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Protein

Homeobox protein Hox-D9

Gene

HOXD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Caution

It is uncertain whether Met-1 or Met-11 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi285 – 344HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP28356

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D9
Alternative name(s):
Homeobox protein Hox-4C
Homeobox protein Hox-5.2
Gene namesi
Name:HOXD9
Synonyms:HOX4C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000128709.11
HGNCiHGNC:5140 HOXD9
MIMi142982 gene
neXtProtiNX_P28356

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3235
OpenTargetsiENSG00000128709
PharmGKBiPA29414

Polymorphism and mutation databases

BioMutaiHOXD9
DMDMi294862543

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002201 – 352Homeobox protein Hox-D9Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP28356
PaxDbiP28356
PeptideAtlasiP28356
PRIDEiP28356

PTM databases

iPTMnetiP28356
PhosphoSitePlusiP28356

Expressioni

Developmental stagei

Expressed in the developing limb buds.

Gene expression databases

BgeeiENSG00000128709
CleanExiHS_HOXD9
GenevisibleiP28356 HS

Organism-specific databases

HPAiHPA068683

Interactioni

Protein-protein interaction databases

BioGridi109475, 9 interactors
IntActiP28356, 3 interactors
STRINGi9606.ENSP00000249499

Structurei

3D structure databases

ProteinModelPortaliP28356
SMRiP28356
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi125 – 159Gly-richAdd BLAST35
Compositional biasi131 – 140Poly-Gly10
Compositional biasi175 – 188Ser/Thr-richAdd BLAST14

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231180
HOVERGENiHBG016849
InParanoidiP28356
KOiK09294
OMAiSGLYHPY
OrthoDBiEOG091G0LON
PhylomeDBiP28356
TreeFamiTF317819

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR006711 Hox9_activation_N
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF04617 Hox9_act, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28356-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGGSAGRLK MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGAQGRPA
60 70 80 90 100
GVADGPAATA AEFASCSFAP RSAVFSASWS AVPSQPPAAA AMSGLYHPYV
110 120 130 140 150
PPPPLAASAS EPGRYVRSWM EPLPGFPGGA GGGGGGGGGG PGRGPSPGPS
160 170 180 190 200
GPANGRHYGI KPETRAAPAP ATAASTTSSS STSLSSSSKR TECSVARESQ
210 220 230 240 250
GSSGPEFSCN SFLQEKAAAA TGGTGPGAGI GAATGTGGSS EPSACSDHPI
260 270 280 290 300
PGCSLKEEEK QHSQPQQQQL DPNNPAANWI HARSTRKKRC PYTKYQTLEL
310 320 330 340 350
EKEFLFNMYL TRDRRYEVAR ILNLTERQVK IWFQNRRMKM KKMSKEKCPK

GD
Length:352
Mass (Da):36,495
Last modified:April 20, 2010 - v5
Checksum:iECBFE68B48C0F532
GO

Sequence cautioni

The sequence AAH44855 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA42016 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144 – 156GPSPG…PANGR → VPALAPAAQPTGC in AAH44855 (PubMed:15489334).CuratedAdd BLAST13
Sequence conflicti219 – 224AATGGT → GGDGGN in CAA42016 (PubMed:1756725).Curated6
Sequence conflicti276A → E in CAA42016 (PubMed:1756725).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031851269Missing 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59372 mRNA Translation: CAA42016.1 Different initiation.
AC009336 Genomic DNA No translation available.
BC044855 mRNA Translation: AAH44855.2 Different initiation.
X15506 Genomic DNA Translation: CAA33528.1
CCDSiCCDS2267.2
PIRiS18649
RefSeqiNP_055028.3, NM_014213.3
UniGeneiHs.236646

Genome annotation databases

EnsembliENST00000249499; ENSP00000249499; ENSG00000128709
GeneIDi3235
KEGGihsa:3235
UCSCiuc010zex.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHXD9_HUMAN
AccessioniPrimary (citable) accession number: P28356
Secondary accession number(s): Q86ST1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 159 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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