P28336 (NMBR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuromedin-B receptor
Short name=NMB-R

Alternative name(s):
Epididymis tissue protein Li 185a
Neuromedin-B-preferring bombesin receptor

Gene names

Name:

NMBR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for neuromedin-B.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in epididymis (at protein level). Ref.2
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phospholipase C-activating G-protein coupled receptor signaling pathway Traceable author statement PubMed 7838118. Source: ProtInc
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA integral to plasma membrane Traceable author statement PubMed 8391296. Source: ProtInc
Molecular_function	bombesin receptor activity Traceable author statement PubMed 7838118. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Neuromedin-B receptor		PRO_0000069903
Regions
	Topological domain	1 – 41	41	Extracellular Potential
	Transmembrane	42 – 65	24	Helical; Name=1; Potential
	Topological domain	66 – 79	14	Cytoplasmic Potential
	Transmembrane	80 – 99	20	Helical; Name=2; Potential
	Topological domain	100 – 117	18	Extracellular Potential
	Transmembrane	118 – 139	22	Helical; Name=3; Potential
	Topological domain	140 – 156	17	Cytoplasmic Potential
	Transmembrane	157 – 177	21	Helical; Name=4; Potential
	Topological domain	178 – 211	34	Extracellular Potential
	Transmembrane	212 – 235	24	Helical; Name=5; Potential
	Topological domain	236 – 266	31	Cytoplasmic Potential
	Transmembrane	267 – 287	21	Helical; Name=6; Potential
	Topological domain	288 – 299	12	Extracellular Potential
	Transmembrane	300 – 327	28	Helical; Name=7; Potential
	Topological domain	328 – 390	63	Cytoplasmic Potential
Amino acid modifications
	Lipidation	341	1	S-palmitoyl cysteine By similarity
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Glycosylation	16	1	N-linked (GlcNAc...) Potential
	Glycosylation	192	1	N-linked (GlcNAc...) Potential
	Disulfide bond	116 ↔ 198		By similarity
Natural variations
	Natural variant	390	1	L → M. Ref.1 Corresponds to variant rs7453944 [ dbSNP | Ensembl ].		VAR_044513

Sequences

	Sequence		Length	Mass (Da)
	P28336 [UniParc]. Last modified July 22, 2008. Version 2. Checksum: 8BA9AAD4F3B7309F	FASTA	390	43,435
	10 20 30 40 50 60 MPSKSLSNLS VTTGANESGS VPEGWERDFL PASDGTTTEL VIRCVIPSLY LLIITVGLLG 70 80 90 100 110 120 NIMLVKIFIT NSAMRSVPNI FISNLAAGDL LLLLTCVPVD ASRYFFDEWM FGKVGCKLIP 130 140 150 160 170 180 VIQLTSVGVS VFTLTALSAD RYRAIVNPMD MQTSGALLRT CVKAMGIWVV SVLLAVPEAV 190 200 210 220 230 240 FSEVARISSL DNSSFTACIP YPQTDELHPK IHSVLIFLVY FLIPLAIISI YYYHIAKTLI 250 260 270 280 290 300 KSAHNLPGEY NEHTKKQMET RKRLAKIVLV FVGCFIFCWF PNHILYMYRS FNYNEIDPSL 310 320 330 340 350 360 GHMIVTLVAR VLSFGNSCVN PFALYLLSES FRRHFNSQLC CGRKSYQERG TSYLLSSSAV 370 380 390 RMTSLKSNAK NMVTNSVLLN GHSMKQEMAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells." Corjay M.H., Dobrzanski D.J., Way J.M., Viallet J., Shapira H., Worland P., Sausville E.A., Battey J.F. J. Biol. Chem. 266:18771-18779(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-390.
[2]	"Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins." Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W., Zhang C., Jin S., Liu J., Zhu P., Liu Y. Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Epididymis.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M73482 mRNA. Translation: AAA59939.1. GU727635 mRNA. Translation: ADU87637.1. AL589674 Genomic DNA. Translation: CAH70473.1. CH471051 Genomic DNA. Translation: EAW47886.1.
IPI	IPI00002878.
PIR	B41007.
RefSeq	NP_002502.2. NM_002511.2.
UniGene	Hs.654478.
3D structure databases
ProteinModelPortal	P28336.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000258042.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P28336.
Polymorphism databases
DMDM	212286370.
Proteomic databases
PaxDb	P28336.
PRIDE	P28336.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258042; ENSP00000258042; ENSG00000135577.
GeneID	4829.
KEGG	hsa:4829.
UCSC	uc003qiu.3. human.
Organism-specific databases
CTD	4829.
GeneCards	GC06M142438.
H-InvDB	HIX0032977.
HGNC	HGNC:7843. NMBR.
HPA	HPA026665.
MIM	162341. gene.
neXtProt	NX_P28336.
PharmGKB	PA31655.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG328649.
HOGENOM	HOG000230781.
HOVERGEN	HBG004898.
InParanoid	P28336.
KO	K04168.
OMA	IKSAHNL.
OrthoDB	EOG4M398N.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P28336.
Bgee	P28336.
CleanEx	HS_NMBR.
Genevestigator	P28336.
GermOnline	ENSG00000135577. Homo sapiens.
Family and domain databases
InterPro	IPR001556. Bombsn_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001642. NeuroB_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00358. BOMBESINR. PR00237. GPCRRHODOPSN. PR00639. NEUROMEDINBR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P28336.
ChEMBL	CHEMBL3636.
GenomeRNAi	4829.
NextBio	18602.
SOURCE	Search...

Entry information

Entry name

NMBR_HUMAN

Accession

Primary (citable) accession number: P28336
Secondary accession number(s): E9KL38, Q5VUK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	July 22, 2008
Last modified:	May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.