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P28356

- HXD9_HUMAN

UniProt

P28356 - HXD9_HUMAN

Protein

Homeobox protein Hox-D9

Gene

HOXD9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 5 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi285 – 34460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. anterior/posterior pattern specification Source: Ensembl
    3. embryonic forelimb morphogenesis Source: Ensembl
    4. embryonic skeletal system morphogenesis Source: Ensembl
    5. hindlimb morphogenesis Source: Ensembl
    6. mammary gland development Source: Ensembl
    7. peripheral nervous system neuron development Source: Ensembl
    8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    9. proximal/distal pattern formation Source: Ensembl
    10. skeletal muscle tissue development Source: Ensembl
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D9
    Alternative name(s):
    Homeobox protein Hox-4C
    Homeobox protein Hox-5.2
    Gene namesi
    Name:HOXD9
    Synonyms:HOX4C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5140. HOXD9.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29414.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352Homeobox protein Hox-D9PRO_0000200220Add
    BLAST

    Proteomic databases

    MaxQBiP28356.
    PaxDbiP28356.
    PRIDEiP28356.

    PTM databases

    PhosphoSiteiP28356.

    Expressioni

    Developmental stagei

    Expressed in the developing limb buds.

    Gene expression databases

    BgeeiP28356.
    CleanExiHS_HOXD9.
    GenevestigatoriP28356.

    Interactioni

    Protein-protein interaction databases

    BioGridi109475. 8 interactions.
    IntActiP28356. 3 interactions.
    STRINGi9606.ENSP00000249499.

    Structurei

    3D structure databases

    ProteinModelPortaliP28356.
    SMRiP28356. Positions 285-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi125 – 15935Gly-richAdd
    BLAST
    Compositional biasi131 – 14010Poly-Gly
    Compositional biasi175 – 18814Ser/Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG286554.
    HOGENOMiHOG000231180.
    HOVERGENiHBG016849.
    InParanoidiP28356.
    KOiK09294.
    OMAiHEGDEVF.
    OrthoDBiEOG722J9F.
    PhylomeDBiP28356.
    TreeFamiTF317819.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28356-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGGSAGRLK MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGAQGRPA    50
    GVADGPAATA AEFASCSFAP RSAVFSASWS AVPSQPPAAA AMSGLYHPYV 100
    PPPPLAASAS EPGRYVRSWM EPLPGFPGGA GGGGGGGGGG PGRGPSPGPS 150
    GPANGRHYGI KPETRAAPAP ATAASTTSSS STSLSSSSKR TECSVARESQ 200
    GSSGPEFSCN SFLQEKAAAA TGGTGPGAGI GAATGTGGSS EPSACSDHPI 250
    PGCSLKEEEK QHSQPQQQQL DPNNPAANWI HARSTRKKRC PYTKYQTLEL 300
    EKEFLFNMYL TRDRRYEVAR ILNLTERQVK IWFQNRRMKM KKMSKEKCPK 350
    GD 352
    Length:352
    Mass (Da):36,495
    Last modified:April 20, 2010 - v5
    Checksum:iECBFE68B48C0F532
    GO

    Sequence cautioni

    The sequence AAH44855.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAA42016.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti144 – 15613GPSPG…PANGR → VPALAPAAQPTGC in AAH44855. (PubMed:15489334)CuratedAdd
    BLAST
    Sequence conflicti219 – 2246AATGGT → GGDGGN in CAA42016. (PubMed:1756725)Curated
    Sequence conflicti276 – 2761A → E in CAA42016. (PubMed:1756725)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti269 – 2691Missing.1 Publication
    VAR_031851

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59372 mRNA. Translation: CAA42016.1. Different initiation.
    AC009336 Genomic DNA. No translation available.
    BC044855 mRNA. Translation: AAH44855.2. Different initiation.
    X15506 Genomic DNA. Translation: CAA33528.1.
    CCDSiCCDS2267.2.
    PIRiS18649.
    RefSeqiNP_055028.3. NM_014213.3.
    UniGeneiHs.236646.

    Genome annotation databases

    EnsembliENST00000249499; ENSP00000249499; ENSG00000128709.
    GeneIDi3235.
    KEGGihsa:3235.
    UCSCiuc010zex.2. human.

    Polymorphism databases

    DMDMi294862543.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59372 mRNA. Translation: CAA42016.1 . Different initiation.
    AC009336 Genomic DNA. No translation available.
    BC044855 mRNA. Translation: AAH44855.2 . Different initiation.
    X15506 Genomic DNA. Translation: CAA33528.1 .
    CCDSi CCDS2267.2.
    PIRi S18649.
    RefSeqi NP_055028.3. NM_014213.3.
    UniGenei Hs.236646.

    3D structure databases

    ProteinModelPortali P28356.
    SMRi P28356. Positions 285-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109475. 8 interactions.
    IntActi P28356. 3 interactions.
    STRINGi 9606.ENSP00000249499.

    PTM databases

    PhosphoSitei P28356.

    Polymorphism databases

    DMDMi 294862543.

    Proteomic databases

    MaxQBi P28356.
    PaxDbi P28356.
    PRIDEi P28356.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249499 ; ENSP00000249499 ; ENSG00000128709 .
    GeneIDi 3235.
    KEGGi hsa:3235.
    UCSCi uc010zex.2. human.

    Organism-specific databases

    CTDi 3235.
    GeneCardsi GC02P176987.
    HGNCi HGNC:5140. HOXD9.
    MIMi 142982. gene.
    neXtProti NX_P28356.
    PharmGKBi PA29414.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286554.
    HOGENOMi HOG000231180.
    HOVERGENi HBG016849.
    InParanoidi P28356.
    KOi K09294.
    OMAi HEGDEVF.
    OrthoDBi EOG722J9F.
    PhylomeDBi P28356.
    TreeFami TF317819.

    Miscellaneous databases

    GeneWikii HOXD9.
    GenomeRNAii 3235.
    NextBioi 12875.
    PROi P28356.
    SOURCEi Search...

    Gene expression databases

    Bgeei P28356.
    CleanExi HS_HOXD9.
    Genevestigatori P28356.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities."
      Zappavigna V., Renucci A., Izpisua-Belmonte J.-C., Urier G., Peschle C., Duboule D.
      EMBO J. 10:4177-4187(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spinal cord.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    4. "Complementary homeo protein gradients in developing limb buds."
      Oliver G., Sidell N., Fiske N., Heinzmann C., Mohandas T., Sparkes R.S., De Robertis E.M.
      Genes Dev. 3:641-650(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 274-352.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 285-350.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: VARIANT GLN-269 DEL.

    Entry informationi

    Entry nameiHXD9_HUMAN
    AccessioniPrimary (citable) accession number: P28356
    Secondary accession number(s): Q86ST1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 129 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-11 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3