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P28336 (NMBR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuromedin-B receptor

Short name=NMB-R
Alternative name(s):
Epididymis tissue protein Li 185a
Neuromedin-B-preferring bombesin receptor
Gene names
Name:NMBR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for neuromedin-B.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in epididymis (at protein level). Ref.2

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Neuromedin-B receptor
PRO_0000069903

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6524Helical; Name=1; Potential
Topological domain66 – 7914Cytoplasmic Potential
Transmembrane80 – 9920Helical; Name=2; Potential
Topological domain100 – 11718Extracellular Potential
Transmembrane118 – 13922Helical; Name=3; Potential
Topological domain140 – 15617Cytoplasmic Potential
Transmembrane157 – 17721Helical; Name=4; Potential
Topological domain178 – 21134Extracellular Potential
Transmembrane212 – 23524Helical; Name=5; Potential
Topological domain236 – 26631Cytoplasmic Potential
Transmembrane267 – 28721Helical; Name=6; Potential
Topological domain288 – 29912Extracellular Potential
Transmembrane300 – 32728Helical; Name=7; Potential
Topological domain328 – 39063Cytoplasmic Potential

Amino acid modifications

Lipidation3411S-palmitoyl cysteine By similarity
Glycosylation81N-linked (GlcNAc...) Potential
Glycosylation161N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Disulfide bond116 ↔ 198 By similarity

Natural variations

Natural variant3901L → M. Ref.1
Corresponds to variant rs7453944 [ dbSNP | Ensembl ].
VAR_044513

Sequences

Sequence LengthMass (Da)Tools
P28336 [UniParc].

Last modified July 22, 2008. Version 2.
Checksum: 8BA9AAD4F3B7309F

FASTA39043,435
        10         20         30         40         50         60 
MPSKSLSNLS VTTGANESGS VPEGWERDFL PASDGTTTEL VIRCVIPSLY LLIITVGLLG 

        70         80         90        100        110        120 
NIMLVKIFIT NSAMRSVPNI FISNLAAGDL LLLLTCVPVD ASRYFFDEWM FGKVGCKLIP 

       130        140        150        160        170        180 
VIQLTSVGVS VFTLTALSAD RYRAIVNPMD MQTSGALLRT CVKAMGIWVV SVLLAVPEAV 

       190        200        210        220        230        240 
FSEVARISSL DNSSFTACIP YPQTDELHPK IHSVLIFLVY FLIPLAIISI YYYHIAKTLI 

       250        260        270        280        290        300 
KSAHNLPGEY NEHTKKQMET RKRLAKIVLV FVGCFIFCWF PNHILYMYRS FNYNEIDPSL 

       310        320        330        340        350        360 
GHMIVTLVAR VLSFGNSCVN PFALYLLSES FRRHFNSQLC CGRKSYQERG TSYLLSSSAV 

       370        380        390 
RMTSLKSNAK NMVTNSVLLN GHSMKQEMAL 

« Hide

References

« Hide 'large scale' references
[1]"Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells."
Corjay M.H., Dobrzanski D.J., Way J.M., Viallet J., Shapira H., Worland P., Sausville E.A., Battey J.F.
J. Biol. Chem. 266:18771-18779(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-390.
[2]"Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."
Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W., Zhang C., Jin S., Liu J., Zhu P., Liu Y.
Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Epididymis.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73482 mRNA. Translation: AAA59939.1.
GU727635 mRNA. Translation: ADU87637.1.
AL589674 Genomic DNA. Translation: CAH70473.1.
CH471051 Genomic DNA. Translation: EAW47886.1.
CCDSCCDS5196.1.
PIRB41007.
RefSeqNP_002502.2. NM_002511.2.
UniGeneHs.654478.

3D structure databases

ProteinModelPortalP28336.
SMRP28336. Positions 40-335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110893. 1 interaction.
STRING9606.ENSP00000258042.

Chemistry

BindingDBP28336.
ChEMBLCHEMBL3636.
GuidetoPHARMACOLOGY38.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP28336.

Polymorphism databases

DMDM212286370.

Proteomic databases

PaxDbP28336.
PRIDEP28336.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258042; ENSP00000258042; ENSG00000135577.
GeneID4829.
KEGGhsa:4829.
UCSCuc003qiu.3. human.

Organism-specific databases

CTD4829.
GeneCardsGC06M142438.
H-InvDBHIX0032977.
HGNCHGNC:7843. NMBR.
HPAHPA026665.
MIM162341. gene.
neXtProtNX_P28336.
PharmGKBPA31655.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG328649.
HOGENOMHOG000230781.
HOVERGENHBG004898.
InParanoidP28336.
KOK04168.
OMAIKSAHNL.
OrthoDBEOG73V6KG.
PhylomeDBP28336.
TreeFamTF331292.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP28336.
CleanExHS_NMBR.
GenevestigatorP28336.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001556. Bombsn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001642. NeuroB_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
PR00639. NEUROMEDINBR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNeuromedin_B_receptor.
GenomeRNAi4829.
NextBio18602.
PROP28336.
SOURCESearch...

Entry information

Entry nameNMBR_HUMAN
AccessionPrimary (citable) accession number: P28336
Secondary accession number(s): E9KL38, Q5VUK8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 22, 2008
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries