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Protein

Choline O-acetyltransferase

Gene

CHAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.

Catalytic activityi

Acetyl-CoA + choline = CoA + O-acetylcholine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei442Proton acceptor1
Binding sitei558Coenzyme A1
Binding sitei659Coenzyme A1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Neurotransmitter biosynthesis

Enzyme and pathway databases

BioCyciZFISH:HS01006-MONOMER.
BRENDAi2.3.1.6. 2681.
ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-264642. Acetylcholine Neurotransmitter Release Cycle.
SABIO-RKP28329.
SIGNORiP28329.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline O-acetyltransferase (EC:2.3.1.6)
Short name:
CHOACTase
Short name:
ChAT
Short name:
Choline acetylase
Gene namesi
Name:CHAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:1912. CHAT.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • cytosol Source: Reactome
  • nucleus Source: ProtInc
  • presynapse Source: GOC
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Myasthenic syndrome, congenital, 6, presynaptic (CMS6)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS6 affected individuals have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. CMS6 inheritance is autosomal recessive.
See also OMIM:254210
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011666210L → P in CMS6; impaired activity. 1 PublicationCorresponds to variant rs28930071dbSNPEnsembl.1
Natural variantiVAR_011667211P → A in CMS6; impaired activity. 1 PublicationCorresponds to variant rs121912815dbSNPEnsembl.1
Natural variantiVAR_011668305I → T in CMS6; impaired activity. 1 PublicationCorresponds to variant rs28929482dbSNPEnsembl.1
Natural variantiVAR_038605336I → T in CMS6. 1 PublicationCorresponds to variant rs121912823dbSNPEnsembl.1
Natural variantiVAR_011669420R → C in CMS6; impaired activity. 1 PublicationCorresponds to variant rs121912822dbSNPEnsembl.1
Natural variantiVAR_011670441E → K in CMS6; completely lack activity. 1 PublicationCorresponds to variant rs28930070dbSNPEnsembl.1
Natural variantiVAR_011671482R → G in CMS6; impaired activity. 1 PublicationCorresponds to variant rs28929481dbSNPEnsembl.1
Natural variantiVAR_011672498S → L in CMS6; impaired activity. 1 PublicationCorresponds to variant rs121912821dbSNPEnsembl.1
Natural variantiVAR_011673506V → L in CMS6; impaired activity. 1 PublicationCorresponds to variant rs121912817dbSNPEnsembl.1
Natural variantiVAR_011674560R → H in CMS6; impaired activity. 1 PublicationCorresponds to variant rs121912819dbSNPEnsembl.1

Keywords - Diseasei

Congenital myasthenic syndrome, Disease mutation

Organism-specific databases

DisGeNETi1103.
MalaCardsiCHAT.
MIMi254210. phenotype.
OpenTargetsiENSG00000070748.
Orphaneti98914. Presynaptic congenital myasthenic syndromes.
PharmGKBiPA26448.

Chemistry databases

ChEMBLiCHEMBL4039.
DrugBankiDB00122. Choline.
DB00184. Nicotine.

Polymorphism and mutation databases

BioMutaiCHAT.
DMDMi281185509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101541 – 748Choline O-acetyltransferaseAdd BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125PhosphoserineBy similarity1
Modified residuei473PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP28329.
PeptideAtlasiP28329.
PRIDEiP28329.

PTM databases

iPTMnetiP28329.
PhosphoSitePlusiP28329.

Expressioni

Gene expression databases

BgeeiENSG00000070748.
CleanExiHS_CHAT.
ExpressionAtlasiP28329. baseline and differential.
GenevisibleiP28329. HS.

Organism-specific databases

HPAiCAB002313.
HPA048547.

Interactioni

Protein-protein interaction databases

BioGridi107528. 2 interactors.
STRINGi9606.ENSP00000337103.

Chemistry databases

BindingDBiP28329.

Structurei

Secondary structure

1748
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi139 – 150Combined sources12
Helixi151 – 153Combined sources3
Helixi156 – 169Combined sources14
Helixi175 – 189Combined sources15
Beta strandi190 – 192Combined sources3
Helixi195 – 202Combined sources8
Turni203 – 205Combined sources3
Helixi210 – 213Combined sources4
Beta strandi217 – 219Combined sources3
Helixi228 – 250Combined sources23
Beta strandi261 – 263Combined sources3
Beta strandi265 – 267Combined sources3
Helixi271 – 275Combined sources5
Beta strandi276 – 282Combined sources7
Beta strandi285 – 287Combined sources3
Beta strandi289 – 292Combined sources4
Beta strandi300 – 308Combined sources9
Beta strandi311 – 319Combined sources9
Helixi326 – 340Combined sources15
Helixi343 – 345Combined sources3
Helixi350 – 355Combined sources6
Helixi358 – 369Combined sources12
Helixi372 – 382Combined sources11
Beta strandi387 – 390Combined sources4
Helixi400 – 409Combined sources10
Turni413 – 418Combined sources6
Beta strandi424 – 430Combined sources7
Beta strandi436 – 440Combined sources5
Beta strandi442 – 444Combined sources3
Helixi447 – 461Combined sources15
Helixi489 – 508Combined sources20
Beta strandi509 – 516Combined sources8
Helixi521 – 525Combined sources5
Turni526 – 528Combined sources3
Helixi531 – 547Combined sources17
Beta strandi553 – 558Combined sources6
Beta strandi567 – 569Combined sources3
Helixi575 – 585Combined sources11
Helixi587 – 589Combined sources3
Helixi593 – 615Combined sources23
Helixi621 – 634Combined sources14
Helixi640 – 643Combined sources4
Helixi645 – 650Combined sources6
Beta strandi654 – 659Combined sources6
Beta strandi663 – 665Combined sources3
Beta strandi667 – 669Combined sources3
Beta strandi678 – 684Combined sources7
Beta strandi689 – 696Combined sources8
Helixi704 – 722Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FY2X-ray2.25A120-733[»]
2FY3X-ray2.27A120-733[»]
2FY4X-ray2.30A120-733[»]
2FY5X-ray2.60A120-733[»]
ProteinModelPortaliP28329.
SMRiP28329.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28329.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni520 – 532Coenzyme A bindingAdd BLAST13

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3717. Eukaryota.
ENOG410XNZ9. LUCA.
GeneTreeiENSGT00760000119220.
HOGENOMiHOG000233845.
HOVERGENiHBG107717.
InParanoidiP28329.
KOiK00623.
OMAiMQFVVGR.
OrthoDBiEOG091G038F.
PhylomeDBiP28329.
TreeFamiTF313836.

Family and domain databases

InterProiIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERiPTHR22589. PTHR22589. 1 hit.
PfamiPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEiPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform M (identifier: P28329-1) [UniParc]FASTAAdd to basket
Also known as: 83 kDa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLRTAKKRG LGGGGKWKRE EGGGTRGRRE VRPACFLQSG GRGDPGDVGG
60 70 80 90 100
PAGNPGCSPH PRAATRPPPL PAHTPAHTPE WCGAASAEAA EPRRAGPHLC
110 120 130 140 150
IPAPGLTKTP ILEKVPRKMA AKTPSSEESG LPKLPVPPLQ QTLATYLQCM
160 170 180 190 200
RHLVSEEQFR KSQAIVQQFG APGGLGETLQ QKLLERQEKT ANWVSEYWLN
210 220 230 240 250
DMYLNNRLAL PVNSSPAVIF ARQHFPGTDD QLRFAASLIS GVLSYKALLD
260 270 280 290 300
SHSIPTDCAK GQLSGQPLCM KQYYGLFSSY RLPGHTQDTL VAQNSSIMPE
310 320 330 340 350
PEHVIVACCN QFFVLDVVIN FRRLSEGDLF TQLRKIVKMA SNEDERLPPI
360 370 380 390 400
GLLTSDGRSE WAEARTVLVK DSTNRDSLDM IERCICLVCL DAPGGVELSD
410 420 430 440 450
THRALQLLHG GGYSKNGANR WYDKSLQFVV GRDGTCGVVC EHSPFDGIVL
460 470 480 490 500
VQCTEHLLKH VTQSSRKLIR ADSVSELPAP RRLRWKCSPE IQGHLASSAE
510 520 530 540 550
KLQRIVKNLD FIVYKFDNYG KTFIKKQKCS PDAFIQVALQ LAFYRLHRRL
560 570 580 590 600
VPTYESASIR RFQEGRVDNI RSATPEALAF VRAVTDHKAA VPASEKLLLL
610 620 630 640 650
KDAIRAQTAY TVMAITGMAI DNHLLALREL ARAMCKELPE MFMDETYLMS
660 670 680 690 700
NRFVLSTSQV PTTTEMFCCY GPVVPNGYGA CYNPQPETIL FCISSFHSCK
710 720 730 740
ETSSSKFAKA VEESLIDMRD LCSLLPPTES KPLATKEKAT RPSQGHQP
Length:748
Mass (Da):82,536
Last modified:December 15, 2009 - v4
Checksum:iA902364081915391
GO
Isoform S (identifier: P28329-2) [UniParc]FASTAAdd to basket
Also known as: 74 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: MGLRTAKKRG...SAEAAEPRRA → MWPECRDEALSTV

Show »
Length:666
Mass (Da):74,361
Checksum:i3A521459434FF919
GO
Isoform R (identifier: P28329-3) [UniParc]FASTAAdd to basket
Also known as: 70 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Show »
Length:630
Mass (Da):70,394
Checksum:i0BF3CC8F56518326
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151R → Q in CAA39923 (PubMed:1339386).Curated1
Sequence conflicti261 – 262GQ → PE in AAA14245 (PubMed:1337937).Curated2
Sequence conflicti396V → L in AAB23557 (PubMed:1388731).Curated1
Sequence conflicti434G → A in AAA14245 (PubMed:1337937).Curated1
Sequence conflicti529C → S in AAB23557 (PubMed:1388731).Curated1
Sequence conflicti567V → L in AAB23557 (PubMed:1388731).Curated1
Sequence conflicti629 – 630EL → DV in AAB23557 (PubMed:1388731).Curated2
Sequence conflicti664T → M in AAB23557 (PubMed:1388731).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04668347D → E.Corresponds to variant rs3810948dbSNPEnsembl.1
Natural variantiVAR_011675120A → T.3 PublicationsCorresponds to variant rs3810950dbSNPEnsembl.1
Natural variantiVAR_011666210L → P in CMS6; impaired activity. 1 PublicationCorresponds to variant rs28930071dbSNPEnsembl.1
Natural variantiVAR_011667211P → A in CMS6; impaired activity. 1 PublicationCorresponds to variant rs121912815dbSNPEnsembl.1
Natural variantiVAR_046684222R → P.Corresponds to variant rs8178989dbSNPEnsembl.1
Natural variantiVAR_046685243L → F.Corresponds to variant rs8178990dbSNPEnsembl.1
Natural variantiVAR_046686299P → L.Corresponds to variant rs868749dbSNPEnsembl.1
Natural variantiVAR_011668305I → T in CMS6; impaired activity. 1 PublicationCorresponds to variant rs28929482dbSNPEnsembl.1
Natural variantiVAR_038605336I → T in CMS6. 1 PublicationCorresponds to variant rs121912823dbSNPEnsembl.1
Natural variantiVAR_011676392A → G.2 Publications1
Natural variantiVAR_046687400D → N.Corresponds to variant rs8178991dbSNPEnsembl.1
Natural variantiVAR_011669420R → C in CMS6; impaired activity. 1 PublicationCorresponds to variant rs121912822dbSNPEnsembl.1
Natural variantiVAR_011670441E → K in CMS6; completely lack activity. 1 PublicationCorresponds to variant rs28930070dbSNPEnsembl.1
Natural variantiVAR_046688461V → M.4 PublicationsCorresponds to variant rs4838544dbSNPEnsembl.1
Natural variantiVAR_011671482R → G in CMS6; impaired activity. 1 PublicationCorresponds to variant rs28929481dbSNPEnsembl.1
Natural variantiVAR_011672498S → L in CMS6; impaired activity. 1 PublicationCorresponds to variant rs121912821dbSNPEnsembl.1
Natural variantiVAR_011673506V → L in CMS6; impaired activity. 1 PublicationCorresponds to variant rs121912817dbSNPEnsembl.1
Natural variantiVAR_011674560R → H in CMS6; impaired activity. 1 PublicationCorresponds to variant rs121912819dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0007911 – 118Missing in isoform R. 2 PublicationsAdd BLAST118
Alternative sequenceiVSP_0007901 – 95MGLRT…EPRRA → MWPECRDEALSTV in isoform S. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S56138 mRNA. Translation: AAA14245.1.
AF305907 mRNA. Translation: AAK08953.1.
AF305906
, AF305894, AF305895, AF305896, AF305897, AF305898, AF305899, AF305900, AF305901, AF305902, AF305903, AF305904, AF305905 Genomic DNA. Translation: AAK08950.1.
AF305908 mRNA. Translation: AAK08954.1.
AF305906
, AF305894, AF305895, AF305896, AF305897, AF305898, AF305899, AF305900, AF305901, AF305902, AF305903, AF305904, AF305905 Genomic DNA. Translation: AAK08951.1.
AF305909 mRNA. Translation: AAK08955.1.
AF305906
, AF305894, AF305895, AF305896, AF305897, AF305898, AF305899, AF305900, AF305901, AF305902, AF305903, AF305904, AF305905 Genomic DNA. Translation: AAK08952.1.
AC073366 Genomic DNA. No translation available.
CH471187 Genomic DNA. Translation: EAW93086.1.
BC130615 mRNA. Translation: AAI30616.1.
BC130617 mRNA. Translation: AAI30618.1.
S45018 mRNA. Translation: AAB23557.2.
X56585 Genomic DNA. Translation: CAA39923.1.
X56879 Genomic DNA. Translation: CAA40201.1.
CCDSiCCDS44389.1. [P28329-2]
CCDS7232.1. [P28329-1]
CCDS7233.1. [P28329-3]
PIRiI52631. A60202.
RefSeqiNP_001136401.1. NM_001142929.1.
NP_001136405.1. NM_001142933.1.
NP_001136406.1. NM_001142934.1.
NP_065574.3. NM_020549.4.
NP_066264.3. NM_020984.3.
NP_066265.3. NM_020985.3.
NP_066266.3. NM_020986.3.
UniGeneiHs.302002.

Genome annotation databases

EnsembliENST00000337653; ENSP00000337103; ENSG00000070748. [P28329-1]
ENST00000339797; ENSP00000343486; ENSG00000070748. [P28329-3]
ENST00000351556; ENSP00000345878; ENSG00000070748. [P28329-3]
ENST00000395559; ENSP00000378926; ENSG00000070748. [P28329-3]
ENST00000395562; ENSP00000378929; ENSG00000070748. [P28329-2]
GeneIDi1103.
KEGGihsa:1103.
UCSCiuc001jhv.1. human. [P28329-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Choline acetyltransferase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S56138 mRNA. Translation: AAA14245.1.
AF305907 mRNA. Translation: AAK08953.1.
AF305906
, AF305894, AF305895, AF305896, AF305897, AF305898, AF305899, AF305900, AF305901, AF305902, AF305903, AF305904, AF305905 Genomic DNA. Translation: AAK08950.1.
AF305908 mRNA. Translation: AAK08954.1.
AF305906
, AF305894, AF305895, AF305896, AF305897, AF305898, AF305899, AF305900, AF305901, AF305902, AF305903, AF305904, AF305905 Genomic DNA. Translation: AAK08951.1.
AF305909 mRNA. Translation: AAK08955.1.
AF305906
, AF305894, AF305895, AF305896, AF305897, AF305898, AF305899, AF305900, AF305901, AF305902, AF305903, AF305904, AF305905 Genomic DNA. Translation: AAK08952.1.
AC073366 Genomic DNA. No translation available.
CH471187 Genomic DNA. Translation: EAW93086.1.
BC130615 mRNA. Translation: AAI30616.1.
BC130617 mRNA. Translation: AAI30618.1.
S45018 mRNA. Translation: AAB23557.2.
X56585 Genomic DNA. Translation: CAA39923.1.
X56879 Genomic DNA. Translation: CAA40201.1.
CCDSiCCDS44389.1. [P28329-2]
CCDS7232.1. [P28329-1]
CCDS7233.1. [P28329-3]
PIRiI52631. A60202.
RefSeqiNP_001136401.1. NM_001142929.1.
NP_001136405.1. NM_001142933.1.
NP_001136406.1. NM_001142934.1.
NP_065574.3. NM_020549.4.
NP_066264.3. NM_020984.3.
NP_066265.3. NM_020985.3.
NP_066266.3. NM_020986.3.
UniGeneiHs.302002.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FY2X-ray2.25A120-733[»]
2FY3X-ray2.27A120-733[»]
2FY4X-ray2.30A120-733[»]
2FY5X-ray2.60A120-733[»]
ProteinModelPortaliP28329.
SMRiP28329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107528. 2 interactors.
STRINGi9606.ENSP00000337103.

Chemistry databases

BindingDBiP28329.
ChEMBLiCHEMBL4039.
DrugBankiDB00122. Choline.
DB00184. Nicotine.

PTM databases

iPTMnetiP28329.
PhosphoSitePlusiP28329.

Polymorphism and mutation databases

BioMutaiCHAT.
DMDMi281185509.

Proteomic databases

PaxDbiP28329.
PeptideAtlasiP28329.
PRIDEiP28329.

Protocols and materials databases

DNASUi1103.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337653; ENSP00000337103; ENSG00000070748. [P28329-1]
ENST00000339797; ENSP00000343486; ENSG00000070748. [P28329-3]
ENST00000351556; ENSP00000345878; ENSG00000070748. [P28329-3]
ENST00000395559; ENSP00000378926; ENSG00000070748. [P28329-3]
ENST00000395562; ENSP00000378929; ENSG00000070748. [P28329-2]
GeneIDi1103.
KEGGihsa:1103.
UCSCiuc001jhv.1. human. [P28329-1]

Organism-specific databases

CTDi1103.
DisGeNETi1103.
GeneCardsiCHAT.
GeneReviewsiCHAT.
HGNCiHGNC:1912. CHAT.
HPAiCAB002313.
HPA048547.
MalaCardsiCHAT.
MIMi118490. gene.
254210. phenotype.
neXtProtiNX_P28329.
OpenTargetsiENSG00000070748.
Orphaneti98914. Presynaptic congenital myasthenic syndromes.
PharmGKBiPA26448.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3717. Eukaryota.
ENOG410XNZ9. LUCA.
GeneTreeiENSGT00760000119220.
HOGENOMiHOG000233845.
HOVERGENiHBG107717.
InParanoidiP28329.
KOiK00623.
OMAiMQFVVGR.
OrthoDBiEOG091G038F.
PhylomeDBiP28329.
TreeFamiTF313836.

Enzyme and pathway databases

BioCyciZFISH:HS01006-MONOMER.
BRENDAi2.3.1.6. 2681.
ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-264642. Acetylcholine Neurotransmitter Release Cycle.
SABIO-RKP28329.
SIGNORiP28329.

Miscellaneous databases

EvolutionaryTraceiP28329.
GeneWikiiCholine_acetyltransferase.
GenomeRNAii1103.
PROiP28329.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070748.
CleanExiHS_CHAT.
ExpressionAtlasiP28329. baseline and differential.
GenevisibleiP28329. HS.

Family and domain databases

InterProiIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERiPTHR22589. PTHR22589. 1 hit.
PfamiPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEiPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLAT_HUMAN
AccessioniPrimary (citable) accession number: P28329
Secondary accession number(s): A2BDF4
, A2BDF5, Q16488, Q9BQ23, Q9BQ35, Q9BQE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 15, 2009
Last modified: November 2, 2016
This is version 163 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.