Gamma-aminobutyric acid receptor subunit gamma-3 precursor

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P28473 (GBRG3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor subunit gamma-3

Alternative name(s):
GABA(A) receptor subunit gamma-3

Gene names

Name:

Gabrg3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subunit structure	Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Post-translational modification	May be palmitoylated By similarity.
Miscellaneous	This subunit carries the benzodiazepine binding site.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ion channel
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gamma-aminobutyric acid signaling pathway Traceable author statement Ref.1. Source: RGD response to drug Inferred from direct assay Ref.1. Source: RGD
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GABA-A receptor activity Inferred from direct assay Ref.1. Source: RGD chloride channel activity Inferred from direct assay Ref.1. Source: RGD extracellular ligand-gated ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 17

Potential

Chain

18 – 467

450

Gamma-aminobutyric acid receptor subunit gamma-3

PRO_0000000483

Regions

Topological domain

18 – 254

237

Extracellular Probable

Transmembrane

255 – 277

Helical; Probable

Transmembrane

281 – 303

Helical; Probable

Transmembrane

315 – 337

Helical; Probable

Topological domain

338 – 443

106

Cytoplasmic Probable

Transmembrane

444 – 467

Helical; Probable

Amino acid modifications

Glycosylation

110

N-linked (GlcNAc...) Potential

Glycosylation

228

N-linked (GlcNAc...) Potential

Disulfide bond

171 ↔ 185

By similarity

Experimental info

Sequence conflict

416

S → T in CAA44930. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P28473 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 14959F565649D67D
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FASTA

467

54,293

        10         20         30         40         50         60 
MAAKLLLLLC LFSGLHARSR RVEEDDSEDS PSNQKWVLAP KSQDTDVTLI LNKLLREYDK 

        70         80         90        100        110        120 
KLRPDIGIKP TVIDVDIYVN SIGPVSSINM EYQIDIFFAQ TWTDSRLRFN STMKILTLNS 

       130        140        150        160        170        180 
NMVGLIWIPD TIFRNSKTAE AHWITTPNQL LRIWNDGKIL YTLRLTINAE CQLQLHNFPM 

       190        200        210        220        230        240 
DAHACPLTFS SYGYPKEEMI YRWRKNSVEA ADQKSWRLYQ FDFMGLRNTT EIVTTSAGDY 

       250        260        270        280        290        300 
VVMTIYFELS RRMGYFTIQT YIPCILTVVL SWVSFWIKKD ATPARTTLGI TTVLTMTTLS 

       310        320        330        340        350        360 
TIARKSLPRV SYVTAMDLFV TVCFLFVFAA LMEYATLNYY SSCRKPTIRK KKTSLLHPDS 

       370        380        390        400        410        420 
TRWIPDRISL QAPSNYSLLD MRPPPPVMIT LNNSMYWQEF EDTCVYECLD GKDCQSFFCC 

       430        440        450        460 
YEECKSGSWR RGRIHIDVSE LDSYSRVFFP TSFLLFNLVY WVGYLYL

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References

[1]	"The third gamma subunit of the gamma-aminobutyric acid type A receptor family." Herb A., Wisden W., Lueddens H., Puia G., Vicini S., Seeburg P.H. Proc. Natl. Acad. Sci. U.S.A. 89:1433-1437(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The gamma 3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands." Knoflach F., Rhyner T., Villa M., Kellenberger S., Drescher U., Malherbe P., Sigel E., Moehler H. FEBS Lett. 293:191-194(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ZUR-SIV. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M81142 mRNA. Translation: AAA41181.1. X63324 mRNA. Translation: CAA44930.1.
IPI	IPI00200810.
PIR	S19317.
RefSeq	NP_077346.3. NM_024370.3.
UniGene	Rn.10369.
3D structure databases
ProteinModelPortal	P28473.
SMR	P28473. Positions 283-341.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000019971.
Proteomic databases
PaxDb	P28473.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	79211.
KEGG	rno:79211.
UCSC	RGD:621735. rat.
Organism-specific databases
CTD	2567.
RGD	621735. Gabrg3.
Phylogenomic databases
eggNOG	NOG300758.
HOGENOM	HOG000231337.
HOVERGEN	HBG051707.
InParanoid	P28473.
KO	K05186.
OMA	RGRIHID.
Gene expression databases
ArrayExpress	P28473.
Genevestigator	P28473.
GermOnline	ENSRNOG00000014862. Rattus norvegicus.
Family and domain databases
Gene3D	2.70.170.10. 1 hit.
InterPro	IPR006028. GABAA_rcpt. IPR005440. GABBAg3_rcpt. IPR005437. GABBAg_rcpt. IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. [Graphical view]
PANTHER	PTHR18945. PTHR18945. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR00253. GABAARECEPTR. PR01620. GABAARGAMMA. PR01623. GABAARGAMMA3. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P28473.
ChEMBL	CHEMBL336.
NextBio	614604.

Entry information

Entry name

GBRG3_RAT

Accession

Primary (citable) accession number: P28473

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents