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Protein

Calcineurin subunit B type 2

Gene

Ppp3r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi31 – 421Add BLAST12
Calcium bindingi63 – 742Add BLAST12
Calcium bindingi100 – 1113Add BLAST12
Calcium bindingi141 – 1524Add BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-180024. DARPP-32 events.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin subunit B type 2
Alternative name(s):
Calcineurin B-like protein
Short name:
CBLP
Protein phosphatase 2B regulatory subunit 2
Protein phosphatase 3 regulatory subunit B beta isoform
Gene namesi
Name:Ppp3r2
Synonyms:Cblp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi69232. Ppp3r2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000735012 – 176Calcineurin subunit B type 2Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP28470.
PRIDEiP28470.

PTM databases

PhosphoSitePlusiP28470.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSRNOG00000005368.
GenevisibleiP28470. RN.

Interactioni

Subunit structurei

Composed of a catalytic subunit (A) and a regulatory subunit (B).

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007290.

Structurei

3D structure databases

ProteinModelPortaliP28470.
SMRiP28470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 53EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini87 – 122EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini128 – 163EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0034. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00860000133729.
HOGENOMiHOG000233019.
HOVERGENiHBG105307.
InParanoidiP28470.
KOiK06268.
OMAiNNLKDWQ.
OrthoDBiEOG091G0R0W.
PhylomeDBiP28470.
TreeFamiTF105558.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNEASYHSE MGTHFDHDEI KRLGRSFKKM DLDKSGSLSV DEFMSLPELQ
60 70 80 90 100
QNPLVGRVID IFDTDGNGEV DFREFIVGTS QFSVKGDEEQ KLRFAFRIYD
110 120 130 140 150
MDNDGFISNG ELFQVLKMMV GNNLKDWQLQ QLVDKSILVL DKDGDGRISF
160 170
EEFRDVVRTM EIHKKLVVFV DHGQED
Length:176
Mass (Da):20,291
Last modified:January 23, 2007 - v2
Checksum:iEE6D69DE1C8BF179
GO

Sequence cautioni

The sequence AAB20281 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10393 mRNA. Translation: BAA01232.1.
S63991 mRNA. Translation: AAB20281.1. Different initiation.
PIRiJQ1232.
PS0261.
RefSeqiNP_067733.1. NM_021701.2.
UniGeneiRn.42928.

Genome annotation databases

EnsembliENSRNOT00000007290; ENSRNOP00000007290; ENSRNOG00000005368.
GeneIDi29749.
KEGGirno:29749.
UCSCiRGD:69232. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10393 mRNA. Translation: BAA01232.1.
S63991 mRNA. Translation: AAB20281.1. Different initiation.
PIRiJQ1232.
PS0261.
RefSeqiNP_067733.1. NM_021701.2.
UniGeneiRn.42928.

3D structure databases

ProteinModelPortaliP28470.
SMRiP28470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007290.

PTM databases

PhosphoSitePlusiP28470.

Proteomic databases

PaxDbiP28470.
PRIDEiP28470.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007290; ENSRNOP00000007290; ENSRNOG00000005368.
GeneIDi29749.
KEGGirno:29749.
UCSCiRGD:69232. rat.

Organism-specific databases

CTDi5535.
RGDi69232. Ppp3r2.

Phylogenomic databases

eggNOGiKOG0034. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00860000133729.
HOGENOMiHOG000233019.
HOVERGENiHBG105307.
InParanoidiP28470.
KOiK06268.
OMAiNNLKDWQ.
OrthoDBiEOG091G0R0W.
PhylomeDBiP28470.
TreeFamiTF105558.

Enzyme and pathway databases

ReactomeiR-RNO-180024. DARPP-32 events.

Miscellaneous databases

PROiP28470.

Gene expression databases

BgeeiENSRNOG00000005368.
GenevisibleiP28470. RN.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCANB2_RAT
AccessioniPrimary (citable) accession number: P28470
Secondary accession number(s): Q63878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.