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P28344

- MASY_EMENI

UniProt

P28344 - MASY_EMENI

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Protein
Malate synthase, glyoxysomal
Gene
acuE, AN6653
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681Proton acceptor By similarity
Active sitei449 – 4491Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: ASPGD

GO - Biological processi

  1. acetate catabolic process Source: ASPGD
  2. carbon utilization Source: ASPGD
  3. fatty acid catabolic process Source: ASPGD
  4. glyoxylate cycle Source: ASPGD
  5. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase, glyoxysomal (EC:2.3.3.9)
Gene namesi
Name:acuE
ORF Names:AN6653
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. glyoxysome Source: UniProtKB-SubCell
  2. peroxisomal matrix Source: ASPGD
  3. peroxisome Source: ASPGD
Complete GO annotation...

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Malate synthase, glyoxysomal
PRO_0000166861Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00007436.

Structurei

3D structure databases

ProteinModelPortaliP28344.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi537 – 5393Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Belongs to the malate synthase family.

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000238464.
KOiK01638.
OMAiREGDWAC.
OrthoDBiEOG7GXPMK.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28344-1 [UniParc]FASTAAdd to Basket

« Hide

MSQVDAQLKD VAILGSVSNE ARKILTKEAC AFLAILHRTF NPTRKALLQR    50
RVDRQAEIDK GHLPDFLPET KHIRDDPSWK GAPPAPGLVD RRVEITGPTD 100
RKMVVNALNS DVWTYMADFE DSSAPTWDNM INGQINLYDA IRRQVDFKQG 150
QKEYKLRTDR TLPTLIARAR GWHLDEKHFT VDGEPISGSL FDFGLYFFHN 200
AKELVARGFG PYFYLPKMES HLEARLWNDV FNLAQDYIGM PRGTIRGTVL 250
IETITAAFEM EEIIYELRDH SSGLNCGRWD YIFSFIKKFR QHPNFVLPDR 300
SDVTMTVPFM DAYVKLLIKT CHKRGVHAMG GMAAQIPIKD NAEANDKAME 350
GVRADKLREV RAGHDGTWVA HPALASIASE VFNKYMPTPN QMHVRREDVN 400
ITANDLLNTN VPGKITEDGI RKNLNIGLSY MEGWLRGVGC IPINYLMEDA 450
ATAEVSRSQL WQWARHGVTT SEGKKVDKAY ALRLLKEQAD ALAAKGPKGN 500
KFQLAGRYFA GQVTGEDYAD FLTSLLYNEI SSPGTASKL 539
Length:539
Mass (Da):60,797
Last modified:November 16, 2011 - v3
Checksum:iD29334EA211735F8
GO

Sequence cautioni

The sequence CAA39993.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAA58182.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti510 – 5101A → S in CAA39993. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56671 Genomic DNA. Translation: CAA39993.1. Sequence problems.
AACD01000110 Genomic DNA. Translation: EAA58182.1. Sequence problems.
BN001301 Genomic DNA. Translation: CBF71180.1.
PIRiS17773.
RefSeqiXP_664257.1. XM_659165.1.

Genome annotation databases

EnsemblFungiiCADANIAT00007436; CADANIAP00007436; CADANIAG00007436.
GeneIDi2870422.
KEGGiani:AN6653.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56671 Genomic DNA. Translation: CAA39993.1 . Sequence problems.
AACD01000110 Genomic DNA. Translation: EAA58182.1 . Sequence problems.
BN001301 Genomic DNA. Translation: CBF71180.1 .
PIRi S17773.
RefSeqi XP_664257.1. XM_659165.1.

3D structure databases

ProteinModelPortali P28344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00007436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00007436 ; CADANIAP00007436 ; CADANIAG00007436 .
GeneIDi 2870422.
KEGGi ani:AN6653.2.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000238464.
KOi K01638.
OMAi REGDWAC.
OrthoDBi EOG7GXPMK.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .

Family and domain databases

InterProi IPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001363. Malate_synth. 1 hit.
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular organisation of the malate synthase genes of Aspergillus nidulans and Neurospora crassa."
    Sandeman R.A., Hynes M.J., Fincham J.R.S., Connerton I.F.
    Mol. Gen. Genet. 228:445-452(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiMASY_EMENI
AccessioniPrimary (citable) accession number: P28344
Secondary accession number(s): C8V1E0, Q5AYH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 16, 2011
Last modified: June 11, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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