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P28471

- GBRA4_RAT

UniProt

P28471 - GBRA4_RAT

Protein

Gamma-aminobutyric acid receptor subunit alpha-4

Gene

Gabra4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB-KW
    2. extracellular ligand-gated ion channel activity Source: InterPro
    3. GABA-A receptor activity Source: RGD

    GO - Biological processi

    1. central nervous system development Source: Ensembl
    2. gamma-aminobutyric acid signaling pathway Source: InterPro
    3. regulation of response to drug Source: Ensembl

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_199021. GABA A receptor activation.
    REACT_199029. Ligand-gated ion channel transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit alpha-4
    Alternative name(s):
    GABA(A) receptor subunit alpha-4
    Gene namesi
    Name:Gabra4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 14

    Organism-specific databases

    RGDi621670. Gabra4.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 552517Gamma-aminobutyric acid receptor subunit alpha-4PRO_0000000443Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi172 ↔ 186By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP28471.
    PRIDEiP28471.

    PTM databases

    PhosphoSiteiP28471.

    Expressioni

    Gene expression databases

    GenevestigatoriP28471.

    Interactioni

    Subunit structurei

    Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000003191.

    Structurei

    3D structure databases

    ProteinModelPortaliP28471.
    SMRiP28471. Positions 285-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini36 – 258223ExtracellularCuratedAdd
    BLAST
    Topological domaini341 – 521181CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei259 – 28022HelicalCuratedAdd
    BLAST
    Transmembranei285 – 30622HelicalCuratedAdd
    BLAST
    Transmembranei318 – 34023HelicalCuratedAdd
    BLAST
    Transmembranei522 – 54120HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238757.
    GeneTreeiENSGT00550000074441.
    HOVERGENiHBG051707.
    KOiK05175.
    OMAiPNPFSHA.
    OrthoDBiEOG7JX342.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005434. GABBAa4_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR01079. GABAARALPHA.
    PR01617. GABAARALPHA4.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 2 hits.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28471-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSVQKVPAI VLCSGVSLAL LHVLCLATCL NESPGQNSKD EKLCPENFTR    50
    ILDSLLDGYD NRLRPGFGGP VTEVKTDIYV TSFGPVSDVE MEYTMDVFFR 100
    QTWIDKRLKY DGPIEILRLN NMMVTKVWTP DTFFRNGKKS VSHNMTAPNK 150
    LFRIMRNGTI LYTMRLTISA ECPMRLVDFP MDGHACPLKF GSYAYPKSEM 200
    IYTWTKGPEK SVEVPKESSS LVQYDLIGQT VSSETIKSIT GEYIVMTVYF 250
    HLRRKMGYFM IQTYIPCIMT VILSQVSFWI NKESVPARTV FGITTVLTMT 300
    TLSISARHSL PKVSYATAMD WFIAVCFAFV FSALIEFAAV NYFTNIQMQK 350
    AKKKISKPPP EVPAAPVLKE KHTETSLQNT HANLNMRKRT NALVHSESDV 400
    NSRTEVGNHS SKTTAAQESS ETTPKAHLAS SPNPFSRANA AETISAAARG 450
    LSSAASPSPH GTLQPAPLRS ASARPAFGAR LGRIKTTVNT TGVPGNVSAT 500
    PPPSAPPPSG SGTSKIDKYA RILFPVTFGA FNMVYWVVYL SKDTMEKSES 550
    LM 552
    Length:552
    Mass (Da):60,951
    Last modified:December 1, 1992 - v1
    Checksum:i3823335C3554115D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08493 Genomic DNA. Translation: AAC42032.1.
    S55933 mRNA. Translation: AAB19902.1.
    PIRiS17551.
    RefSeqiNP_542154.3. NM_080587.3.
    UniGeneiRn.81205.

    Genome annotation databases

    EnsembliENSRNOT00000003191; ENSRNOP00000003191; ENSRNOG00000002336.
    GeneIDi140675.
    KEGGirno:140675.
    UCSCiRGD:621670. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08493 Genomic DNA. Translation: AAC42032.1 .
    S55933 mRNA. Translation: AAB19902.1 .
    PIRi S17551.
    RefSeqi NP_542154.3. NM_080587.3.
    UniGenei Rn.81205.

    3D structure databases

    ProteinModelPortali P28471.
    SMRi P28471. Positions 285-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000003191.

    Chemistry

    BindingDBi P28471.
    ChEMBLi CHEMBL2096683.
    GuidetoPHARMACOLOGYi 407.

    PTM databases

    PhosphoSitei P28471.

    Proteomic databases

    PaxDbi P28471.
    PRIDEi P28471.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000003191 ; ENSRNOP00000003191 ; ENSRNOG00000002336 .
    GeneIDi 140675.
    KEGGi rno:140675.
    UCSCi RGD:621670. rat.

    Organism-specific databases

    CTDi 2557.
    RGDi 621670. Gabra4.

    Phylogenomic databases

    eggNOGi NOG238757.
    GeneTreei ENSGT00550000074441.
    HOVERGENi HBG051707.
    KOi K05175.
    OMAi PNPFSHA.
    OrthoDBi EOG7JX342.

    Enzyme and pathway databases

    Reactomei REACT_199021. GABA A receptor activation.
    REACT_199029. Ligand-gated ion channel transport.

    Miscellaneous databases

    NextBioi 620671.

    Gene expression databases

    Genevestigatori P28471.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005434. GABBAa4_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR01079. GABAARALPHA.
    PR01617. GABAARALPHA4.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 2 hits.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunit."
      Wisden W., Herb A., Wieland H., Keinaenen K., Lueddens H., Seeburg P.H.
      FEBS Lett. 289:227-230(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGBRA4_RAT
    AccessioniPrimary (citable) accession number: P28471
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3