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P28293

- CATG_MOUSE

UniProt

P28293 - CATG_MOUSE

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Protein

Cathepsin G

Gene
Ctsg
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis.

Catalytic activityi

Specificity similar to chymotrypsin C.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Charge relay system By similarity
Active sitei108 – 1081Charge relay system By similarity
Active sitei201 – 2011Charge relay system By similarity

GO - Molecular functioni

  1. heparin binding Source: Ensembl
  2. serine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. defense response to fungus Source: MGI
  2. defense response to Gram-positive bacterium Source: MGI
  3. negative regulation of growth of symbiont in host Source: MGI
  4. neutrophil mediated killing of gram-positive bacterium Source: MGI
  5. positive regulation of immune response Source: MGI
  6. proteolysis Source: RefGenome
  7. response to lipopolysaccharide Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiREACT_196539. Metabolism of Angiotensinogen to Angiotensins.
REACT_199000. Activation of Matrix Metalloproteinases.
REACT_199052. Degradation of the extracellular matrix.

Protein family/group databases

MEROPSiS01.133.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin G (EC:3.4.21.20)
Alternative name(s):
Vimentin-specific protease
Short name:
VSP
Gene namesi
Name:Ctsg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:88563. Ctsg.

Subcellular locationi

Membrane
Note: Strongly associated with membranes.

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. extracellular space Source: Ensembl
  3. intermediate filament Source: UniProtKB-KW
  4. plasma membrane Source: Ensembl
  5. secretory granule Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarityAdd
BLAST
Propeptidei19 – 202Activation peptidePRO_0000027514
Chaini21 – 261241Cathepsin GPRO_0000027515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 65 By similarity
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi142 ↔ 207 By similarity
Disulfide bondi172 ↔ 186 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiP28293.

PTM databases

PhosphoSiteiP28293.

Expressioni

Gene expression databases

ArrayExpressiP28293.
BgeeiP28293.
CleanExiMM_CTSG.
GenevestigatoriP28293.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015583.

Structurei

3D structure databases

ProteinModelPortaliP28293.
SMRiP28293. Positions 21-243.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 243223Peptidase S1Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP28293.
KOiK01319.
OMAiNIRNDIM.
OrthoDBiEOG7RRF7Z.
PhylomeDBiP28293.
TreeFamiTF333630.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28293-1 [UniParc]FASTAAdd to Basket

« Hide

MQPLLLLLTF ILLQGDEAGK IIGGREARPH SYPYMAFLLI QSPEGLSACG    50
GFLVREDFVL TAAHCLGSSI NVTLGAHNIQ MRERTQQLIT VLRAIRHPDY 100
NPQNIRNDIM LLQLRRRARR SGSVKPVALP QASKKLQPGD LCTVAGWGRV 150
SQSRGTNVLQ EVQLRVQMDQ MCANRFQFYN SQTQICVGNP RERKSAFRGD 200
SGGPLVCSNV AQGIVSYGSN NGNPPAVFTK IQSFMPWIKR TMRRFAPRYQ 250
RPANSLSQAQ T 261
Length:261
Mass (Da):29,096
Last modified:October 1, 1996 - v2
Checksum:i5EFA1A6E10E1D7FC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511G → S AA sequence 1 Publication
Sequence conflicti56 – 561E → G AA sequence 1 Publication
Sequence conflicti60 – 601L → P AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96801 Genomic DNA. Translation: AAA37376.1.
X70057 Genomic DNA. Translation: CAA49661.1.
X78544 mRNA. Translation: CAA55290.1.
CCDSiCCDS27142.1.
PIRiS40162.
RefSeqiNP_031826.1. NM_007800.1.
UniGeneiMm.4858.

Genome annotation databases

EnsembliENSMUST00000015583; ENSMUSP00000015583; ENSMUSG00000040314.
GeneIDi13035.
KEGGimmu:13035.
UCSCiuc007ubn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96801 Genomic DNA. Translation: AAA37376.1 .
X70057 Genomic DNA. Translation: CAA49661.1 .
X78544 mRNA. Translation: CAA55290.1 .
CCDSi CCDS27142.1.
PIRi S40162.
RefSeqi NP_031826.1. NM_007800.1.
UniGenei Mm.4858.

3D structure databases

ProteinModelPortali P28293.
SMRi P28293. Positions 21-243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000015583.

Chemistry

BindingDBi P28293.
ChEMBLi CHEMBL5622.

Protein family/group databases

MEROPSi S01.133.

PTM databases

PhosphoSitei P28293.

Proteomic databases

PRIDEi P28293.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015583 ; ENSMUSP00000015583 ; ENSMUSG00000040314 .
GeneIDi 13035.
KEGGi mmu:13035.
UCSCi uc007ubn.1. mouse.

Organism-specific databases

CTDi 1511.
MGIi MGI:88563. Ctsg.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P28293.
KOi K01319.
OMAi NIRNDIM.
OrthoDBi EOG7RRF7Z.
PhylomeDBi P28293.
TreeFami TF333630.

Enzyme and pathway databases

Reactomei REACT_196539. Metabolism of Angiotensinogen to Angiotensins.
REACT_199000. Activation of Matrix Metalloproteinases.
REACT_199052. Degradation of the extracellular matrix.

Miscellaneous databases

NextBioi 282916.
PROi P28293.
SOURCEi Search...

Gene expression databases

ArrayExpressi P28293.
Bgeei P28293.
CleanExi MM_CTSG.
Genevestigatori P28293.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene."
    Heusel J.W., Scarpati E.M., Jenkins N.A., Gilbert D.J., Copeland N.G., Shapiro S.D., Ley T.J.
    Blood 81:1614-1623(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Swiss Webster.
    Tissue: Embryonic fibroblast.
  2. Kulmburg P., Baumruker T., Werner F.
    Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Huang R., Aveskogh M., Hellman L.T.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Leaden X A1.
  4. "Purification and characterization of a vimentin-specific protease in mouse myeloid leukemia cells. Regulation during differentiation and identity with cathepsin G."
    Nakamura N., Tsuru A., Hirayoshi K., Nagata K.
    Eur. J. Biochem. 205:947-954(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-60.

Entry informationi

Entry nameiCATG_MOUSE
AccessioniPrimary (citable) accession number: P28293
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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