SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P28345

- MASY_NEUCR

UniProt

P28345 - MASY_NEUCR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Malate synthase, glyoxysomal
Gene
acu-9, NCU10007
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681Proton acceptor By similarity
Active sitei449 – 4491Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase, glyoxysomal (EC:2.3.3.9)
Alternative name(s):
Acetate utilization protein 9
Gene namesi
Name:acu-9
ORF Names:NCU10007
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Subcellular locationi

GO - Cellular componenti

  1. glyoxysome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Malate synthase, glyoxysomal
PRO_0000166862Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU10007.1.

Structurei

3D structure databases

ProteinModelPortaliP28345.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi540 – 5423Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Belongs to the malate synthase family.

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000238464.
KOiK01638.
OMAiSIWQWIR.
OrthoDBiEOG7GXPMK.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28345-1 [UniParc]FASTAAdd to Basket

« Hide

MASVETLLQG VTISGPIEEH QRKILTPQAL SFVALLHRSF NQTRKNLLER    50
RQLRQAEIDR GVLPDFLPET KHIRENPTWK GAPPAPGLVD RRVEITGPTD 100
RKMVVNALNS DVYTYMADFE DSSAPTWANM VNGQVNLYDA IRRQIDFKQG 150
PKEYKLRTDR TLPTLIVRPR GWHLEEKHVT IDGEPVSGSL FDFGLYFFHN 200
AKELVQRGFG PYFYLPKMES HLEARLWNDA FNLAQDYVGI PRGTIRGTVL 250
IETILAAFEM DEIIYELREH SSGLNCGRWD YIFSTIKKFR NHSSFVLPDR 300
SCVTMTVPFM DAYVKLLIQT CHKRGVHAMG GMAAQIPIKD DKAANDKAME 350
GVRADKLREA RAGHDGTWVA HPALASIALE VFNKHMPTPN QLFNRREDVK 400
IGQQDLLNMN VPGSITEEGI RKNLNIGLGY MEAWIRGVGC VPINYLMEDA 450
ATAEVSRSQL WQWVKHGVTT AEGKRVDKSY ALKLLKEQTD ELASKAPQGN 500
KFNLAAQYFA TQVTGEDYAD FLTSLLYNEI TSAGNSLPAS KL 542
Length:542
Mass (Da):61,180
Last modified:April 13, 2004 - v2
Checksum:iEE0F085DD30DAC20
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 532QL → HV in CAA39994. 1 Publication
Sequence conflicti83 – 875PPAPG → APAAPP1 Publication
Sequence conflicti95 – 951I → M in CAA39994. 1 Publication
Sequence conflicti215 – 2151L → P in CAA39994. 1 Publication
Sequence conflicti242 – 2432RG → LS in CAA39994. 1 Publication
Sequence conflicti255 – 2551L → T in CAA39994. 1 Publication
Sequence conflicti265 – 2651Y → F in CAA39994. 1 Publication
Sequence conflicti269 – 2713EHS → NHT in CAA39994. 1 Publication
Sequence conflicti276 – 2783CGR → RGG in CAA39994. 1 Publication
Sequence conflicti284 – 2852ST → PF in CAA39994. 1 Publication
Sequence conflicti288 – 2947KFRNHSS → EVRRFPN in CAA39994. 1 Publication
Sequence conflicti302 – 3021C → D in CAA39994. 1 Publication
Sequence conflicti311 – 3111D → E in CAA39994. 1 Publication
Sequence conflicti319 – 3257QTCHKRG → KTLHRLV in CAA39994. 1 Publication
Sequence conflicti331 – 3311Missing in CAA39994. 1 Publication
Sequence conflicti415 – 4151I → S in CAA39994. 1 Publication
Sequence conflicti418 – 4181E → D in CAA39994. 1 Publication
Sequence conflicti426 – 4261I → T in CAA39994. 1 Publication
Sequence conflicti431 – 4333MEA → TEP in CAA39994. 1 Publication
Sequence conflicti444 – 4474NYLM → KHPQ in CAA39994. 1 Publication
Sequence conflicti467 – 4671G → R in CAA39994. 1 Publication
Sequence conflicti475 – 4751R → H in CAA39994. 1 Publication
Sequence conflicti479 – 4813SYA → RYP in CAA39994. 1 Publication
Sequence conflicti488 – 4947QTDELAS → ADRQRLA in CAA39994. 1 Publication
Sequence conflicti511 – 5111T → S in CAA39994. 1 Publication
Sequence conflicti524 – 5241S → C in CAA39994. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56672 Genomic DNA. Translation: CAA39994.1.
CM002236 Genomic DNA. Translation: ESA43774.1.
CM002236 Genomic DNA. Translation: ESA43775.1.
PIRiS17774.
RefSeqiXP_959453.1. XM_954360.2.
UniGeneiNcr.14021.

Genome annotation databases

EnsemblFungiiEFNCRT00000008728; EFNCRP00000008710; EFNCRG00000008714.
GeneIDi3875600.
KEGGincr:NCU10007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56672 Genomic DNA. Translation: CAA39994.1 .
CM002236 Genomic DNA. Translation: ESA43774.1 .
CM002236 Genomic DNA. Translation: ESA43775.1 .
PIRi S17774.
RefSeqi XP_959453.1. XM_954360.2.
UniGenei Ncr.14021.

3D structure databases

ProteinModelPortali P28345.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5141.NCU10007.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000008728 ; EFNCRP00000008710 ; EFNCRG00000008714 .
GeneIDi 3875600.
KEGGi ncr:NCU10007.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000238464.
KOi K01638.
OMAi SIWQWIR.
OrthoDBi EOG7GXPMK.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .

Family and domain databases

InterProi IPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001363. Malate_synth. 1 hit.
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular organisation of the malate synthase genes of Aspergillus nidulans and Neurospora crassa."
    Sandeman R.A., Hynes M.J., Fincham J.R.S., Connerton I.F.
    Mol. Gen. Genet. 228:445-452(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiMASY_NEUCR
AccessioniPrimary (citable) accession number: P28345
Secondary accession number(s): Q7RV95, V5IPX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 13, 2004
Last modified: June 11, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi