P28293 (CATG_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 103.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cathepsin G EC=3.4.21.20 Alternative name(s): Vimentin-specific protease Short name=VSP | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) [Reference proteome] | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus![]() |
Protein attributes
| Sequence length | 261 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. |
| Catalytic activity | Specificity similar to chymotrypsin C. |
| Subcellular location | Membrane. Note: Strongly associated with membranes. |
| Sequence similarities | Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | By similarity | ||||||||
| Propeptide | 19 – 20 | 2 | Activation peptide | PRO_0000027514 | |||||||
| Chain | 21 – 261 | 241 | Cathepsin G | PRO_0000027515 | |||||||
Regions | |||||||||||
| Domain | 21 – 243 | 223 | Peptidase S1 | ||||||||
Sites | |||||||||||
| Active site | 64 | 1 | Charge relay system By similarity | ||||||||
| Active site | 108 | 1 | Charge relay system By similarity | ||||||||
| Active site | 201 | 1 | Charge relay system By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 71 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 49 ↔ 65 | By similarity | |||||||||
| Disulfide bond | 142 ↔ 207 | By similarity | |||||||||
| Disulfide bond | 172 ↔ 186 | By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 51 | 1 | G → S AA sequence Ref.4 | ||||||||
| Sequence conflict | 56 | 1 | E → G AA sequence Ref.4 | ||||||||
| Sequence conflict | 60 | 1 | L → P AA sequence Ref.4 | ||||||||
Sequences
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References
| [1] | "Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene." Heusel J.W., Scarpati E.M., Jenkins N.A., Gilbert D.J., Copeland N.G., Shapiro S.D., Ley T.J. Blood 81:1614-1623(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Swiss Webster. Tissue: Embryonic fibroblast. |
| [2] | Kulmburg P., Baumruker T., Werner F. Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. |
| [3] | Huang R., Aveskogh M., Hellman L.T. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Leaden X A1. |
| [4] | "Purification and characterization of a vimentin-specific protease in mouse myeloid leukemia cells. Regulation during differentiation and identity with cathepsin G." Nakamura N., Tsuru A., Hirayoshi K., Nagata K. Eur. J. Biochem. 205:947-954(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-60. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M96801 Genomic DNA. Translation: AAA37376.1. X70057 Genomic DNA. Translation: CAA49661.1. X78544 mRNA. Translation: CAA55290.1. |
| IPI | IPI00118696. |
| PIR | S40162. |
| RefSeq | NP_031826.1. NM_007800.1. |
| UniGene | Mm.4858. |
3D structure databases | |
| ProteinModelPortal | P28293. |
| SMR | P28293. Positions 21-243. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 10090.ENSMUSP00000015583. |
Protein family/group databases | |
| MEROPS | S01.133. |
PTM databases | |
| PhosphoSite | P28293. |
Proteomic databases | |
| PRIDE | P28293. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000015583; ENSMUSP00000015583; ENSMUSG00000040314. |
| GeneID | 13035. |
| KEGG | mmu:13035. |
Organism-specific databases | |
| CTD | 1511. |
| MGI | MGI:88563. Ctsg. |
Phylogenomic databases | |
| eggNOG | COG5640. |
| HOGENOM | HOG000251820. |
| HOVERGEN | HBG013304. |
| InParanoid | P28293. |
| KO | K01319. |
| OMA | RTQQHIT. |
| OrthoDB | EOG4KWJTW. |
Gene expression databases | |
| ArrayExpress | P28293. |
| Bgee | P28293. |
| CleanEx | MM_CTSG. |
| Genevestigator | P28293. |
| GermOnline | ENSMUSG00000040314. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR009003. Trypsin-like_Pept_dom. [Graphical view] |
| Pfam | PF00089. Trypsin. 1 hit. [Graphical view] |
| PRINTS | PR00722. CHYMOTRYPSIN. |
| SMART | SM00020. Tryp_SPc. 1 hit. [Graphical view] |
| SUPFAM | SSF50494. Pept_Ser_Cys. 1 hit. |
| PROSITE | PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| BindingDB | P28293. |
| ChEMBL | CHEMBL5622. |
| NextBio | 282916. |
| SOURCE | Search... |
Entry information
| Entry name | CATG_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P28293 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
