Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P28469 (ADH1A_MACMU)

Last modified January 19, 2010. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 1A
    EC=1.1.1.1
Alternative name(s):
    Alcohol dehydrogenase subunit alpha
Gene names
Name: ADH1A
Synonyms: ADH1
OrganismMacaca mulatta (Rhesus macaque)
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Hide | Top

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homodimer or heterodimer of closely related subunits By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Hide | Top

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   PTMAcetylation
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalcohol dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 375374Alcohol dehydrogenase 1A
PRO_0000160659

Regions

Nucleotide binding200 – 2056NAD By similarity
Nucleotide binding293 – 2953NAD By similarity

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding681Zinc 1; catalytic By similarity
Metal binding981Zinc 2 By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1121Zinc 2 By similarity
Metal binding1751Zinc 1; catalytic By similarity
Binding site2241NAD By similarity
Binding site2291NAD By similarity
Binding site3701NAD By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P28469-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 8B0DDC03673AA8DA

FASTA37539,913
        10         20         30         40         50         60 
MSTAGKVIKC KAAVLWEVMK PFSIEDVEVA PPKAYEVRIK MVTVGICGTD DHVVSGTMVT 

        70         80         90        100        110        120 
PLPVILGHEA AGIVESVGEG VTTVEPGDKV IPLALPQCGK CRICKTPERN YCLKNDVSNP 

       130        140        150        160        170        180 
RGTLQDGTSR FTCRGKPIHH FLGVSTFSQY TVVDENAVAK IDAASPMEKV CLIGCGFSTG 

       190        200        210        220        230        240 
YGSAVKVAKV TPGSTCAVFG LGGVGLSAVM GCKAAGAARI IAVDINKDKF AKAKELGATE 

       250        260        270        280        290        300 
CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ 

       310        320        330        340        350        360 
NLSINPMLLL TGRTWKGAVY GGFKSKEDIP KLVADFMAKK FSLDALITHV LPFEKINEGF 

       370 
DLLRSGKSIR TILTF

« Hide

Hide | Top

References

[1]"Alpha-isoenzyme of alcohol dehydrogenase from monkey liver. Cloning, expression, mechanism, coenzyme, and substrate specificity."
Light D.R., Dennis M.S., Forsythe I.J., Liu C.C., Green D.W., Kratzer D., Plapp B.V.
J. Biol. Chem. 267:12592-12599(1992) [PubMed: 1618764] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M81807 mRNA. Translation: AAA36830.1.
PIRI55359.
RefSeqNP_001036230.1.
UniGeneMmu.3289

3D structure databases

SMRP28469. Positions 2-375.
ModBaseSearch...

Protein-protein interaction databases

STRINGP28469.

Genome annotation databases

EnsemblENSMMUT00000041961; ENSMMUP00000034970; ENSMMUG00000018738; Macaca mulatta. [Genome view]
GeneID707682.
KEGGmcc:707682.

Organism-specific databases

CTD707682.

Phylogenomic databases

eggNOGprNOG19139.
HOVERGENP28469.

Enzyme and pathway databases

BRENDA1.1.1.1. 1774.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameADH1A_MACMU
AccessionPrimary (citable) accession number: P28469
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: January 19, 2010
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents