P28359 (HXD10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-D10

Alternative name(s):
Homeobox protein Hox-4.5
Homeobox protein Hox-5.3

Gene names

Name:	Hoxd10
Synonyms:	Hox-4.5, Hoxd-10

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Developmental stage	Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the second or third lumbar pre-vetrebrae. Ref.4
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult locomotory behavior Inferred from genetic interaction PubMed 10642795. Source: MGI anterior/posterior pattern specification Inferred from genetic interaction PubMed 10642795PubMed 12869760. Source: MGI embryonic limb morphogenesis Inferred from genetic interaction PubMed 12869760. Source: MGI embryonic skeletal system morphogenesis Inferred from genetic interaction PubMed 10642795. Source: MGI forelimb morphogenesis Inferred from genetic interaction PubMed 10642795. Source: MGI hindlimb morphogenesis Inferred from genetic interaction PubMed 10642795. Source: MGI neuromuscular process Inferred from genetic interaction PubMed 18065432. Source: MGI peripheral nervous system neuron development Inferred from genetic interaction PubMed 10642795. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 16672333PubMed 1756725. Source: MGI proximal/distal pattern formation Inferred from genetic interaction PubMed 12869760. Source: MGI skeletal muscle tissue development Inferred from genetic interaction PubMed 10642795. Source: MGI spinal cord motor neuron cell fate specification Inferred from genetic interaction PubMed 18065432. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from direct assay PubMed 1756725. Source: MGI chromatin binding Inferred from direct assay PubMed 16672333. Source: MGI sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 1756725. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Gmnn	O88513	2	EBI-445929,EBI-445922

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Homeobox protein Hox-D10		PRO_0000200227
Regions
	DNA binding	266 – 325	60	Homeobox
Experimental info
	Sequence conflict	184	1	G → A in CAA44541. Ref.1
	Sequence conflict	189	1	Q → E in CAA44541. Ref.1
	Sequence conflict	207	1	G → A in CAA44541. Ref.1
	Sequence conflict	268	1	K → E Ref.1
	Sequence conflict	268	1	K → E Ref.3
	Sequence conflict	268	1	K → E Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P28359 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: 974ABDB417F9F90D	FASTA	340	38,328
	10 20 30 40 50 60 MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT CGLLPSLAKR 70 80 90 100 110 120 EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT CSFTANIKEE SNCCMYSDKR 130 140 150 160 170 180 NKLISAEVPS YQRLVPESCP VENPEVPVPG YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL 190 200 210 220 230 240 NPRGAAKPQL SAAQLQMEKK MNESASGQEP TKVSQVESPE AKGGLPEDRS CLAEVSVSSP 250 260 270 280 290 300 EVQEKESKEE IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS 310 320 330 340 KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4." Renucci A.G.P., Zappavigna V., Zakany J., Izpisua-Belmonte J.-C., Buerki K., Douboule D. EMBO J. 11:1459-1468(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney and Limb.
[3]	"Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads." Dolle P., Duboule D. EMBO J. 8:1507-1515(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-325.
[4]	"The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes." Duboule D., Dolle P. EMBO J. 8:1497-1505(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-325, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X62669 Genomic DNA. Translation: CAA44541.1. BC013463 mRNA. Translation: AAH13463.1. BC048690 mRNA. Translation: AAH48690.1. X14715 Genomic DNA. Translation: CAB57814.1.
IPI	IPI00119646.
PIR	S20879.
RefSeq	NP_038582.2. NM_013554.5.
UniGene	Mm.24420.
3D structure databases
ProteinModelPortal	P28359.
SMR	P28359. Positions 267-325.
ModBase	Search...
Protein-protein interaction databases
IntAct	P28359. 1 interaction.
MINT	MINT-1172392.
PTM databases
PhosphoSite	P28359.
Proteomic databases
PRIDE	P28359.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000061745; ENSMUSP00000062412; ENSMUSG00000050368.
GeneID	15430.
KEGG	mmu:15430.
UCSC	uc008kdx.2. mouse.
Organism-specific databases
CTD	3236.
MGI	MGI:96202. Hoxd10.
Phylogenomic databases
eggNOG	NOG241114.
GeneTree	ENSGT00700000104054.
HOGENOM	HOG000231182.
HOVERGEN	HBG052934.
InParanoid	P28359.
KO	K09295.
OMA	NPRGSAK.
OrthoDB	EOG4RV2RP.
Gene expression databases
ArrayExpress	P28359.
Bgee	P28359.
CleanEx	MM_HOXD10.
Genevestigator	P28359.
GermOnline	ENSMUSG00000050368. Mus musculus.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288190.
SOURCE	Search...

Entry information

Entry name

HXD10_MOUSE

Accession

Primary (citable) accession number: P28359
Secondary accession number(s): Q91WU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	September 5, 2006
Last modified:	May 29, 2013
This is version 123 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program