P28469 (ADH1A_MACMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase 1A
EC=1.1.1.1

Alternative name(s):
Alcohol dehydrogenase subunit alpha

Gene names

Name:	ADH1A
Synonyms:	ADH1

Organism

Macaca mulatta (Rhesus macaque)

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Homodimer or heterodimer of closely related subunits By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 375	374	Alcohol dehydrogenase 1A		PRO_0000160659
Regions
	Nucleotide binding	200 – 205	6	NAD By similarity
	Nucleotide binding	293 – 295	3	NAD By similarity
Sites
	Metal binding	47	1	Zinc 1; catalytic By similarity
	Metal binding	68	1	Zinc 1; catalytic By similarity
	Metal binding	98	1	Zinc 2 By similarity
	Metal binding	101	1	Zinc 2 By similarity
	Metal binding	104	1	Zinc 2 By similarity
	Metal binding	112	1	Zinc 2 By similarity
	Metal binding	175	1	Zinc 1; catalytic By similarity
	Binding site	224	1	NAD By similarity
	Binding site	229	1	NAD By similarity
	Binding site	370	1	NAD By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P28469 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 8B0DDC03673AA8DA	FASTA	375	39,913
	10 20 30 40 50 60 MSTAGKVIKC KAAVLWEVMK PFSIEDVEVA PPKAYEVRIK MVTVGICGTD DHVVSGTMVT 70 80 90 100 110 120 PLPVILGHEA AGIVESVGEG VTTVEPGDKV IPLALPQCGK CRICKTPERN YCLKNDVSNP 130 140 150 160 170 180 RGTLQDGTSR FTCRGKPIHH FLGVSTFSQY TVVDENAVAK IDAASPMEKV CLIGCGFSTG 190 200 210 220 230 240 YGSAVKVAKV TPGSTCAVFG LGGVGLSAVM GCKAAGAARI IAVDINKDKF AKAKELGATE 250 260 270 280 290 300 CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ 310 320 330 340 350 360 NLSINPMLLL TGRTWKGAVY GGFKSKEDIP KLVADFMAKK FSLDALITHV LPFEKINEGF 370 DLLRSGKSIR TILTF

References

[1]	"Alpha-isoenzyme of alcohol dehydrogenase from monkey liver. Cloning, expression, mechanism, coenzyme, and substrate specificity." Light D.R., Dennis M.S., Forsythe I.J., Liu C.C., Green D.W., Kratzer D., Plapp B.V. J. Biol. Chem. 267:12592-12599(1992) [PubMed: 1618764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M81807 mRNA. Translation: AAA36830.1.
PIR	I55359.
RefSeq	NP_001036230.1. NM_001042765.1.
UniGene	Mmu.3289.
3D structure databases
ProteinModelPortal	P28469.
SMR	P28469. Positions 2-375.
ModBase	Search...
Protein-protein interaction databases
STRING	P28469.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMMUT00000041961; ENSMMUP00000034970; ENSMMUG00000018738.
GeneID	707682.
KEGG	mcc:707682.
Organism-specific databases
CTD	124.
Phylogenomic databases
eggNOG	prNOG19139.
GeneTree	ENSGT00430000030800.
HOVERGEN	HBG000195.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K13951.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 2 hits.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1A_MACMU

Accession

Primary (citable) accession number: P28469

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program