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P28340

- DPOD1_HUMAN

UniProt

P28340 - DPOD1_HUMAN

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Protein

DNA polymerase delta catalytic subunit

Gene
POLD1, POLD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Cofactori

Binds 1 4Fe-4S cluster By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1012 – 10121Zinc By similarity
Metal bindingi1015 – 10151Zinc By similarity
Metal bindingi1026 – 10261Zinc By similarity
Metal bindingi1029 – 10291Zinc By similarity
Metal bindingi1058 – 10581Iron-sulfur (4Fe-4S) By similarity
Metal bindingi1061 – 10611Iron-sulfur (4Fe-4S) By similarity
Metal bindingi1071 – 10711Iron-sulfur (4Fe-4S) By similarity
Metal bindingi1076 – 10761Iron-sulfur (4Fe-4S) By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1012 – 102918CysA-typeAdd
BLAST

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: RefGenome
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. chromatin binding Source: UniProtKB
  4. DNA binding Source: UniProtKB
  5. DNA-directed DNA polymerase activity Source: UniProtKB
  6. metal ion binding Source: UniProtKB-KW
  7. nucleotide binding Source: InterPro
  8. protein binding Source: UniProtKB

GO - Biological processi

  1. base-excision repair Source: Reactome
  2. base-excision repair, gap-filling Source: UniProtKB
  3. DNA repair Source: Reactome
  4. DNA replication Source: UniProtKB
  5. DNA replication, removal of RNA primer Source: RefGenome
  6. DNA replication proofreading Source: RefGenome
  7. DNA strand elongation involved in DNA replication Source: Reactome
  8. DNA synthesis involved in DNA repair Source: UniProtKB
  9. fatty acid homeostasis Source: UniProtKB
  10. mitotic cell cycle Source: Reactome
  11. nucleic acid phosphodiester bond hydrolysis Source: GOC
  12. nucleotide-excision repair Source: Reactome
  13. nucleotide-excision repair, DNA gap filling Source: UniProtKB
  14. regulation of mitotic cell cycle Source: RefGenome
  15. response to UV Source: ProtInc
  16. small molecule metabolic process Source: Reactome
  17. telomere maintenance Source: Reactome
  18. telomere maintenance via recombination Source: Reactome
  19. telomere maintenance via semi-conservative replication Source: Reactome
  20. transcription-coupled nucleotide-excision repair Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

4Fe-4S, DNA-binding, Iron, Iron-sulfur, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_1128. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.
REACT_1385. Processive synthesis on the lagging strand.
REACT_160176. Cytosolic iron-sulfur cluster assembly.
REACT_1792. Polymerase switching.
REACT_1838. Leading Strand Synthesis.
REACT_1993. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
REACT_2192. Removal of DNA patch containing abasic residue.
REACT_378. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
REACT_70. Removal of the Flap Intermediate.
REACT_7961. Telomere C-strand (Lagging Strand) Synthesis.
REACT_7987. Polymerase switching on the C-strand of the telomere.
REACT_7999. Removal of the Flap Intermediate from the C-strand.
REACT_8027. Processive synthesis on the C-strand of the telomere.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase delta catalytic subunit (EC:2.7.7.7)
Alternative name(s):
DNA polymerase subunit delta p125
Gene namesi
Name:POLD1
Synonyms:POLD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:9175. POLD1.

Subcellular locationi

GO - Cellular componenti

  1. aggresome Source: HPA
  2. cytoplasm Source: HPA
  3. delta DNA polymerase complex Source: RefGenome
  4. nucleoplasm Source: Reactome
  5. nucleotide-excision repair complex Source: UniProtKB
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Colorectal cancer 10 (CRCS10) [MIM:612591]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti478 – 4781S → N in CRCS10; associated with disease susceptibility. 1 Publication
VAR_069335
Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome (MDPL) [MIM:615381]: An autosomal dominant systemic disorder characterized by prominent loss of subcutaneous fat, metabolic abnormalities including insulin resistance and diabetes mellitus, sclerodermatous skin, and a facial appearance characterized by mandibular hypoplasia. Sensorineural deafness occurs late in the first or second decades of life.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti605 – 6051Missing in MDPL; the mutant enzyme lacks DNA polymerase ability; has decreased exonuclease activity; can bind DNA but is unable to interact with and incorporate dNTPs. 1 Publication
VAR_070231

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi612591. phenotype.
615381. phenotype.
Orphaneti363649. Mandibular hypoplasia-deafness-progeroid syndrome.
PharmGKBiPA33496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11071107DNA polymerase delta catalytic subunitPRO_0000046442Add
BLAST

Proteomic databases

MaxQBiP28340.
PaxDbiP28340.
PRIDEiP28340.

PTM databases

PhosphoSiteiP28340.

Miscellaneous databases

PMAP-CutDBP28340.

Expressioni

Tissue specificityi

Expressed across a panel of tissues, with high levels of expression in heart and lung.1 Publication

Gene expression databases

ArrayExpressiP28340.
BgeeiP28340.
CleanExiHS_POLD1.
GenevestigatoriP28340.

Organism-specific databases

HPAiCAB004375.
HPA046524.

Interactioni

Subunit structurei

Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. The 125 kDa subunit contains the polymerase active site and most likely the active site for the 3'-5' exonuclease activity. Interacts with WRNIP1. Interacts with POLD4 and PCNA.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PCNAP120042EBI-716569,EBI-358311
POLD2P490059EBI-716569,EBI-372354
POLD4Q9HCU810EBI-716569,EBI-864968
WRNIP1Q96S552EBI-716569,EBI-2513471

Protein-protein interaction databases

BioGridi111420. 48 interactions.
IntActiP28340. 18 interactions.
MINTiMINT-1414678.
STRINGi9606.ENSP00000262266.

Structurei

3D structure databases

ProteinModelPortaliP28340.
SMRiP28340. Positions 124-1000.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi4 – 1916Nuclear localization signal Reviewed predictionAdd
BLAST
Motifi1058 – 107619CysB motifAdd
BLAST

Domaini

The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes By similarity.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1012 – 102918CysA-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG0417.
HOGENOMiHOG000036616.
HOVERGENiHBG051395.
KOiK02327.
PhylomeDBiP28340.
TreeFamiTF352785.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
IPR025687. Znf-C4pol.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
PF14260. zf-C4pol. 1 hit.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28340-1 [UniParc]FASTAAdd to Basket

« Hide

MDGKRRPGPG PGVPPKRARG GLWDDDDAPR PSQFEEDLAL MEEMEAEHRL     50
QEQEEEELQS VLEGVADGQV PPSAIDPRWL RPTPPALDPQ TEPLIFQQLE 100
IDHYVGPAQP VPGGPPPSRG SVPVLRAFGV TDEGFSVCCH IHGFAPYFYT 150
PAPPGFGPEH MGDLQRELNL AISRDSRGGR ELTGPAVLAV ELCSRESMFG 200
YHGHGPSPFL RITVALPRLV APARRLLEQG IRVAGLGTPS FAPYEANVDF 250
EIRFMVDTDI VGCNWLELPA GKYALRLKEK ATQCQLEADV LWSDVVSHPP 300
EGPWQRIAPL RVLSFDIECA GRKGIFPEPE RDPVIQICSL GLRWGEPEPF 350
LRLALTLRPC APILGAKVQS YEKEEDLLQA WSTFIRIMDP DVITGYNIQN 400
FDLPYLISRA QTLKVQTFPF LGRVAGLCSN IRDSSFQSKQ TGRRDTKVVS 450
MVGRVQMDML QVLLREYKLR SYTLNAVSFH FLGEQKEDVQ HSIITDLQNG 500
NDQTRRRLAV YCLKDAYLPL RLLERLMVLV NAVEMARVTG VPLSYLLSRG 550
QQVKVVSQLL RQAMHEGLLM PVVKSEGGED YTGATVIEPL KGYYDVPIAT 600
LDFSSLYPSI MMAHNLCYTT LLRPGTAQKL GLTEDQFIRT PTGDEFVKTS 650
VRKGLLPQIL ENLLSARKRA KAELAKETDP LRRQVLDGRQ LALKVSANSV 700
YGFTGAQVGK LPCLEISQSV TGFGRQMIEK TKQLVESKYT VENGYSTSAK 750
VVYGDTDSVM CRFGVSSVAE AMALGREAAD WVSGHFPSPI RLEFEKVYFP 800
YLLISKKRYA GLLFSSRPDA HDRMDCKGLE AVRRDNCPLV ANLVTASLRR 850
LLIDRDPEGA VAHAQDVISD LLCNRIDISQ LVITKELTRA ASDYAGKQAH 900
VELAERMRKR DPGSAPSLGD RVPYVIISAA KGVAAYMKSE DPLFVLEHSL 950
PIDTQYYLEQ QLAKPLLRIF EPILGEGRAE AVLLRGDHTR CKTVLTGKVG 1000
GLLAFAKRRN CCIGCRTVLS HQGAVCEFCQ PRESELYQKE VSHLNALEER 1050
FSRLWTQCQR CQGSLHEDVI CTSRDCPIFY MRKKVRKDLE DQEQLLRRFG 1100
PPGPEAW 1107
Length:1,107
Mass (Da):123,631
Last modified:July 19, 2004 - v2
Checksum:i9D04D34AB4AEE810
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51R → W.
Corresponds to variant rs9282830 [ dbSNP | Ensembl ].
VAR_048878
Natural varianti19 – 191R → H.1 Publication
Corresponds to variant rs3218773 [ dbSNP | Ensembl ].
VAR_019340
Natural varianti21 – 211G → C.
Corresponds to variant rs9282831 [ dbSNP | Ensembl ].
VAR_048879
Natural varianti30 – 301R → W.2 Publications
Corresponds to variant rs3218772 [ dbSNP | Ensembl ].
VAR_016146
Natural varianti119 – 1191R → H.3 Publications
Corresponds to variant rs1726801 [ dbSNP | Ensembl ].
VAR_019341
Natural varianti145 – 1451A → D Found in a colorectal sample; somatic mutation. 1 Publication
VAR_069333
Natural varianti173 – 1731S → N.2 Publications
Corresponds to variant rs1726803 [ dbSNP | Ensembl ].
VAR_019342
Natural varianti177 – 1771R → H.1 Publication
Corresponds to variant rs3218750 [ dbSNP | Ensembl ].
VAR_019343
Natural varianti347 – 3471P → L.
Corresponds to variant rs2230243 [ dbSNP | Ensembl ].
VAR_048880
Natural varianti461 – 4611Q → H Found in a colorectal sample; somatic mutation. 1 Publication
VAR_069334
Natural varianti478 – 4781S → N in CRCS10; associated with disease susceptibility. 1 Publication
VAR_069335
Natural varianti605 – 6051Missing in MDPL; the mutant enzyme lacks DNA polymerase ability; has decreased exonuclease activity; can bind DNA but is unable to interact with and incorporate dNTPs. 1 Publication
VAR_070231
Natural varianti787 – 7871P → L Found in a colorectal sample; somatic mutation. 1 Publication
VAR_069336
Natural varianti808 – 8081R → H Found in a colorectal sample; somatic mutation. 1 Publication
VAR_069337
Natural varianti849 – 8491R → H.1 Publication
Corresponds to variant rs3218775 [ dbSNP | Ensembl ].
VAR_019344
Natural varianti864 – 8641A → T Found in a colorectal sample; somatic mutation. 1 Publication
VAR_069338
Natural varianti1086 – 10861R → Q.1 Publication
Corresponds to variant rs3219457 [ dbSNP | Ensembl ].
VAR_019345

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti472 – 4721Y → H in AAA58439. 1 Publication
Sequence conflicti776 – 7761R → G in AAA35768. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M80397 mRNA. Translation: AAA58439.1.
M81735 mRNA. Translation: AAA35768.1.
AY129569 Genomic DNA. Translation: AAM76971.1.
BC008800 mRNA. Translation: AAH08800.1.
CCDSiCCDS12795.1.
PIRiA41618.
RefSeqiNP_001243778.1. NM_001256849.1.
NP_002682.2. NM_002691.3.
UniGeneiHs.279413.

Genome annotation databases

EnsembliENST00000440232; ENSP00000406046; ENSG00000062822.
ENST00000599857; ENSP00000473052; ENSG00000062822.
GeneIDi5424.
KEGGihsa:5424.
UCSCiuc002psb.5. human.

Polymorphism databases

DMDMi50403732.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M80397 mRNA. Translation: AAA58439.1 .
M81735 mRNA. Translation: AAA35768.1 .
AY129569 Genomic DNA. Translation: AAM76971.1 .
BC008800 mRNA. Translation: AAH08800.1 .
CCDSi CCDS12795.1.
PIRi A41618.
RefSeqi NP_001243778.1. NM_001256849.1.
NP_002682.2. NM_002691.3.
UniGenei Hs.279413.

3D structure databases

ProteinModelPortali P28340.
SMRi P28340. Positions 124-1000.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111420. 48 interactions.
IntActi P28340. 18 interactions.
MINTi MINT-1414678.
STRINGi 9606.ENSP00000262266.

Chemistry

BindingDBi P28340.
ChEMBLi CHEMBL2735.

PTM databases

PhosphoSitei P28340.

Polymorphism databases

DMDMi 50403732.

Proteomic databases

MaxQBi P28340.
PaxDbi P28340.
PRIDEi P28340.

Protocols and materials databases

DNASUi 5424.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000440232 ; ENSP00000406046 ; ENSG00000062822 .
ENST00000599857 ; ENSP00000473052 ; ENSG00000062822 .
GeneIDi 5424.
KEGGi hsa:5424.
UCSCi uc002psb.5. human.

Organism-specific databases

CTDi 5424.
GeneCardsi GC19P050889.
H-InvDB HIX0202825.
HGNCi HGNC:9175. POLD1.
HPAi CAB004375.
HPA046524.
MIMi 174761. gene.
612591. phenotype.
615381. phenotype.
neXtProti NX_P28340.
Orphaneti 363649. Mandibular hypoplasia-deafness-progeroid syndrome.
PharmGKBi PA33496.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0417.
HOGENOMi HOG000036616.
HOVERGENi HBG051395.
KOi K02327.
PhylomeDBi P28340.
TreeFami TF352785.

Enzyme and pathway databases

Reactomei REACT_1128. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.
REACT_1385. Processive synthesis on the lagging strand.
REACT_160176. Cytosolic iron-sulfur cluster assembly.
REACT_1792. Polymerase switching.
REACT_1838. Leading Strand Synthesis.
REACT_1993. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
REACT_2192. Removal of DNA patch containing abasic residue.
REACT_378. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
REACT_70. Removal of the Flap Intermediate.
REACT_7961. Telomere C-strand (Lagging Strand) Synthesis.
REACT_7987. Polymerase switching on the C-strand of the telomere.
REACT_7999. Removal of the Flap Intermediate from the C-strand.
REACT_8027. Processive synthesis on the C-strand of the telomere.

Miscellaneous databases

GeneWikii POLD1.
GenomeRNAii 5424.
NextBioi 20985.
PMAP-CutDB P28340.
PROi P28340.
SOURCEi Search...

Gene expression databases

ArrayExpressi P28340.
Bgeei P28340.
CleanExi HS_POLD1.
Genevestigatori P28340.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProi IPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
IPR025687. Znf-C4pol.
[Graphical view ]
Pfami PF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
PF14260. zf-C4pol. 1 hit.
[Graphical view ]
PRINTSi PR00106. DNAPOLB.
SMARTi SM00486. POLBc. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
PROSITEi PS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene."
    Chung D.W., Zhang J., Tan C.-K., Davie E.W., So A.G., Downey K.M.
    Proc. Natl. Acad. Sci. U.S.A. 88:11197-11201(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TRP-30.
  2. "Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta."
    Yang C.-L., Chang L.-S., Zhang P., Hao H., Zhu L., Toomey N.L., Lee M.Y.W.T.
    Nucleic Acids Res. 20:735-745(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS HIS-119 AND ASN-173.
  3. NIEHS SNPs program
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-19; TRP-30; HIS-119; ASN-173; HIS-177; HIS-849 AND GLN-1086.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-119.
    Tissue: Lymph.
  5. "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta."
    Tsurimoto T., Shinozaki A., Yano M., Seki M., Enomoto T.
    Genes Cells 10:13-22(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WRNIP1.
  6. "Functional roles of p12, the fourth subunit of human DNA polymerase delta."
    Li H., Xie B., Zhou Y., Rahmeh A., Trusa S., Zhang S., Gao Y., Lee E.Y., Lee M.Y.
    J. Biol. Chem. 281:14748-14755(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH POLD4 AND PCNA.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: TISSUE SPECIFICITY, VARIANT MDPL SER-605 DEL.
  10. Cited for: VARIANT CRCS10 ASN-478, VARIANTS ASP-145; HIS-461; LEU-787; HIS-808 AND THR-864.

Entry informationi

Entry nameiDPOD1_HUMAN
AccessioniPrimary (citable) accession number: P28340
Secondary accession number(s): Q8NER3, Q96H98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi