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Protein

Homeobox protein Hox-D10

Gene

Hoxd10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi266 – 325HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • forelimb morphogenesis Source: MGI
  • hindlimb morphogenesis Source: MGI
  • neuromuscular process Source: MGI
  • peripheral nervous system neuron development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • proximal/distal pattern formation Source: MGI
  • regulation of gene expression Source: MGI
  • single fertilization Source: MGI
  • skeletal muscle tissue development Source: MGI
  • skeletal system development Source: MGI
  • spinal cord motor neuron cell fate specification Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D10
Alternative name(s):
Homeobox protein Hox-4.5
Homeobox protein Hox-5.3
Gene namesi
Name:Hoxd10
Synonyms:Hox-4.5, Hoxd-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96202 Hoxd10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002271 – 340Homeobox protein Hox-D10Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei238PhosphoserineCombined sources1
Modified residuei239PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP28359
PaxDbiP28359
PRIDEiP28359

PTM databases

iPTMnetiP28359
PhosphoSitePlusiP28359

Expressioni

Developmental stagei

Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the second or third lumbar pre-vertebrae.1 Publication

Gene expression databases

BgeeiENSMUSG00000050368
CleanExiMM_HOXD10
GenevisibleiP28359 MM

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi2003925 interactors.
IntActiP28359 2 interactors.
STRINGi10090.ENSMUSP00000062412

Structurei

3D structure databases

ProteinModelPortaliP28359
SMRiP28359
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231182
HOVERGENiHBG052934
InParanoidiP28359
KOiK09295
OMAiNPRGSAK
OrthoDBiEOG091G0LON
PhylomeDBiP28359
TreeFamiTF317819

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT
60 70 80 90 100
CGLLPSLAKR EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT
110 120 130 140 150
CSFTANIKEE SNCCMYSDKR NKLISAEVPS YQRLVPESCP VENPEVPVPG
160 170 180 190 200
YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL NPRGAAKPQL SAAQLQMEKK
210 220 230 240 250
MNESASGQEP TKVSQVESPE AKGGLPEDRS CLAEVSVSSP EVQEKESKEE
260 270 280 290 300
IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS
310 320 330 340
KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS
Length:340
Mass (Da):38,328
Last modified:September 5, 2006 - v2
Checksum:i974ABDB417F9F90D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184G → A in CAA44541 (PubMed:1348690).Curated1
Sequence conflicti189Q → E in CAA44541 (PubMed:1348690).Curated1
Sequence conflicti207G → A in CAA44541 (PubMed:1348690).Curated1
Sequence conflicti268K → E (PubMed:1348690).Curated1
Sequence conflicti268K → E (PubMed:2569970).Curated1
Sequence conflicti268K → E (PubMed:2569969).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62669 Genomic DNA Translation: CAA44541.1
BC013463 mRNA Translation: AAH13463.1
BC048690 mRNA Translation: AAH48690.1
X14715 Genomic DNA Translation: CAB57814.1
CCDSiCCDS16141.1
PIRiS20879
RefSeqiNP_038582.2, NM_013554.5
UniGeneiMm.24420

Genome annotation databases

EnsembliENSMUST00000061745; ENSMUSP00000062412; ENSMUSG00000050368
GeneIDi15430
KEGGimmu:15430
UCSCiuc008kdx.3 mouse

Similar proteinsi

Entry informationi

Entry nameiHXD10_MOUSE
AccessioniPrimary (citable) accession number: P28359
Secondary accession number(s): Q91WU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome