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P28359

- HXD10_MOUSE

UniProt

P28359 - HXD10_MOUSE

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Protein

Homeobox protein Hox-D10

Gene

Hoxd10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi266 – 32560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. anterior/posterior pattern specification Source: MGI
  3. embryonic limb morphogenesis Source: MGI
  4. embryonic skeletal system morphogenesis Source: MGI
  5. forelimb morphogenesis Source: MGI
  6. hindlimb morphogenesis Source: MGI
  7. neuromuscular process Source: MGI
  8. peripheral nervous system neuron development Source: MGI
  9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  10. proximal/distal pattern formation Source: MGI
  11. regulation of gene expression Source: MGI
  12. single fertilization Source: MGI
  13. skeletal muscle tissue development Source: MGI
  14. skeletal system development Source: MGI
  15. spinal cord motor neuron cell fate specification Source: MGI
  16. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D10
Alternative name(s):
Homeobox protein Hox-4.5
Homeobox protein Hox-5.3
Gene namesi
Name:Hoxd10
Synonyms:Hox-4.5, Hoxd-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96202. Hoxd10.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Homeobox protein Hox-D10PRO_0000200227Add
BLAST

Proteomic databases

MaxQBiP28359.
PRIDEiP28359.

PTM databases

PhosphoSiteiP28359.

Expressioni

Developmental stagei

Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the second or third lumbar pre-vetrebrae.1 Publication

Gene expression databases

BgeeiP28359.
CleanExiMM_HOXD10.
GenevestigatoriP28359.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GmnnO885132EBI-445929,EBI-445922

Protein-protein interaction databases

BioGridi200392. 5 interactions.
IntActiP28359. 1 interaction.
MINTiMINT-1172392.

Structurei

3D structure databases

ProteinModelPortaliP28359.
SMRiP28359. Positions 267-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG241114.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231182.
HOVERGENiHBG052934.
InParanoidiP28359.
KOiK09295.
OMAiNPRGSAK.
OrthoDBiEOG7VDXPP.
PhylomeDBiP28359.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28359-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT
60 70 80 90 100
CGLLPSLAKR EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT
110 120 130 140 150
CSFTANIKEE SNCCMYSDKR NKLISAEVPS YQRLVPESCP VENPEVPVPG
160 170 180 190 200
YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL NPRGAAKPQL SAAQLQMEKK
210 220 230 240 250
MNESASGQEP TKVSQVESPE AKGGLPEDRS CLAEVSVSSP EVQEKESKEE
260 270 280 290 300
IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS
310 320 330 340
KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS
Length:340
Mass (Da):38,328
Last modified:September 5, 2006 - v2
Checksum:i974ABDB417F9F90D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841G → A in CAA44541. (PubMed:1348690)Curated
Sequence conflicti189 – 1891Q → E in CAA44541. (PubMed:1348690)Curated
Sequence conflicti207 – 2071G → A in CAA44541. (PubMed:1348690)Curated
Sequence conflicti268 – 2681K → E(PubMed:1348690)Curated
Sequence conflicti268 – 2681K → E(PubMed:2569970)Curated
Sequence conflicti268 – 2681K → E(PubMed:2569969)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62669 Genomic DNA. Translation: CAA44541.1.
BC013463 mRNA. Translation: AAH13463.1.
BC048690 mRNA. Translation: AAH48690.1.
X14715 Genomic DNA. Translation: CAB57814.1.
CCDSiCCDS16141.1.
PIRiS20879.
RefSeqiNP_038582.2. NM_013554.5.
UniGeneiMm.24420.

Genome annotation databases

EnsembliENSMUST00000061745; ENSMUSP00000062412; ENSMUSG00000050368.
GeneIDi15430.
KEGGimmu:15430.
UCSCiuc008kdx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62669 Genomic DNA. Translation: CAA44541.1 .
BC013463 mRNA. Translation: AAH13463.1 .
BC048690 mRNA. Translation: AAH48690.1 .
X14715 Genomic DNA. Translation: CAB57814.1 .
CCDSi CCDS16141.1.
PIRi S20879.
RefSeqi NP_038582.2. NM_013554.5.
UniGenei Mm.24420.

3D structure databases

ProteinModelPortali P28359.
SMRi P28359. Positions 267-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200392. 5 interactions.
IntActi P28359. 1 interaction.
MINTi MINT-1172392.

PTM databases

PhosphoSitei P28359.

Proteomic databases

MaxQBi P28359.
PRIDEi P28359.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061745 ; ENSMUSP00000062412 ; ENSMUSG00000050368 .
GeneIDi 15430.
KEGGi mmu:15430.
UCSCi uc008kdx.2. mouse.

Organism-specific databases

CTDi 3236.
MGIi MGI:96202. Hoxd10.

Phylogenomic databases

eggNOGi NOG241114.
GeneTreei ENSGT00760000118834.
HOGENOMi HOG000231182.
HOVERGENi HBG052934.
InParanoidi P28359.
KOi K09295.
OMAi NPRGSAK.
OrthoDBi EOG7VDXPP.
PhylomeDBi P28359.
TreeFami TF317819.

Miscellaneous databases

NextBioi 288190.
PROi P28359.
SOURCEi Search...

Gene expression databases

Bgeei P28359.
CleanExi MM_HOXD10.
Genevestigatori P28359.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4."
    Renucci A.G.P., Zappavigna V., Zakany J., Izpisua-Belmonte J.-C., Buerki K., Douboule D.
    EMBO J. 11:1459-1468(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney and Limb.
  3. "Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads."
    Dolle P., Duboule D.
    EMBO J. 8:1507-1515(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-325.
  4. "The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes."
    Duboule D., Dolle P.
    EMBO J. 8:1497-1505(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-325, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiHXD10_MOUSE
AccessioniPrimary (citable) accession number: P28359
Secondary accession number(s): Q91WU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3