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P28470

- CANB2_RAT

UniProt

P28470 - CANB2_RAT

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Protein
Calcineurin subunit B type 2
Gene
Ppp3r2, Cblp
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi31 – 42121
Add
BLAST
Calcium bindingi63 – 74122
Add
BLAST
Calcium bindingi100 – 111123
Add
BLAST
Calcium bindingi141 – 152124
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin subunit B type 2
Alternative name(s):
Calcineurin B-like protein
Short name:
CBLP
Protein phosphatase 2B regulatory subunit 2
Protein phosphatase 3 regulatory subunit B beta isoform
Gene namesi
Name:Ppp3r2
Synonyms:Cblp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi69232. Ppp3r2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 176175Calcineurin subunit B type 2
PRO_0000073501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PRIDEiP28470.

PTM databases

PhosphoSiteiP28470.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

GenevestigatoriP28470.

Interactioni

Subunit structurei

Composed of a catalytic subunit (A) and a regulatory subunit (B).

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007290.

Structurei

3D structure databases

ProteinModelPortaliP28470.
SMRiP28470. Positions 2-170.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 5336EF-hand 1
Add
BLAST
Domaini50 – 8536EF-hand 2
Add
BLAST
Domaini87 – 12236EF-hand 3
Add
BLAST
Domaini128 – 16336EF-hand 4
Add
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00750000117505.
HOGENOMiHOG000233019.
HOVERGENiHBG105307.
InParanoidiP28470.
KOiK06268.
OMAiNNLKDWQ.
OrthoDBiEOG75QR5D.
PhylomeDBiP28470.
TreeFamiTF105558.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00036. EF-hand_1. 2 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28470-1 [UniParc]FASTAAdd to Basket

« Hide

MGNEASYHSE MGTHFDHDEI KRLGRSFKKM DLDKSGSLSV DEFMSLPELQ    50
QNPLVGRVID IFDTDGNGEV DFREFIVGTS QFSVKGDEEQ KLRFAFRIYD 100
MDNDGFISNG ELFQVLKMMV GNNLKDWQLQ QLVDKSILVL DKDGDGRISF 150
EEFRDVVRTM EIHKKLVVFV DHGQED 176
Length:176
Mass (Da):20,291
Last modified:January 23, 2007 - v2
Checksum:iEE6D69DE1C8BF179
GO

Sequence cautioni

The sequence AAB20281.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10393 mRNA. Translation: BAA01232.1.
S63991 mRNA. Translation: AAB20281.1. Different initiation.
PIRiJQ1232.
PS0261.
RefSeqiNP_067733.1. NM_021701.2.
UniGeneiRn.42928.

Genome annotation databases

EnsembliENSRNOT00000007290; ENSRNOP00000007290; ENSRNOG00000005368.
GeneIDi29749.
KEGGirno:29749.
UCSCiRGD:69232. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10393 mRNA. Translation: BAA01232.1 .
S63991 mRNA. Translation: AAB20281.1 . Different initiation.
PIRi JQ1232.
PS0261.
RefSeqi NP_067733.1. NM_021701.2.
UniGenei Rn.42928.

3D structure databases

ProteinModelPortali P28470.
SMRi P28470. Positions 2-170.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000007290.

PTM databases

PhosphoSitei P28470.

Proteomic databases

PRIDEi P28470.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000007290 ; ENSRNOP00000007290 ; ENSRNOG00000005368 .
GeneIDi 29749.
KEGGi rno:29749.
UCSCi RGD:69232. rat.

Organism-specific databases

CTDi 5535.
RGDi 69232. Ppp3r2.

Phylogenomic databases

eggNOGi COG5126.
GeneTreei ENSGT00750000117505.
HOGENOMi HOG000233019.
HOVERGENi HBG105307.
InParanoidi P28470.
KOi K06268.
OMAi NNLKDWQ.
OrthoDBi EOG75QR5D.
PhylomeDBi P28470.
TreeFami TF105558.

Miscellaneous databases

NextBioi 610273.
PROi P28470.

Gene expression databases

Genevestigatori P28470.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF00036. EF-hand_1. 2 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 4 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of a novel testis-specific calcineurin B-like protein."
    Mukai H., Chang C.D., Tanaka H., Ito A., Kuno T., Tanaka C.
    Biochem. Biophys. Res. Commun. 179:1325-1330(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.

Entry informationi

Entry nameiCANB2_RAT
AccessioniPrimary (citable) accession number: P28470
Secondary accession number(s): Q63878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi