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Protein

Homeobox protein MSX-2

Gene

MSX2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional regulator in bone development. Binds to DNA (By similarity). Morphogenetic role.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi134 – 193HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processOsteogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MSX-2
Alternative name(s):
Homeobox protein Hox-8
Short name:
CHOX-8
Short name:
GHox-8
Gene namesi
Name:MSX2
Synonyms:HOX8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491021 – 259Homeobox protein MSX-2Add BLAST259

Proteomic databases

PaxDbiP28362
PRIDEiP28362

Expressioni

Gene expression databases

BgeeiENSGALG00000026180

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004650

Structurei

3D structure databases

ProteinModelPortaliP28362
SMRiP28362
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Msh homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0492 Eukaryota
ENOG410YT2J LUCA
GeneTreeiENSGT00910000143987
HOGENOMiHOG000231922
HOVERGENiHBG005205
InParanoidiP28362
KOiK09341
OMAiPLGYSMY
OrthoDBiEOG091G0P1V
PhylomeDBiP28362
TreeFamiTF350699

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPSKAKEV FSSDEEGPAA GAEEHHKVKV SSLPFSVEAL MSDKKPPKEL
60 70 80 90 100
PLAAAGGSAD GATVGTSRNL LLPGHGSRDA HSPPGALTKT FDTASVKSEN
110 120 130 140 150
SEDGTSWIQE AGRYSPPPRH LSPTACTLRK HKTNRKPRTP FTTSQLLALE
160 170 180 190 200
RKFRQKQYLS IAERAEFSSS LNLTETQVKI WFQNRRAKAK RLQEAELEKL
210 220 230 240 250
KMAAKPMLPS GFSLPFPINS PIQAASLYGT SYPFHRPVLP IPPVGLYATP

VGYSMYHLS
Length:259
Mass (Da):28,235
Last modified:November 1, 1995 - v2
Checksum:i375405ED73E59786
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58S → N in CAA44007 (PubMed:1685987).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64478 mRNA Translation: AAB20018.1
X62097 mRNA Translation: CAA44007.1
X62541 mRNA Translation: CAA44425.1
PIRiJS0660
RefSeqiNP_989890.1, NM_204559.1
UniGeneiGga.4977

Genome annotation databases

EnsembliENSGALT00000065242; ENSGALP00000046638; ENSGALG00000038848
GeneIDi395245
KEGGigga:395245

Similar proteinsi

Entry informationi

Entry nameiMSX2_CHICK
AccessioniPrimary (citable) accession number: P28362
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health