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Protein

Putative peptide chain release factor homolog

Gene

prfH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Could be involved in translational termination.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:EG11496-MONOMER.
ECOL316407:JW0226-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peptide chain release factor homolog
Short name:
RF-H
Gene namesi
Name:prfH
Ordered Locus Names:b0236, JW0226
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11496. prfH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001668571 – 166Putative peptide chain release factor homologAdd BLAST166

Proteomic databases

PRIDEiP28369.

Interactioni

Protein-protein interaction databases

BioGridi4259764. 6 interactors.
IntActiP28369. 1 interactor.
STRINGi316407.85674391.

Structurei

3D structure databases

ProteinModelPortaliP28369.
SMRiP28369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 132Poly-Gln4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108S2Y. Bacteria.
COG1186. LUCA.
HOGENOMiHOG000117078.
InParanoidiP28369.
KOiK02839.
OMAiHARKNWF.
PhylomeDBiP28369.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000352. Pep_chain_release_fac_I_II.
IPR017509. Release_fac_PrfH.
[Graphical view]
PfamiPF00472. RF-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03072. release_prfH. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLETETGRYS DTLRSALVSL DGDNAWALSE SWCGTIQWIC PSPYRPHHGR
60 70 80 90 100
KNWFLGIGRF TADEQEQSDA IRYETLRSSG PGGQHVNKTD SAVRATHLAS
110 120 130 140 150
GISVKVQSER SQHANKRLAR LLIAWKLEQQ QQENSAALKS QRRMFHHQIE
160
RGNPRRTFTG MAFIEG
Length:166
Mass (Da):18,834
Last modified:September 19, 2006 - v2
Checksum:i7555352297B51280
GO

Sequence cautioni

The sequence M34034 differs from that shown. Reason: Frameshift at position 32.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34034 Unassigned DNA. No translation available.
U70214 Genomic DNA. Translation: AAB08656.1.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAA77905.2.
PIRiE64748.

Genome annotation databases

EnsemblBacteriaiBAA77905; BAA77905; BAA77905.
KEGGiecj:JW0226.
PATRICi48659665. VBIEscCol107702_0230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34034 Unassigned DNA. No translation available.
U70214 Genomic DNA. Translation: AAB08656.1.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAA77905.2.
PIRiE64748.

3D structure databases

ProteinModelPortaliP28369.
SMRiP28369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259764. 6 interactors.
IntActiP28369. 1 interactor.
STRINGi316407.85674391.

Proteomic databases

PRIDEiP28369.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA77905; BAA77905; BAA77905.
KEGGiecj:JW0226.
PATRICi48659665. VBIEscCol107702_0230.

Organism-specific databases

EchoBASEiEB1459.
EcoGeneiEG11496. prfH.

Phylogenomic databases

eggNOGiENOG4108S2Y. Bacteria.
COG1186. LUCA.
HOGENOMiHOG000117078.
InParanoidiP28369.
KOiK02839.
OMAiHARKNWF.
PhylomeDBiP28369.

Enzyme and pathway databases

BioCyciEcoCyc:EG11496-MONOMER.
ECOL316407:JW0226-MONOMER.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000352. Pep_chain_release_fac_I_II.
IPR017509. Release_fac_PrfH.
[Graphical view]
PfamiPF00472. RF-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03072. release_prfH. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRFH_ECOLI
AccessioniPrimary (citable) accession number: P28369
Secondary accession number(s): P77246
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 19, 2006
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.