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P28470

- CANB2_RAT

UniProt

P28470 - CANB2_RAT

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Protein

Calcineurin subunit B type 2

Gene

Ppp3r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi31 – 42121Add
BLAST
Calcium bindingi63 – 74122Add
BLAST
Calcium bindingi100 – 111123Add
BLAST
Calcium bindingi141 – 152124Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_242934. DARPP-32 events.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin subunit B type 2
Alternative name(s):
Calcineurin B-like protein
Short name:
CBLP
Protein phosphatase 2B regulatory subunit 2
Protein phosphatase 3 regulatory subunit B beta isoform
Gene namesi
Name:Ppp3r2
Synonyms:Cblp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi69232. Ppp3r2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 176175Calcineurin subunit B type 2PRO_0000073501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PRIDEiP28470.

PTM databases

PhosphoSiteiP28470.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

GenevestigatoriP28470.

Interactioni

Subunit structurei

Composed of a catalytic subunit (A) and a regulatory subunit (B).

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007290.

Structurei

3D structure databases

ProteinModelPortaliP28470.
SMRiP28470. Positions 2-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 5336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini87 – 12236EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini128 – 16336EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000119179.
HOGENOMiHOG000233019.
HOVERGENiHBG105307.
InParanoidiP28470.
KOiK06268.
OMAiNNLKDWQ.
OrthoDBiEOG75QR5D.
PhylomeDBiP28470.
TreeFamiTF105558.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00036. EF-hand_1. 2 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28470-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNEASYHSE MGTHFDHDEI KRLGRSFKKM DLDKSGSLSV DEFMSLPELQ
60 70 80 90 100
QNPLVGRVID IFDTDGNGEV DFREFIVGTS QFSVKGDEEQ KLRFAFRIYD
110 120 130 140 150
MDNDGFISNG ELFQVLKMMV GNNLKDWQLQ QLVDKSILVL DKDGDGRISF
160 170
EEFRDVVRTM EIHKKLVVFV DHGQED
Length:176
Mass (Da):20,291
Last modified:January 23, 2007 - v2
Checksum:iEE6D69DE1C8BF179
GO

Sequence cautioni

The sequence AAB20281.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10393 mRNA. Translation: BAA01232.1.
S63991 mRNA. Translation: AAB20281.1. Different initiation.
PIRiJQ1232.
PS0261.
RefSeqiNP_067733.1. NM_021701.2.
UniGeneiRn.42928.

Genome annotation databases

EnsembliENSRNOT00000007290; ENSRNOP00000007290; ENSRNOG00000005368.
GeneIDi29749.
KEGGirno:29749.
UCSCiRGD:69232. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10393 mRNA. Translation: BAA01232.1 .
S63991 mRNA. Translation: AAB20281.1 . Different initiation.
PIRi JQ1232.
PS0261.
RefSeqi NP_067733.1. NM_021701.2.
UniGenei Rn.42928.

3D structure databases

ProteinModelPortali P28470.
SMRi P28470. Positions 2-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000007290.

PTM databases

PhosphoSitei P28470.

Proteomic databases

PRIDEi P28470.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000007290 ; ENSRNOP00000007290 ; ENSRNOG00000005368 .
GeneIDi 29749.
KEGGi rno:29749.
UCSCi RGD:69232. rat.

Organism-specific databases

CTDi 5535.
RGDi 69232. Ppp3r2.

Phylogenomic databases

eggNOGi COG5126.
GeneTreei ENSGT00760000119179.
HOGENOMi HOG000233019.
HOVERGENi HBG105307.
InParanoidi P28470.
KOi K06268.
OMAi NNLKDWQ.
OrthoDBi EOG75QR5D.
PhylomeDBi P28470.
TreeFami TF105558.

Enzyme and pathway databases

Reactomei REACT_242934. DARPP-32 events.

Miscellaneous databases

NextBioi 610273.
PROi P28470.

Gene expression databases

Genevestigatori P28470.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF00036. EF-hand_1. 2 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 4 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of a novel testis-specific calcineurin B-like protein."
    Mukai H., Chang C.D., Tanaka H., Ito A., Kuno T., Tanaka C.
    Biochem. Biophys. Res. Commun. 179:1325-1330(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.

Entry informationi

Entry nameiCANB2_RAT
AccessioniPrimary (citable) accession number: P28470
Secondary accession number(s): Q63878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3