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P28470 (CANB2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcineurin subunit B type 2
Alternative name(s):
Calcineurin B-like protein
Short name=CBLP
Protein phosphatase 2B regulatory subunit 2
Protein phosphatase 3 regulatory subunit B beta isoform
Gene names
Name:Ppp3r2
Synonyms:Cblp
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Subunit structure

Composed of a catalytic subunit (A) and a regulatory subunit (B).

Tissue specificity

Testis specific. Ref.1

Miscellaneous

This protein has four functional calcium-binding sites.

Sequence similarities

Belongs to the calcineurin regulatory subunit family.

Contains 4 EF-hand domains.

Sequence caution

The sequence AAB20281.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   DomainRepeat
   LigandCalcium
Metal-binding
   PTMLipoprotein
Myristate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytosol

Traceable author statement. Source: Reactome

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 176175Calcineurin subunit B type 2
PRO_0000073501

Regions

Domain18 – 5336EF-hand 1
Domain50 – 8536EF-hand 2
Domain87 – 12236EF-hand 3
Domain128 – 16336EF-hand 4
Calcium binding31 – 42121
Calcium binding63 – 74122
Calcium binding100 – 111123
Calcium binding141 – 152124

Amino acid modifications

Lipidation21N-myristoyl glycine By similarity

Sequences

Sequence LengthMass (Da)Tools
P28470 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: EE6D69DE1C8BF179

FASTA17620,291
        10         20         30         40         50         60 
MGNEASYHSE MGTHFDHDEI KRLGRSFKKM DLDKSGSLSV DEFMSLPELQ QNPLVGRVID 

        70         80         90        100        110        120 
IFDTDGNGEV DFREFIVGTS QFSVKGDEEQ KLRFAFRIYD MDNDGFISNG ELFQVLKMMV 

       130        140        150        160        170 
GNNLKDWQLQ QLVDKSILVL DKDGDGRISF EEFRDVVRTM EIHKKLVVFV DHGQED 

« Hide

References

[1]"cDNA cloning of a novel testis-specific calcineurin B-like protein."
Mukai H., Chang C.D., Tanaka H., Ito A., Kuno T., Tanaka C.
Biochem. Biophys. Res. Commun. 179:1325-1330(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10393 mRNA. Translation: BAA01232.1.
S63991 mRNA. Translation: AAB20281.1. Different initiation.
PIRJQ1232.
PS0261.
RefSeqNP_067733.1. NM_021701.2.
UniGeneRn.42928.

3D structure databases

ProteinModelPortalP28470.
SMRP28470. Positions 2-170.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000007290.

PTM databases

PhosphoSiteP28470.

Proteomic databases

PRIDEP28470.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000007290; ENSRNOP00000007290; ENSRNOG00000005368.
GeneID29749.
KEGGrno:29749.
UCSCRGD:69232. rat.

Organism-specific databases

CTD5535.
RGD69232. Ppp3r2.

Phylogenomic databases

eggNOGCOG5126.
GeneTreeENSGT00730000110542.
HOGENOMHOG000233019.
HOVERGENHBG105307.
InParanoidP28470.
KOK06268.
OMANNLKDWQ.
OrthoDBEOG75QR5D.
TreeFamTF105558.

Gene expression databases

GenevestigatorP28470.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF00036. EF-hand_1. 2 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 4 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio610273.
PROP28470.

Entry information

Entry nameCANB2_RAT
AccessionPrimary (citable) accession number: P28470
Secondary accession number(s): Q63878
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families