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Protein

Neuromedin-B receptor

Gene

NMBR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for neuromedin-B.

GO - Molecular functioni

  1. bombesin receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-B receptor
Short name:
NMB-R
Alternative name(s):
Epididymis tissue protein Li 185a
Neuromedin-B-preferring bombesin receptor
Gene namesi
Name:NMBR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:7843. NMBR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Transmembranei42 – 6524Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini66 – 7914CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei80 – 9920Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini100 – 11718ExtracellularSequence AnalysisAdd
BLAST
Transmembranei118 – 13922Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini140 – 15617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini178 – 21134ExtracellularSequence AnalysisAdd
BLAST
Transmembranei212 – 23524Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini236 – 26631CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei267 – 28721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini288 – 29912ExtracellularSequence AnalysisAdd
BLAST
Transmembranei300 – 32728Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini328 – 39063CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Neuromedin-B receptorPRO_0000069903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi116 ↔ 198PROSITE-ProRule annotation
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
Lipidationi341 – 3411S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP28336.
PRIDEiP28336.

PTM databases

PhosphoSiteiP28336.

Expressioni

Tissue specificityi

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

BgeeiP28336.
CleanExiHS_NMBR.
GenevestigatoriP28336.

Interactioni

Protein-protein interaction databases

BioGridi110893. 1 interaction.
STRINGi9606.ENSP00000258042.

Structurei

3D structure databases

ProteinModelPortaliP28336.
SMRiP28336. Positions 40-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG328649.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP28336.
KOiK04168.
OMAiIKSAHNL.
OrthoDBiEOG73V6KG.
PhylomeDBiP28336.
TreeFamiTF331292.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001642. NeuroB_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
PR00639. NEUROMEDINBR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKSLSNLS VTTGANESGS VPEGWERDFL PASDGTTTEL VIRCVIPSLY
60 70 80 90 100
LLIITVGLLG NIMLVKIFIT NSAMRSVPNI FISNLAAGDL LLLLTCVPVD
110 120 130 140 150
ASRYFFDEWM FGKVGCKLIP VIQLTSVGVS VFTLTALSAD RYRAIVNPMD
160 170 180 190 200
MQTSGALLRT CVKAMGIWVV SVLLAVPEAV FSEVARISSL DNSSFTACIP
210 220 230 240 250
YPQTDELHPK IHSVLIFLVY FLIPLAIISI YYYHIAKTLI KSAHNLPGEY
260 270 280 290 300
NEHTKKQMET RKRLAKIVLV FVGCFIFCWF PNHILYMYRS FNYNEIDPSL
310 320 330 340 350
GHMIVTLVAR VLSFGNSCVN PFALYLLSES FRRHFNSQLC CGRKSYQERG
360 370 380 390
TSYLLSSSAV RMTSLKSNAK NMVTNSVLLN GHSMKQEMAL
Length:390
Mass (Da):43,435
Last modified:July 22, 2008 - v2
Checksum:i8BA9AAD4F3B7309F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti390 – 3901L → M.1 Publication
Corresponds to variant rs7453944 [ dbSNP | Ensembl ].
VAR_044513

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73482 mRNA. Translation: AAA59939.1.
GU727635 mRNA. Translation: ADU87637.1.
AL589674 Genomic DNA. Translation: CAH70473.1.
CH471051 Genomic DNA. Translation: EAW47886.1.
CCDSiCCDS5196.1.
PIRiB41007.
RefSeqiNP_002502.2. NM_002511.2.
UniGeneiHs.654478.

Genome annotation databases

EnsembliENST00000258042; ENSP00000258042; ENSG00000135577.
GeneIDi4829.
KEGGihsa:4829.
UCSCiuc003qiu.3. human.

Polymorphism databases

DMDMi212286370.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73482 mRNA. Translation: AAA59939.1.
GU727635 mRNA. Translation: ADU87637.1.
AL589674 Genomic DNA. Translation: CAH70473.1.
CH471051 Genomic DNA. Translation: EAW47886.1.
CCDSiCCDS5196.1.
PIRiB41007.
RefSeqiNP_002502.2. NM_002511.2.
UniGeneiHs.654478.

3D structure databases

ProteinModelPortaliP28336.
SMRiP28336. Positions 40-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110893. 1 interaction.
STRINGi9606.ENSP00000258042.

Chemistry

BindingDBiP28336.
ChEMBLiCHEMBL3636.
GuidetoPHARMACOLOGYi38.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP28336.

Polymorphism databases

DMDMi212286370.

Proteomic databases

PaxDbiP28336.
PRIDEiP28336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258042; ENSP00000258042; ENSG00000135577.
GeneIDi4829.
KEGGihsa:4829.
UCSCiuc003qiu.3. human.

Organism-specific databases

CTDi4829.
GeneCardsiGC06M142438.
H-InvDBHIX0032977.
HGNCiHGNC:7843. NMBR.
MIMi162341. gene.
neXtProtiNX_P28336.
PharmGKBiPA31655.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG328649.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP28336.
KOiK04168.
OMAiIKSAHNL.
OrthoDBiEOG73V6KG.
PhylomeDBiP28336.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiNeuromedin_B_receptor.
GenomeRNAii4829.
NextBioi18602.
PROiP28336.
SOURCEiSearch...

Gene expression databases

BgeeiP28336.
CleanExiHS_NMBR.
GenevestigatoriP28336.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001642. NeuroB_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
PR00639. NEUROMEDINBR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells."
    Corjay M.H., Dobrzanski D.J., Way J.M., Viallet J., Shapira H., Worland P., Sausville E.A., Battey J.F.
    J. Biol. Chem. 266:18771-18779(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-390.
  2. "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."
    Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W., Zhang C., Jin S., Liu J., Zhu P., Liu Y.
    Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Epididymis.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNMBR_HUMAN
AccessioniPrimary (citable) accession number: P28336
Secondary accession number(s): E9KL38, Q5VUK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 22, 2008
Last modified: March 4, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.