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Protein

Gamma-aminobutyric acid receptor subunit gamma-3

Gene

Gabrg3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  • chloride channel activity Source: RGD
  • extracellular ligand-gated ion channel activity Source: InterPro
  • GABA-A receptor activity Source: RGD

GO - Biological processi

  • chloride transmembrane transport Source: GOC
  • gamma-aminobutyric acid signaling pathway Source: RGD
  • response to drug Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit gamma-3
Alternative name(s):
GABA(A) receptor subunit gamma-3
Gene namesi
Name:Gabrg3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621735. Gabrg3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 254237ExtracellularCuratedAdd
BLAST
Transmembranei255 – 27723HelicalCuratedAdd
BLAST
Transmembranei281 – 30323HelicalCuratedAdd
BLAST
Transmembranei315 – 33723HelicalCuratedAdd
BLAST
Topological domaini338 – 443106CytoplasmicCuratedAdd
BLAST
Transmembranei444 – 46724HelicalCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1907607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 467450Gamma-aminobutyric acid receptor subunit gamma-3PRO_0000000483Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence analysis
Disulfide bondi171 ↔ 185By similarity
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

May be palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP28473.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019971.

Structurei

3D structure databases

ProteinModelPortaliP28473.
SMRiP28473. Positions 283-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP28473.
KOiK05186.
OrthoDBiEOG7JX342.
PhylomeDBiP28473.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR005440. GABBAg3_rcpt.
IPR005437. GABBAg_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01620. GABAARGAMMA.
PR01623. GABAARGAMMA3.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKLLLLLC LFSGLHARSR RVEEDDSEDS PSNQKWVLAP KSQDTDVTLI
60 70 80 90 100
LNKLLREYDK KLRPDIGIKP TVIDVDIYVN SIGPVSSINM EYQIDIFFAQ
110 120 130 140 150
TWTDSRLRFN STMKILTLNS NMVGLIWIPD TIFRNSKTAE AHWITTPNQL
160 170 180 190 200
LRIWNDGKIL YTLRLTINAE CQLQLHNFPM DAHACPLTFS SYGYPKEEMI
210 220 230 240 250
YRWRKNSVEA ADQKSWRLYQ FDFMGLRNTT EIVTTSAGDY VVMTIYFELS
260 270 280 290 300
RRMGYFTIQT YIPCILTVVL SWVSFWIKKD ATPARTTLGI TTVLTMTTLS
310 320 330 340 350
TIARKSLPRV SYVTAMDLFV TVCFLFVFAA LMEYATLNYY SSCRKPTIRK
360 370 380 390 400
KKTSLLHPDS TRWIPDRISL QAPSNYSLLD MRPPPPVMIT LNNSMYWQEF
410 420 430 440 450
EDTCVYECLD GKDCQSFFCC YEECKSGSWR RGRIHIDVSE LDSYSRVFFP
460
TSFLLFNLVY WVGYLYL
Length:467
Mass (Da):54,293
Last modified:December 1, 1992 - v1
Checksum:i14959F565649D67D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti416 – 4161S → T in CAA44930 (PubMed:1660002).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81142 mRNA. Translation: AAA41181.1.
X63324 mRNA. Translation: CAA44930.1.
PIRiS19317.
RefSeqiNP_077346.3. NM_024370.3.
UniGeneiRn.10369.

Genome annotation databases

GeneIDi79211.
KEGGirno:79211.
UCSCiRGD:621735. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81142 mRNA. Translation: AAA41181.1.
X63324 mRNA. Translation: CAA44930.1.
PIRiS19317.
RefSeqiNP_077346.3. NM_024370.3.
UniGeneiRn.10369.

3D structure databases

ProteinModelPortaliP28473.
SMRiP28473. Positions 283-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019971.

Chemistry

ChEMBLiCHEMBL1907607.

Proteomic databases

PaxDbiP28473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79211.
KEGGirno:79211.
UCSCiRGD:621735. rat.

Organism-specific databases

CTDi2567.
RGDi621735. Gabrg3.

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP28473.
KOiK05186.
OrthoDBiEOG7JX342.
PhylomeDBiP28473.
TreeFamiTF315453.

Miscellaneous databases

PROiP28473.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR005440. GABBAg3_rcpt.
IPR005437. GABBAg_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01620. GABAARGAMMA.
PR01623. GABAARGAMMA3.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The third gamma subunit of the gamma-aminobutyric acid type A receptor family."
    Herb A., Wisden W., Lueddens H., Puia G., Vicini S., Seeburg P.H.
    Proc. Natl. Acad. Sci. U.S.A. 89:1433-1437(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The gamma 3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands."
    Knoflach F., Rhyner T., Villa M., Kellenberger S., Drescher U., Malherbe P., Sigel E., Moehler H.
    FEBS Lett. 293:191-194(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ZUR-SIV.
    Tissue: Brain.

Entry informationi

Entry nameiGBRG3_RAT
AccessioniPrimary (citable) accession number: P28473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 8, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This subunit carries the benzodiazepine binding site.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.