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P28332

- ADH6_HUMAN

UniProt

P28332 - ADH6_HUMAN

Protein

Alcohol dehydrogenase 6

Gene

ADH6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An alcohol + NAD+ = an aldehyde or ketone + NADH.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi47 – 471Zinc 1; catalyticBy similarity
    Metal bindingi69 – 691Zinc 1; catalyticBy similarity
    Metal bindingi99 – 991Zinc 2By similarity
    Metal bindingi102 – 1021Zinc 2By similarity
    Metal bindingi105 – 1051Zinc 2By similarity
    Metal bindingi113 – 1131Zinc 2By similarity
    Metal bindingi175 – 1751Zinc 1; catalyticBy similarity
    Binding sitei224 – 2241NADBy similarity
    Binding sitei229 – 2291NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi200 – 2056NADBy similarity
    Nucleotide bindingi293 – 2953NADBy similarity

    GO - Molecular functioni

    1. alcohol dehydrogenase (NAD) activity Source: UniProtKB
    2. alcohol dehydrogenase activity, zinc-dependent Source: InterPro
    3. ethanol binding Source: InterPro
    4. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. ethanol oxidation Source: UniProtKB
    2. response to ethanol Source: UniProtKB
    3. small molecule metabolic process Source: Reactome
    4. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_34. Ethanol oxidation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alcohol dehydrogenase 6 (EC:1.1.1.1)
    Gene namesi
    Name:ADH6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:255. ADH6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24576.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368Alcohol dehydrogenase 6PRO_0000160687Add
    BLAST

    Proteomic databases

    MaxQBiP28332.
    PaxDbiP28332.
    PRIDEiP28332.

    PTM databases

    PhosphoSiteiP28332.

    Expressioni

    Tissue specificityi

    Stomach and liver.

    Gene expression databases

    ArrayExpressiP28332.
    BgeeiP28332.
    CleanExiHS_ADH6.
    GenevestigatoriP28332.

    Interactioni

    Protein-protein interaction databases

    BioGridi106642. 8 interactions.
    IntActiP28332. 8 interactions.
    STRINGi9606.ENSP00000378359.

    Structurei

    3D structure databases

    ProteinModelPortaliP28332.
    SMRiP28332. Positions 3-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1062.
    HOGENOMiHOG000294674.
    HOVERGENiHBG000195.
    KOiK13952.
    OMAiCINQINT.
    PhylomeDBiP28332.
    TreeFamiTF300429.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR028633. ADH6.
    IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PTHR11695:SF307. PTHR11695:SF307. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 2 hits.
    PROSITEiPS00059. ADH_ZINC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P28332-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCTTGQVIRC KAAILWKPGA PFSIEEVEVA PPKAKEVRIK VVATGLCGTE    50
    MKVLGSKHLD LLYPTILGHE GAGIVESIGE GVSTVKPGDK VITLFLPQCG 100
    ECTSCLNSEG NFCIQFKQSK TQLMSDGTSR FTCKGKSIYH FGNTSTFCEY 150
    TVIKEISVAK IDAVAPLEKV CLISCGFSTG FGAAINTAKV TPGSTCAVFG 200
    LGGVGLSVVM GCKAAGAARI IGVDVNKEKF KKAQELGATE CLNPQDLKKP 250
    IQEVLFDMTD AGIDFCFEAI GNLDVLAAAL ASCNESYGVC VVVGVLPASV 300
    QLKISGQLFF SGRSLKGSVF GGWKSRQHIP KLVADYMAEK LNLDPLITHT 350
    LNLDKINEAV ELMKTGKW 368
    Length:368
    Mass (Da):39,089
    Last modified:July 28, 2009 - v2
    Checksum:iC7E33043F6B4CA9B
    GO
    Isoform 2 (identifier: P28332-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         368-368: W → CIRCILLL

    Show »
    Length:375
    Mass (Da):39,831
    Checksum:i53DA496C0DDE2CBA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21C → S in AAA35509. (PubMed:1881901)Curated
    Sequence conflicti2 – 21C → S in BAG52607. (PubMed:14702039)Curated
    Sequence conflicti2 – 21C → S in AAX44051. 1 PublicationCurated
    Sequence conflicti266 – 2661C → R in BAG52607. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti102 – 1021C → G.1 Publication
    Corresponds to variant rs28720152 [ dbSNP | Ensembl ].
    VAR_022655
    Natural varianti114 – 1141I → V.1 Publication
    Corresponds to variant rs28720153 [ dbSNP | Ensembl ].
    VAR_022656
    Natural varianti151 – 1511T → P.
    Corresponds to variant rs34582580 [ dbSNP | Ensembl ].
    VAR_048198

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei368 – 3681W → CIRCILLL in isoform 2. 1 PublicationVSP_037702

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84402
    , M84403, M84404, M84405, M84406, M84407, M84408, M84409 Genomic DNA. Translation: AAA35509.1.
    AK092768 mRNA. Translation: BAG52607.1.
    AY962311 Genomic DNA. Translation: AAX44051.1.
    AP002026 Genomic DNA. No translation available.
    CCDSiCCDS3647.1. [P28332-1]
    CCDS43255.1. [P28332-2]
    PIRiA41274. DEHUA6.
    RefSeqiNP_000663.1. NM_000672.3.
    NP_001095940.1. NM_001102470.1.
    UniGeneiHs.586161.

    Genome annotation databases

    EnsembliENST00000237653; ENSP00000237653; ENSG00000172955. [P28332-1]
    ENST00000394899; ENSP00000378359; ENSG00000172955. [P28332-2]
    GeneIDi130.
    KEGGihsa:130.
    UCSCiuc003huo.2. human. [P28332-2]
    uc003hup.4. human. [P28332-1]

    Polymorphism databases

    DMDMi254763246.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84402
    , M84403 , M84404 , M84405 , M84406 , M84407 , M84408 , M84409 Genomic DNA. Translation: AAA35509.1 .
    AK092768 mRNA. Translation: BAG52607.1 .
    AY962311 Genomic DNA. Translation: AAX44051.1 .
    AP002026 Genomic DNA. No translation available.
    CCDSi CCDS3647.1. [P28332-1 ]
    CCDS43255.1. [P28332-2 ]
    PIRi A41274. DEHUA6.
    RefSeqi NP_000663.1. NM_000672.3.
    NP_001095940.1. NM_001102470.1.
    UniGenei Hs.586161.

    3D structure databases

    ProteinModelPortali P28332.
    SMRi P28332. Positions 3-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106642. 8 interactions.
    IntActi P28332. 8 interactions.
    STRINGi 9606.ENSP00000378359.

    Chemistry

    BindingDBi P28332.
    ChEMBLi CHEMBL2096668.
    DrugBanki DB01048. Abacavir.

    PTM databases

    PhosphoSitei P28332.

    Polymorphism databases

    DMDMi 254763246.

    Proteomic databases

    MaxQBi P28332.
    PaxDbi P28332.
    PRIDEi P28332.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000237653 ; ENSP00000237653 ; ENSG00000172955 . [P28332-1 ]
    ENST00000394899 ; ENSP00000378359 ; ENSG00000172955 . [P28332-2 ]
    GeneIDi 130.
    KEGGi hsa:130.
    UCSCi uc003huo.2. human. [P28332-2 ]
    uc003hup.4. human. [P28332-1 ]

    Organism-specific databases

    CTDi 130.
    GeneCardsi GC04M100123.
    HGNCi HGNC:255. ADH6.
    MIMi 103735. gene.
    neXtProti NX_P28332.
    PharmGKBi PA24576.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1062.
    HOGENOMi HOG000294674.
    HOVERGENi HBG000195.
    KOi K13952.
    OMAi CINQINT.
    PhylomeDBi P28332.
    TreeFami TF300429.

    Enzyme and pathway databases

    Reactomei REACT_34. Ethanol oxidation.

    Miscellaneous databases

    GeneWikii ADH6.
    GenomeRNAii 130.
    NextBioi 517.
    PROi P28332.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28332.
    Bgeei P28332.
    CleanExi HS_ADH6.
    Genevestigatori P28332.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR028633. ADH6.
    IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    PTHR11695:SF307. PTHR11695:SF307. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 2 hits.
    PROSITEi PS00059. ADH_ZINC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme."
      Yasunami M., Chen C.-S., Yoshida A.
      Proc. Natl. Acad. Sci. U.S.A. 88:7610-7614(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Small intestine.
    3. NIEHS SNPs program
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-102 AND VAL-114.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiADH6_HUMAN
    AccessioniPrimary (citable) accession number: P28332
    Secondary accession number(s): B3KS45, Q58F53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3