SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P28338

- GSTT1_MUSDO

UniProt

P28338 - GSTT1_MUSDO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutathione S-transferase 1
Gene
Gst1, Gst-1
Organism
Musca domestica (House fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1 (EC:2.5.1.18)
Alternative name(s):
GST class-theta
Gene namesi
Name:Gst1
Synonyms:Gst-1
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Glutathione S-transferase 1
PRO_0000185965Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP28338.
SMRiP28338. Positions 1-207.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8080GST N-terminal
Add
BLAST
Domaini86 – 207122GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 523Glutathione binding By similarity
Regioni64 – 663Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28338-1 [UniParc]FASTAAdd to Basket

« Hide

MDFYYLPGSA PCRSVLMTAK ALGIELNKKL LNLQAGEHLK PEFLKINPQH    50
TIPTLVDGDF ALWESRAIMV YLVEKYGKTD SLFPKCPKKR AVINQRLYFD 100
MGTLYKSFAD YYYPQIFAKA PADPELFKKI ETAFDFLNTF LKGHEYAAGD 150
SLTVADLALL ASVSTFEVAS FDFSKYPNVA KWYANLKTVA PGWEENWAGC 200
LEFKKYFG 208
Length:208
Mass (Da):23,651
Last modified:December 1, 1992 - v1
Checksum:i9CB1649F1184EE25
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61302 Genomic DNA. Translation: CAA43599.1.
M83249 mRNA. Translation: AAA29294.1.
PIRiA42045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61302 Genomic DNA. Translation: CAA43599.1 .
M83249 mRNA. Translation: AAA29294.1 .
PIRi A42045.

3D structure databases

ProteinModelPortali P28338.
SMRi P28338. Positions 1-207.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a glutathione S-transferase overproduced in an insecticide-resistant strain of the housefly (Musca domestica)."
    Wang J., McCommas S., Syvanen M.
    Mol. Gen. Genet. 227:260-266(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Insect glutathione S-transferases. Biochemical characteristics of the major forms from houseflies susceptible and resistant to insecticides."
    Fournier D., Bride J.-M., Poirie M., Berge J.-B., Plapp F.W.
    J. Biol. Chem. 267:1840-1845(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Germinal and somatic products of Mu1 excision from the Bronze-1 gene of Zea mays."
    Britt A.B., Walbot V.
    Mol. Gen. Genet. 227:267-276(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGSTT1_MUSDO
AccessioniPrimary (citable) accession number: P28338
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi