P28337 (GCST_CHICK) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 78.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Aminomethyltransferase, mitochondrial EC=2.1.2.10 Alternative name(s): Glycine cleavage system T protein Short name=GCVT | ||
| Gene names |
| ||
| Organism | Gallus gallus (Chicken) [Reference proteome] | ||
| Taxonomic identifier | 9031 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus![]() |
Protein attributes
| Sequence length | 392 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | The glycine cleavage system catalyzes the degradation of glycine. |
| Catalytic activity | [Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. |
| Subunit structure | The glycine cleavage system is composed of four proteins: P, T, L and H. |
| Subcellular location | |
| Sequence similarities | Belongs to the GcvT family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Molecular function | Aminotransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | glycine catabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular_component | mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 16 | 16 | Mitochondrion | ||||||
| Chain | 17 – 392 | 376 | Aminomethyltransferase, mitochondrial | PRO_0000010757 | |||||
Sites | |||||||||
| Binding site | 221 | 1 | Substrate By similarity | ||||||
| Binding site | 250 | 1 | Substrate By similarity | ||||||
| Binding site | 388 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Molecular cloning of a cDNA encoding chicken T-protein of the glycine cleavage system and expression of the functional protein in Escherichia coli. Effect of mRNA secondary structure in the translational initiation region on expression." Okamura-Ikeda K., Fujiwara K., Motokawa Y. J. Biol. Chem. 267:18284-18290(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Isolation and sequence determination of cDNA encoding T-protein of the glycine cleavage system." Okamura-Ikeda K., Fujiwara K., Yamamoto M., Hiraga K., Motokawa Y. J. Biol. Chem. 266:4917-4921(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 179-392. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D11162 mRNA. Translation: BAA01937.1. |
| IPI | IPI00578487. |
| PIR | A44167. |
| RefSeq | NP_990119.1. NM_204788.1. |
| UniGene | Gga.1002. |
3D structure databases | |
| ProteinModelPortal | P28337. |
| SMR | P28337. Positions 22-389. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P28337. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 395566. |
| KEGG | gga:395566. |
Organism-specific databases | |
| CTD | 275. |
Phylogenomic databases | |
| HOVERGEN | HBG005822. |
| KO | K00605. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:MONOMER-12927. |
Family and domain databases | |
| Gene3D | 3.30.1360.120. 2 hits. |
| InterPro | IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR027266. TrmE/GcvT_dom1. [Graphical view] |
| PANTHER | PTHR13847:SF5. PTHR13847:SF5. 1 hit. |
| Pfam | PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view] |
| PIRSF | PIRSF006487. GcvT. 1 hit. |
| TIGRFAMs | TIGR00528. gcvT. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 20815640. |
Entry information
| Entry name | GCST_CHICK | ||||||||
| Accession | Primary (citable) accession number: P28337 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
