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P28359

- HXD10_MOUSE

UniProt

P28359 - HXD10_MOUSE

Protein

Homeobox protein Hox-D10

Gene

Hoxd10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi266 – 32560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding Source: InterPro
    5. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. adult locomotory behavior Source: MGI
    2. anterior/posterior pattern specification Source: MGI
    3. embryonic limb morphogenesis Source: MGI
    4. embryonic skeletal system morphogenesis Source: MGI
    5. forelimb morphogenesis Source: MGI
    6. hindlimb morphogenesis Source: MGI
    7. neuromuscular process Source: MGI
    8. peripheral nervous system neuron development Source: MGI
    9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    10. proximal/distal pattern formation Source: MGI
    11. regulation of gene expression Source: MGI
    12. single fertilization Source: MGI
    13. skeletal muscle tissue development Source: MGI
    14. skeletal system development Source: MGI
    15. spinal cord motor neuron cell fate specification Source: MGI
    16. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D10
    Alternative name(s):
    Homeobox protein Hox-4.5
    Homeobox protein Hox-5.3
    Gene namesi
    Name:Hoxd10
    Synonyms:Hox-4.5, Hoxd-10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:96202. Hoxd10.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Homeobox protein Hox-D10PRO_0000200227Add
    BLAST

    Proteomic databases

    PRIDEiP28359.

    PTM databases

    PhosphoSiteiP28359.

    Expressioni

    Developmental stagei

    Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the second or third lumbar pre-vetrebrae.1 Publication

    Gene expression databases

    BgeeiP28359.
    CleanExiMM_HOXD10.
    GenevestigatoriP28359.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GmnnO885132EBI-445929,EBI-445922

    Protein-protein interaction databases

    BioGridi200392. 5 interactions.
    IntActiP28359. 1 interaction.
    MINTiMINT-1172392.

    Structurei

    3D structure databases

    ProteinModelPortaliP28359.
    SMRiP28359. Positions 267-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG241114.
    GeneTreeiENSGT00750000117229.
    HOGENOMiHOG000231182.
    HOVERGENiHBG052934.
    InParanoidiP28359.
    KOiK09295.
    OMAiNPRGSAK.
    OrthoDBiEOG7VDXPP.
    PhylomeDBiP28359.
    TreeFamiTF317819.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28359-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT    50
    CGLLPSLAKR EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT 100
    CSFTANIKEE SNCCMYSDKR NKLISAEVPS YQRLVPESCP VENPEVPVPG 150
    YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL NPRGAAKPQL SAAQLQMEKK 200
    MNESASGQEP TKVSQVESPE AKGGLPEDRS CLAEVSVSSP EVQEKESKEE 250
    IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS 300
    KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS 340
    Length:340
    Mass (Da):38,328
    Last modified:September 5, 2006 - v2
    Checksum:i974ABDB417F9F90D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti184 – 1841G → A in CAA44541. (PubMed:1348690)Curated
    Sequence conflicti189 – 1891Q → E in CAA44541. (PubMed:1348690)Curated
    Sequence conflicti207 – 2071G → A in CAA44541. (PubMed:1348690)Curated
    Sequence conflicti268 – 2681K → E(PubMed:1348690)Curated
    Sequence conflicti268 – 2681K → E(PubMed:2569970)Curated
    Sequence conflicti268 – 2681K → E(PubMed:2569969)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62669 Genomic DNA. Translation: CAA44541.1.
    BC013463 mRNA. Translation: AAH13463.1.
    BC048690 mRNA. Translation: AAH48690.1.
    X14715 Genomic DNA. Translation: CAB57814.1.
    CCDSiCCDS16141.1.
    PIRiS20879.
    RefSeqiNP_038582.2. NM_013554.5.
    UniGeneiMm.24420.

    Genome annotation databases

    EnsembliENSMUST00000061745; ENSMUSP00000062412; ENSMUSG00000050368.
    GeneIDi15430.
    KEGGimmu:15430.
    UCSCiuc008kdx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62669 Genomic DNA. Translation: CAA44541.1 .
    BC013463 mRNA. Translation: AAH13463.1 .
    BC048690 mRNA. Translation: AAH48690.1 .
    X14715 Genomic DNA. Translation: CAB57814.1 .
    CCDSi CCDS16141.1.
    PIRi S20879.
    RefSeqi NP_038582.2. NM_013554.5.
    UniGenei Mm.24420.

    3D structure databases

    ProteinModelPortali P28359.
    SMRi P28359. Positions 267-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200392. 5 interactions.
    IntActi P28359. 1 interaction.
    MINTi MINT-1172392.

    PTM databases

    PhosphoSitei P28359.

    Proteomic databases

    PRIDEi P28359.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061745 ; ENSMUSP00000062412 ; ENSMUSG00000050368 .
    GeneIDi 15430.
    KEGGi mmu:15430.
    UCSCi uc008kdx.2. mouse.

    Organism-specific databases

    CTDi 3236.
    MGIi MGI:96202. Hoxd10.

    Phylogenomic databases

    eggNOGi NOG241114.
    GeneTreei ENSGT00750000117229.
    HOGENOMi HOG000231182.
    HOVERGENi HBG052934.
    InParanoidi P28359.
    KOi K09295.
    OMAi NPRGSAK.
    OrthoDBi EOG7VDXPP.
    PhylomeDBi P28359.
    TreeFami TF317819.

    Miscellaneous databases

    NextBioi 288190.
    PROi P28359.
    SOURCEi Search...

    Gene expression databases

    Bgeei P28359.
    CleanExi MM_HOXD10.
    Genevestigatori P28359.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4."
      Renucci A.G.P., Zappavigna V., Zakany J., Izpisua-Belmonte J.-C., Buerki K., Douboule D.
      EMBO J. 11:1459-1468(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney and Limb.
    3. "Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads."
      Dolle P., Duboule D.
      EMBO J. 8:1507-1515(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-325.
    4. "The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes."
      Duboule D., Dolle P.
      EMBO J. 8:1497-1505(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-325, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiHXD10_MOUSE
    AccessioniPrimary (citable) accession number: P28359
    Secondary accession number(s): Q91WU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3