Reviewed,
UniProtKB/Swiss-Prot P28332 (ADH6_HUMAN)
Last modified
June 16, 2009.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Alcohol dehydrogenase 6 EC=1.1.1.1 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 368 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | An alcohol + NAD+ = an aldehyde or ketone + NADH. |
| Cofactor | Binds 2 zinc ions per subunit By similarity. |
| Subcellular location | |
| Tissue specificity | Stomach and liver. |
| Miscellaneous | There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6. |
| Sequence similarities | Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Ligand | Metal-binding NAD Zinc |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | ethanol oxidation Inferred from direct assay. Source: UniProtKB oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW response to ethanolInferred from direct assay. Source: UniProtKB |
| Cellular component | cytosol Inferred from Experiment. Source: Reactome |
| Molecular function | alcohol dehydrogenase activity, zinc-dependent Inferred from Experiment. Source: Reactome electron carrier activityInferred from direct assay. Source: UniProtKB zinc ion bindingTraceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 368 | 368 | Alcohol dehydrogenase 6 | PRO_0000160687 | |||||
Regions | |||||||||
| Nucleotide binding | 200 – 205 | 6 | NAD By similarity | ||||||
| Nucleotide binding | 293 – 295 | 3 | NAD By similarity | ||||||
Sites | |||||||||
| Metal binding | 47 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 69 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 99 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 102 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 105 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 113 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 175 | 1 | Zinc 1; catalytic By similarity | ||||||
| Binding site | 224 | 1 | NAD By similarity | ||||||
| Binding site | 229 | 1 | NAD By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 102 | 1 | C → G: dbSNP rs28720152. Ref.2 | VAR_022655 | |||||
| Natural variant | 114 | 1 | I → V: dbSNP rs28720153. Ref.2 | VAR_022656 | |||||
| Natural variant | 151 | 1 | T → P: dbSNP rs34582580. | VAR_048198 | |||||
Sequences
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References
| [1] | "A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme." Yasunami M., Chen C.-S., Yoshida A. Proc. Natl. Acad. Sci. U.S.A. 88:7610-7614(1991) [PubMed: 1881901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver. |
| [2] | NIEHS SNPs program Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-102 AND VAL-114. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
M84402 M84409 Genomic DNA. Translation: AAA35509.1. AY962311 Genomic DNA. Translation: AAX44051.1. | |
| IPI | IPI00292698. |
| PIR | DEHUA6. A41274. |
| RefSeq | NP_000663.1. |
| UniGene | Hs.586161 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HEU based on UniProtKB P00327. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P28332. |
Proteomic databases | |
| PRIDE | P28332. |
Genome annotation databases | |
| Ensembl | ENSG00000172955. Homo sapiens. [Contig view] |
| GeneID | 130. |
| KEGG | hsa:130. |
Organism-specific databases | |
| GeneCards | GC04M100373. |
| HGNC | HGNC:255. ADH6. |
| MIM | 103735. gene. |
| PharmGKB | PA24576. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P28332. |
| HOVERGEN | P28332. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.1. 247. |
| Reactome | REACT_13433. Biological oxidations. |
Gene expression databases | |
| ArrayExpress | P28332. |
| Bgee | P28332. |
| CleanEx | HS_ADH6. |
| GermOnline | ENSG00000172955. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. [Graphical view] |
| PANTHER | PTHR11695. ADH_Sf_Zn. 1 hit. |
| Pfam | PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view] |
| PROSITE | PS00059. ADH_ZINC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB01048. Abacavir. DB00157. NADH. |
| NextBio | 517. |
| SOURCE | Search... |
Entry information
| Entry name | ADH6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P28332 Secondary accession number(s): Q58F53 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


