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P28292

- CCL2_RABIT

UniProt

P28292 - CCL2_RABIT

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Protein

C-C motif chemokine 2

Gene
CCL2, SCYA2
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name:
MCP-1
Small-inducible cytokine A2
Gene namesi
Name:CCL2
Synonyms:SCYA2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarityAdd
BLAST
Chaini24 – 125102C-C motif chemokine 2PRO_0000005152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid By similarity
Disulfide bondi34 ↔ 59 By similarity
Disulfide bondi35 ↔ 75 By similarity
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi112 – 1121N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium By similarity.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000015636.

Structurei

3D structure databases

ProteinModelPortaliP28292.
SMRiP28292. Positions 24-99.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46819.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28292-1 [UniParc]FASTAAdd to Basket

« Hide

MKVSATLLCL LLIAVAFSSH VLAQPDAVNS PVTCCYTFTN KTISVKRLMS    50
YRRINSTKCP KEAVIFMTKL AKGICADPKQ KWVQDAIANL DKKMQTPKTL 100
TSYSTTQEHT TNLSSTRTPS TTTSL 125
Length:125
Mass (Da):13,776
Last modified:December 1, 1992 - v1
Checksum:i24C3A542CB6A47EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57440 mRNA. Translation: AAA31386.1.
PIRiI46857.
RefSeqiNP_001075763.1. NM_001082294.1.
UniGeneiOcu.1921.

Genome annotation databases

GeneIDi100009130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57440 mRNA. Translation: AAA31386.1 .
PIRi I46857.
RefSeqi NP_001075763.1. NM_001082294.1.
UniGenei Ocu.1921.

3D structure databases

ProteinModelPortali P28292.
SMRi P28292. Positions 24-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000015636.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100009130.

Organism-specific databases

CTDi 6347.

Phylogenomic databases

eggNOGi NOG46819.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Neutrophil attractant/activation protein-1 and monocyte chemoattractant protein-1 in rabbit. cDNA cloning and their expression in spleen cells."
    Yoshimura T., Yuhki N.
    J. Immunol. 146:3483-3488(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Spleen.

Entry informationi

Entry nameiCCL2_RABIT
AccessioniPrimary (citable) accession number: P28292
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: March 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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