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Protein

Calcineurin subunit B type 2

Gene

Ppp3r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Miscellaneous

This protein has four functional calcium-binding sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi31 – 421Add BLAST12
Calcium bindingi63 – 742Add BLAST12
Calcium bindingi100 – 1113Add BLAST12
Calcium bindingi141 – 1524Add BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin subunit B type 2
Alternative name(s):
Calcineurin B-like protein
Short name:
CBLP
Protein phosphatase 2B regulatory subunit 2
Protein phosphatase 3 regulatory subunit B beta isoform
Gene namesi
Name:Ppp3r2
Synonyms:Cblp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi69232 Ppp3r2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000735012 – 176Calcineurin subunit B type 2Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP28470
PRIDEiP28470

PTM databases

PhosphoSitePlusiP28470

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSRNOG00000005368
GenevisibleiP28470 RN

Interactioni

Subunit structurei

Composed of a catalytic subunit (A) and a regulatory subunit (B).

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007290

Structurei

3D structure databases

ProteinModelPortaliP28470
SMRiP28470
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 53EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini87 – 122EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini128 – 163EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0034 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00860000133729
HOGENOMiHOG000233019
HOVERGENiHBG105307
InParanoidiP28470
KOiK06268
OMAiFSIYDMD
OrthoDBiEOG091G0R0W
PhylomeDBiP28470
TreeFamiTF105558

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNEASYHSE MGTHFDHDEI KRLGRSFKKM DLDKSGSLSV DEFMSLPELQ
60 70 80 90 100
QNPLVGRVID IFDTDGNGEV DFREFIVGTS QFSVKGDEEQ KLRFAFRIYD
110 120 130 140 150
MDNDGFISNG ELFQVLKMMV GNNLKDWQLQ QLVDKSILVL DKDGDGRISF
160 170
EEFRDVVRTM EIHKKLVVFV DHGQED
Length:176
Mass (Da):20,291
Last modified:January 23, 2007 - v2
Checksum:iEE6D69DE1C8BF179
GO

Sequence cautioni

The sequence AAB20281 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10393 mRNA Translation: BAA01232.1
S63991 mRNA Translation: AAB20281.1 Different initiation.
PIRiJQ1232
PS0261
RefSeqiNP_067733.1, NM_021701.2
UniGeneiRn.42928

Genome annotation databases

EnsembliENSRNOT00000007290; ENSRNOP00000007290; ENSRNOG00000005368
GeneIDi29749
KEGGirno:29749
UCSCiRGD:69232 rat

Similar proteinsi

Entry informationi

Entry nameiCANB2_RAT
AccessioniPrimary (citable) accession number: P28470
Secondary accession number(s): Q63878
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome