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Protein

Quinone oxidoreductase 1

Gene

qorA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NADPH + 2 quinone = NADP+ + 2 semiquinone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NADP1 Publication
Binding sitei192 – 1921NADP1 Publication
Binding sitei216 – 2161NADP; via carbonyl oxygen1 Publication
Binding sitei317 – 3171NADP1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi42 – 465NADP1 Publication
Nucleotide bindingi152 – 1532NADP1 Publication
Nucleotide bindingi173 – 1775NADP1 Publication
Nucleotide bindingi238 – 2414NADP1 Publication
Nucleotide bindingi264 – 2663NADP1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciEcoCyc:QOR-MONOMER.
ECOL316407:JW4011-MONOMER.
MetaCyc:QOR-MONOMER.
RETL1328306-WGS:GSTH-1125-MONOMER.
RETL1328306-WGS:GSTH-2088-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinone oxidoreductase 1 (EC:1.6.5.5)
Alternative name(s):
NADPH:quinone reductase 1
Zeta-crystallin homolog protein
Gene namesi
Name:qorA
Synonyms:hcz, qor, qor1
Ordered Locus Names:b4051, JW4011
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11492. qorA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki
  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Quinone oxidoreductase 1PRO_0000160901Add
BLAST

Proteomic databases

EPDiP28304.
PaxDbiP28304.
PRIDEiP28304.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi4260805. 6 interactions.
DIPiDIP-10631N.
IntActiP28304. 5 interactions.
MINTiMINT-1267314.
STRINGi511145.b4051.

Structurei

Secondary structure

1
327
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97Combined sources
Helixi13 – 153Combined sources
Beta strandi17 – 204Combined sources
Beta strandi30 – 3910Combined sources
Helixi42 – 487Combined sources
Beta strandi55 – 595Combined sources
Beta strandi65 – 728Combined sources
Beta strandi84 – 885Combined sources
Beta strandi95 – 1028Combined sources
Helixi103 – 1053Combined sources
Beta strandi106 – 1083Combined sources
Helixi115 – 13319Combined sources
Beta strandi143 – 1486Combined sources
Helixi152 – 16413Combined sources
Beta strandi167 – 1748Combined sources
Helixi175 – 18410Combined sources
Beta strandi187 – 1915Combined sources
Turni192 – 1943Combined sources
Helixi197 – 2048Combined sources
Turni205 – 2073Combined sources
Beta strandi210 – 2156Combined sources
Helixi219 – 2213Combined sources
Helixi222 – 2276Combined sources
Beta strandi229 – 2379Combined sources
Helixi251 – 2555Combined sources
Beta strandi260 – 2623Combined sources
Helixi266 – 2694Combined sources
Helixi273 – 28816Combined sources
Helixi298 – 3003Combined sources
Beta strandi301 – 3033Combined sources
Helixi304 – 3063Combined sources
Helixi307 – 3159Combined sources
Beta strandi324 – 3263Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QORX-ray2.20A/B1-327[»]
ProteinModelPortaliP28304.
SMRiP28304. Positions 2-327.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28304.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EE6. Bacteria.
COG0604. LUCA.
HOGENOMiHOG000294672.
InParanoidiP28304.
KOiK00344.
OMAiTDGKKCP.
PhylomeDBiP28304.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRIEFHKH GGPEVLQAVE FTPADPAENE IQVENKAIGI NFIDTYIRSG
60 70 80 90 100
LYPPPSLPSG LGTEAAGIVS KVGSGVKHIK AGDRVVYAQS ALGAYSSVHN
110 120 130 140 150
IIADKAAILP AAISFEQAAA SFLKGLTVYY LLRKTYEIKP DEQFLFHAAA
160 170 180 190 200
GGVGLIACQW AKALGAKLIG TVGTAQKAQS ALKAGAWQVI NYREEDLVER
210 220 230 240 250
LKEITGGKKV RVVYDSVGRD TWERSLDCLQ RRGLMVSFGN SSGAVTGVNL
260 270 280 290 300
GILNQKGSLY VTRPSLQGYI TTREELTEAS NELFSLIASG VIKVDVAEQQ
310 320
KYPLKDAQRA HEILESRATQ GSSLLIP
Length:327
Mass (Da):35,172
Last modified:December 1, 1992 - v1
Checksum:iA6355B12DBA513B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02312 Genomic DNA. Translation: AAA23691.1.
U00006 Genomic DNA. Translation: AAC43145.1.
U00096 Genomic DNA. Translation: AAC77021.1.
AP009048 Genomic DNA. Translation: BAE78053.1.
PIRiS45529.
RefSeqiNP_418475.1. NC_000913.3.
WP_000235508.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77021; AAC77021; b4051.
BAE78053; BAE78053; BAE78053.
GeneIDi948556.
KEGGiecj:JW4011.
eco:b4051.
PATRICi32123641. VBIEscCol129921_4169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02312 Genomic DNA. Translation: AAA23691.1.
U00006 Genomic DNA. Translation: AAC43145.1.
U00096 Genomic DNA. Translation: AAC77021.1.
AP009048 Genomic DNA. Translation: BAE78053.1.
PIRiS45529.
RefSeqiNP_418475.1. NC_000913.3.
WP_000235508.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QORX-ray2.20A/B1-327[»]
ProteinModelPortaliP28304.
SMRiP28304. Positions 2-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260805. 6 interactions.
DIPiDIP-10631N.
IntActiP28304. 5 interactions.
MINTiMINT-1267314.
STRINGi511145.b4051.

Proteomic databases

EPDiP28304.
PaxDbiP28304.
PRIDEiP28304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77021; AAC77021; b4051.
BAE78053; BAE78053; BAE78053.
GeneIDi948556.
KEGGiecj:JW4011.
eco:b4051.
PATRICi32123641. VBIEscCol129921_4169.

Organism-specific databases

EchoBASEiEB1455.
EcoGeneiEG11492. qorA.

Phylogenomic databases

eggNOGiENOG4105EE6. Bacteria.
COG0604. LUCA.
HOGENOMiHOG000294672.
InParanoidiP28304.
KOiK00344.
OMAiTDGKKCP.
PhylomeDBiP28304.

Enzyme and pathway databases

BioCyciEcoCyc:QOR-MONOMER.
ECOL316407:JW4011-MONOMER.
MetaCyc:QOR-MONOMER.
RETL1328306-WGS:GSTH-1125-MONOMER.
RETL1328306-WGS:GSTH-2088-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP28304.
PROiP28304.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQOR1_ECOLI
AccessioniPrimary (citable) accession number: P28304
Secondary accession number(s): Q2M6Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.