1170 1180 1190 1200 YMRADEADST LRQHDVEVDA TLKSLNNQIE SIRSPDGSRK NPARTCQDLK LCHPEWKSGD 1210 1220 1230 1240 1250 1260 YWIDPNQGCT LDAMKVFCNM ETGETCVYPN PATVPRKNWW SSKSKEKKHI WFGETMNGGF 1270 1280 1290 1300 1310 1320 HFSYGDGNLA PNTANVQMTF LRLLSTEGSQ NITYHCKNSI AYLDEAAGNL KKALLIQGSN 1330 1340 1350 1360 1370 1380 DVEMRAEGNS RFTYTALKDG CTKHTGKWGK TVIEYRSQKT SRLPIIDIAP MDIGGAEQEF 1390 GVDIGPVCFL
	Isoform 4 [UniParc]. Checksum: 0D7D97A4DD9E1540	FASTA	1,458	139,027
	10 20 30 40 50 60 MIRLGAPQSL VLLTLLIAAV LRCQGQDAQE AGSCLQNGQR YKDKDVWKPS SCRICVCDTG 70 80 90 100 110 120 NVLCDDIICE DPDCLNPEIP FGECCPICPA DLATASGKLG PKIIGPRGPP GPQGAPGPRG 130 140 150 160 170 180 RDGEPGTPGN PGPAGPPGPP GPPGLSAGNF AAQMAGGYDE KAGGAQMGVM QGPMGPMGPR 190 200 210 220 230 240 GPPGPAGAPG PQGFQGNPGE PGEPGVSGPM GPRGPPGPAG KPGDDGEAGK PGKSGERGLP 250 260 270 280 290 300 GPQGARGFPG TPGLPGVKGH RGYPGLDGAK GEAGAPGVKG ESGSPGENGS PGPMGPRGLP 310 320 330 340 350 360 GERGRTGPAG AAGARGNDGQ PGPAGPPGPV GPAGGPGFPG APGAKGEAGP TGARGPEGAQ 370 380 390 400 410 420 GSRGEPGNPG SPGPAGASGN PGTDGIPGAK GSAGAPGIAG APGFPGPRGP PGPQGATGPL 430 440 450 460 470 480 GPKGQAGEPG IAGFKGDQGP KGETGPAGPQ GAPGPAGEEG KRGARGEPGG AGPIGPPGER 490 500 510 520 530 540 GAPGNRGFPG QDGLAGPKGA PGERGPSGLT GPKGANGDPG RPGEPGLPGA RGLTGRPGDA 550 560 570 580 590 600 GPQGKVGPSG APGEDGRPGP PGPQGARGQP GVMGFPGPKG ANGEPGKAGE KGLAGAPGLR 610 620 630 640 650 660 GLPGKDGETG AAGPPGPSGP AGERGEQGAP GPSGFQGLPG PPGPPGEGGK QGDQGIPGEA 670 680 690 700 710 720 GAPGLVGPRG ERGFPGERGS PGAQGLQGPR GLPGTPGTDG PKGAAGPDGP PGAQGPPGLQ 730 740 750 760 770 780 GMPGERGAAG IAGPKGDRGD VGEKGPEGAP GKDGGRGLTG PIGPPGPAGA NGEKGEVGPP 790 800 810 820 830 840 GPSGSTGARG APGERGETGP PGPAGFAGPP GADGQPGAKG DQGEAGQKGD AGAPGPQGPS 850 860 870 880 890 900 GAPGPQGPTG VTGPKGARGA QGPPGATGFP GAAGRVGPPG ANGNPGPAGP PGPAGKDGPK 910 920 930 940 950 960 GVRGDSGPPG RAGDPGLQGP AGAPGEKGEP GDDGPSGLDG PPGPQGLAGQ RGIVGLPGQR 970 980 990 1000 1010 1020 GERGFPGLPG PSGEPGKQGA PGASGDRGPP GPVGPPGLTG PAGEPGREGS PGADGPPGRD 1030 1040 1050 1060 1070 1080 GAAGVKGDRG ETGALGAPGA PGPPGSPGPA GPTGKQGDRG EAGAQGPMGP SGPAGARGIA 1090 1100 1110 1120 1130 1140 GPQGPRGDKG ESGEQGERGL KGHRGFTGLQ GLPGPPGPSG DQGASGPAGP SGPRGPPGPV 1150 1160 1170 1180 1190 1200 GPSGKDGSNG IPGPIGPPGP RGRSGETGPV GPPGSPGPPG PPGPPGPGID MSAFAGLGQR 1210 1220 1230 1240 1250 1260 EKGPDPMQYM RADEADSTLR QHDVEVDATL KSLNNQIESI RSPDGSRKNP ARTCQDLKLC 1270 1280 1290 1300 1310 1320 HPEWKSGDYW IDPNQGCTLD AMKVFCNMET GETCVYPNPA TVPRKNWWSS KSKEKKHIWF 1330 1340 1350 1360 1370 1380 GETMNGGFHF SYGDGNLAPN TANVQMTFLR LLSTEGSQNI TYHCKNSIAY LDEAAGNLKK 1390 1400 1410 1420 1430 1440 ALLIQGSNDV EMRAEGNSRF TYTALKDGCT KHTGKWGKTV IEYRSQKTSR LPIIDIAPMD 1450 IGGAEQEFGV DIGPVCFL
	Isoform 5 [UniParc]. Checksum: 88086B838B2876F9	FASTA	1,441	137,868
	10 20 30 40 50 60 MIRLGAPQSL VLLTLLIAAV LRCQGQDAQE AGSCLQNGQR YKDKDVWKPS SCRICVCDTG 70 80 90 100 110 120 NVLCDDIICE DPDCLNPEIP FGECCPICPA DLATASGKLG PKGQKGEPGD IRDGPAGEQG 130 140 150 160 170 180 PRGDRGDKGE KNFAAQMAGG YDEKAGGAQM GVMQGPMGPM GPRGPPGPAG APGPQGFQGN 190 200 210 220 230 240 PGEPGEPGVS GPMGPRGPPG PAGKPGDDGE AGKPGKSGER GLPGPQGARG FPGTPGLPGV 250 260 270 280 290 300 KGHRGYPGLD GAKGEAGAPG VKGESGSPGE NGSPGPMGPR GLPGERGRTG PAGAAGARGN 310 320 330 340 350 360 DGQPGPAGPP GPVGPAGGPG FPGAPGAKGE AGPTGARGPE GAQGSRGEPG NPGSPGPAGA 370 380 390 400 410 420 SGNPGTDGIP GAKGSAGAPG IAGAPGFPGP RGPPGPQGAT GPLGPKGQAG EPGIAGFKGD 430 440 450 460 470 480 QGPKGETGPA GPQGAPGPAG EEGKRGARGE PGGAGPIGPP GERGAPGNRG FPGQDGLAGP 490 500 510 520 530 540 KGAPGERGPS GLTGPKGANG DPGRPGEPGL PGARGLTGRP GDAGPQGKVG PSGAPGEDGR 550 560 570 580 590 600 PGPPGPQGAR GQPGVMGFPG PKGANGEPGK AGEKGLAGAP GLRGLPGKDG ETGAAGPPGP 610 620 630 640 650 660 SGPAGERGEQ GAPGPSGFQG LPGPPGPPGE GGKQGDQGIP GEAGAPGLVG PRGERGFPGE 670 680 690 700 710 720 RGSPGAQGLQ GPRGLPGTPG TDGPKGAAGP DGPPGAQGPP GLQGMPGERG AAGIAGPKGD 730 740 750 760 770 780 RGDVGEKGPE GAPGKDGGRG LTGPIGPPGP AGANGEKGEV GPPGPSGSTG ARGAPGERGE 790 800 810 820 830 840 TGPPGPAGFA GPPGADGQPG AKGDQGEAGQ KGDAGAPGPQ GPSGAPGPQG PTGVTGPKGA 850 860 870 880 890 900 RGAQGPPGAT GFPGAAGRVG PPGANGNPGP AGPPGPAGKD GPKGVRGDSG PPGRAGDPGL 910 920 930 940 950 960 QGPAGAPGEK GEPGDDGPSG LDGPPGPQGL AGQRGIVGLP GQRGERGFPG LPGPSGEPGK 970 980 990 1000 1010 1020 QGAPGASGDR GPPGPVGPPG LTGPAGEPGR EGSPGADGPP GRDGAAGVKG DRGETGALGA 1030 1040 1050 1060 1070 1080 PGAPGPPGSP GPAGPTGKQG DRGEAGAQGP MGPSGPAGAR GIAGPQGPRG DKGESGEQGE 1090 1100 1110 1120 1130 1140 RGLKGHRGFT GLQGLPGPPG PSGDQGASGP AGPSGPRGPP GPVGPSGKDG SNGIPGPIGP 1150 1160 1170 1180 1190 1200 PGPRGRSGET GPVGPPGSPG PPGPPGPPGP GIDMSAFAGL GQREKGPDPM QYMRADEADS 1210 1220 1230 1240 1250 1260 TLRQHDVEVD ATLKSLNNQI ESIRSPDGSR KNPARTCQDL KLCHPEWKSG DYWIDPNQGC 1270 1280 1290 1300 1310 1320 TLDAMKVFCN METGETCVYP NPATVPRKNW WSSKSKEKKH IWFGETMNGG FHFSYGDGNL 1330 1340 1350 1360 1370 1380 APNTANVQMT FLRLLSTEGS QNITYHCKNS IAYLDEAAGN LKKALLIQGS NDVEMRAEGN 1390 1400 1410 1420 1430 1440 SRFTYTALKD GCTKHTGKWG KTVIEYRSQK TSRLPIIDIA PMDIGGAEQE FGVDIGPVCF L
	Isoform 6 [UniParc]. Checksum: AB4C30D6A44C5DDE	FASTA	1,441	137,785
	10 20 30 40 50 60 MIRLGAPQSL VLLTLLIAAV LRCQGQDAQE AGSCLQNGQR YKDKDVWKPS SCRICVCDTG 70 80 90 100 110 120 NVLCDDIICE DPDCLNPEIP FGECCPICPA DLATASGKLG PKIIGPRGPP GPQGPAGEQG 130 140 150 160 170 180 PRGDRGDKGE KNFAAQMAGG YDEKAGGAQM GVMQGPMGPM GPRGPPGPAG APGPQGFQGN 190 200 210 220 230 240 PGEPGEPGVS GPMGPRGPPG PAGKPGDDGE AGKPGKSGER GLPGPQGARG FPGTPGLPGV 250 260 270 280 290 300 KGHRGYPGLD GAKGEAGAPG VKGESGSPGE NGSPGPMGPR GLPGERGRTG PAGAAGARGN 310 320 330 340 350 360 DGQPGPAGPP GPVGPAGGPG FPGAPGAKGE AGPTGARGPE GAQGSRGEPG NPGSPGPAGA 370 380 390 400 410 420 SGNPGTDGIP GAKGSAGAPG IAGAPGFPGP RGPPGPQGAT GPLGPKGQAG EPGIAGFKGD 430 440 450 460 470 480 QGPKGETGPA GPQGAPGPAG EEGKRGARGE PGGAGPIGPP GERGAPGNRG FPGQDGLAGP 490 500 510 520 530 540 KGAPGERGPS GLTGPKGANG DPGRPGEPGL PGARGLTGRP GDAGPQGKVG PSGAPGEDGR 550 560 570 580 590 600 PGPPGPQGAR GQPGVMGFPG PKGANGEPGK AGEKGLAGAP GLRGLPGKDG ETGAAGPPGP 610 620 630 640 650 660 SGPAGERGEQ GAPGPSGFQG LPGPPGPPGE GGKQGDQGIP GEAGAPGLVG PRGERGFPGE 670 680 690 700 710 720 RGSPGAQGLQ GPRGLPGTPG TDGPKGAAGP DGPPGAQGPP GLQGMPGERG AAGIAGPKGD 730 740 750 760 770 780 RGDVGEKGPE GAPGKDGGRG LTGPIGPPGP AGANGEKGEV GPPGPSGSTG ARGAPGERGE 790 800 810 820 830 840 TGPPGPAGFA GPPGADGQPG AKGDQGEAGQ KGDAGAPGPQ GPSGAPGPQG PTGVTGPKGA 850 860 870 880 890 900 RGAQGPPGAT GFPGAAGRVG PPGANGNPGP AGPPGPAGKD GPKGVRGDSG PPGRAGDPGL 910 920 930 940 950 960 QGPAGAPGEK GEPGDDGPSG LDGPPGPQGL AGQRGIVGLP GQRGERGFPG LPGPSGEPGK 970 980 990 1000 1010 1020 QGAPGASGDR GPPGPVGPPG LTGPAGEPGR EGSPGADGPP GRDGAAGVKG DRGETGALGA 1030 1040 1050 1060 1070 1080 PGAPGPPGSP GPAGPTGKQG DRGEAGAQGP MGPSGPAGAR GIAGPQGPRG DKGESGEQGE 1090 1100 1110 1120 1130 1140 RGLKGHRGFT GLQGLPGPPG PSGDQGASGP AGPSGPRGPP GPVGPSGKDG SNGIPGPIGP 1150 1160 1170 1180 1190 1200 PGPRGRSGET GPVGPPGSPG PPGPPGPPGP GIDMSAFAGL GQREKGPDPM QYMRADEADS 1210 1220 1230 1240 1250 1260 TLRQHDVEVD ATLKSLNNQI ESIRSPDGSR KNPARTCQDL KLCHPEWKSG DYWIDPNQGC 1270 1280 1290 1300 1310 1320 TLDAMKVFCN METGETCVYP NPATVPRKNW WSSKSKEKKH IWFGETMNGG FHFSYGDGNL 1330 1340 1350 1360 1370 1380 APNTANVQMT FLRLLSTEGS QNITYHCKNS IAYLDEAAGN LKKALLIQGS NDVEMRAEGN 1390 1400 1410 1420 1430 1440 SRFTYTALKD GCTKHTGKWG KTVIEYRSQK TSRLPIIDIA PMDIGGAEQE FGVDIGPVCF L
	Isoform 7 [UniParc]. Checksum: F0173B07E7C72D5C	FASTA	1,419	134,722
	10 20 30 40 50 60 MIRLGAPQSL VLLTLLIAAV LRCQGQDARK LGPKGQKGEP GDIRDIIGPR GPPGPQGPAG 70 80 90 100 110 120 EQGPRGDRGD KGEKGAPGPR GRDGEPGTPG NPGPAGPPGP PGPPGLSAGN FAAQMAGGYD 130 140 150 160 170 180 EKAGGAQMGV MQGPMGPMGP RGPPGPAGAP GPQGFQGNPG EPGEPGVSGP MGPRGPPGPA 190 200 210 220 230 240 GKPGDDGEAG KPGKSGERGL PGPQGARGFP GTPGLPGVKG HRGYPGLDGA KGEAGAPGVK 250 260 270 280 290 300 GESGSPGENG SPGPMGPRGL PGERGRTGPA GAAGARGNDG QPGPAGPPGP VGPAGGPGFP 310 320 330 340 350 360 GAPGAKGEAG PTGARGPEGA QGSRGEPGNP GSPGPAGASG NPGTDGIPGA KGSAGAPGIA 370 380 390 400 410 420 GAPGFPGPRG PPGPQGATGP LGPKGQAGEP GIAGFKGDQG PKGETGPAGP QGAPGPAGEE 430 440 450 460 470 480 GKRGARGEPG GAGPIGPPGE RGAPGNRGFP GQDGLAGPKG APGERGPSGL TGPKGANGDP 490 500 510 520 530 540 GRPGEPGLPG ARGLTGRPGD AGPQGKVGPS GAPGEDGRPG PPGPQGARGQ PGVMGFPGPK 550 560 570 580 590 600 GANGEPGKAG EKGLAGAPGL RGLPGKDGET GAAGPPGPSG PAGERGEQGA PGPSGFQGLP 610 620 630 640 650 660 GPPGPPGEGG KQGDQGIPGE AGAPGLVGPR GERGFPGERG SPGAQGLQGP RGLPGTPGTD 670 680 690 700 710 720 GPKGAAGPDG PPGAQGPPGL QGMPGERGAA GIAGPKGDRG DVGEKGPEGA PGKDGGRGLT 730 740 750 760 770 780 GPIGPPGPAG ANGEKGEVGP PGPSGSTGAR GAPGERGETG PPGPAGFAGP PGADGQPGAK 790 800 810 820 830 840 GDQGEAGQKG DAGAPGPQGP SGAPGPQGPT GVTGPKGARG AQGPPGATGF PGAAGRVGPP 850 860 870 880 890 900 GANGNPGPAG PPGPAGKDGP KGVRGDSGPP GRAGDPGLQG PAGAPGEKGE PGDDGPSGLD 910 920 930 940 950 960 GPPGPQGLAG QRGIVGLPGQ RGERGFPGLP GPSGEPGKQG APGASGDRGP PGPVGPPGLT 970 980 990 1000 1010 1020 GPAGEPGREG SPGADGPPGR DGAAGVKGDR GETGALGAPG APGPPGSPGP AGPTGKQGDR 1030 1040 1050 1060 1070 1080 GEAGAQGPMG PSGPAGARGI AGPQGPRGDK GESGEQGERG LKGHRGFTGL QGLPGPPGPS 1090 1100 1110 1120 1130 1140 GDQGASGPAG PSGPRGPPGP VGPSGKDGSN GIPGPIGPPG PRGRSGETGP VGPPGSPGPP 1150 1160 1170 1180 1190 1200 GPPGPPGPGI DMSAFAGLGQ REKGPDPMQY MRADEADSTL RQHDVEVDAT LKSLNNQIES 1210 1220 1230 1240 1250 1260 IRSPDGSRKN PARTCQDLKL CHPEWKSGDY WIDPNQGCTL DAMKVFCNME TGETCVYPNP 1270 1280 1290 1300 1310 1320 ATVPRKNWWS SKSKEKKHIW FGETMNGGFH FSYGDGNLAP NTANVQMTFL RLLSTEGSQN 1330 1340 1350 1360 1370 1380 ITYHCKNSIA YLDEAAGNLK KALLIQGSND VEMRAEGNSR FTYTALKDGC TKHTGKWGKT 1390 1400 1410 VIEYRSQKTS RLPIIDIAPM DIGGAEQEFG VDIGPVCFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse type II collagen gene. Complete nucleotide sequence, exon structure, and alternative splicing." Metsaeranta M., Toman D., de Crombrugghe B., Vuorio E. J. Biol. Chem. 266:16862-16869(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 7). Strain: C57BL/6. Tissue: Brain, Eye and Olfactory epithelium.
[3]	"Expression of the mouse alpha 1(II) collagen gene is not restricted to cartilage during development." Cheah K.S., Lau E.T., Au P.K., Tam P.P. Development 111:945-953(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28, DEVELOPMENTAL STAGE.
[4]	"The mouse Col2a-1 gene is highly conserved and is linked to Int-1 on chromosome 15." Cheah K.S., Au P.K., Lau E.T., Little P.F., Stubbs L. Mamm. Genome 1:171-183(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28; 1031-1145 AND 1359-1487.
[5]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 597-1487. Strain: C57BL/6J. Tissue: Head.
[6]	"Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs." Metsaeranta M., Toman D., de Crombrugghe B., Vuorio E. Biochim. Biophys. Acta 1089:241-243(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1483-1487.
[7]	"A missense mutation in the mouse Col2a1 gene causes spondyloepiphyseal dysplasia congenita, hearing loss, and retinoschisis." Donahue L.R., Chang B., Mohan S., Miyakoshi N., Wergedal J.E., Baylink D.J., Hawes N.L., Rosen C.J., Ward-Bailey P., Zheng Q.Y., Bronson R.T., Johnson K.R., Davisson M.T. J. Bone Miner. Res. 18:1612-1621(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT SEDC CYS-989.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M65161 Genomic DNA. Translation: AAA68099.1.
M65161 Genomic DNA. Translation: AAA68100.1.
M65161 Genomic DNA. Translation: AAA68101.1.
M65161 Genomic DNA. Translation: AAA68102.1.
BC030913 mRNA. Translation: AAH30913.1.
BC051383 mRNA. Translation: AAH51383.1.
BC052326 mRNA. Translation: AAH52326.1.
BC082331 mRNA. Translation: AAH82331.1.
S63190 Genomic DNA. Translation: AAB19627.1.
M63708 Genomic DNA. Translation: AAA37436.1.
M63709 Genomic DNA. Translation: AAC06113.1.
M63710 Genomic DNA. Translation: AAA37435.1.
AK028295 mRNA. Translation: BAC25865.1. Different initiation.
X57982 Genomic DNA. Translation: CAA41047.1.

IPI

IPI00471183.
IPI00621255.
IPI00622890.
IPI00623625.
IPI00828467.
IPI00828653.
IPI00828753.

PIR

A41182.
B41182.

RefSeq

NP_001106987.2. NM_001113515.2.
NP_112440.2. NM_031163.3.

UniGene

Mm.2423.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2W65	X-ray	2.21	E	530-538	[»]

ProteinModelPortal

P28481.

SMR

P28481. Positions 29-96, 1271-1487.

ModBase

Search...

Protein-protein interaction databases

IntAct

P28481. 1 interaction.

PTM databases

PhosphoSite

P28481.

Proteomic databases

PaxDb

P28481.

PRIDE

P28481.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000023123; ENSMUSP00000023123; ENSMUSG00000022483.
ENSMUST00000088355; ENSMUSP00000085693; ENSMUSG00000022483.

GeneID

12824.

KEGG

mmu:12824.

UCSC

uc007xlp.2. mouse.
uc007xlq.2. mouse.

Organism-specific databases

CTD

1280.

MGI

MGI:88452. Col2a1.

Phylogenomic databases

eggNOG

NOG12793.

GeneTree

ENSGT00660000095287.

HOVERGEN

HBG004933.

InParanoid

P28481.

KO

K06236.

OMA

SSCRICV.

OrthoDB

EOG4FTW1C.

Gene expression databases

ArrayExpress

P28481.

Bgee

P28481.

CleanEx

MM_COL2A1.

Genevestigator

P28481.

GermOnline

ENSMUSG00000022483. Mus musculus.

Family and domain databases

InterPro

IPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR001007. VWF_C.
[Graphical view]

Pfam

PF01410. COLFI. 1 hit.
PF01391. Collagen. 11 hits.
PF00093. VWC. 1 hit.
[Graphical view]

ProDom

PD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00038. COLFI. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]

PROSITE

PS51461. NC1_FIB. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

ProtoNet

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Other

ChiTaRS

COL2A1. mouse.

EvolutionaryTrace

P28481.

NextBio

282306.

SOURCE

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Entry information

Entry name

CO2A1_MOUSE

Accession

Primary (citable) accession number: P28481
Secondary accession number(s): Q61428 , Q62031, Q62032, Q62033, Q641K3, Q6LDB1, Q6LDI8, Q6LDI9, Q80VY3, Q80X38, Q8CEF7, Q8K0N6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 131 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program