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Protein

Homeobox protein MSX-2

Gene

MSX2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional regulator in bone development. Binds to DNA (By similarity). Morphogenetic role.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi134 – 193HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processOsteogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MSX-2
Alternative name(s):
Homeobox protein Hox-8
Short name:
CHOX-8
Short name:
GHox-8
Gene namesi
Name:MSX2
Synonyms:HOX8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491021 – 259Homeobox protein MSX-2Add BLAST259

Proteomic databases

PaxDbiP28362.
PRIDEiP28362.

Expressioni

Gene expression databases

BgeeiENSGALG00000026180.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004650.

Structurei

3D structure databases

ProteinModelPortaliP28362.
SMRiP28362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Msh homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0492. Eukaryota.
ENOG410YT2J. LUCA.
GeneTreeiENSGT00900000140771.
HOGENOMiHOG000231922.
HOVERGENiHBG005205.
InParanoidiP28362.
KOiK09341.
OMAiPLGYSMY.
OrthoDBiEOG091G0P1V.
PhylomeDBiP28362.
TreeFamiTF350699.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P28362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPSKAKEV FSSDEEGPAA GAEEHHKVKV SSLPFSVEAL MSDKKPPKEL
60 70 80 90 100
PLAAAGGSAD GATVGTSRNL LLPGHGSRDA HSPPGALTKT FDTASVKSEN
110 120 130 140 150
SEDGTSWIQE AGRYSPPPRH LSPTACTLRK HKTNRKPRTP FTTSQLLALE
160 170 180 190 200
RKFRQKQYLS IAERAEFSSS LNLTETQVKI WFQNRRAKAK RLQEAELEKL
210 220 230 240 250
KMAAKPMLPS GFSLPFPINS PIQAASLYGT SYPFHRPVLP IPPVGLYATP

VGYSMYHLS
Length:259
Mass (Da):28,235
Last modified:November 1, 1995 - v2
Checksum:i375405ED73E59786
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58S → N in CAA44007 (PubMed:1685987).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64478 mRNA. Translation: AAB20018.1.
X62097 mRNA. Translation: CAA44007.1.
X62541 mRNA. Translation: CAA44425.1.
PIRiJS0660.
RefSeqiNP_989890.1. NM_204559.1.
UniGeneiGga.4977.

Genome annotation databases

EnsembliENSGALT00000065242; ENSGALP00000046638; ENSGALG00000038848.
GeneIDi395245.
KEGGigga:395245.

Similar proteinsi

Entry informationi

Entry nameiMSX2_CHICK
AccessioniPrimary (citable) accession number: P28362
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1995
Last modified: November 22, 2017
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families