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P28332

- ADH6_HUMAN

UniProt

P28332 - ADH6_HUMAN

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Protein
Alcohol dehydrogenase 6
Gene
ADH6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Zinc 1; catalytic By similarity
Metal bindingi69 – 691Zinc 1; catalytic By similarity
Metal bindingi99 – 991Zinc 2 By similarity
Metal bindingi102 – 1021Zinc 2 By similarity
Metal bindingi105 – 1051Zinc 2 By similarity
Metal bindingi113 – 1131Zinc 2 By similarity
Metal bindingi175 – 1751Zinc 1; catalytic By similarity
Binding sitei224 – 2241NAD By similarity
Binding sitei229 – 2291NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi200 – 2056NAD By similarity
Nucleotide bindingi293 – 2953NAD By similarity

GO - Molecular functioni

  1. alcohol dehydrogenase (NAD) activity Source: UniProtKB
  2. alcohol dehydrogenase activity, zinc-dependent Source: InterPro
  3. ethanol binding Source: InterPro
  4. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. ethanol oxidation Source: UniProtKB
  2. response to ethanol Source: UniProtKB
  3. small molecule metabolic process Source: Reactome
  4. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiREACT_34. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 6 (EC:1.1.1.1)
Gene namesi
Name:ADH6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:255. ADH6.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Alcohol dehydrogenase 6
PRO_0000160687Add
BLAST

Proteomic databases

MaxQBiP28332.
PaxDbiP28332.
PRIDEiP28332.

PTM databases

PhosphoSiteiP28332.

Expressioni

Tissue specificityi

Stomach and liver.

Gene expression databases

ArrayExpressiP28332.
BgeeiP28332.
CleanExiHS_ADH6.
GenevestigatoriP28332.

Interactioni

Protein-protein interaction databases

BioGridi106642. 8 interactions.
IntActiP28332. 8 interactions.
STRINGi9606.ENSP00000378359.

Structurei

3D structure databases

ProteinModelPortaliP28332.
SMRiP28332. Positions 3-367.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1062.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
KOiK13952.
OMAiCINQINT.
PhylomeDBiP28332.
TreeFamiTF300429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR028633. ADH6.
IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PTHR11695:SF307. PTHR11695:SF307. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P28332-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MCTTGQVIRC KAAILWKPGA PFSIEEVEVA PPKAKEVRIK VVATGLCGTE    50
MKVLGSKHLD LLYPTILGHE GAGIVESIGE GVSTVKPGDK VITLFLPQCG 100
ECTSCLNSEG NFCIQFKQSK TQLMSDGTSR FTCKGKSIYH FGNTSTFCEY 150
TVIKEISVAK IDAVAPLEKV CLISCGFSTG FGAAINTAKV TPGSTCAVFG 200
LGGVGLSVVM GCKAAGAARI IGVDVNKEKF KKAQELGATE CLNPQDLKKP 250
IQEVLFDMTD AGIDFCFEAI GNLDVLAAAL ASCNESYGVC VVVGVLPASV 300
QLKISGQLFF SGRSLKGSVF GGWKSRQHIP KLVADYMAEK LNLDPLITHT 350
LNLDKINEAV ELMKTGKW 368
Length:368
Mass (Da):39,089
Last modified:July 28, 2009 - v2
Checksum:iC7E33043F6B4CA9B
GO
Isoform 2 (identifier: P28332-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-368: W → CIRCILLL

Show »
Length:375
Mass (Da):39,831
Checksum:i53DA496C0DDE2CBA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021C → G.1 Publication
Corresponds to variant rs28720152 [ dbSNP | Ensembl ].
VAR_022655
Natural varianti114 – 1141I → V.1 Publication
Corresponds to variant rs28720153 [ dbSNP | Ensembl ].
VAR_022656
Natural varianti151 – 1511T → P.
Corresponds to variant rs34582580 [ dbSNP | Ensembl ].
VAR_048198

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei368 – 3681W → CIRCILLL in isoform 2.
VSP_037702

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21C → S in AAA35509. 1 Publication
Sequence conflicti2 – 21C → S in BAG52607. 1 Publication
Sequence conflicti2 – 21C → S in AAX44051. 1 Publication
Sequence conflicti266 – 2661C → R in BAG52607. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84402
, M84403, M84404, M84405, M84406, M84407, M84408, M84409 Genomic DNA. Translation: AAA35509.1.
AK092768 mRNA. Translation: BAG52607.1.
AY962311 Genomic DNA. Translation: AAX44051.1.
AP002026 Genomic DNA. No translation available.
CCDSiCCDS3647.1. [P28332-1]
CCDS43255.1. [P28332-2]
PIRiA41274. DEHUA6.
RefSeqiNP_000663.1. NM_000672.3.
NP_001095940.1. NM_001102470.1.
UniGeneiHs.586161.

Genome annotation databases

EnsembliENST00000237653; ENSP00000237653; ENSG00000172955. [P28332-1]
ENST00000394899; ENSP00000378359; ENSG00000172955. [P28332-2]
GeneIDi130.
KEGGihsa:130.
UCSCiuc003huo.2. human. [P28332-2]
uc003hup.4. human. [P28332-1]

Polymorphism databases

DMDMi254763246.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84402
, M84403 , M84404 , M84405 , M84406 , M84407 , M84408 , M84409 Genomic DNA. Translation: AAA35509.1 .
AK092768 mRNA. Translation: BAG52607.1 .
AY962311 Genomic DNA. Translation: AAX44051.1 .
AP002026 Genomic DNA. No translation available.
CCDSi CCDS3647.1. [P28332-1 ]
CCDS43255.1. [P28332-2 ]
PIRi A41274. DEHUA6.
RefSeqi NP_000663.1. NM_000672.3.
NP_001095940.1. NM_001102470.1.
UniGenei Hs.586161.

3D structure databases

ProteinModelPortali P28332.
SMRi P28332. Positions 3-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106642. 8 interactions.
IntActi P28332. 8 interactions.
STRINGi 9606.ENSP00000378359.

Chemistry

BindingDBi P28332.
ChEMBLi CHEMBL2096668.
DrugBanki DB01048. Abacavir.
DB00157. NADH.

PTM databases

PhosphoSitei P28332.

Polymorphism databases

DMDMi 254763246.

Proteomic databases

MaxQBi P28332.
PaxDbi P28332.
PRIDEi P28332.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000237653 ; ENSP00000237653 ; ENSG00000172955 . [P28332-1 ]
ENST00000394899 ; ENSP00000378359 ; ENSG00000172955 . [P28332-2 ]
GeneIDi 130.
KEGGi hsa:130.
UCSCi uc003huo.2. human. [P28332-2 ]
uc003hup.4. human. [P28332-1 ]

Organism-specific databases

CTDi 130.
GeneCardsi GC04M100123.
HGNCi HGNC:255. ADH6.
MIMi 103735. gene.
neXtProti NX_P28332.
PharmGKBi PA24576.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1062.
HOGENOMi HOG000294674.
HOVERGENi HBG000195.
KOi K13952.
OMAi CINQINT.
PhylomeDBi P28332.
TreeFami TF300429.

Enzyme and pathway databases

Reactomei REACT_34. Ethanol oxidation.

Miscellaneous databases

GeneWikii ADH6.
GenomeRNAii 130.
NextBioi 517.
PROi P28332.
SOURCEi Search...

Gene expression databases

ArrayExpressi P28332.
Bgeei P28332.
CleanExi HS_ADH6.
Genevestigatori P28332.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR028633. ADH6.
IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
PTHR11695:SF307. PTHR11695:SF307. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 2 hits.
PROSITEi PS00059. ADH_ZINC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme."
    Yasunami M., Chen C.-S., Yoshida A.
    Proc. Natl. Acad. Sci. U.S.A. 88:7610-7614(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Small intestine.
  3. NIEHS SNPs program
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-102 AND VAL-114.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiADH6_HUMAN
AccessioniPrimary (citable) accession number: P28332
Secondary accession number(s): B3KS45, Q58F53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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