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Protein

Quinone oxidoreductase 1

Gene

qorA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NADPH + 2 quinone = NADP+ + 2 semiquinone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei130NADP1 Publication1
Binding sitei192NADP1 Publication1
Binding sitei216NADP; via carbonyl oxygen1 Publication1
Binding sitei317NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi42 – 46NADP1 Publication5
Nucleotide bindingi152 – 153NADP1 Publication2
Nucleotide bindingi173 – 177NADP1 Publication5
Nucleotide bindingi238 – 241NADP1 Publication4
Nucleotide bindingi264 – 266NADP1 Publication3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciEcoCyc:QOR-MONOMER.
ECOL316407:JW4011-MONOMER.
MetaCyc:QOR-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinone oxidoreductase 1 (EC:1.6.5.5)
Alternative name(s):
NADPH:quinone reductase 1
Zeta-crystallin homolog protein
Gene namesi
Name:qorA
Synonyms:hcz, qor, qor1
Ordered Locus Names:b4051, JW4011
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11492. qorA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki
  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001609011 – 327Quinone oxidoreductase 1Add BLAST327

Proteomic databases

EPDiP28304.
PaxDbiP28304.
PRIDEiP28304.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi4260805. 6 interactors.
DIPiDIP-10631N.
IntActiP28304. 5 interactors.
MINTiMINT-1267314.
STRINGi511145.b4051.

Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Helixi13 – 15Combined sources3
Beta strandi17 – 20Combined sources4
Beta strandi30 – 39Combined sources10
Helixi42 – 48Combined sources7
Beta strandi55 – 59Combined sources5
Beta strandi65 – 72Combined sources8
Beta strandi84 – 88Combined sources5
Beta strandi95 – 102Combined sources8
Helixi103 – 105Combined sources3
Beta strandi106 – 108Combined sources3
Helixi115 – 133Combined sources19
Beta strandi143 – 148Combined sources6
Helixi152 – 164Combined sources13
Beta strandi167 – 174Combined sources8
Helixi175 – 184Combined sources10
Beta strandi187 – 191Combined sources5
Turni192 – 194Combined sources3
Helixi197 – 204Combined sources8
Turni205 – 207Combined sources3
Beta strandi210 – 215Combined sources6
Helixi219 – 221Combined sources3
Helixi222 – 227Combined sources6
Beta strandi229 – 237Combined sources9
Helixi251 – 255Combined sources5
Beta strandi260 – 262Combined sources3
Helixi266 – 269Combined sources4
Helixi273 – 288Combined sources16
Helixi298 – 300Combined sources3
Beta strandi301 – 303Combined sources3
Helixi304 – 306Combined sources3
Helixi307 – 315Combined sources9
Beta strandi324 – 326Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QORX-ray2.20A/B1-327[»]
ProteinModelPortaliP28304.
SMRiP28304.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28304.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EE6. Bacteria.
COG0604. LUCA.
HOGENOMiHOG000294672.
InParanoidiP28304.
KOiK00344.
OMAiTDGKKCP.
PhylomeDBiP28304.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRIEFHKH GGPEVLQAVE FTPADPAENE IQVENKAIGI NFIDTYIRSG
60 70 80 90 100
LYPPPSLPSG LGTEAAGIVS KVGSGVKHIK AGDRVVYAQS ALGAYSSVHN
110 120 130 140 150
IIADKAAILP AAISFEQAAA SFLKGLTVYY LLRKTYEIKP DEQFLFHAAA
160 170 180 190 200
GGVGLIACQW AKALGAKLIG TVGTAQKAQS ALKAGAWQVI NYREEDLVER
210 220 230 240 250
LKEITGGKKV RVVYDSVGRD TWERSLDCLQ RRGLMVSFGN SSGAVTGVNL
260 270 280 290 300
GILNQKGSLY VTRPSLQGYI TTREELTEAS NELFSLIASG VIKVDVAEQQ
310 320
KYPLKDAQRA HEILESRATQ GSSLLIP
Length:327
Mass (Da):35,172
Last modified:December 1, 1992 - v1
Checksum:iA6355B12DBA513B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02312 Genomic DNA. Translation: AAA23691.1.
U00006 Genomic DNA. Translation: AAC43145.1.
U00096 Genomic DNA. Translation: AAC77021.1.
AP009048 Genomic DNA. Translation: BAE78053.1.
PIRiS45529.
RefSeqiNP_418475.1. NC_000913.3.
WP_000235508.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77021; AAC77021; b4051.
BAE78053; BAE78053; BAE78053.
GeneIDi948556.
KEGGiecj:JW4011.
eco:b4051.
PATRICi32123641. VBIEscCol129921_4169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02312 Genomic DNA. Translation: AAA23691.1.
U00006 Genomic DNA. Translation: AAC43145.1.
U00096 Genomic DNA. Translation: AAC77021.1.
AP009048 Genomic DNA. Translation: BAE78053.1.
PIRiS45529.
RefSeqiNP_418475.1. NC_000913.3.
WP_000235508.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QORX-ray2.20A/B1-327[»]
ProteinModelPortaliP28304.
SMRiP28304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260805. 6 interactors.
DIPiDIP-10631N.
IntActiP28304. 5 interactors.
MINTiMINT-1267314.
STRINGi511145.b4051.

Proteomic databases

EPDiP28304.
PaxDbiP28304.
PRIDEiP28304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77021; AAC77021; b4051.
BAE78053; BAE78053; BAE78053.
GeneIDi948556.
KEGGiecj:JW4011.
eco:b4051.
PATRICi32123641. VBIEscCol129921_4169.

Organism-specific databases

EchoBASEiEB1455.
EcoGeneiEG11492. qorA.

Phylogenomic databases

eggNOGiENOG4105EE6. Bacteria.
COG0604. LUCA.
HOGENOMiHOG000294672.
InParanoidiP28304.
KOiK00344.
OMAiTDGKKCP.
PhylomeDBiP28304.

Enzyme and pathway databases

BioCyciEcoCyc:QOR-MONOMER.
ECOL316407:JW4011-MONOMER.
MetaCyc:QOR-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP28304.
PROiP28304.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQOR1_ECOLI
AccessioniPrimary (citable) accession number: P28304
Secondary accession number(s): Q2M6Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.