Reviewed, UniProtKB/Swiss-Prot P28470 (CANB2_RAT)

Names and origin

Protein names

Recommended name:
    Calcineurin subunit B type 2
Alternative name(s):
    Protein phosphatase 2B regulatory subunit 2
    Protein phosphatase 3 regulatory subunit B beta isoform
    Calcineurin B-like protein
      Short name=CBLP

Gene names

Name:	Ppp3r2
Synonyms:	Cblp

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Subunit structure	Composed of a catalytic subunit (A) and a regulatory subunit (B).
Tissue specificity	Testis specific. Ref.1
Miscellaneous	This protein has four functional calcium-binding sites.
Sequence similarities	Belongs to the calcineurin regulatory subunit family. Contains 4 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium
PTM	Lipoprotein Myristate
Gene Ontology (GO)
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 176	175	Calcineurin subunit B type 2		PRO_0000073501
Regions
	Domain	18 – 53	36	EF-hand 1
	Domain	50 – 85	36	EF-hand 2
	Domain	87 – 122	36	EF-hand 3
	Domain	128 – 163	36	EF-hand 4
	Calcium binding	31 – 42	12	1
	Calcium binding	63 – 74	12	2
	Calcium binding	100 – 111	12	3
	Calcium binding	141 – 152	12	4
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P28470-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: EE6D69DE1C8BF179	FASTA	176	20,291
	10 20 30 40 50 60 MGNEASYHSE MGTHFDHDEI KRLGRSFKKM DLDKSGSLSV DEFMSLPELQ QNPLVGRVID 70 80 90 100 110 120 IFDTDGNGEV DFREFIVGTS QFSVKGDEEQ KLRFAFRIYD MDNDGFISNG ELFQVLKMMV 130 140 150 160 170 GNNLKDWQLQ QLVDKSILVL DKDGDGRISF EEFRDVVRTM EIHKKLVVFV DHGQED

References

[1]	"cDNA cloning of a novel testis-specific calcineurin B-like protein." Mukai H., Chang C.D., Tanaka H., Ito A., Kuno T., Tanaka C. Biochem. Biophys. Res. Commun. 179:1325-1330(1991) [PubMed: 1718268] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D10393 mRNA. Translation: BAA01232.1. S63991 mRNA. Translation: AAB20281.1. Different initiation.
IPI	IPI00231892.
PIR	JQ1232. PS0261.
RefSeq	NP_067733.1.
UniGene	Rn.42928
3D structure databases
HSSP	HSSP built from PDB template 1TCO based on UniProtKB P06705.
SMR	P28470. Positions 2-170.
ModBase	Search...
Protein-protein interaction databases
STRING	P28470.
Genome annotation databases
Ensembl	ENSRNOT00000007290; ENSRNOP00000007290; ENSRNOG00000005368; Rattus norvegicus. [Genome view]
GeneID	29749.
KEGG	rno:29749.
UCSC	NM_021701. rat.
Organism-specific databases
CTD	29749.
RGD	69232. Ppp3r2.
Phylogenomic databases
HOVERGEN	P28470.
OMA	PAEMCSH.
Gene expression databases
ArrayExpress	P28470.
Genevestigator	P28470.
GermOnline	ENSRNOG00000005368. Rattus norvegicus.
Family and domain databases
InterPro	IPR011992. EF-Hand_type. IPR018248. EF_hand. IPR018247. EF_HAND_1_Ca_BS. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca_bd. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
Pfam	PF00036. efhand. 3 hits. [Graphical view]
ProDom	PD000012. EF-hand. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00054. EFh. 4 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 4 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	610273.

Entry information

Entry name

CANB2_RAT

Accession

Primary (citable) accession number: P28470
Secondary accession number(s): Q63878

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)