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P28292

- CCL2_RABIT

UniProt

P28292 - CCL2_RABIT

Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemotactic factor that attracts monocytes, but not neutrophils.

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 2
    Alternative name(s):
    Monocyte chemoattractant protein 1
    Monocyte chemotactic protein 1
    Short name:
    MCP-1
    Small-inducible cytokine A2
    Gene namesi
    Name:CCL2
    Synonyms:SCYA2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 125102C-C motif chemokine 2PRO_0000005152Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi34 ↔ 59By similarity
    Disulfide bondi35 ↔ 75By similarity
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Interactioni

    Subunit structurei

    Monomer or homodimer; in equilibrium.By similarity

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000015636.

    Structurei

    3D structure databases

    ProteinModelPortaliP28292.
    SMRiP28292. Positions 24-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46819.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28292-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSATLLCL LLIAVAFSSH VLAQPDAVNS PVTCCYTFTN KTISVKRLMS    50
    YRRINSTKCP KEAVIFMTKL AKGICADPKQ KWVQDAIANL DKKMQTPKTL 100
    TSYSTTQEHT TNLSSTRTPS TTTSL 125
    Length:125
    Mass (Da):13,776
    Last modified:December 1, 1992 - v1
    Checksum:i24C3A542CB6A47EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57440 mRNA. Translation: AAA31386.1.
    PIRiI46857.
    RefSeqiNP_001075763.1. NM_001082294.1.
    UniGeneiOcu.1921.

    Genome annotation databases

    GeneIDi100009130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57440 mRNA. Translation: AAA31386.1 .
    PIRi I46857.
    RefSeqi NP_001075763.1. NM_001082294.1.
    UniGenei Ocu.1921.

    3D structure databases

    ProteinModelPortali P28292.
    SMRi P28292. Positions 24-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000015636.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100009130.

    Organism-specific databases

    CTDi 6347.

    Phylogenomic databases

    eggNOGi NOG46819.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neutrophil attractant/activation protein-1 and monocyte chemoattractant protein-1 in rabbit. cDNA cloning and their expression in spleen cells."
      Yoshimura T., Yuhki N.
      J. Immunol. 146:3483-3488(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New Zealand white.
      Tissue: Spleen.

    Entry informationi

    Entry nameiCCL2_RABIT
    AccessioniPrimary (citable) accession number: P28292
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3