Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-D10

Gene

Hoxd10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi266 – 325HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: MGI

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • forelimb morphogenesis Source: MGI
  • hindlimb morphogenesis Source: MGI
  • neuromuscular process Source: MGI
  • peripheral nervous system neuron development Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • proximal/distal pattern formation Source: MGI
  • regulation of gene expression Source: MGI
  • single fertilization Source: MGI
  • skeletal muscle tissue development Source: MGI
  • skeletal system development Source: MGI
  • spinal cord motor neuron cell fate specification Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D10
Alternative name(s):
Homeobox protein Hox-4.5
Homeobox protein Hox-5.3
Gene namesi
Name:Hoxd10
Synonyms:Hox-4.5, Hoxd-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96202. Hoxd10.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002271 – 340Homeobox protein Hox-D10Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei238PhosphoserineCombined sources1
Modified residuei239PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP28359.
PaxDbiP28359.
PRIDEiP28359.

PTM databases

iPTMnetiP28359.
PhosphoSitePlusiP28359.

Expressioni

Developmental stagei

Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the second or third lumbar pre-vertebrae.1 Publication

Gene expression databases

BgeeiENSMUSG00000050368.
CleanExiMM_HOXD10.
GenevisibleiP28359. MM.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi200392. 5 interactors.
IntActiP28359. 2 interactors.
MINTiMINT-1172392.
STRINGi10090.ENSMUSP00000062412.

Structurei

3D structure databases

ProteinModelPortaliP28359.
SMRiP28359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231182.
HOVERGENiHBG052934.
InParanoidiP28359.
KOiK09295.
OMAiNPRGSAK.
OrthoDBiEOG091G0LON.
PhylomeDBiP28359.
TreeFamiTF317819.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P28359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT
60 70 80 90 100
CGLLPSLAKR EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT
110 120 130 140 150
CSFTANIKEE SNCCMYSDKR NKLISAEVPS YQRLVPESCP VENPEVPVPG
160 170 180 190 200
YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL NPRGAAKPQL SAAQLQMEKK
210 220 230 240 250
MNESASGQEP TKVSQVESPE AKGGLPEDRS CLAEVSVSSP EVQEKESKEE
260 270 280 290 300
IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS
310 320 330 340
KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS
Length:340
Mass (Da):38,328
Last modified:September 5, 2006 - v2
Checksum:i974ABDB417F9F90D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184G → A in CAA44541 (PubMed:1348690).Curated1
Sequence conflicti189Q → E in CAA44541 (PubMed:1348690).Curated1
Sequence conflicti207G → A in CAA44541 (PubMed:1348690).Curated1
Sequence conflicti268K → E (PubMed:1348690).Curated1
Sequence conflicti268K → E (PubMed:2569970).Curated1
Sequence conflicti268K → E (PubMed:2569969).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62669 Genomic DNA. Translation: CAA44541.1.
BC013463 mRNA. Translation: AAH13463.1.
BC048690 mRNA. Translation: AAH48690.1.
X14715 Genomic DNA. Translation: CAB57814.1.
CCDSiCCDS16141.1.
PIRiS20879.
RefSeqiNP_038582.2. NM_013554.5.
UniGeneiMm.24420.

Genome annotation databases

EnsembliENSMUST00000061745; ENSMUSP00000062412; ENSMUSG00000050368.
GeneIDi15430.
KEGGimmu:15430.
UCSCiuc008kdx.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62669 Genomic DNA. Translation: CAA44541.1.
BC013463 mRNA. Translation: AAH13463.1.
BC048690 mRNA. Translation: AAH48690.1.
X14715 Genomic DNA. Translation: CAB57814.1.
CCDSiCCDS16141.1.
PIRiS20879.
RefSeqiNP_038582.2. NM_013554.5.
UniGeneiMm.24420.

3D structure databases

ProteinModelPortaliP28359.
SMRiP28359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200392. 5 interactors.
IntActiP28359. 2 interactors.
MINTiMINT-1172392.
STRINGi10090.ENSMUSP00000062412.

PTM databases

iPTMnetiP28359.
PhosphoSitePlusiP28359.

Proteomic databases

MaxQBiP28359.
PaxDbiP28359.
PRIDEiP28359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061745; ENSMUSP00000062412; ENSMUSG00000050368.
GeneIDi15430.
KEGGimmu:15430.
UCSCiuc008kdx.3. mouse.

Organism-specific databases

CTDi3236.
MGIiMGI:96202. Hoxd10.

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231182.
HOVERGENiHBG052934.
InParanoidiP28359.
KOiK09295.
OMAiNPRGSAK.
OrthoDBiEOG091G0LON.
PhylomeDBiP28359.
TreeFamiTF317819.

Miscellaneous databases

PROiPR:P28359.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050368.
CleanExiMM_HOXD10.
GenevisibleiP28359. MM.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHXD10_MOUSE
AccessioniPrimary (citable) accession number: P28359
Secondary accession number(s): Q91WU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 5, 2006
Last modified: May 10, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.