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P28336

- NMBR_HUMAN

UniProt

P28336 - NMBR_HUMAN

Protein

Neuromedin-B receptor

Gene

NMBR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Receptor for neuromedin-B.

    GO - Molecular functioni

    1. bombesin receptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc
    2. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuromedin-B receptor
    Short name:
    NMB-R
    Alternative name(s):
    Epididymis tissue protein Li 185a
    Neuromedin-B-preferring bombesin receptor
    Gene namesi
    Name:NMBR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:7843. NMBR.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31655.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Neuromedin-B receptorPRO_0000069903Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi116 ↔ 198PROSITE-ProRule annotation
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Lipidationi341 – 3411S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP28336.
    PRIDEiP28336.

    PTM databases

    PhosphoSiteiP28336.

    Expressioni

    Tissue specificityi

    Expressed in epididymis (at protein level).1 Publication

    Gene expression databases

    BgeeiP28336.
    CleanExiHS_NMBR.
    GenevestigatoriP28336.

    Organism-specific databases

    HPAiHPA026665.

    Interactioni

    Protein-protein interaction databases

    BioGridi110893. 1 interaction.
    STRINGi9606.ENSP00000258042.

    Structurei

    3D structure databases

    ProteinModelPortaliP28336.
    SMRiP28336. Positions 40-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini66 – 7914CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini100 – 11718ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini140 – 15617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 21134ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 26631CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini288 – 29912ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini328 – 39063CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6524Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei80 – 9920Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei118 – 13922Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei212 – 23524Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei300 – 32728Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG328649.
    HOGENOMiHOG000230781.
    HOVERGENiHBG004898.
    InParanoidiP28336.
    KOiK04168.
    OMAiIKSAHNL.
    OrthoDBiEOG73V6KG.
    PhylomeDBiP28336.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001556. Bombsn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001642. NeuroB_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00358. BOMBESINR.
    PR00237. GPCRRHODOPSN.
    PR00639. NEUROMEDINBR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28336-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSKSLSNLS VTTGANESGS VPEGWERDFL PASDGTTTEL VIRCVIPSLY    50
    LLIITVGLLG NIMLVKIFIT NSAMRSVPNI FISNLAAGDL LLLLTCVPVD 100
    ASRYFFDEWM FGKVGCKLIP VIQLTSVGVS VFTLTALSAD RYRAIVNPMD 150
    MQTSGALLRT CVKAMGIWVV SVLLAVPEAV FSEVARISSL DNSSFTACIP 200
    YPQTDELHPK IHSVLIFLVY FLIPLAIISI YYYHIAKTLI KSAHNLPGEY 250
    NEHTKKQMET RKRLAKIVLV FVGCFIFCWF PNHILYMYRS FNYNEIDPSL 300
    GHMIVTLVAR VLSFGNSCVN PFALYLLSES FRRHFNSQLC CGRKSYQERG 350
    TSYLLSSSAV RMTSLKSNAK NMVTNSVLLN GHSMKQEMAL 390
    Length:390
    Mass (Da):43,435
    Last modified:July 22, 2008 - v2
    Checksum:i8BA9AAD4F3B7309F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti390 – 3901L → M.1 Publication
    Corresponds to variant rs7453944 [ dbSNP | Ensembl ].
    VAR_044513

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73482 mRNA. Translation: AAA59939.1.
    GU727635 mRNA. Translation: ADU87637.1.
    AL589674 Genomic DNA. Translation: CAH70473.1.
    CH471051 Genomic DNA. Translation: EAW47886.1.
    CCDSiCCDS5196.1.
    PIRiB41007.
    RefSeqiNP_002502.2. NM_002511.2.
    UniGeneiHs.654478.

    Genome annotation databases

    EnsembliENST00000258042; ENSP00000258042; ENSG00000135577.
    GeneIDi4829.
    KEGGihsa:4829.
    UCSCiuc003qiu.3. human.

    Polymorphism databases

    DMDMi212286370.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73482 mRNA. Translation: AAA59939.1 .
    GU727635 mRNA. Translation: ADU87637.1 .
    AL589674 Genomic DNA. Translation: CAH70473.1 .
    CH471051 Genomic DNA. Translation: EAW47886.1 .
    CCDSi CCDS5196.1.
    PIRi B41007.
    RefSeqi NP_002502.2. NM_002511.2.
    UniGenei Hs.654478.

    3D structure databases

    ProteinModelPortali P28336.
    SMRi P28336. Positions 40-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110893. 1 interaction.
    STRINGi 9606.ENSP00000258042.

    Chemistry

    BindingDBi P28336.
    ChEMBLi CHEMBL3636.
    GuidetoPHARMACOLOGYi 38.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P28336.

    Polymorphism databases

    DMDMi 212286370.

    Proteomic databases

    PaxDbi P28336.
    PRIDEi P28336.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258042 ; ENSP00000258042 ; ENSG00000135577 .
    GeneIDi 4829.
    KEGGi hsa:4829.
    UCSCi uc003qiu.3. human.

    Organism-specific databases

    CTDi 4829.
    GeneCardsi GC06M142438.
    H-InvDB HIX0032977.
    HGNCi HGNC:7843. NMBR.
    HPAi HPA026665.
    MIMi 162341. gene.
    neXtProti NX_P28336.
    PharmGKBi PA31655.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG328649.
    HOGENOMi HOG000230781.
    HOVERGENi HBG004898.
    InParanoidi P28336.
    KOi K04168.
    OMAi IKSAHNL.
    OrthoDBi EOG73V6KG.
    PhylomeDBi P28336.
    TreeFami TF331292.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Neuromedin_B_receptor.
    GenomeRNAii 4829.
    NextBioi 18602.
    PROi P28336.
    SOURCEi Search...

    Gene expression databases

    Bgeei P28336.
    CleanExi HS_NMBR.
    Genevestigatori P28336.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001556. Bombsn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001642. NeuroB_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00358. BOMBESINR.
    PR00237. GPCRRHODOPSN.
    PR00639. NEUROMEDINBR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells."
      Corjay M.H., Dobrzanski D.J., Way J.M., Viallet J., Shapira H., Worland P., Sausville E.A., Battey J.F.
      J. Biol. Chem. 266:18771-18779(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-390.
    2. "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."
      Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W., Zhang C., Jin S., Liu J., Zhu P., Liu Y.
      Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Epididymis.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNMBR_HUMAN
    AccessioniPrimary (citable) accession number: P28336
    Secondary accession number(s): E9KL38, Q5VUK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3