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P28359 (HXD10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D10
Alternative name(s):
Homeobox protein Hox-4.5
Homeobox protein Hox-5.3
Gene names
Name:Hoxd10
Synonyms:Hox-4.5, Hoxd-10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Developmental stage

Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the second or third lumbar pre-vetrebrae. Ref.4

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult locomotory behavior

Inferred from genetic interaction PubMed 10642795. Source: MGI

anterior/posterior pattern specification

Inferred from genetic interaction PubMed 10642795PubMed 12869760. Source: MGI

embryonic limb morphogenesis

Inferred from genetic interaction PubMed 12869760. Source: MGI

embryonic skeletal system morphogenesis

Inferred from genetic interaction PubMed 10642795. Source: MGI

forelimb morphogenesis

Inferred from genetic interaction PubMed 10642795. Source: MGI

hindlimb morphogenesis

Inferred from genetic interaction PubMed 10642795. Source: MGI

neuromuscular process

Inferred from genetic interaction PubMed 18065432. Source: MGI

peripheral nervous system neuron development

Inferred from genetic interaction PubMed 10642795. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16672333PubMed 1756725. Source: MGI

proximal/distal pattern formation

Inferred from genetic interaction PubMed 12869760. Source: MGI

regulation of gene expression

Inferred from genetic interaction PubMed 23760953. Source: MGI

single fertilization

Inferred from genetic interaction PubMed 23760953. Source: MGI

skeletal muscle tissue development

Inferred from genetic interaction PubMed 10642795. Source: MGI

skeletal system development

Inferred from mutant phenotype PubMed 9409668. Source: MGI

spinal cord motor neuron cell fate specification

Inferred from genetic interaction PubMed 18065432. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from direct assay PubMed 1756725. Source: MGI

chromatin binding

Inferred from direct assay PubMed 16672333. Source: MGI

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 1756725. Source: MGI

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GmnnO885132EBI-445929,EBI-445922

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Homeobox protein Hox-D10
PRO_0000200227

Regions

DNA binding266 – 32560Homeobox

Experimental info

Sequence conflict1841G → A in CAA44541. Ref.1
Sequence conflict1891Q → E in CAA44541. Ref.1
Sequence conflict2071G → A in CAA44541. Ref.1
Sequence conflict2681K → E Ref.1
Sequence conflict2681K → E Ref.3
Sequence conflict2681K → E Ref.4

Sequences

Sequence LengthMass (Da)Tools
P28359 [UniParc].

Last modified September 5, 2006. Version 2.
Checksum: 974ABDB417F9F90D

FASTA34038,328
        10         20         30         40         50         60 
MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT CGLLPSLAKR 

        70         80         90        100        110        120 
EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT CSFTANIKEE SNCCMYSDKR 

       130        140        150        160        170        180 
NKLISAEVPS YQRLVPESCP VENPEVPVPG YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL 

       190        200        210        220        230        240 
NPRGAAKPQL SAAQLQMEKK MNESASGQEP TKVSQVESPE AKGGLPEDRS CLAEVSVSSP 

       250        260        270        280        290        300 
EVQEKESKEE IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS 

       310        320        330        340 
KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS 

« Hide

References

« Hide 'large scale' references
[1]"Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4."
Renucci A.G.P., Zappavigna V., Zakany J., Izpisua-Belmonte J.-C., Buerki K., Douboule D.
EMBO J. 11:1459-1468(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney and Limb.
[3]"Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads."
Dolle P., Duboule D.
EMBO J. 8:1507-1515(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-325.
[4]"The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes."
Duboule D., Dolle P.
EMBO J. 8:1497-1505(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-325, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62669 Genomic DNA. Translation: CAA44541.1.
BC013463 mRNA. Translation: AAH13463.1.
BC048690 mRNA. Translation: AAH48690.1.
X14715 Genomic DNA. Translation: CAB57814.1.
PIRS20879.
RefSeqNP_038582.2. NM_013554.5.
UniGeneMm.24420.

3D structure databases

ProteinModelPortalP28359.
SMRP28359. Positions 233-325.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200392. 5 interactions.
IntActP28359. 1 interaction.
MINTMINT-1172392.

PTM databases

PhosphoSiteP28359.

Proteomic databases

PRIDEP28359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061745; ENSMUSP00000062412; ENSMUSG00000050368.
GeneID15430.
KEGGmmu:15430.
UCSCuc008kdx.2. mouse.

Organism-specific databases

CTD3236.
MGIMGI:96202. Hoxd10.

Phylogenomic databases

eggNOGNOG241114.
GeneTreeENSGT00750000117229.
HOGENOMHOG000231182.
HOVERGENHBG052934.
InParanoidP28359.
KOK09295.
OMANPRGSAK.
OrthoDBEOG7VDXPP.
PhylomeDBP28359.
TreeFamTF317819.

Gene expression databases

BgeeP28359.
CleanExMM_HOXD10.
GenevestigatorP28359.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288190.
PROP28359.
SOURCESearch...

Entry information

Entry nameHXD10_MOUSE
AccessionPrimary (citable) accession number: P28359
Secondary accession number(s): Q91WU9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries