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P28356

- HXD9_HUMAN

UniProt

P28356 - HXD9_HUMAN

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Protein

Homeobox protein Hox-D9

Gene

HOXD9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi285 – 34460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. anterior/posterior pattern specification Source: Ensembl
  3. embryonic forelimb morphogenesis Source: Ensembl
  4. embryonic skeletal system morphogenesis Source: Ensembl
  5. hindlimb morphogenesis Source: Ensembl
  6. mammary gland development Source: Ensembl
  7. peripheral nervous system neuron development Source: Ensembl
  8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. proximal/distal pattern formation Source: Ensembl
  10. single fertilization Source: Ensembl
  11. skeletal muscle tissue development Source: Ensembl
  12. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D9
Alternative name(s):
Homeobox protein Hox-4C
Homeobox protein Hox-5.2
Gene namesi
Name:HOXD9
Synonyms:HOX4C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:5140. HOXD9.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Homeobox protein Hox-D9PRO_0000200220Add
BLAST

Proteomic databases

MaxQBiP28356.
PaxDbiP28356.
PRIDEiP28356.

PTM databases

PhosphoSiteiP28356.

Expressioni

Developmental stagei

Expressed in the developing limb buds.

Gene expression databases

BgeeiP28356.
CleanExiHS_HOXD9.
GenevestigatoriP28356.

Interactioni

Protein-protein interaction databases

BioGridi109475. 8 interactions.
IntActiP28356. 3 interactions.
STRINGi9606.ENSP00000249499.

Structurei

3D structure databases

ProteinModelPortaliP28356.
SMRiP28356. Positions 285-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi125 – 15935Gly-richAdd
BLAST
Compositional biasi131 – 14010Poly-Gly
Compositional biasi175 – 18814Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG286554.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231180.
HOVERGENiHBG016849.
InParanoidiP28356.
KOiK09294.
OMAiHEGDEVF.
OrthoDBiEOG722J9F.
PhylomeDBiP28356.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28356-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGGSAGRLK MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGAQGRPA
60 70 80 90 100
GVADGPAATA AEFASCSFAP RSAVFSASWS AVPSQPPAAA AMSGLYHPYV
110 120 130 140 150
PPPPLAASAS EPGRYVRSWM EPLPGFPGGA GGGGGGGGGG PGRGPSPGPS
160 170 180 190 200
GPANGRHYGI KPETRAAPAP ATAASTTSSS STSLSSSSKR TECSVARESQ
210 220 230 240 250
GSSGPEFSCN SFLQEKAAAA TGGTGPGAGI GAATGTGGSS EPSACSDHPI
260 270 280 290 300
PGCSLKEEEK QHSQPQQQQL DPNNPAANWI HARSTRKKRC PYTKYQTLEL
310 320 330 340 350
EKEFLFNMYL TRDRRYEVAR ILNLTERQVK IWFQNRRMKM KKMSKEKCPK

GD
Length:352
Mass (Da):36,495
Last modified:April 20, 2010 - v5
Checksum:iECBFE68B48C0F532
GO

Sequence cautioni

The sequence AAH44855.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA42016.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 15613GPSPG…PANGR → VPALAPAAQPTGC in AAH44855. (PubMed:15489334)CuratedAdd
BLAST
Sequence conflicti219 – 2246AATGGT → GGDGGN in CAA42016. (PubMed:1756725)Curated
Sequence conflicti276 – 2761A → E in CAA42016. (PubMed:1756725)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti269 – 2691Missing.1 Publication
VAR_031851

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59372 mRNA. Translation: CAA42016.1. Different initiation.
AC009336 Genomic DNA. No translation available.
BC044855 mRNA. Translation: AAH44855.2. Different initiation.
X15506 Genomic DNA. Translation: CAA33528.1.
CCDSiCCDS2267.2.
PIRiS18649.
RefSeqiNP_055028.3. NM_014213.3.
UniGeneiHs.236646.

Genome annotation databases

EnsembliENST00000249499; ENSP00000249499; ENSG00000128709.
GeneIDi3235.
KEGGihsa:3235.
UCSCiuc010zex.2. human.

Polymorphism databases

DMDMi294862543.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59372 mRNA. Translation: CAA42016.1 . Different initiation.
AC009336 Genomic DNA. No translation available.
BC044855 mRNA. Translation: AAH44855.2 . Different initiation.
X15506 Genomic DNA. Translation: CAA33528.1 .
CCDSi CCDS2267.2.
PIRi S18649.
RefSeqi NP_055028.3. NM_014213.3.
UniGenei Hs.236646.

3D structure databases

ProteinModelPortali P28356.
SMRi P28356. Positions 285-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109475. 8 interactions.
IntActi P28356. 3 interactions.
STRINGi 9606.ENSP00000249499.

PTM databases

PhosphoSitei P28356.

Polymorphism databases

DMDMi 294862543.

Proteomic databases

MaxQBi P28356.
PaxDbi P28356.
PRIDEi P28356.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249499 ; ENSP00000249499 ; ENSG00000128709 .
GeneIDi 3235.
KEGGi hsa:3235.
UCSCi uc010zex.2. human.

Organism-specific databases

CTDi 3235.
GeneCardsi GC02P176987.
HGNCi HGNC:5140. HOXD9.
MIMi 142982. gene.
neXtProti NX_P28356.
PharmGKBi PA29414.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG286554.
GeneTreei ENSGT00760000118834.
HOGENOMi HOG000231180.
HOVERGENi HBG016849.
InParanoidi P28356.
KOi K09294.
OMAi HEGDEVF.
OrthoDBi EOG722J9F.
PhylomeDBi P28356.
TreeFami TF317819.

Miscellaneous databases

GeneWikii HOXD9.
GenomeRNAii 3235.
NextBioi 12875.
PROi P28356.
SOURCEi Search...

Gene expression databases

Bgeei P28356.
CleanExi HS_HOXD9.
Genevestigatori P28356.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view ]
PIRSFi PIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities."
    Zappavigna V., Renucci A., Izpisua-Belmonte J.-C., Urier G., Peschle C., Duboule D.
    EMBO J. 10:4177-4187(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spinal cord.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "Complementary homeo protein gradients in developing limb buds."
    Oliver G., Sidell N., Fiske N., Heinzmann C., Mohandas T., Sparkes R.S., De Robertis E.M.
    Genes Dev. 3:641-650(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 274-352.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 285-350.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: VARIANT GLN-269 DEL.

Entry informationi

Entry nameiHXD9_HUMAN
AccessioniPrimary (citable) accession number: P28356
Secondary accession number(s): Q86ST1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 130 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-11 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3