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P28357

- HXD9_MOUSE

UniProt

P28357 - HXD9_MOUSE

Protein

Homeobox protein Hox-D9

Gene

Hoxd9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi272 – 33160HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. adult locomotory behavior Source: MGI
    2. anterior/posterior pattern specification Source: MGI
    3. embryonic forelimb morphogenesis Source: MGI
    4. embryonic skeletal system development Source: MGI
    5. embryonic skeletal system morphogenesis Source: MGI
    6. forelimb morphogenesis Source: MGI
    7. hindlimb morphogenesis Source: MGI
    8. mammary gland development Source: MGI
    9. peripheral nervous system neuron development Source: MGI
    10. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    11. proximal/distal pattern formation Source: MGI
    12. regulation of gene expression Source: MGI
    13. single fertilization Source: MGI
    14. skeletal muscle tissue development Source: MGI
    15. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D9
    Alternative name(s):
    Homeobox protein Hox-4.4
    Homeobox protein Hox-5.2
    Gene namesi
    Name:Hoxd9
    Synonyms:Hox-4.4, Hoxd-9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:96210. Hoxd9.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Homeobox protein Hox-D9PRO_0000200221Add
    BLAST

    Proteomic databases

    PRIDEiP28357.

    PTM databases

    PhosphoSiteiP28357.

    Expressioni

    Developmental stagei

    Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the first lumbar pre-vetrebrae.1 Publication

    Gene expression databases

    BgeeiP28357.
    CleanExiMM_HOXD9.
    GenevestigatoriP28357.

    Interactioni

    Protein-protein interaction databases

    BioGridi200399. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP28357.
    SMRiP28357. Positions 246-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi113 – 14028Gly-richAdd
    BLAST
    Compositional biasi119 – 13113Poly-GlyAdd
    BLAST
    Compositional biasi163 – 17614Ser/Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG286554.
    GeneTreeiENSGT00750000117229.
    HOGENOMiHOG000231180.
    HOVERGENiHBG016849.
    InParanoidiQ3UMQ3.
    KOiK09294.
    OMAiHEGDEVF.
    OrthoDBiEOG722J9F.
    PhylomeDBiP28357.
    TreeFamiTF317819.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28357-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGTQGRPA GVADGPAAAT    50
    AEFASCSFAP KSSVFSASWS AVAAQPPAAA TMSGLYHPYV SPPPLAAAEP 100
    GRYVRSWMEP LPGFPGGAGG GGGSGGGGGG GPGPVPSPGG PANGRHYGIK 150
    PETGAAPAPA AASTSSSSST SSSSSSKRTE CSAARESQGS GGPEFPCNSF 200
    LRDKAAAATG NGPGVGIGTG PGAVGSSEPS ACSDHPSPGC SLKEEEKQPP 250
    QPPQQQLDPN NPAANWIHAR STRKKRCPYT KYQTLELEKE FLFNMYLTRD 300
    RRYEVARILN LTERQVKIWF QNRRMKMKKM SKEKCPKGD 339
    Length:339
    Mass (Da):34,992
    Last modified:December 1, 1992 - v1
    Checksum:i370DC47C6929F7E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62669 Genomic DNA. Translation: CAA44542.1.
    AK134427 mRNA. Translation: BAE22140.1.
    AK144746 mRNA. Translation: BAE26045.1.
    AL928644 Genomic DNA. Translation: CAM20529.1.
    BC019150 mRNA. Translation: AAH19150.1.
    X14714 Genomic DNA. Translation: CAB57813.1.
    CCDSiCCDS16142.1.
    PIRiS20880.
    RefSeqiNP_038583.1. NM_013555.4.
    UniGeneiMm.26544.

    Genome annotation databases

    EnsembliENSMUST00000059272; ENSMUSP00000058490; ENSMUSG00000043342.
    GeneIDi15438.
    KEGGimmu:15438.
    UCSCiuc008kdz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62669 Genomic DNA. Translation: CAA44542.1 .
    AK134427 mRNA. Translation: BAE22140.1 .
    AK144746 mRNA. Translation: BAE26045.1 .
    AL928644 Genomic DNA. Translation: CAM20529.1 .
    BC019150 mRNA. Translation: AAH19150.1 .
    X14714 Genomic DNA. Translation: CAB57813.1 .
    CCDSi CCDS16142.1.
    PIRi S20880.
    RefSeqi NP_038583.1. NM_013555.4.
    UniGenei Mm.26544.

    3D structure databases

    ProteinModelPortali P28357.
    SMRi P28357. Positions 246-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200399. 3 interactions.

    PTM databases

    PhosphoSitei P28357.

    Proteomic databases

    PRIDEi P28357.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059272 ; ENSMUSP00000058490 ; ENSMUSG00000043342 .
    GeneIDi 15438.
    KEGGi mmu:15438.
    UCSCi uc008kdz.1. mouse.

    Organism-specific databases

    CTDi 3235.
    MGIi MGI:96210. Hoxd9.

    Phylogenomic databases

    eggNOGi NOG286554.
    GeneTreei ENSGT00750000117229.
    HOGENOMi HOG000231180.
    HOVERGENi HBG016849.
    InParanoidi Q3UMQ3.
    KOi K09294.
    OMAi HEGDEVF.
    OrthoDBi EOG722J9F.
    PhylomeDBi P28357.
    TreeFami TF317819.

    Miscellaneous databases

    NextBioi 288218.
    PROi P28357.
    SOURCEi Search...

    Gene expression databases

    Bgeei P28357.
    CleanExi MM_HOXD9.
    Genevestigatori P28357.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4."
      Renucci A.G.P., Zappavigna V., Zakany J., Izpisua-Belmonte J.-C., Buerki K., Douboule D.
      EMBO J. 11:1459-1468(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung and Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    5. "Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads."
      Dolle P., Duboule D.
      EMBO J. 8:1507-1515(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 272-331.
    6. "The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes."
      Duboule D., Dolle P.
      EMBO J. 8:1497-1505(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 272-331, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiHXD9_MOUSE
    AccessioniPrimary (citable) accession number: P28357
    Secondary accession number(s): A2ASM9, Q3UMQ3, Q3UYS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3