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P28470

- CANB2_RAT

UniProt

P28470 - CANB2_RAT

Protein

Calcineurin subunit B type 2

Gene

Ppp3r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi31 – 42121Add
    BLAST
    Calcium bindingi63 – 74122Add
    BLAST
    Calcium bindingi100 – 111123Add
    BLAST
    Calcium bindingi141 – 152124Add
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: RGD

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcineurin subunit B type 2
    Alternative name(s):
    Calcineurin B-like protein
    Short name:
    CBLP
    Protein phosphatase 2B regulatory subunit 2
    Protein phosphatase 3 regulatory subunit B beta isoform
    Gene namesi
    Name:Ppp3r2
    Synonyms:Cblp
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi69232. Ppp3r2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 176175Calcineurin subunit B type 2PRO_0000073501Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    PRIDEiP28470.

    PTM databases

    PhosphoSiteiP28470.

    Expressioni

    Tissue specificityi

    Testis specific.1 Publication

    Gene expression databases

    GenevestigatoriP28470.

    Interactioni

    Subunit structurei

    Composed of a catalytic subunit (A) and a regulatory subunit (B).

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000007290.

    Structurei

    3D structure databases

    ProteinModelPortaliP28470.
    SMRiP28470. Positions 2-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 5336EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini87 – 12236EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini128 – 16336EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    GeneTreeiENSGT00750000117505.
    HOGENOMiHOG000233019.
    HOVERGENiHBG105307.
    InParanoidiP28470.
    KOiK06268.
    OMAiNNLKDWQ.
    OrthoDBiEOG75QR5D.
    PhylomeDBiP28470.
    TreeFamiTF105558.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF00036. EF-hand_1. 2 hits.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 4 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28470-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNEASYHSE MGTHFDHDEI KRLGRSFKKM DLDKSGSLSV DEFMSLPELQ    50
    QNPLVGRVID IFDTDGNGEV DFREFIVGTS QFSVKGDEEQ KLRFAFRIYD 100
    MDNDGFISNG ELFQVLKMMV GNNLKDWQLQ QLVDKSILVL DKDGDGRISF 150
    EEFRDVVRTM EIHKKLVVFV DHGQED 176
    Length:176
    Mass (Da):20,291
    Last modified:January 23, 2007 - v2
    Checksum:iEE6D69DE1C8BF179
    GO

    Sequence cautioni

    The sequence AAB20281.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10393 mRNA. Translation: BAA01232.1.
    S63991 mRNA. Translation: AAB20281.1. Different initiation.
    PIRiJQ1232.
    PS0261.
    RefSeqiNP_067733.1. NM_021701.2.
    UniGeneiRn.42928.

    Genome annotation databases

    EnsembliENSRNOT00000007290; ENSRNOP00000007290; ENSRNOG00000005368.
    GeneIDi29749.
    KEGGirno:29749.
    UCSCiRGD:69232. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10393 mRNA. Translation: BAA01232.1 .
    S63991 mRNA. Translation: AAB20281.1 . Different initiation.
    PIRi JQ1232.
    PS0261.
    RefSeqi NP_067733.1. NM_021701.2.
    UniGenei Rn.42928.

    3D structure databases

    ProteinModelPortali P28470.
    SMRi P28470. Positions 2-170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000007290.

    PTM databases

    PhosphoSitei P28470.

    Proteomic databases

    PRIDEi P28470.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000007290 ; ENSRNOP00000007290 ; ENSRNOG00000005368 .
    GeneIDi 29749.
    KEGGi rno:29749.
    UCSCi RGD:69232. rat.

    Organism-specific databases

    CTDi 5535.
    RGDi 69232. Ppp3r2.

    Phylogenomic databases

    eggNOGi COG5126.
    GeneTreei ENSGT00750000117505.
    HOGENOMi HOG000233019.
    HOVERGENi HBG105307.
    InParanoidi P28470.
    KOi K06268.
    OMAi NNLKDWQ.
    OrthoDBi EOG75QR5D.
    PhylomeDBi P28470.
    TreeFami TF105558.

    Miscellaneous databases

    NextBioi 610273.
    PROi P28470.

    Gene expression databases

    Genevestigatori P28470.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF00036. EF-hand_1. 2 hits.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 4 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of a novel testis-specific calcineurin B-like protein."
      Mukai H., Chang C.D., Tanaka H., Ito A., Kuno T., Tanaka C.
      Biochem. Biophys. Res. Commun. 179:1325-1330(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Testis.

    Entry informationi

    Entry nameiCANB2_RAT
    AccessioniPrimary (citable) accession number: P28470
    Secondary accession number(s): Q63878
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein has four functional calcium-binding sites.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3