Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P28476

- GBRR2_HUMAN

UniProt

P28476 - GBRR2_HUMAN

Protein

Gamma-aminobutyric acid receptor subunit rho-2

Gene

GABRR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 5 (31 Oct 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission.

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB-KW
    2. extracellular ligand-gated ion channel activity Source: InterPro
    3. GABA-A receptor activity Source: ProtInc

    GO - Biological processi

    1. gamma-aminobutyric acid signaling pathway Source: Ensembl
    2. ion transmembrane transport Source: Reactome
    3. signal transduction Source: ProtInc
    4. synaptic transmission Source: Reactome
    5. transmembrane transport Source: Reactome
    6. transport Source: ProtInc
    7. visual perception Source: Ensembl

    Keywords - Molecular functioni

    Chloride channel, Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_25168. GABA A (rho) receptor activation.
    REACT_25387. Ligand-gated ion channel transport.
    SignaLinkiP28476.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit rho-2
    Alternative name(s):
    GABA(A) receptor subunit rho-2
    GABA(C) receptor
    Gene namesi
    Name:GABRR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4091. GABRR2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: Reactome
    5. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28506.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 465445Gamma-aminobutyric acid receptor subunit rho-2PRO_0000000488Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi178 ↔ 192By similarity
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP28476.
    PRIDEiP28476.

    PTM databases

    PhosphoSiteiP28476.

    Expressioni

    Gene expression databases

    ArrayExpressiP28476.
    BgeeiP28476.
    GenevestigatoriP28476.

    Organism-specific databases

    HPAiHPA016467.

    Interactioni

    Subunit structurei

    Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000386029.

    Structurei

    3D structure databases

    ProteinModelPortaliP28476.
    SMRiP28476. Positions 64-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 260240ExtracellularCuratedAdd
    BLAST
    Topological domaini347 – 44397CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei261 – 28121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei444 – 46421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77438.
    HOGENOMiHOG000231335.
    HOVERGENiHBG051707.
    InParanoidiP28476.
    KOiK05190.
    OMAiDEHDFSM.
    OrthoDBiEOG712TVZ.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR008059. GABAAa_rho2_rcpt.
    IPR008057. GABAAa_rho_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00253. GABAARECEPTR.
    PR01670. GABAARRHO.
    PR01672. GABAARRHO2.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform 1 (identifier: P28476-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPYFTRLILF LFCLMVLVES RKPKRKRWTG QVEMPKPSHL YKKNLDVTKI    50
    RKGKPQQLLR VDEHDFSMRP AFGGPAIPVG VDVQVESLDS ISEVDMDFTM 100
    TLYLRHYWKD ERLAFSSASN KSMTFDGRLV KKIWVPDVFF VHSKRSFTHD 150
    TTTDNIMLRV FPDGHVLYSM RITVTAMCNM DFSHFPLDSQ TCSLELESYA 200
    YTDEDLMLYW KNGDESLKTD EKISLSQFLI QKFHTTSRLA FYSSTGWYNR 250
    LYINFTLRRH IFFFLLQTYF PATLMVMLSW VSFWIDRRAV PARVSLGITT 300
    VLTMTTIITG VNASMPRVSY VKAVDIYLWV SFVFVFLSVL EYAAVNYLTT 350
    VQERKERKLR EKFPCMCGML HSKTMMLDGS YSESEANSLA GYPRSHILTE 400
    EERQDKIVVH LGLSGEANAA RKKGLLKGQT GFRIFQNTHA IDKYSRLIFP 450
    ASYIFFNLIY WSVFS 465
    Length:465
    Mass (Da):54,151
    Last modified:October 31, 2012 - v5
    Checksum:i209700077636A395
    GO
    Isoform 2 (identifier: P28476-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MVKPGGICSATGYWKAAFCLTDVHKM

    Note: Isoform 2 could be translated from an upstream initiator ATG located in frame within the first coding exon. The probability of a signal peptide within this isoform is very low. No experimental confirmation available.

    Show »
    Length:490
    Mass (Da):56,817
    Checksum:i18F3AF79BD2D2B13
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti209 – 2091Y → H in AAA52510. (PubMed:1315307)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MVKPGGICSATGYWKAAFCL TDVHKM in isoform 2. CuratedVSP_044373

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86868 mRNA. Translation: AAA52510.1.
    AL121833 Genomic DNA. Translation: CAC07339.2.
    BC130352 mRNA. Translation: AAI30353.1.
    BC130354 mRNA. Translation: AAI30355.1.
    CCDSiCCDS5020.3. [P28476-1]
    PIRiA38079.
    RefSeqiNP_002034.3. NM_002043.3. [P28476-1]
    UniGeneiHs.719891.

    Genome annotation databases

    EnsembliENST00000402938; ENSP00000386029; ENSG00000111886. [P28476-1]
    GeneIDi2570.
    KEGGihsa:2570.
    UCSCiuc003pnb.3. human. [P28476-1]

    Polymorphism databases

    DMDMi410516956.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86868 mRNA. Translation: AAA52510.1 .
    AL121833 Genomic DNA. Translation: CAC07339.2 .
    BC130352 mRNA. Translation: AAI30353.1 .
    BC130354 mRNA. Translation: AAI30355.1 .
    CCDSi CCDS5020.3. [P28476-1 ]
    PIRi A38079.
    RefSeqi NP_002034.3. NM_002043.3. [P28476-1 ]
    UniGenei Hs.719891.

    3D structure databases

    ProteinModelPortali P28476.
    SMRi P28476. Positions 64-353.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000386029.

    Chemistry

    BindingDBi P28476.
    ChEMBLi CHEMBL2109242.
    DrugBanki DB00546. Adinazolam.
    DB01558. Bromazepam.
    DB01594. Cinolazepam.
    DB01559. Clotiazepam.
    DB00829. Diazepam.
    DB01215. Estazolam.
    DB01567. Fludiazepam.
    DB00690. Flurazepam.
    DB00801. Halazepam.
    DB00683. Midazolam.
    DB01595. Nitrazepam.
    DB00842. Oxazepam.
    DB01588. Prazepam.
    DB01589. Quazepam.
    DB00231. Temazepam.
    DB00897. Triazolam.
    GuidetoPHARMACOLOGYi 421.

    PTM databases

    PhosphoSitei P28476.

    Polymorphism databases

    DMDMi 410516956.

    Proteomic databases

    PaxDbi P28476.
    PRIDEi P28476.

    Protocols and materials databases

    DNASUi 2570.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000402938 ; ENSP00000386029 ; ENSG00000111886 . [P28476-1 ]
    GeneIDi 2570.
    KEGGi hsa:2570.
    UCSCi uc003pnb.3. human. [P28476-1 ]

    Organism-specific databases

    CTDi 2570.
    GeneCardsi GC06M089967.
    H-InvDB HIX0200918.
    HGNCi HGNC:4091. GABRR2.
    HPAi HPA016467.
    MIMi 137162. gene.
    neXtProti NX_P28476.
    PharmGKBi PA28506.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77438.
    HOGENOMi HOG000231335.
    HOVERGENi HBG051707.
    InParanoidi P28476.
    KOi K05190.
    OMAi DEHDFSM.
    OrthoDBi EOG712TVZ.
    TreeFami TF315453.

    Enzyme and pathway databases

    Reactomei REACT_25168. GABA A (rho) receptor activation.
    REACT_25387. Ligand-gated ion channel transport.
    SignaLinki P28476.

    Miscellaneous databases

    ChiTaRSi GABRR2. human.
    GeneWikii GABRR2.
    GenomeRNAii 2570.
    NextBioi 10165.
    PROi P28476.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28476.
    Bgeei P28476.
    Genevestigatori P28476.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR008059. GABAAa_rho2_rcpt.
    IPR008057. GABAAa_rho_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00253. GABAARECEPTR.
    PR01670. GABAARRHO.
    PR01672. GABAARRHO2.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4."
      Cutting G.R., Curristin S., Zoghbi H., O'Hara B., Seldin M.F., Uhl G.R.
      Genomics 12:801-806(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiGBRR2_HUMAN
    AccessioniPrimary (citable) accession number: P28476
    Secondary accession number(s): A2BDE4, Q9H153
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 149 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3